CN1117088C - 1,4,7,10－四氮杂环十二烷－1,4,7－三乙酸及其盐的制备方法 - Google Patents

1,4,7,10－四氮杂环十二烷－1,4,7－三乙酸及其盐的制备方法 Download PDF

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Publication number
CN1117088C
CN1117088C CN98803621A CN98803621A CN1117088C CN 1117088 C CN1117088 C CN 1117088C CN 98803621 A CN98803621 A CN 98803621A CN 98803621 A CN98803621 A CN 98803621A CN 1117088 C CN1117088 C CN 1117088C
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China
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compound
salt
solution
acid
reaction
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Expired - Lifetime
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CN98803621A
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English (en)
Chinese (zh)
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CN1251094A (zh
Inventor
G·里帕
A·斯卡拉
M·穆鲁
E·帕尼塔
C·F·维斯卡迪
M·奥索尼奥
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Bracco International BV
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Bracco SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CN98803621A 1997-06-11 1998-06-08 1,4,7,10－四氮杂环十二烷－1,4,7－三乙酸及其盐的制备方法 Expired - Lifetime CN1117088C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001373A IT1292130B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
ITMI97A001373 1997-06-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB021495890A Division CN1215063C (zh) 1997-06-11 1998-06-08 1，4，7，10－四氮杂环十二烷－1，4，7－三乙酸单－n－取代衍生物的制备方法

Publications (2)

Publication Number Publication Date
CN1251094A CN1251094A (zh) 2000-04-19
CN1117088C true CN1117088C (zh) 2003-08-06

Family

ID=11377338

Family Applications (2)

Application Number Title Priority Date Filing Date
CN98803621A Expired - Lifetime CN1117088C (zh) 1997-06-11 1998-06-08 1,4,7,10－四氮杂环十二烷－1,4,7－三乙酸及其盐的制备方法
CNB021495890A Expired - Lifetime CN1215063C (zh) 1997-06-11 1998-06-08 1，4，7，10－四氮杂环十二烷－1，4，7－三乙酸单－n－取代衍生物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB021495890A Expired - Lifetime CN1215063C (zh) 1997-06-11 1998-06-08 1，4，7，10－四氮杂环十二烷－1，4，7－三乙酸单－n－取代衍生物的制备方法

Country Status (14)

Country Link
US (2) US5962679A (enrdf_load_stackoverflow)
EP (1) EP0989974B1 (enrdf_load_stackoverflow)
JP (2) JP4445042B2 (enrdf_load_stackoverflow)
CN (2) CN1117088C (enrdf_load_stackoverflow)
AT (1) ATE224379T1 (enrdf_load_stackoverflow)
AU (1) AU738506B2 (enrdf_load_stackoverflow)
DE (1) DE69808086T2 (enrdf_load_stackoverflow)
ES (1) ES2184302T3 (enrdf_load_stackoverflow)
IL (1) IL131255A (enrdf_load_stackoverflow)
IN (1) IN186470B (enrdf_load_stackoverflow)
IT (1) IT1292130B1 (enrdf_load_stackoverflow)
NO (1) NO312548B1 (enrdf_load_stackoverflow)
WO (1) WO1998056776A1 (enrdf_load_stackoverflow)
ZA (1) ZA985023B (enrdf_load_stackoverflow)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US6838557B1 (en) * 2002-10-01 2005-01-04 Board Of Regents The University Of Texas System Process for making a chelating agent for labeling biomolecules using preformed active esters
US6852854B1 (en) 2002-10-01 2005-02-08 Psiloquest Inc. Preformed carboxylated active ester for labeling biomolecules
US20050033106A1 (en) * 2003-07-08 2005-02-10 Wing Tak Wong Synthesis of tris N-alkylated 1,4,7,10-tetraazacyclododecanes
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CN103232403B (zh) * 2013-05-09 2016-04-27 浙江凯普化工有限公司 一种氮杂环的制备方法
CN105377309A (zh) * 2013-05-30 2016-03-02 伯拉考成像股份公司 荧光固体脂质纳米颗粒组合物及其制备
CN108084105B (zh) * 2016-11-23 2020-07-24 四川科伦药物研究院有限公司 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3870569A4 (en) * 2018-10-24 2022-08-24 Biophore India Pharmaceuticals Pvt. Ltd. NEW PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELATING TRIACETIC ACID 2,2',2''-(10-(2-HYDROXYPROPYL)-1,4,7,10-TETRA AZACYCLODODECANE-1,4,7-TRIYL) AND ITS COMPLEXES WITH PARAMAGNETIC METALLIC IONS
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210114742A (ko) 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN113549025B (zh) * 2021-07-14 2023-07-25 江苏美迪克化学品有限公司 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004336A1 (en) * 1990-08-29 1992-03-19 Bracco Industria Chimica S.P.A. Intermediates for chelating agents with prefixed symmetry and process for their preparation
US5386028A (en) * 1992-06-04 1995-01-31 Schering Aktiengesellschaft Process for the production of N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives and their metal complexes
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004336A1 (en) * 1990-08-29 1992-03-19 Bracco Industria Chimica S.P.A. Intermediates for chelating agents with prefixed symmetry and process for their preparation
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5386028A (en) * 1992-06-04 1995-01-31 Schering Aktiengesellschaft Process for the production of N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives and their metal complexes
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof

Also Published As

Publication number Publication date
EP0989974A1 (en) 2000-04-05
ITMI971373A1 (it) 1998-12-11
EP0989974B1 (en) 2002-09-18
ES2184302T3 (es) 2003-04-01
JP4445042B2 (ja) 2010-04-07
IL131255A0 (en) 2001-01-28
US6054581A (en) 2000-04-25
WO1998056776A1 (en) 1998-12-17
NO995924D0 (no) 1999-12-03
NO312548B1 (no) 2002-05-27
AU738506B2 (en) 2001-09-20
ITMI971373A0 (enrdf_load_stackoverflow) 1997-06-11
JP5204724B2 (ja) 2013-06-05
JP2002503238A (ja) 2002-01-29
ATE224379T1 (de) 2002-10-15
NO995924L (no) 2000-01-26
CN1473819A (zh) 2004-02-11
IN186470B (enrdf_load_stackoverflow) 2001-09-08
JP2009242405A (ja) 2009-10-22
CN1251094A (zh) 2000-04-19
IT1292130B1 (it) 1999-01-25
US5962679A (en) 1999-10-05
DE69808086T2 (de) 2003-06-05
ZA985023B (en) 1999-01-20
IL131255A (en) 2004-01-04
AU8436998A (en) 1998-12-30
DE69808086D1 (de) 2002-10-24
CN1215063C (zh) 2005-08-17

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Owner name: BRACCO INTERNATIONAL B.V.

Free format text: FORMER OWNER: BRACCO S. P. A.

Effective date: 20031128

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Effective date of registration: 20031128

Patentee after: Bracco International B. V.

Patentee before: Bracco S. P. A.

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Granted publication date: 20030806