CN111700852A - Toothpaste containing degreased periplaneta americana extract and preparation method thereof - Google Patents
Toothpaste containing degreased periplaneta americana extract and preparation method thereof Download PDFInfo
- Publication number
- CN111700852A CN111700852A CN202010268789.4A CN202010268789A CN111700852A CN 111700852 A CN111700852 A CN 111700852A CN 202010268789 A CN202010268789 A CN 202010268789A CN 111700852 A CN111700852 A CN 111700852A
- Authority
- CN
- China
- Prior art keywords
- periplaneta americana
- degreased
- toothpaste
- extract solution
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Insects & Arthropods (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Husbandry (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses toothpaste containing degreased periplaneta americana extract and a preparation method thereof. The components are as follows: 2-6% of degreased periplaneta americana water extract solution, 3-8% of green tea extract solution, 20-50% of sorbitol, 4000.5-3.5% of PEG, 0.05-0.2% of trisodium phosphate, 15-40% of water, 10-18% of silicon dioxide, 0.1-0.8% of carrageenan, 0.2-1.0% of carboxymethyl cellulose, 30.01-0.04% of cooling agent ws, 0.06% of cooling agent ws-230.01, 0.1-0.5% of titanium dioxide, 0.1-1.2% of fresh mint DLIT-0060.5, 3-10% of sodium dodecyl sulfonate and 0.1-0.8% of nipagin methyl ester. The toothpaste can clean tartar and whiten teeth, and can relieve gingival bleeding and swelling and pain, repair oral ulcer and periodontitis, reduce dental plaque, refresh breath, resist allergy, effectively relieve tooth allergy symptoms, and finally achieve the purposes of nourishing teeth, protecting gums and firming teeth.
Description
Technical Field
The invention belongs to the field of oral cleaning and nursing products, and particularly relates to toothpaste containing a degreased periplaneta americana extract and a preparation method of the toothpaste.
Background
Toothpaste is a common cleaning product used in daily life, and is defined by the american dental association as a substance used with a toothbrush to clean the surfaces of teeth. The Chinese toothpaste industry Association defines that toothpaste is a daily necessity for cleaning teeth, protecting oral hygiene and being safe to human body together with a toothbrush. According to the definition of toothpaste, toothpaste should meet the following requirements: (1) can remove pellicle and plaque from tooth surface without damaging enamel and dentin; (2) has good function of cleaning the oral cavity and the periphery thereof; (3) no toxicity and no stimulation to oral mucosa; (4) has comfortable fragrance and taste, and has cool and fresh feeling after use; (5) easy to use, and is extruded into uniform, bright and soft strips; (6) the cleaning agent is easy to clean from the oral cavity, teeth and toothbrush; (7) the storage agent has good chemical and physical stability, and ensures that each index meets the standard requirement in the storage period; (8) has reasonable cost performance.
The functional toothpaste is added with functional components to inhibit tooth demineralization or promote tooth remineralization, so as to control the formation of dental caries, or reduce bacterial plaque and the acidity thereof so as to prevent the occurrence of dental caries; or adding chemical components to inhibit dental plaque and/or relieve inflammation such as gingival swelling and bleeding; or has effects in resisting dentin sensitivity symptoms (such as short and sharp pain caused by chemical and physical stimulation such as cold, heat, sour, sweet, probing, etc.) of teeth
Periplaneta Americana (Periplaneta Americana Linnaeus), commonly known as "Blatta seu Periplaneta", is the largest volume of insects in the Blattaceae family, with adult bodies 29-40 mm long, reddish brown, and wings growing above the ventral extremities. The tentacles are very long, with large butterfly brown patches in the middle of the anterior chest plate and full yellow bands at the rear edges of the patches. Periplaneta americana is native to south America, has wide food habits, and is favored by sugar and starch.
Periplaneta americana is a traditional Chinese medicinal material, is first found in Bencao gang mu Shi Yi (compendium of materia Medica), and is also called Shijiang and Tenebrio molitor, and is used as a medicine by adults. Is cold in nature, salty in taste, toxic, pungent in flavor, and has effects of removing blood stasis, resolving food stagnation, removing toxic substance, inducing diuresis, and relieving swelling. Modern researches find that the effective components of the periplaneta americana have the effects of protecting liver, repairing, resisting inflammation, easing pain, resisting tumors, improving immunity and the like. The anti-ulcer active substance of the periplaneta americana extract is a polypeptide component, and the grease has no effect of preventing and treating peptic ulcer and can also aggravate the ulcer degree.
Disclosure of Invention
The invention aims to provide toothpaste containing degreased periplaneta americana extract and a preparation method thereof. The degreased periplaneta Americana extract effectively removes harmful ingredients such as periplaneta Americana grease with the effect of aggravating ulcer and other ineffective ingredients, and enriches effective active ingredient polypeptides in the periplaneta Americana. The toothpaste can clean tartar and whiten teeth, and can relieve gingival bleeding and swelling and pain, repair oral ulcer and periodontitis, reduce dental plaque, refresh breath, resist allergy, effectively relieve tooth allergy symptoms, and finally achieve the purposes of nourishing teeth, protecting gums and firming teeth.
In order to achieve the purpose, the invention adopts the technical scheme that: a toothpaste containing degreased periplaneta americana extract is prepared from the following components in percentage by mass: 2-6% of degreased periplaneta americana water extract solution, 3-8% of green tea extract solution, 20-50% of sorbitol, 4000.5-3.5% of PEG, 0.05-0.2% of trisodium phosphate, 15-40% of water, 10-18% of silicon dioxide, 0.1-0.8% of carrageenan, 0.2-1.0% of carboxymethyl cellulose, 30.01-0.04% of cooling agent ws, 0.06% of cooling agent ws-230.01, 0.1-0.5% of titanium dioxide, 0.1-1.2% of fresh mint DLIT-0060.5, 3-10% of sodium dodecyl sulfonate and 0.1-0.8% of nipagin methyl ester.
Preferably, the toothpaste containing the degreased periplaneta americana extract is prepared from the following components in percentage by mass: 3-5% of degreased periplaneta americana water extract solution, 5-7% of green tea extract solution, 40-60% of sorbitol, 4001.5-2.5% of PEG, 0.08-0.12% of trisodium phosphate, 16-32% of water, 15-18% of silicon dioxide, 0.1-0.3% of carrageenan, 0.6-1% of carboxymethyl cellulose, 30.01-0.03% of cooling agent ws, 0.06% of cooling agent ws-230.04%, 0.2-0.4% of titanium dioxide, 0.1-1.2% of fresh mint DLIT-0060.9, 6-8% of sodium dodecyl sulfonate and 0.1-0.3% of methylparaben.
The toothpaste containing the degreased periplaneta americana extract is prepared by the following process:
1. weighing the components for producing the toothpaste according to the parts by weight;
2. adding degreased periplaneta americana extract solution, green tea extract solution, sodium dodecyl sulfate and trisodium phosphate into a water phase pot, dissolving and dispersing in water to form a mixture A;
3. adding silicon dioxide, carrageenan and carboxymethyl cellulose into a powder pot, and uniformly stirring to form a mixture B;
4. adding sorbitol, PEG400, fresh mint DLIT-006, refrigerant WS-2, refrigerant WS-23 and methyl hydroxybenzoate into an oil phase pot, and mixing to obtain mixture C;
5. adding the mixture A, the mixture B and the mixture C into a paste making pot, uniformly mixing, adding titanium dioxide, and stirring for 60 minutes under vacuum to obtain paste D;
6. and (4) degassing the paste body D in vacuum for 30 minutes, and filling to obtain the toothpaste containing the degreased periplaneta americana extract.
On the basis of the common knowledge in the field, the above preferred conditions can be combined randomly to obtain the preferred embodiments of the invention.
The reagents and starting materials used in the present invention are commercially available.
The invention has the beneficial effects that:
1. the added green tea extract can cooperate with the antiulcer activity of polypeptide components in the degreased periplaneta americana extract, more effectively repair oral mucosa ulcer and resist dentin sensitivity.
2. The toothpaste prepared by the process disclosed by the invention can clean tartar and whiten teeth, and can relieve gingival bleeding and swelling and pain, repair dental ulcer and periodontitis, reduce dental plaque, refresh breath, resist allergy, effectively relieve tooth allergy symptoms, and finally achieve the purposes of nourishing teeth, protecting gums and firming teeth.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.
The toothpaste containing the degreased periplaneta americana extract in each specific embodiment is prepared by the following process:
1. weighing the components for producing the toothpaste according to the parts by weight;
2. adding degreased periplaneta americana extract solution, green tea extract solution, sodium dodecyl sulfate and trisodium phosphate into a water phase pot, dissolving and dispersing in water to form a mixture A;
3. adding silicon dioxide, carrageenan and carboxymethyl cellulose into a powder pot, and uniformly stirring to form a mixture B;
4. adding sorbitol, PEG400, fresh mint DLIT-006, cooling agent WS-2, cooling agent WS-23 and methyl hydroxybenzoate into an oil phase pot, and mixing to obtain mixture C;
5. adding the mixture A, the mixture B and the mixture C into a paste making pot, uniformly mixing, adding titanium dioxide, and stirring for 60 minutes under vacuum to obtain paste D;
6. and (4) degassing the paste body D in vacuum for 30 minutes, and filling to obtain the toothpaste containing the degreased periplaneta americana extract.
The present invention is further illustrated by the following specific examples, which are provided for illustrative purposes only and do not limit the scope of the present invention.
Example 1
The toothpaste containing the degreased periplaneta americana extract comprises the following components in percentage by weight: 3.5% of degreased periplaneta americana water extract solution, 5.4% of green tea extract solution, 40% of sorbitol, PEG 4002%, 0.09% of trisodium phosphate, 23% of water, 16% of silicon dioxide, 0.3% of carrageenan, 0.8% of carboxymethyl cellulose, 30.03% of cooling agents ws, 230.06% of cooling agents ws, 0.3% of titanium dioxide, 0.32% of fresh mint DLIT-0061.0%, 7.4% of sodium dodecyl sulfate and 0.12% of methylparaben.
Example 2
The toothpaste containing the degreased periplaneta americana extract comprises the following components in percentage by weight: 3.9% of degreased periplaneta americana water extract solution, 6% of green tea extract solution, 42% of sorbitol, 4001.5% of PEG, 0.11% of trisodium phosphate, 25% of water, 15.5% of silicon dioxide, 0.4% of carrageenan, 0.65% of carboxymethyl cellulose, 0.02% of cooling agent ws, 230.05% of cooling agent ws, 0.25% of titanium dioxide, DLIT-0061.1% of fresh mint, 2.8% of sodium dodecyl sulfate and 0.72% of nipagin methyl ester.
Example 3
The toothpaste containing the degreased periplaneta americana extract comprises the following components in percentage by weight: 4.3% of degreased periplaneta americana water extract solution, 5.3% of green tea extract solution, 41.3% of sorbitol, 4001.7% of PEG, 0.09% of trisodium phosphate, 22.4% of water, 16.5% of silicon dioxide, 0.25% of carrageenan, 0.75% of carboxymethyl cellulose, 30.03% of cooling agents, 230.06% of cooling agents, 0.21% of titanium dioxide, DLIT-0060.9% of fresh mint, 6.1% of sodium dodecyl sulfate and 0.11% of methyl paraben.
Example 4
The toothpaste containing the degreased periplaneta americana extract comprises the following components in percentage by weight: 3.8% of degreased periplaneta americana water extract solution, 6.7% of green tea extract solution, 44.5% of sorbitol, 4002.0% of PEG, 0.11% of trisodium phosphate, 15.76% of water, 17.2% of silicon dioxide, 0.22% of carrageenan, 0.82% of carboxymethyl cellulose, 30.02% of cooling agents, 230.05% of cooling agents, 0.32% of titanium dioxide, DLIT-0061.15% of fresh mint, 7.2% of sodium dodecyl sulfate and 0.15% of nipagin methyl ester.
Example 5
The toothpaste containing the degreased periplaneta americana extract comprises the following components in percentage by weight: 4.2% of degreased periplaneta americana water extract solution, 5.2% of green tea extract solution, 40.1% of sorbitol, 4001.8% of PEG, 0.12% of trisodium phosphate, 21.73% of water, 16.8% of silicon dioxide, 0.16% of carrageenan, 0.75% of carboxymethyl cellulose, 30.03% of cooling agents, 230.04% of cooling agents, 0.27% of titanium dioxide, DLIT-0061.1% of fresh mint, 7.6% of sodium dodecyl sulfate and 0.1% of methylparaben.
The components and mass percentages of the toothpaste of the above examples are shown in Table 1
Evaluation of toothpaste efficacy:
1. test samples: the toothpastes prepared in examples 1 to 5.
2. The test population: chinese female/male, 18-65 years old, unlimited in sex, 144, 72 in experimental group, 72 in control group (containing 20% shedding rate). (1) Healthy, no systemic disease and no other similar experimental studies were enrolled for three months. (2) Procedures willing to sign informed consent and complete a medical history questionnaire to proactively perform the study. (3) There were 20 natural teeth with an appreciable surface, with good hygiene practices. (4) The subject has dental plaque, PI ≧ 2.0. (5) The subject had gingivitis, GI ≥ 1.0, and BI index ≥ 1.0.
3. The test method comprises the following steps: test group, 1cm of the toothpaste of the above embodiment is taken for effective tooth brushing each time, 3 minutes for each time, and 1 time for each day of morning and evening; in the control group, 1cm of toothpaste simulating agent is taken for effective tooth brushing each time, 3 minutes for each time, and 1 time for each day of morning and evening.
4. Clinical examination index:
4.1 doctor Plaque Index (PI) and examination method
Plaque index scoring criteria:
0 min-tooth surface without plaque
1 minute-scattered and punctate bacterial plaque at gingival margin of neck
2 minutes-plaque width at the neck of the tooth does not exceed 1mm, but below the surface 1/3
3 cents-plaque coverage of the cervical region is more than 1mm wide, but below the tooth surface 1/3
4 minutes-plaque coverage area between tooth surfaces 1/3 and 2/3
5 minutes-the plaque covered area accounts for above the tooth surface 2/3
The checking method comprises the following steps: the labial and lingual surfaces of all teeth except the third molar were examined. The plaque stain was stained with a plaque stain and scored according to the area of the dental plaque on the surface.
PI reduction rate ═ PI score sum before use toothpaste-PI score sum after use toothpaste)/PI score sum before use toothpaste × 100%
4.2 doctor Bleeding Index (BI) and examination method
Bleeding index scoring criteria:
0 min-healthy gum, no inflammation and bleeding
1 minute-inflammatory change of gum color, no bleeding of probe
2 min-some bleeding after probing
3 min-bleeding with the Probe and spreading along the gingival margin
4 fen-full bleeding and overflow of gingival sulcus
5 min-automatic bleeding
The checking method comprises the following steps: the gingival sulcus or pocket is gently probed with a blunt periodontal probe, and the presence and extent of bleeding is observed 30 seconds after the probe is removed.
BI reduction rate ═ (sum of BI scores before toothpaste use-sum of BI scores after toothpaste use)/sum of BI scores before toothpaste use × 100%
4.3 Gum Index (GI) of doctor and examination method
Gingival index scoring standard:
0 min-normal gingiva
Score 1-mild inflammation: slight change of gum color, mild hyperemia, no bleeding with probe
2 points-moderate: bleeding, edema, slippery and spying bleeding of gum
Score 3-severe inflammation: gingival congestion, edema, ulcer, spontaneous hemorrhage
The checking method comprises the following steps: a blunt periodontal probe was used in conjunction with visual examination. The gingiva around each tooth of the whole mouth was examined, and the surrounding gingiva was divided into buccal-mesial, buccal-central, buccal-distal and palatal. The score for each tooth was the average of 4 facer scores, and each score was the average of all examined teeth scores.
GI reduction rate ═ GI score sum before use toothpaste-GI score sum after use toothpaste)/GI score sum before use toothpaste x 100%.
5. And (3) test results:
5.1 Baseline examination results are shown in Table 2
5.2 clinical examination results are shown in Table 3
Conclusion analysis: (1) compared with the control toothpaste, the tested dental plaque indexes show the effect which is obviously lower than the basic value (P <0.05) after the experimental toothpaste is used for 8 weeks and 12 weeks; (2) the improvement in bleeding symptoms of the tested teeth was significantly better than the control toothpaste (P <0.05) after 12 weeks of use of the experimental toothpaste compared to the control toothpaste; (3) the improvement in gingival inflammation of the tested teeth was significantly better than the control toothpaste (P <0.05) after 12 weeks of use of the experimental toothpaste compared to the control toothpaste.
Clinical tests and evaluations of dental plaque, gingivitis and bleeding indexes show that the toothpaste prepared in the examples 1 to 5 has obvious efficacy and good market prospect.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and such modifications and adaptations are intended to be within the scope of the invention.
Claims (3)
1. The toothpaste containing the degreased periplaneta americana extract is characterized by being prepared from the following components in percentage by mass: 2-6% of degreased periplaneta americana water extract solution, 3-8% of green tea extract solution, 20-50% of sorbitol, 4000.5-3.5% of PEG, 0.05-0.2% of trisodium phosphate, 15-40% of water, 10-18% of silicon dioxide, 0.1-0.8% of carrageenan, 0.2-1.0% of carboxymethyl cellulose, 30.01-0.04% of cooling agent ws, 0.06% of cooling agent ws-230.01, 0.1-0.5% of titanium dioxide, 0.1-1.2% of fresh mint DLIT-0060.5, 3-10% of sodium dodecyl sulfonate and 0.1-0.8% of nipagin methyl ester.
2. The toothpaste containing the defatted periplaneta americana extract as claimed in claim 1 is characterized by being prepared from the following components in percentage by mass: 3-5% of degreased periplaneta americana water extract solution, 5-7% of green tea extract solution, 40-60% of sorbitol, 4001.5-2.5% of PEG, 0.08-0.12% of trisodium phosphate, 16-32% of water, 15-18% of silicon dioxide, 0.1-0.3% of carrageenan, 0.6-1% of carboxymethyl cellulose, 30.01-0.03% of cooling agent ws, 0.06% of cooling agent ws-230.04%, 0.2-0.4% of titanium dioxide, 0.1-1.2% of fresh mint DLIT-0060.9, 6-8% of sodium dodecyl sulfonate and 0.1-0.3% of methylparaben.
3. The toothpaste containing the defatted periplaneta americana extract as claimed in claim 2, which is prepared by the following process:
3.1. weighing the components for producing the toothpaste according to the parts by weight;
3.2. adding degreased periplaneta americana extract solution, green tea extract solution, sodium dodecyl sulfate and trisodium phosphate into a water phase pot, dissolving and dispersing in water to form a mixture A;
3.3. adding silicon dioxide, carrageenan and carboxymethyl cellulose into a powder pot, and uniformly stirring to form a mixture B;
3.4. adding sorbitol, PEG400, fresh mint DLIT-006, refrigerant WS-2, refrigerant WS-23 and methyl hydroxybenzoate into an oil phase pot, and mixing to obtain mixture C;
3.5. adding the mixture A, the mixture B and the mixture C into a paste making pot, uniformly mixing, adding titanium dioxide, and stirring for 60 minutes under vacuum to obtain paste D;
3.6. and (4) degassing the paste body D in vacuum for 30 minutes, and filling to obtain the toothpaste containing the degreased periplaneta americana extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010268789.4A CN111700852A (en) | 2020-04-08 | 2020-04-08 | Toothpaste containing degreased periplaneta americana extract and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010268789.4A CN111700852A (en) | 2020-04-08 | 2020-04-08 | Toothpaste containing degreased periplaneta americana extract and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111700852A true CN111700852A (en) | 2020-09-25 |
Family
ID=72537069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010268789.4A Pending CN111700852A (en) | 2020-04-08 | 2020-04-08 | Toothpaste containing degreased periplaneta americana extract and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111700852A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939345A (en) * | 2006-09-30 | 2007-04-04 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN103222988A (en) * | 2013-01-15 | 2013-07-31 | 四川好医生攀西药业有限责任公司 | Periplaneta americana extract and its preparation method and use |
| CN103451017A (en) * | 2013-08-16 | 2013-12-18 | 德利宝(广州)香料有限公司 | Preparation methods of essence and toothpaste containing natural green tea extract |
| CN104644460A (en) * | 2015-03-06 | 2015-05-27 | 北京华素制药股份有限公司 | Medicinal toothpaste composition and preparation method and application thereof |
| CN105476947A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Toothpaste containing periplaneta Americana and preparation method thereof |
-
2020
- 2020-04-08 CN CN202010268789.4A patent/CN111700852A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939345A (en) * | 2006-09-30 | 2007-04-04 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN103222988A (en) * | 2013-01-15 | 2013-07-31 | 四川好医生攀西药业有限责任公司 | Periplaneta americana extract and its preparation method and use |
| CN103451017A (en) * | 2013-08-16 | 2013-12-18 | 德利宝(广州)香料有限公司 | Preparation methods of essence and toothpaste containing natural green tea extract |
| CN104644460A (en) * | 2015-03-06 | 2015-05-27 | 北京华素制药股份有限公司 | Medicinal toothpaste composition and preparation method and application thereof |
| CN105476947A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Toothpaste containing periplaneta Americana and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张鹏等著: "美洲大蠊及其不同提取物对急性免疫性肝损伤保护作用的比较", 《安徽医科大学学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104666185B (en) | A kind of liquid tooth paste and preparation method thereof | |
| Lang et al. | Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 6 months | |
| CN103830145B (en) | A kind of toothpaste containing biological peptide and Chinese medicine | |
| RU2293551C1 (en) | Composition for mouth cavity disease prophylaxis | |
| CN106924106B (en) | Toothpaste for inhibiting dental plaque and relieving gingival inflammation | |
| CN107595750B (en) | Active anti-inflammation toothpaste | |
| CN106726773A (en) | A kind of whitening stain removing toothpaste and preparation method thereof | |
| CN107184476A (en) | A kind of antibacterial mouthwash and preparation method thereof | |
| Furumoto et al. | Subjective and clinical evaluation of oral lubricants in xerostomic patients | |
| CN103417443B (en) | Oleum menthae toothpaste | |
| Wolff et al. | Effect of toothbrushing with 0.4% stannous fluoride and 0.22% sodium fluoride gel on gingivitis for 18 months | |
| JPH10152426A (en) | Sanitary agent for oral cavity containing chinese medicine | |
| CN107753398A (en) | A kind of antibacterial mouthwash of anti-inflammatory and preparation method thereof | |
| CN110731935A (en) | toothpaste for diminishing inflammation and relieving pain | |
| CN105997774A (en) | Hemostatic and anti-inflammatory toothpaste and preparation method thereof | |
| CN111700852A (en) | Toothpaste containing degreased periplaneta americana extract and preparation method thereof | |
| CN105943478A (en) | Toothpaste with efficacies of brightening and whitening teeth and diminishing inflammation and preparation method of toothpaste | |
| CN106074305B (en) | A kind of Noni fruit toothpaste and preparation method thereof with oral mucosa protective effect | |
| CN107496318A (en) | A kind of desensitizing toothpaste of American-cockroach-extract-containing | |
| CN103417400B (en) | Containing vinegar toothpaste | |
| JPH01502111A (en) | Oral hygiene medicine | |
| US20070292372A1 (en) | Gel composition for improving oral health, system including the composition, and methods of using and forming same | |
| CN112220707A (en) | Tooth sensitivity resisting biological lysozyme toothpaste composition | |
| CN103446033A (en) | Propolis health care toothpaste | |
| AU2019100471A4 (en) | Methods and compositions for reducing tooth, root and dentin sensitivity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210128 Address after: Room 470-2, bonded building, west of bonded Road, Airport Economic Zone, Hangzhou, Zhejiang 310000 Applicant after: Hangzhou haishijia Technology Co.,Ltd. Address before: Room 470-2, bonded building, west of bonded Road, Airport Economic Zone, Hangzhou, Zhejiang 310000 Applicant before: Hangzhou haishijia Technology Co.,Ltd. Applicant before: ZHEJIANG JINGXIN PHARMACEUTICAL Co.,Ltd. Applicant before: INNER MONGOLIA JINGXIN PHARMACEUTICAL Co.,Ltd. Applicant before: SHANGHAI JINGXIN BIOLOGICAL MEDICAL Co.,Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200925 |