JP2016513682A - 抗血漿カリクレイン抗体 - Google Patents

抗血漿カリクレイン抗体 Download PDF

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Publication number
JP2016513682A
JP2016513682A JP2016502334A JP2016502334A JP2016513682A JP 2016513682 A JP2016513682 A JP 2016513682A JP 2016502334 A JP2016502334 A JP 2016502334A JP 2016502334 A JP2016502334 A JP 2016502334A JP 2016513682 A JP2016513682 A JP 2016513682A
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antibody
pkal
isolated antibody
human
antibodies
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Japanese (ja)
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JP2016513682A5 (enExample
Inventor
ニクソン，アンドリュー
ケンニストン，ジョン，エー．
コミュー，ステファン，アール．
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ダイアックス コーポレーション
ダイアックス コーポレーション
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Publication of JP2016513682A publication Critical patent/JP2016513682A/ja
Publication of JP2016513682A5 publication Critical patent/JP2016513682A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
JP2016502334A 2013-03-15 2014-03-14 抗血漿カリクレイン抗体 Pending JP2016513682A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791822P 2013-03-15 2013-03-15
US61/791,822 2013-03-15
PCT/US2014/027100 WO2014152232A2 (en) 2013-03-15 2014-03-14 Anti-plasma kallikrein antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019167295A Division JP2020007354A (ja) 2013-03-15 2019-09-13 抗血漿カリクレイン抗体

Publications (2)

Publication Number Publication Date
JP2016513682A true JP2016513682A (ja) 2016-05-16
JP2016513682A5 JP2016513682A5 (enExample) 2017-04-13

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Family Applications (2)

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JP2016502334A Pending JP2016513682A (ja) 2013-03-15 2014-03-14 抗血漿カリクレイン抗体
JP2019167295A Pending JP2020007354A (ja) 2013-03-15 2019-09-13 抗血漿カリクレイン抗体

Family Applications After (1)

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JP2019167295A Pending JP2020007354A (ja) 2013-03-15 2019-09-13 抗血漿カリクレイン抗体

Country Status (10)

Country Link
US (4) US20160017055A1 (enExample)
EP (2) EP3594244A1 (enExample)
JP (2) JP2016513682A (enExample)
KR (1) KR20150132473A (enExample)
CN (3) CN118406688A (enExample)
AU (4) AU2014240045A1 (enExample)
CA (2) CA3208188A1 (enExample)
HK (1) HK1218762A1 (enExample)
IL (2) IL292121B2 (enExample)
WO (1) WO2014152232A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502572A (ja) * 2015-01-02 2018-02-01 ダイアックス コーポレーション 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
US10913802B2 (en) 2015-07-21 2021-02-09 Dyax Corp. Monoclonal antibody inhibitor of factor XIIA

Families Citing this family (18)

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ES2905545T3 (es) 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
KR102011156B1 (ko) 2011-01-06 2019-08-16 다이액스 코포레이션 혈장 칼리크레인 결합 단백질
JP2016513682A (ja) 2013-03-15 2016-05-16 ダイアックス コーポレーション 抗血漿カリクレイン抗体
ES3065185T3 (en) 2014-01-21 2026-05-04 Takeda Pharmaceuticals Co Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
IL247942B (en) 2014-03-27 2022-09-01 Dyax Corp Compositions and methods for drops in macular edema as a result of diabetes
CA3290174A1 (en) * 2015-03-30 2026-03-02 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack
US11286307B2 (en) * 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
KR20200067195A (ko) * 2017-10-18 2020-06-11 리젠엑스바이오 인크. 완전-인간 번역후 변형된 항체 치료제
EP3843840A1 (en) * 2018-08-30 2021-07-07 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US20230038502A1 (en) 2019-06-11 2023-02-09 Shire Human Genetic Therapies, Inc. Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein
AU2020392243A1 (en) 2019-11-28 2022-06-16 Regenxbio Inc. Microdystrophin gene therapy constructs and uses thereof
AU2021209045A1 (en) 2020-01-13 2022-07-28 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
WO2021202948A2 (en) * 2020-04-04 2021-10-07 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating acute respiratory distress syndrome
EP4263614A1 (en) * 2020-12-16 2023-10-25 Takeda Pharmaceutical Company Limited Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein
CN114790245B (zh) * 2021-01-25 2026-08-11 成都康弘生物科技有限公司 一种抗体及其用途
WO2022156799A1 (zh) * 2021-01-25 2022-07-28 成都康弘生物科技有限公司 一种抗体及其用途
CN114790247A (zh) * 2021-01-25 2022-07-26 成都康弘生物科技有限公司 同时结合人血浆激肽释放酶和血浆前激肽释放酶的抗体及其用途
AU2022214914A1 (en) * 2021-01-28 2023-08-17 Astria Therapeutics, Inc. Plasma kallikrein antibodies and uses thereof

Citations (3)

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US20100285507A1 (en) * 2007-03-21 2010-11-11 Je-Yeol Cho Plasma kallikrein fragments as diagnostic biomarkers for lung cancers
US20110200611A1 (en) * 2010-01-06 2011-08-18 Dyax Corp. Plasma kallikrein binding proteins
WO2012094587A1 (en) * 2011-01-06 2012-07-12 Dyax Corp. Plasma kallikrein binding proteins

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KR20210142006A (ko) 2019-03-14 2021-11-23 다케다 파머수티컬 컴패니 리미티드 유전성 혈관부종 발작의 치료를 위한 혈장 칼리크레인 저해제 및 이의 용도

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502572A (ja) * 2015-01-02 2018-02-01 ダイアックス コーポレーション 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
JP2020186248A (ja) * 2015-01-02 2020-11-19 ダイアックス コーポレーション 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
JP7003347B2 (ja) 2015-01-02 2022-02-04 武田薬品工業株式会社 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
JP2022023038A (ja) * 2015-01-02 2022-02-07 武田薬品工業株式会社 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
US11390687B2 (en) 2015-01-02 2022-07-19 Takeda Pharmaceutical Company Limited Bispecific antibodies against plasma kallikrein and Factor XII
JP7241827B2 (ja) 2015-01-02 2023-03-17 武田薬品工業株式会社 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
JP2023065659A (ja) * 2015-01-02 2023-05-12 武田薬品工業株式会社 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
JP7635285B2 (ja) 2015-01-02 2025-02-25 武田薬品工業株式会社 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
US12240918B2 (en) 2015-01-02 2025-03-04 Takeda Pharmaceutical Company Limited Bispecific antibodies against plasma kallikrein and factor XII
US10913802B2 (en) 2015-07-21 2021-02-09 Dyax Corp. Monoclonal antibody inhibitor of factor XIIA
US12415866B2 (en) 2015-07-21 2025-09-16 Takeda Pharmaceutical Company Limited Monoclonal antibody inhibitor of Factor XIIa

Also Published As

Publication number Publication date
CN111704672B (zh) 2024-06-04
KR20150132473A (ko) 2015-11-25
AU2019200638B2 (en) 2021-01-28
CN105051068A (zh) 2015-11-11
US20160017055A1 (en) 2016-01-21
AU2021200144A1 (en) 2021-03-18
AU2019200638A1 (en) 2019-02-21
EP2970502A2 (en) 2016-01-20
CN111704672A (zh) 2020-09-25
CA3208188A1 (en) 2014-09-25
IL292121A (en) 2022-06-01
WO2014152232A3 (en) 2014-11-13
EP3594244A1 (en) 2020-01-15
JP2020007354A (ja) 2020-01-16
US20190185580A1 (en) 2019-06-20
IL241334A0 (en) 2015-11-30
IL241334B (en) 2022-05-01
CA2906624A1 (en) 2014-09-25
AU2021200144B2 (en) 2024-06-20
US11299553B2 (en) 2022-04-12
EP2970502A4 (en) 2016-11-30
US12110343B2 (en) 2024-10-08
IL292121B2 (en) 2024-02-01
US20250129182A1 (en) 2025-04-24
AU2014240045A1 (en) 2015-09-10
BR112015022282A2 (pt) 2017-10-10
AU2024219756A1 (en) 2024-10-10
CN118406688A (zh) 2024-07-30
US20230002509A1 (en) 2023-01-05
IL292121B1 (en) 2023-10-01
HK1218762A1 (zh) 2017-03-10
WO2014152232A2 (en) 2014-09-25

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