CN104171648A - Feed additive capable of promoting liver health of fish - Google Patents
Feed additive capable of promoting liver health of fish Download PDFInfo
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- CN104171648A CN104171648A CN201410359787.0A CN201410359787A CN104171648A CN 104171648 A CN104171648 A CN 104171648A CN 201410359787 A CN201410359787 A CN 201410359787A CN 104171648 A CN104171648 A CN 104171648A
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Abstract
The invention discloses a feed additive capable of promoting the liver health of fish. The feed additive capable of promoting the liver health of fish is composed of the following constituents in total 100 percentage by mass: 15-20% of bile acid, 10-15% of tauric acid, 10-15% of beta-glucan, 8-12% of mannan oligosaccharide, 5-8% of L-carnitine, 6-10% of choline and the balance of fillers; the added amount of the feed additive capable of promoting the liver health of fish, disclosed by the invention, is 0.1-0.2% of the total mass of the feed; the feed additive is capable of reducing the accumulation of fat in the fish liver, improving the capacity of the fish liver for transferring fat, reducing the metabolism burdens of the liver, and improving the health conditions of fish bodies and promoting growth; during the use of the feed additive disclosed by the invention, the main formula of the feed does not need to be changed specially, thus reducing the labour and material costs during the production process of the feed; the raw materials of the feed additive disclosed by the invention are mainly prepared from animal tissues and beer yeast and are stable in source; therefore, the feed additive is natural, environment-friendly, safe and non-toxic.
Description
Technical field:
The present invention relates to a kind of feed addictive, be specifically related to a kind of feed addictive that promotes fish liver health.
Background technology:
China is aquaculture big country, and aquaculture amount has occupied the whole world 70%, 2013 year China's aquatic feeds output that since 1,2012 year, aquaculture output accounted for global output throughout the year and reaches 1,900 ten thousand tons, accounts for 50% of global output.But along with the fast development of the leading culture fishery of high-density breeding pattern, the frequency of cultured fishes outbreak of disease and scale also day by day rise, caused serious impact to further developing of aquaculture.Trace it to its cause, mainly that the high enterprise of the shortage of the high-quality feed raw materials such as fish meal and price causes other cheap vegetality feedstuff constantly to increase as the scope of application and the consumption of dregs of beans, the dish dregs of rice, peanut press pulp, cotton dregs etc., thereby cause the harmonious destruction of feed nutrition, the increase of ANFs content, feed to digest and assimilate the problems such as decrease in efficiency and damage enteron aisle and liver health, these have all brought serious consequence to the ecological environment in the growth of cultured fishes, health and cultivation waters.
Liver is one of most important metabolism organ of fish, and the health of liver directly has influence on growth and the health of whole fish body, in the industry the liver health of cultured fishes is quite paid attention at present.Bibliographical information some nutrient or the lipometabolic impact of lipopenicillinase factor pair fish liver (Du Zhenyu etc., 2002; Haitao Zhang etc., 2004), and adipose metabolism mechanism is studied to discussion.Wang Hualang etc. disclose a kind of compound additive (ZL200810028597.5) that prevents cobia fatty liver, Wang Zhuoduo etc. disclose a kind of mixed feed and preparation method (ZL201110152285.7) that can improve fish fatty liver and body colour, Zhang Lu etc. disclose a kind of Chinese herbal feed additive (ZL201110161326.9) of preventing and treating cultured freshwater fish auxotype liver and gall syndrome, but these published Patents are mainly from nutrient formulation or Chinese herb feed additive, need in actual use feed formula to make very large adjustment, and Chinese herb feed additive is due to complicated component, be difficult to active ingredient wherein to carry out qualitative and quantitative analysis, these factors are all brought great difficulty to actual promoting the use of.
Summary of the invention:
The object of this invention is to provide and a kind ofly can promote cultured fishes liver health, reduce Liver fatty deposition and other hepatic disease, and can be widely used in the feed addictive of all kinds of aquaculture fish.The feed addictive of promotion fish liver health of the present invention is a kind ofly to produce simple, functional components and content is clear and the functional feedstuff additive that is easy to extensively promote the use of.
The feed addictive of promotion fish liver health of the present invention; it is characterized in that; by mass percent 100%; composed of the following components: bile acid 15～20%, taurine 10～15%, beta glucan 10～15%; manna oligosacchride 8～12%; VBT 5～8%, choline 6～10%, all the other are filler.
Described bile acid is produced from animal bile, concrete preparation method's list of references (reliction etc., hyodesoxycholic acid Study on extraction, 2004), described beta glucan and manna oligosacchride extract from beer yeast cells wall, concrete extracting method list of references (Duan Shenglin etc. adopt catalysis self-dissolving and biological wall breaking technology to extract beer yeast cells wall polysaccharide, 2012).
Described filler, is preferably chaff powder.
The taurine using in the present invention, VBT, choline and chaff powder are known conventional material, all can buy from market.
Of the present inventionly a kind ofly promote the preparation method of the feed addictive of fish liver health to be: bile acid, taurine, beta glucan, manna oligosacchride, choline and chaff powder fully to be mixed by mass percentage and be dried and make powder, be promoted the feed addictive of fish liver health.
The feed addictive of promotion fish liver health of the present invention is to use like this: when feed granulating, add feed addictive of the present invention, its addition is 0.1～0.2% of feed gross mass.
The present invention uses animal bile acid, taurine and yeast immune polysaccharide (beta glucan and manna oligosacchride), vitamin D 3-analogies (VBT and choline) to carry out reasonable compatibility first; can effectively improve fish liver metabolic function; promote that fat transfer goes out liver cell; add Chinese herring body to fatty metabolic rate; and strengthen liver detoxification function, prevention and maintenance hepatic injury etc.The colored liver of the appearance that collaboration feed is fed in fish process, white liver, hepatitis, fatty liver or other hepatic disease all can play good preventive and therapeutic effect.
The present invention is directed to the collaboration feed problems such as the Liver fatty deposition that occurs in cultured fishes process, hepatic disease of feeding; prepare a kind of functional feedstuff additive, its active ingredient is the various bioactivators such as bile acid, taurine, beta glucan, manna oligosacchride, VBT and choline.Bile acid and taurine can increase the dissolubility of lipid and cholesterol, effectively improve animal absorbing fat, liposoluble vitamin and cholesterol; Beta glucan and manna oligosacchride can be safeguarded that animal intestinal is healthy, adsorb bacterium and virus and impel its quickening to excrete, strengthen Fish Immunity, promote growth of animal and improve food utilization efficiency; Thereby VBT and choline promote the lipid in muscle to enter mitochondrial oxidation decomposes, promotes the fat in liver by blood, to be transported away and prevented the deposition of fat in liver cell by liver with phospholipid form.
The main function composition bile acid of the feed addictive of promotion fish liver health of the present invention derives from animal tissue, and beta glucan and manna oligosacchride derive from beer yeast cells wall, all belong to natural materials, and use procedure has safe, nontoxic feature.
The related composition of feed addictive of promotion fish liver health of the present invention all can carry out quantitative analysis, and it is promoted the use of, and science is reliable more, and reparation technology and use procedure are simple.
Through long-term culture experiments of cultured fishes such as Tilapia mossambica, snakehead, California perch, grass carps, prove, the feed addictive of promotion fish liver health provided by the invention can effectively reduce fat deposition amount in fish liver, improves liver health, reduces pathogenesis of fatty liver rate, reduce fat content in blood, can strengthen Fish Immunity and antioxidant ability of organism simultaneously, and effectively promote to improve food utilization efficiency by fish bulk-growth.
The growth-promoting effect of the feed addictive of promotion fish liver health of the present invention is better than the single bile acid product (Tan Yonggang etc. of bibliographical information; 2008) and single taurine product (Luo Li etc.; 2006); reduce liver and blood fat content and safeguard that the effect of liver health is better than single choline product (Huang Kai etc.; 2007) and single taurine product (Luo Yiwen etc., 2013).
The present invention has following technique effect: (1) reduces the accumulation of fat in fish liver, improves fish liver and transports fatty ability, alleviates liver metabolism burden, improves fish body health status and promotes growth; (2) this product is pulvis, and the addition in feed is 0.1-0.2%, and it is all very convenient to produce with adding procedure; (3) with by adjusting feedstuff promote fish body health and growth phase ratio, the use of this product does not need the large formula of feed to make special adjustment, has reduced the man power and material's cost in production of fodder process; (4) this raw materials of feed additives is mainly produced from animal tissue and brewer's yeast, steady sources, and there is the feature of natural environmental-protective, safety non-toxic.
Accompanying drawing explanation:
Fig. 1 is fish liver internal anatomy, and wherein, A is control group liver, and B is experimental group liver;
Fig. 2 is fish liver histotomy figure, and wherein, A is control group liver, and B is experimental group liver.
The specific embodiment:
Following examples are to further illustrate of the present invention, rather than limitation of the present invention.
Embodiment 1:
By mass percent 100%, get respectively bile acid 15%, taurine 10%, beta glucan 10%, manna oligosacchride 8%, VBT 8%, choline 6%, chaff powder 43% fully mixes and is dried makes powder, is promoted the feed addictive of fish liver health;
The Tilapia mossambica of choosing initial body weight and be 245.56 ± 1.34g/ tail carries out the cage culture experiment of 2 months by a definite date, experimental group is thrown something and fed and has been added the feed of the prepared feed addictive of the present embodiment, addition is 0.2% of common commercial feeding quality, the control group common commercial feed of throwing something and feeding.Test last determination experiment fish rate of body weight gain, feed coefficient, liver body ratio and hepatic fat content, and the content of the MDA in serum, cholesterol, triglycerides, HDL, low-density lipoprotein and glutamic-pyruvic transaminase and vigor are sampled to detection.The results are shown in Table 1.
Each index determining result of table 1. control group and experimental group
Result shows, feed addictive prepared by the present embodiment adds in feed by 0.2% mass ratio, can significantly improve Tilapia mossambica rate of body weight gain, significantly reduce feed coefficient, significantly reduce mda content in hepatic fat content and serum, and effectively reduce content and the activity of cholesterol in serum, triglycerides, HDL, low-density lipoprotein and glutamic-pyruvic transaminase, tilapia fatty liver is occurred and hepatic disease has played good prevention effect.
Embodiment 2:
By mass percent 100%, get respectively bile acid 20%, taurine 15%, beta glucan 15%, manna oligosacchride 12%, VBT 5%, choline 10%, chaff powder 23% fully mixes and is dried makes powder, is promoted the feed addictive of fish liver health;
The snakehead of choosing initial body weight 158.94 ± 1.63g/ tail carries out the cage culture experiment of 3 months by a definite date, experimental group is thrown something and fed and has been added the additive described in the embodiment of the present invention two, addition is 0.1% of common commercial feeding quality, the control group common commercial feed of throwing something and feeding.Test last determination experiment fish rate of body weight gain, feed coefficient, liver body ratio, dirty body ratio and coefficient of condition, and the MDA in serum, cholesterol, triglycerides, HDL, low-density lipoprotein content and glutamic-pyruvic transaminase and superoxide dismutase activity are sampled to detection.The results are shown in Table 2.
Each index determining result of table 2. control group and experimental group
Result shows, feed addictive prepared by the present embodiment adds in feed by 0.1% mass ratio, significantly improved the rate of body weight gain of snakehead, significantly reduced the activity of feed coefficient, muscle fat content and serum glutamic pyruvic transminase, the content of coefficient of condition and Triglycerides in Serum, MDA all decreases simultaneously, in addition in serum, activity of SOD significantly raises, illustrate that additive of the present invention makes snakehead strengthen the repellence of oxygen free radical injury, has promoted the health of fish liver.
Embodiment 3:
By mass percent 100%, get respectively bile acid 18%, taurine 12%; beta glucan 12%, manna oligosacchride 10%, VBT 8%; choline 8%, chaff powder 32% fully mixes and is dried makes powder, is promoted the feed addictive of fish liver health.
In the perch common commercial feed of California, add the prepared feed addictive of the present embodiment 0.15%, carry out the pond culture experiment of 7 months by a definite date, from fry, raise the adult fish that reaches listing specification always, the control group common commercial feed of throwing something and feeding.Respectively experimental group and control group fish body are dissected to also observation period liver health situation, result as shown in Figure 1.From Fig. 1, can obviously find out, control group liver color shoals, and presents the hepatic disease symptoms such as typical colored liver and white liver, experimental group liver cerise, and smooth in appearance is glossy, is healthy liver.
Respectively experimental group and control group fish liver tissue are carried out to section statining and microscope inspection, result as shown in Figure 2.As can be seen from Figure 2, hepatolysis in control group liver section, cell boundaries are fuzzy, nucleus marginalisation phenomenon, and obvious liver physalis and fat drop have been observed, in experimental group liver section, liver cell border is obvious, nucleus is positioned at cell central authorities, and cellular morphology is normal, fat-free.
Claims (6)
1. a feed addictive that promotes fish liver health; it is characterized in that; by mass percent 100%; composed of the following components: bile acid 15～20%, taurine 10～15%, beta glucan 10～15%; manna oligosacchride 8～12%; VBT 5～8%, choline 6～10%, all the other are filler.
2. the feed addictive of promotion fish liver health according to claim 1, is characterized in that, described filler is chaff powder.
3. the feed addictive of promotion fish liver health according to claim 1, is characterized in that, described fish are Tilapia mossambica, snakehead, California perch, grass carp.
4. the feed addictive of promotion fish liver health according to claim 1, is characterized in that, by mass percent 100%, composed of the following components: bile acid 18%; taurine 12%, beta glucan 12%, manna oligosacchride 10%; VBT 8%, choline 8%, filler 32%.
5. the feed addictive of promotion fish liver health according to claim 1, is characterized in that, by mass percent 100%, composed of the following components: bile acid 15%; taurine 10%, beta glucan 10%, manna oligosacchride 8%; VBT 8%, choline 6%, filler 43%.
6. the feed addictive of promotion fish liver health according to claim 1, is characterized in that, by mass percent 100%, composed of the following components: bile acid 20%; taurine 15%, beta glucan 15%, manna oligosacchride 12%; VBT 5%, choline 10%, filler 23%.
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| CN104397429A (en) * | 2014-12-05 | 2015-03-11 | 湛江市海荣饲料有限公司 | Additive premix for stereo cultivation of Tilapia mossambica as well as preparation method and use method thereof |
| CN104664170A (en) * | 2015-03-20 | 2015-06-03 | 广东海大集团股份有限公司 | Feed additive for preventing fatty liver of largemouth bass |
| CN105124203A (en) * | 2015-08-11 | 2015-12-09 | 中粮饲料有限公司 | Grass carp growth performance improving feed and preparation method thereof |
| CN105166577A (en) * | 2015-10-21 | 2015-12-23 | 青岛玛斯特生物技术有限公司 | Compound emulsifier for increasing fat utilization rate of aquatic feed |
| CN105230986A (en) * | 2015-10-29 | 2016-01-13 | 广东汇海农牧科技集团有限公司 | Green healthy tilapia feed |
| CN105614159A (en) * | 2015-12-25 | 2016-06-01 | 湖州海皇生物科技有限公司 | Puffed mixed feed for local ophicephalus argus in whole process |
| CN105639191A (en) * | 2015-12-31 | 2016-06-08 | 西南大学 | Feed additive for protecting intestinal health of hybrid snakehead fish and preparation method of feed additive |
| CN105724839A (en) * | 2016-03-10 | 2016-07-06 | 广州市番禺区大川饲料有限公司 | Assorted feed for preventing liver of tilapia from becoming yellow |
| CN106616067A (en) * | 2017-02-24 | 2017-05-10 | 广东恒兴饲料实业股份有限公司 | Growth promoter for adult hybrid tilapia as well as preparation method and use method of growth promoter |
| CN107594225A (en) * | 2017-10-27 | 2018-01-19 | 无锡华诺威动物保健品有限公司 | A kind of feed addictive of fish liver health and preparation method thereof |
| CN108323628A (en) * | 2018-01-29 | 2018-07-27 | 珠海联鲲生物科技有限公司 | A kind of premix and its application for grass carp liver and gallbladder protection |
| CN108522858A (en) * | 2018-07-09 | 2018-09-14 | 山东龙昌动物保健品有限公司 | Application of the bile acid in preparing the feed addictive for Micropterus salmoides |
| CN108606187A (en) * | 2018-04-19 | 2018-10-02 | 广东联鲲集团有限公司 | It is a kind of prevent golden pomfret hepatic disease additive and its application |
| CN109198263A (en) * | 2018-09-26 | 2019-01-15 | 佛山市顺德区旺海饲料实业有限公司 | A kind of liver and gallbladder protection feed addictive of Chinese snake head, expanded pellet diet and preparation method thereof |
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
| CN109497354A (en) * | 2019-01-03 | 2019-03-22 | 中国海洋大学 | Larimichthys crocea feed addictive, mixed feed and its preparation method and application |
| CN110537627A (en) * | 2019-09-16 | 2019-12-06 | 江门市旺海饲料实业有限公司 | Feed additive and feed |
| CN110651915A (en) * | 2019-09-20 | 2020-01-07 | 福建天马科技集团股份有限公司 | Compound functional additive for large yellow croaker puffed compound feed and preparation method thereof |
| CN111972566A (en) * | 2020-08-24 | 2020-11-24 | 固安桑普生化技术有限公司 | Puffed sinking feed for promoting liver and pancreas health of procambarus clarkii and preparation method thereof |
| CN113331321A (en) * | 2020-05-09 | 2021-09-03 | 新希望六和股份有限公司 | Nutritional feed for regulating and controlling liver health development of micropterus salmoides |
| CN114343082A (en) * | 2021-12-31 | 2022-04-15 | 无锡华诺威动物保健品有限公司 | Fish feed additive, application thereof and fish culture feed |
| CN115736139A (en) * | 2022-12-21 | 2023-03-07 | 江西省农业科学院畜牧兽医研究所 | Feed additive for reducing fat content in liver of cultured fish and preparation method thereof |
| CN115956638A (en) * | 2022-12-09 | 2023-04-14 | 无锡华诺威动物保健品有限公司 | Composition with liver-strengthening stress-resistant effect and application thereof |
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| CN104397429A (en) * | 2014-12-05 | 2015-03-11 | 湛江市海荣饲料有限公司 | Additive premix for stereo cultivation of Tilapia mossambica as well as preparation method and use method thereof |
| CN104664170A (en) * | 2015-03-20 | 2015-06-03 | 广东海大集团股份有限公司 | Feed additive for preventing fatty liver of largemouth bass |
| CN105124203A (en) * | 2015-08-11 | 2015-12-09 | 中粮饲料有限公司 | Grass carp growth performance improving feed and preparation method thereof |
| CN105166577A (en) * | 2015-10-21 | 2015-12-23 | 青岛玛斯特生物技术有限公司 | Compound emulsifier for increasing fat utilization rate of aquatic feed |
| CN105230986A (en) * | 2015-10-29 | 2016-01-13 | 广东汇海农牧科技集团有限公司 | Green healthy tilapia feed |
| CN105614159A (en) * | 2015-12-25 | 2016-06-01 | 湖州海皇生物科技有限公司 | Puffed mixed feed for local ophicephalus argus in whole process |
| CN105639191A (en) * | 2015-12-31 | 2016-06-08 | 西南大学 | Feed additive for protecting intestinal health of hybrid snakehead fish and preparation method of feed additive |
| CN105639191B (en) * | 2015-12-31 | 2019-08-30 | 西南大学 | A kind of feed addictive and preparation method thereof for protecting hybridized snakehead fish intestinal health |
| CN105724839A (en) * | 2016-03-10 | 2016-07-06 | 广州市番禺区大川饲料有限公司 | Assorted feed for preventing liver of tilapia from becoming yellow |
| CN106616067A (en) * | 2017-02-24 | 2017-05-10 | 广东恒兴饲料实业股份有限公司 | Growth promoter for adult hybrid tilapia as well as preparation method and use method of growth promoter |
| CN107594225A (en) * | 2017-10-27 | 2018-01-19 | 无锡华诺威动物保健品有限公司 | A kind of feed addictive of fish liver health and preparation method thereof |
| CN108323628A (en) * | 2018-01-29 | 2018-07-27 | 珠海联鲲生物科技有限公司 | A kind of premix and its application for grass carp liver and gallbladder protection |
| CN108606187A (en) * | 2018-04-19 | 2018-10-02 | 广东联鲲集团有限公司 | It is a kind of prevent golden pomfret hepatic disease additive and its application |
| CN108522858A (en) * | 2018-07-09 | 2018-09-14 | 山东龙昌动物保健品有限公司 | Application of the bile acid in preparing the feed addictive for Micropterus salmoides |
| CN109198263A (en) * | 2018-09-26 | 2019-01-15 | 佛山市顺德区旺海饲料实业有限公司 | A kind of liver and gallbladder protection feed addictive of Chinese snake head, expanded pellet diet and preparation method thereof |
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
| CN109464435B (en) * | 2018-11-30 | 2021-06-29 | 河南师范大学 | Pharmaceutical composition for preventing and treating fish liver inflammation |
| CN109497354A (en) * | 2019-01-03 | 2019-03-22 | 中国海洋大学 | Larimichthys crocea feed addictive, mixed feed and its preparation method and application |
| CN110537627A (en) * | 2019-09-16 | 2019-12-06 | 江门市旺海饲料实业有限公司 | Feed additive and feed |
| CN110651915A (en) * | 2019-09-20 | 2020-01-07 | 福建天马科技集团股份有限公司 | Compound functional additive for large yellow croaker puffed compound feed and preparation method thereof |
| CN113331321B (en) * | 2020-05-09 | 2023-08-22 | 新希望六和股份有限公司 | Nutritional feed for regulating liver health development of young micropterus salmoides |
| CN113331321A (en) * | 2020-05-09 | 2021-09-03 | 新希望六和股份有限公司 | Nutritional feed for regulating and controlling liver health development of micropterus salmoides |
| CN111972566A (en) * | 2020-08-24 | 2020-11-24 | 固安桑普生化技术有限公司 | Puffed sinking feed for promoting liver and pancreas health of procambarus clarkii and preparation method thereof |
| CN114343082A (en) * | 2021-12-31 | 2022-04-15 | 无锡华诺威动物保健品有限公司 | Fish feed additive, application thereof and fish culture feed |
| CN115956638A (en) * | 2022-12-09 | 2023-04-14 | 无锡华诺威动物保健品有限公司 | Composition with liver-strengthening stress-resistant effect and application thereof |
| CN115956638B (en) * | 2022-12-09 | 2024-02-23 | 无锡华诺威动物保健品有限公司 | Composition with liver strengthening and stress resisting effects and application thereof |
| CN115736139A (en) * | 2022-12-21 | 2023-03-07 | 江西省农业科学院畜牧兽医研究所 | Feed additive for reducing fat content in liver of cultured fish and preparation method thereof |
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Application publication date: 20141203 |