CN111770924A - 用于治疗乳腺癌的雌激素受体降解剂 - Google Patents
用于治疗乳腺癌的雌激素受体降解剂 Download PDFInfo
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- CN111770924A CN111770924A CN201980015908.0A CN201980015908A CN111770924A CN 111770924 A CN111770924 A CN 111770924A CN 201980015908 A CN201980015908 A CN 201980015908A CN 111770924 A CN111770924 A CN 111770924A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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Abstract
本发明涉及某些新颖化合物或其药用盐，它们具有抗癌活性并且因此潜在有用于治疗人体或动物体的方法。本发明还涉及用于制造所述化合物的方法、含有它们的药物组合物以及它们在治疗方法中的用途，例如用于制造供预防或治疗温血动物(如人)的癌症用的药物，包括用于预防或治疗癌症。本发明还涉及为雌激素受体的选择性下调调节剂的化合物。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018081947 | 2018-04-04 | ||
| CNPCT/CN2018/081947 | 2018-04-04 | ||
| PCT/CN2019/081314 WO2019192533A1 (zh) | 2018-04-04 | 2019-04-03 | 用于治疗乳腺癌的雌激素受体降解剂 |
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| CN111770924A true CN111770924A (zh) | 2020-10-13 |
| CN111770924B CN111770924B (zh) | 2023-05-09 |
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| CN201910267855.3A Active CN110343101B (zh) | 2018-04-04 | 2019-04-03 | 用于治疗乳腺癌的雌激素受体降解剂 |
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| WO2019192533A1 (zh) * | 2018-04-04 | 2019-10-10 | 深圳福沃药业有限公司 | 用于治疗乳腺癌的雌激素受体降解剂 |
| WO2021139756A1 (zh) * | 2020-01-10 | 2021-07-15 | 江苏恒瑞医药股份有限公司 | 三环四氢异喹啉类衍生物、其制备方法及其在医药上的应用 |
| EP4310079A1 (en) * | 2021-03-15 | 2024-01-24 | Shenzhen Forward Pharmaceuticals Co., Limited | Estrogen receptor antagonist |
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| AU2014281511A1 (en) * | 2013-06-19 | 2015-12-03 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator and uses thereof |
| KR20180071274A (ko) * | 2015-10-01 | 2018-06-27 | 올레마 파마슈티컬스 인코포레이티드 | 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물 |
| RU2734501C2 (ru) * | 2016-02-05 | 2020-10-19 | Инвентисбио Инк. | Селективные ингибиторы эстрогеновых рецепторов и их применение |
| TW201803870A (zh) * | 2016-04-20 | 2018-02-01 | 阿斯特捷利康公司 | 化學化合物 |
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2019
- 2019-04-03 WO PCT/CN2019/081314 patent/WO2019192533A1/zh active Application Filing
- 2019-04-03 CN CN201980015908.0A patent/CN111770924B/zh active Active
- 2019-04-03 CN CN201910267855.3A patent/CN110343101B/zh active Active
Patent Citations (7)
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| WO2005009389A2 (en) * | 2003-07-23 | 2005-02-03 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| CN105814043A (zh) * | 2013-12-09 | 2016-07-27 | Ucb生物制药私人有限公司 | 用作tnf活性调节剂的三唑并吡啶衍生物 |
| CN106661018A (zh) * | 2014-06-13 | 2017-05-10 | 默沙东公司 | 用作神经原纤维缠结显像剂的吡咯并[2,3‑c]吡啶 |
| CN107108611A (zh) * | 2014-12-18 | 2017-08-29 | 豪夫迈·罗氏有限公司 | 四氢‑吡啶并[3,4‑b]吲哚雌激素受体调节剂及其用途 |
| WO2018005249A1 (en) * | 2016-06-28 | 2018-01-04 | Merck Sharp & Dohme Corp. | Benzoisoquinolinone m1 receptor positive allosteric modulators |
| CN110343101A (zh) * | 2018-04-04 | 2019-10-18 | 深圳福沃药业有限公司 | 用于治疗乳腺癌的雌激素受体降解剂 |
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| Publication number | Publication date |
|---|---|
| CN110343101A (zh) | 2019-10-18 |
| CN111770924B (zh) | 2023-05-09 |
| CN110343101B (zh) | 2022-07-12 |
| WO2019192533A1 (zh) | 2019-10-10 |
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