CN113519853A - 一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂 - Google Patents
一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂 Download PDFInfo
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Abstract
一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂，由以下配方组成：山梨糖醇、野樱莓果粉、玉米低聚肽、甜菊糖苷、白藜芦醇、NMN原料、硬脂酸镁，制备方式为：将NMN原料研磨至10000目的超细粉，再超声处理，然后制微囊，再与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得，本发明制备的制剂可以有效的提高NMN原料的吸收效率，避免胃液对NMN的消化作用，于肠道吸收。
Description
技术领域
本发明属于保健品、食品、药品制剂领域，具体涉及一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂。
背景技术
野樱莓原产于北美洲东部，又被称为“不老莓”，是一种营养价值很高的水果。它富含花青素，既具有非常强的抗氧化性，也具有提高免疫力、抗衰老、抗癌、抗心血管疾病、促进视红素再合成等多种生理活性。在欧美和东亚地区，这种水果已经作为重要的食品原料，但是在我国，这种水果尚未用于食品行业，其深加工产品亦有待开发。细胞衰老理论指出，机体衰老主要是由于细胞功能的减退，而细胞功能减退，很大程度上是由线粒体发生功能障碍导致的。线粒体是身体的能量工厂。当线粒体损伤时，导致过多活性氧(即氧化自由基)的生成。
烟酰胺腺嘌呤单核苷酸(NMN)是一种人体内的生理物质，存在于包括人类细胞在内的所有活细胞中。NMN是很多酶的辅助因子，这些酶大部分都可催化氧化还原反应。NMN具有抗衰老、提升免疫力、治疗心脑血管疾病等作用。
NMN的疗效虽然被哈佛大学等高端的学术期刊报道频率较高是基于其临床的动物试验得出的，但是小白鼠与人体有数百倍的体重差距，如果按照对应剂量服用则需要服用大量的NMN原料，因此需要开发一种吸收效率高的剂型。
发明内容
基于背景技术中提到的问题，本发明拟提供一种可以提高吸收效率的技术方案，本发明是由以下方案组成的：
一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂，由以下配方组成：山梨糖醇、野樱莓果粉、玉米低聚肽、甜菊糖苷、白藜芦醇、NMN原料、硬脂酸镁。
所述的复合制剂，按重量分数配比：山梨糖醇5-10份、野樱莓果粉5-15份、玉米低聚肽2-5份、甜菊糖苷0.5-1份、白藜芦醇0.5-2份、NMN原料1-5份、硬脂酸镁3-5份。
所述的复合制剂，按重量分数配比：山梨糖醇10份、野樱莓果粉5份、玉米低聚肽2份、甜菊糖苷0.5份、白藜芦醇0.5份、NMN原料3份、硬脂酸镁3份。
制备方法为：
(1)将NMN原料研磨至10000目的超细粉，具体方法为：
A:粗粉制得：将冷却至室温的椰子灰放入规格为2L的球磨机中，将直径为0.6mm、0.8mm的高铬钢球研磨球按照重量比为5:2混合，所述高铬钢球加入总重量为2-3kg,研磨120min，得到粗粉；
B:细粉制得：制得的粗粉加入2L球磨机中，再加入总炭黑重量5-8％的水，配成炭浆，将直径为0.2mm、0.3mm的高铬钢球研磨球按照重量比为5:3混合，所述高铬钢球加入总重量为1-2kg,研磨4h,烘干将水分去除，得到细粉；
C:超细粉制得：制得的粗粉加入2L球磨机中，再加入重量12-18％的水，配成浆，将直径为0.1mm的高铬钢球研磨球，所述高铬钢球加入总重量为0.5kg,研磨4h,烘干将水分去除，得到10000目的NMN原料；
(2)超声处理:向超声仪中加入步骤(1)制得的超细粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
(3)将超声后的NMN原料加入5倍体积当量的壁材明胶；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为80℃，制成微囊制剂；干燥4h，既得NMN原料微囊；
(4)将步骤(3)得到的NMN原料微囊与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
本发明的有益效果
(1)本发明制备的制剂可以有效的提高NMN原料的吸收效率。
(2)本发明制备的制剂微囊可以避免胃液对NMN的消化作用，于肠道吸收。
具体实施方式
以下实施例用于进一步阐述本发明，但不应理解为对本发明权利要求书请求保护范围的限制。
实施例1
配方为：山梨糖醇10份、野樱莓果粉5份、玉米低聚肽2份、甜菊糖苷0.5份、白藜芦醇0.5份、NMN原料3份、硬脂酸镁3份。制备方法为：
(1)将NMN原料研磨至10000目的超细粉，具体方法为：
A:粗粉制得：将冷却至室温的椰子灰放入规格为2L的球磨机中，将直径为0.6mm、0.8mm的高铬钢球研磨球按照重量比为5:2混合，所述高铬钢球加入总重量为2kg,研磨120min，得到粗粉；
B:细粉制得：制得的粗粉加入2L球磨机中，再加入总炭黑重量5-8％的水，配成炭浆，将直径为0.2mm、0.3mm的高铬钢球研磨球按照重量比为5:3混合，所述高铬钢球加入总重量为1-2kg,研磨4h,烘干将水分去除，得到细粉；
C:超细粉制得：制得的粗粉加入2L球磨机中，再加入重量12-18％的水，配成浆，将直径为0.1mm的高铬钢球研磨球，所述高铬钢球加入总重量为0.5kg,研磨4h,烘干将水分去除，得到10000目的NMN原料；
(2)超声处理:向超声仪中加入步骤(1)制得的超细粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
(3)将超声后的NMN原料加入5倍体积当量的壁材明胶；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为80℃，制成微囊制剂；干燥4h，既得NMN原料微囊；
(4)将步骤(3)得到的NMN原料微囊与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
实施例2
山梨糖醇8份、野樱莓果粉5份、玉米低聚肽2份、甜菊糖苷0.6份、白藜芦醇0.7份、NMN原料2份、硬脂酸镁4份。
其余制备同实施例1。
对比例1
配方为：山梨糖醇10份、野樱莓果粉5份、玉米低聚肽2份、甜菊糖苷0.5份、白藜芦醇0.5份、NMN原料3份、硬脂酸镁3份。制备方法为：上述配方混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
将实施例1-2和对比例1所制的制剂进行测试。
昆明小鼠，36-38g，雌150只，雄150只(约80周大)，上海实验动物中心购买。室温18-22℃，相对湿度维持在60％-70％，光照12hr∶12hr(光∶暗)，使用前适应环境3天。
药效学实验：
材料和方法：
实验材料:实施例1-2所制备的产品和对比例1所制备的保健品。
实验动物：昆明种小鼠(约80周大)；选用80周的老年小鼠。
给药方法：与食品一起喂食，每天早上8点一次。
小鼠生存实验：将300只80周大小鼠分成3组正常喂养。(每组100只，雌雄各50只)。
实验方法：参照保健食品功能学评价程序与检验方法规范(卫生部2003年版)，小鼠存活时间见表1，每周一对存活的衰老小鼠进行负重游泳测试，所负重量为小鼠体重的10％，直至力竭，记录小鼠游泳时长(S),取平均值，结果见表2。
表1小鼠生存实验结果
表2
| 第一周 | 第二周 | 第三周 | 第四周 | 第五周 | 第六周 | |
| 实施例1 | 35.2s | 27.5s | 25.2s | 21.6s | 17.3s | 12.2s |
| 实施例2 | 37.1s | 26.1s | 18.3s | 16.5s | 13.9.6s | 12.0s |
| 对比例1 | 20.6s | 12.6s | 10.3S | 7.6s | 5.5s | 4.2s |
采用荧光探针测试技术分别测试喂实施例1-2和对比例1之前的小鼠细胞内NAD+的含量，8点喂食后，9点-10点取各组鼠，实时测试组1-6小鼠细胞内NAD+的含量。计算出NAD+的增量，计算公式为：测试后-测试前/测试前x100％，其结果见表3。
表3
| 实验组别 | NAD+增量(％) |
| 实施例1 | 36(±0.6)％ |
| 实施例2 | 34(±0.7)％ |
| 对比例1 | 12(±0.85)％ |
Claims (4)
1.一种有助于吸收的nmn野樱莓多肽抗衰老复合制剂，其特征在于，由以下配方组成：山梨糖醇、野樱莓果粉、玉米低聚肽、甜菊糖苷、白藜芦醇、NMN原料、硬脂酸镁。
2.根据权利要求1所述的复合制剂，其特征在于，按重量分数配比：山梨糖醇5-10份、野樱莓果粉5-15份、玉米低聚肽2-5份、甜菊糖苷0.5-1份、白藜芦醇0.5-2份、NMN原料1-5份、硬脂酸镁3-5份。
3.根据权利要求1或2所述的复合制剂，其特征在于，按重量分数配比：山梨糖醇10份、野樱莓果粉5份、玉米低聚肽2份、甜菊糖苷0.5份、白藜芦醇0.5份、NMN原料3份、硬脂酸镁3份。
4.如权利要求1-3任意一项所述的复合制剂，其特征在于，制备方法为：
(1)将NMN原料研磨至10000目的超细粉，具体方法为：
A:粗粉制得：将冷却至室温的椰子灰放入规格为2L的球磨机中，将直径为0.6mm、0.8mm的高铬钢球研磨球按照重量比为5:2混合，所述高铬钢球加入总重量为2-3kg,研磨120min，得到粗粉；
B:细粉制得：制得的粗粉加入2L球磨机中，再加入总炭黑重量5-8％的水，配成炭浆，将直径为0.2mm、0.3mm的高铬钢球研磨球按照重量比为5:3混合，所述高铬钢球加入总重量为1-2kg,研磨4h,烘干将水分去除，得到细粉；
C:超细粉制得：制得的粗粉加入2L球磨机中，再加入重量12-18％的水，配成浆，将直径为0.1mm的高铬钢球研磨球，所述高铬钢球加入总重量为0.5kg,研磨4h,烘干将水分去除，得到10000目的NMN原料；
(2)超声处理:向超声仪中加入步骤(1)制得的超细粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
(3)将超声后的NMN原料加入5倍体积当量的壁材明胶；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为80℃，制成微囊制剂；干燥4h，既得NMN原料微囊；
(4)将步骤(3)得到的NMN原料微囊与余下的物质混合粉碎、过筛控制目数为150目；干燥制粒，压片既得。
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| CN111728211A (zh) * | 2020-07-08 | 2020-10-02 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种野樱莓多肽抗衰老复合制剂及其制备方法 |
| CN111728217A (zh) * | 2020-07-07 | 2020-10-02 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种玛咖纳豆制品复合制剂及其制备方法 |
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| CN111728217A (zh) * | 2020-07-07 | 2020-10-02 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种玛咖纳豆制品复合制剂及其制备方法 |
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