CN111728211A - 一种野樱莓多肽抗衰老复合制剂及其制备方法 - Google Patents
一种野樱莓多肽抗衰老复合制剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种野樱莓多肽抗衰老复合制剂及其制备方法，本发明属于保健品食品制剂领域。该制剂由以下配方组成：大豆肽粉、野樱莓果粉、菊粉、玉米低聚肽、红樱桃果粉、甜菊糖苷、白藜芦醇、银耳多糖、烟酰胺、熊果苷；采用野樱莓与烟酰胺相复合与直接添加野樱莓与β烟酰胺单核苷酸(NMN)相复合得到的制剂相比，具有更高的经济效应，且抗衰老效果与直接添加β烟酰胺单核苷酸更好，体内NAD+浓度升高可以有效防止DNA突变导致的衰老和癌变。
Description
技术领域
本发明属于保健品、食品、药品制剂领域，具体涉及一种野樱莓多肽抗衰老复合制剂及其制备方法。
背景技术
野樱莓原产于北美洲东部，又被称为“不老莓”，是一种营养价值很高的水果。它富含花青素，既具有非常强的抗氧化性，也具有提高免疫力、抗衰老、抗癌、抗心血管疾病、促进视红素再合成等多种生理活性。在欧美和东亚地区，这种水果已经作为重要的食品原料，但是在我国，这种水果尚未用于食品行业，其深加工产品亦有待开发。细胞衰老理论指出，机体衰老主要是由于细胞功能的减退，而细胞功能减退，很大程度上是由线粒体发生功能障碍导致的。线粒体是身体的能量工厂。当线粒体损伤时，导致过多活性氧(即氧化自由基)的生成。
活性氧引起线粒体蛋白、脂类和核酸氧化损伤，并由此进一步抑制氧化磷酸化和加重活性氧生成，使得细胞不能产生足够的能量，最终走向凋亡，这就是人会慢慢衰老的原因。研究表明，在整个能量生产和损伤发生的过程中，NAD+水平高低就尤为重要了。NAD+全名烟酰胺腺嘌呤双核苷酸，又称辅酶I或者诺加因子，参与人体内上千种氧化还原的酶反应。
β烟酰胺单核苷酸(NMN)可以直接参与细胞内NAD+的合成。因此补充NMN可以很好地延缓衰老，有望预防和治疗与衰老相关的疾病，但是NMN在市场的价格十分昂贵制约了该抗衰老适用人群的选择。
烟酰胺又称尼克酰胺，是烟酸的酰胺化合物，烟酰胺与5-磷酸核糖-1-焦磷酸在体内的烟酰胺磷酸核糖转移酶的作用下可以转化成β烟酰胺单核苷酸(NMN)，进而进一步转化成NAD+。
现有技术中尚没有将烟酰胺与5-磷酸核糖-1-焦磷酸复合使用得到β烟酰胺单核苷酸(NMN)，进一步的NMN在体内参与转化成NAD+的技术。
发明内容
针对上述背景技术中提到的不足以及存在的问题，本发明拟公开一种抗衰老效果好的保健品、食品的配方及工艺。
一种野樱莓多肽抗衰老复合制剂，其特征在于，由以下配方组成：大豆肽粉、野樱莓果粉、菊粉、玉米低聚肽、红樱桃果粉、甜菊糖苷、植物提取白藜芦醇、银耳多糖、烟酰胺、熊果苷。
作为优选，所述的复合制剂，按重量分数配比：大豆肽粉5-8份、野樱莓果粉5-15份、菊粉2-3份、玉米低聚肽5-10份、红樱桃果粉1-3份、甜菊糖苷0.5-1份、白藜芦醇0.5-2份、银耳多糖0.5-2份、烟酰胺0.1-0.5份、熊果苷3-5份。
作为优选，所述的复合制剂，按重量分数配比：大豆肽粉5份、野樱莓果粉10份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、烟酰胺0.3份、熊果苷3份。
所述的复合制剂，制备方法为：
(1)所述野樱莓果粉的制备过程为：将新鲜的野樱莓榨汁，烘干，制粒，控制粒径100目；
(2)将步骤(1)得到的野樱莓果粉与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
本发明的有益效果在于：
(1)本发明采用野樱莓与烟酰胺相复合与直接添加野樱莓与β烟酰胺单核苷酸(NMN)相复合得到的制剂相比，具有更高的经济效应，且抗衰老效果与直接添加β烟酰胺单核苷酸(NMN)更好。
(2)野樱莓中富含花青素，抗DNA突变效果良好，对转化合成NAD+有促进作用，与添加的NMN有相辅的效果，体内NAD+浓度升高可以有效防止DNA突变导致的衰老和癌变。
具体实施方案
以下实施例用于进一步阐述本发明，但不应理解为对本发明权利要求书请求保护范围的限制。
实施例1
配比为：大豆肽粉5份、野樱莓果粉10份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、烟酰胺0.3份、熊果苷3份。
制备方法为：
所述野樱莓果粉的制备过程为：将新鲜的野樱莓榨汁，烘干，制粒，控制粒径100目；将步骤(1)得到的野樱莓果粉与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
实施例2
配比为：大豆肽粉8份、野樱莓果粉10份、菊粉3份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多糖1份、烟酰胺0.3份、熊果苷3份。
制备方法为：
所述野樱莓果粉的制备过程为：将新鲜的野樱莓榨汁，烘干，制粒，控制粒径100目；将步骤(1)得到的野樱莓果粉与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
实施例3
配比为：大豆肽粉8份、野樱莓果粉10份、菊粉3份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多糖1份、烟酰胺0.3份、熊果苷4份。
所述野樱莓果粉的制备过程为：将新鲜的野樱莓榨汁，烘干，制粒，控制粒径100目；将步骤(1)得到的野樱莓果粉与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
对比例1
配比为：大豆肽粉5份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、烟酰胺0.3份、熊果苷3份其余制作工艺同实施例1。
对比例2
配比为：大豆肽粉5份、野樱莓果粉12份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、熊果苷3份。其余制作工艺同实施例1。
对比例3
配比为：大豆肽粉5份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、熊果苷3份。其余制作工艺同实施例1。
对比例4
配比为：大豆肽粉5份、野樱莓果粉10份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、NMN0.3份、熊果苷3份。其余制作工艺同实施例1。
将实施例1-3和对比例1-4所制的制剂进行测试。
昆明小鼠，36-38g，雌350只，雄350只(约80周大)，上海实验动物中心购买。室温18-22℃，相对湿度维持在60％-70％，光照12hr∶12hr(光∶暗)，使用前适应环境3天。
药效学实验：
材料和方法：
实验材料:实施例1-3所制备的保健品和对比例1-3所制备的保健品。
实验动物：昆明种小鼠(约80周大)；选用80周的老年小鼠。
给药方法：与食品一起喂食，每天早上8点一次。
小鼠生存实验：将700只80周大小鼠分成7组正常喂养。(每组100只，雌雄各50只)。
实验方法：参照保健食品功能学评价程序与检验方法规范(卫生部2003年版)，小鼠存活时间见表1，每周一对存活的衰老小鼠进行负重游泳测试，所负重量为小鼠体重的10％，直至力竭，记录小鼠游泳时长(S),取平均值，结果见表2。
表1小鼠生存实验结果
表2
采用荧光探针测试技术分别测试喂实施例1-3和对比例1-3之前的小鼠细胞内NAD+的含量，8点喂食后，9点-10点取各组鼠，实时测试组1-6小鼠细胞内NAD+的含量。计算出NAD+的增量，计算公式为：测试后-测试前/测试前x100％，其结果见表3。
表3
| 实验组别 | NAD+增量(％) |
| 实施例1 | 32(±0.5)％ |
| 实施例2 | 31(±1)％ |
| 实施例3 | 35(±1.2)％ |
| 对比例1 | 16(±1)％ |
| 对比例2 | 5(±2)％ |
| 对比例3 | 2(±1)％ |
| 对比例4 | 27.8(±0.6)％ |
从表1、2可以看出，本发明配方中的野樱莓果粉与烟酰胺对小鼠衰老有明显的抑制作用，与直接添加NMN相比有更好的转化效率和抗衰老效果，野樱莓果粉可以提高转化成NAD+的转化效率。
Claims (5)
1.一种野樱莓多肽抗衰老复合制剂，其特征在于，由以下配方组成：大豆肽粉、野樱莓果粉、菊粉、玉米低聚肽、红樱桃果粉、甜菊糖苷、植物提取白藜芦醇、银耳多糖、烟酰胺、熊果苷。
2.根据权利要求1所述的复合制剂，其特征在于，按重量分数配比：大豆肽粉5-8份、野樱莓果粉5-15份、菊粉2-3份、玉米低聚肽5-10份、红樱桃果粉1-3份、甜菊糖苷0.5-1份、白藜芦醇0.5-2份、银耳多糖0.5-2份、烟酰胺0.1-0.5份、熊果苷3-5份。
3.根据权利要求1或2所述的复合制剂，其特征在于，按重量分数配比：大豆肽粉5份、野樱莓果粉10份、菊粉2份、玉米低聚肽6份、红樱桃果粉2份、甜菊糖苷0.5份、白藜芦醇1份、银耳多醣1份、烟酰胺0.3份、熊果苷3份。
4.如权利要求1-3任意一项所述的复合制剂，其特征在于，制备方法为：
(1)所述野樱莓果粉的制备过程为：将新鲜的野樱莓榨汁，烘干，制粒，控制粒径100目；
将步骤(1)得到的野樱莓果粉与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
5.根据权利要求1所属的复合制剂，其特征在于，所述制剂可以是片剂、压片糖果剂、固体饮料剂、胶囊、粒剂、水剂、肠溶制剂或注射剂中任意一种。
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