CN111704672B - 抗血浆激肽释放酶抗体 - Google Patents

抗血浆激肽释放酶抗体 Download PDF

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Publication number
CN111704672B
CN111704672B CN202010662282.7A CN202010662282A CN111704672B CN 111704672 B CN111704672 B CN 111704672B CN 202010662282 A CN202010662282 A CN 202010662282A CN 111704672 B CN111704672 B CN 111704672B
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gly
ser
antibody
thr
ile
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Chinese (zh)
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CN111704672A (zh
Inventor
A·尼克森
J·A·肯尼斯顿
S·R·科莫
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
CN202010662282.7A 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体 Active CN111704672B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010662282.7A CN111704672B (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361791822P 2013-03-15 2013-03-15
US61/791,822 2013-03-15
PCT/US2014/027100 WO2014152232A2 (en) 2013-03-15 2014-03-14 Anti-plasma kallikrein antibodies
CN201480015180.9A CN105051068A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体
CN202010662282.7A CN111704672B (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480015180.9A Division CN105051068A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体

Publications (2)

Publication Number Publication Date
CN111704672A CN111704672A (zh) 2020-09-25
CN111704672B true CN111704672B (zh) 2024-06-04

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Application Number Title Priority Date Filing Date
CN202010662282.7A Active CN111704672B (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体
CN201480015180.9A Pending CN105051068A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体
CN202410615191.6A Pending CN118406688A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201480015180.9A Pending CN105051068A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体
CN202410615191.6A Pending CN118406688A (zh) 2013-03-15 2014-03-14 抗血浆激肽释放酶抗体

Country Status (10)

Country Link
US (4) US20160017055A1 (enExample)
EP (2) EP3594244A1 (enExample)
JP (2) JP2016513682A (enExample)
KR (1) KR20150132473A (enExample)
CN (3) CN111704672B (enExample)
AU (4) AU2014240045A1 (enExample)
CA (2) CA3208188A1 (enExample)
HK (1) HK1218762A1 (enExample)
IL (2) IL292121B2 (enExample)
WO (1) WO2014152232A2 (enExample)

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PT3096798T (pt) 2014-01-21 2021-02-25 Dyax Corp Proteínas de ligação à calicreína plasmática e seus usos no tratamento de angioedema hereditário
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IL305207A (en) * 2015-03-30 2023-10-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and their uses to prevent the outbreak of hereditary angioedema
KR102794955B1 (ko) 2015-07-21 2025-04-15 다케다 파머수티컬 컴패니 리미티드 Xiia 인자의 단일클론 항체 저해제
CN116077648A (zh) 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
CN111727201A (zh) * 2017-10-18 2020-09-29 再生生物股份有限公司 完全人源翻译后修饰的抗体治疗剂
AU2019328324B2 (en) * 2018-08-30 2025-06-19 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
JP2022536692A (ja) 2019-06-11 2022-08-18 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 調節不全の血漿カリクレインによって媒介される疾患の治療のための抗体のアデノ随伴ウイルスベクター送達
MX2022008649A (es) 2020-01-13 2022-09-23 Takeda Pharmaceuticals Co Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico.
EP4126219A2 (en) * 2020-04-04 2023-02-08 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating acute respiratory distress syndrome
JP2023554066A (ja) 2020-12-16 2023-12-26 武田薬品工業株式会社 血漿カリクレインの制御不全によって媒介される疾患の処置のための抗体のアデノ随伴ウイルスベクター送達
WO2022156798A1 (zh) * 2021-01-25 2022-07-28 成都康弘生物科技有限公司 一种抗体及其用途
WO2022156799A1 (zh) * 2021-01-25 2022-07-28 成都康弘生物科技有限公司 一种抗体及其用途

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AU2019200638A1 (en) 2019-02-21
US12110343B2 (en) 2024-10-08
IL241334A0 (en) 2015-11-30
EP2970502A2 (en) 2016-01-20
JP2020007354A (ja) 2020-01-16
AU2021200144B2 (en) 2024-06-20
AU2014240045A1 (en) 2015-09-10
CA3208188A1 (en) 2014-09-25
US20230002509A1 (en) 2023-01-05
EP2970502A4 (en) 2016-11-30
US20190185580A1 (en) 2019-06-20
HK1218762A1 (zh) 2017-03-10
BR112015022282A2 (pt) 2017-10-10
IL292121B1 (en) 2023-10-01
AU2019200638B2 (en) 2021-01-28
US11299553B2 (en) 2022-04-12
IL292121A (en) 2022-06-01
JP2016513682A (ja) 2016-05-16
AU2021200144A1 (en) 2021-03-18
AU2024219756A1 (en) 2024-10-10
IL292121B2 (en) 2024-02-01
WO2014152232A2 (en) 2014-09-25
EP3594244A1 (en) 2020-01-15
WO2014152232A3 (en) 2014-11-13
CA2906624A1 (en) 2014-09-25
CN118406688A (zh) 2024-07-30
US20160017055A1 (en) 2016-01-21
CN105051068A (zh) 2015-11-11
CN111704672A (zh) 2020-09-25
US20250129182A1 (en) 2025-04-24
IL241334B (en) 2022-05-01
KR20150132473A (ko) 2015-11-25

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