CN105997774A - Hemostatic and anti-inflammatory toothpaste and preparation method thereof - Google Patents
Hemostatic and anti-inflammatory toothpaste and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention provides hemostatic and anti-inflammatory toothpaste and a preparation method thereof. Compared with the prior art, the toothpaste has the effects of stopping bleeding, diminishing inflammation, preventing and treating heat inflammation invasion, repairing the mucosal tissue wound surface and enhancing the resistance of mouth mucosa by adding a lily extracting solution, a bletilla striata extracting solution, a lucid ganoderma extracting solution, a fructus lycii extracting solution and an umbilicaria esculenta and dendrobium extractive. The toothpaste improves the health condition of the gingival and the oral cavity and improves the immunity of the oral cavity. The moistening degree of the toothpaste is high, and a user will not feel dry, rough or uncomfortable in the oral cavity after using the toothpaste to brush the teeth. The prepared toothpaste is mild in feature and high in safety and has no side effect.
Description
Technical field
The invention belongs to cosmetics of everyday use field, be specifically related to a kind of hemostasis and anti-inflammation toothpaste and preparation thereof
Method.
Background technology
Along with the raising of people's living standard, the health of tooth is increasingly paid close attention to by people.Now,
Along with the raising of quality of life, the supply of high-carbohydrate food is enriched, and all kinds of odontopathies are the most gradually
Displaying, gingival hemorrhage is also one of modal odontopathy.
Gingival hemorrhage is one of department of stomatology common sympton, refers to that gingiva is idiopathic or due to slightly
Stimulate cause to bleed on a small quantity.The lighter show as only sucking, brush teeth, when chewing harder food
With the blood streak in saliva, severe one is the most hemorrhage more even spontaneous when gingiva is by minimal irritation
Hemorrhage.It is said that in general, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingiva goes out
Blood is more common in periodontitis and gingivitis patients.Gingival hemorrhage is a kind of physiology too early of gingiva tissue
Degradation phenomena, will thoroughly solve a difficult problem for gingival hemorrhage, is also intended to from starting with at all, to supplement
Gingiva nutrition is basic, it is provided that the nutrition that gingiva can be allowed directly to absorb, and makes the gingiva tissue of degeneration
Again improve immunity, could fundamentally solve a series of tooth mouths that gingival hemorrhage is brought
Chamber problem.
Toothpaste, as one of essential items cleaning tooth, it is desirable to while cleaning, also
The functions such as treatment oral disease can be played.Existing toothpaste contain abrasivus, washing foam agent,
Binding agent, wetting agent, sweeting agent, aromatic, its bacteriostasis is frequently not highly desirable,
More do not have the effect of hemostasis, antiinflammatory.
Summary of the invention
It is an object of the invention to provide a kind of hemostasis and anti-inflammation toothpaste and preparation method thereof, containing stone
The natural extract compositions such as dry measure used in former times, Umbillcaria esculenta, Bulbus Lilii, the Pseudobulbus Bletillae (Rhizoma Bletillae), Ganoderma, have heat-clearing and toxic substances removing, hemostasis
The effect of antiinflammatory.
Present invention also offers a kind of hemostasis and anti-inflammation toothpaste, including the raw material of following weight portion:
The preparation method of described Umbillcaria esculenta extract is:
By Umbillcaria esculenta steep raising, clean and remove back side burr, chopping, carry in 90-100 DEG C of heating decoction
Take 3 times, add 6-12 times amount water for the 1st time, extract 0.5-2h, add 4-10 times amount the 2nd time
Water, extracts 0.5-1.5h, adds 3-8 times amount water for the 3rd time, extracts 0.5-1.5h, filters every time
Crossing, merging filtrate, 3-6 times of g/ml of the volume concentration of filtrate to Umbillcaria esculenta weight, after filtration
Vacuum drying, obtains Umbillcaria esculenta extract.
The preparation method of described Herba Dendrobii extract is:
Herba Dendrobii is crushed into powder, soaks 0.5-1h, decoct in 90-100 DEG C of heating and extract 3 times,
Add 8-15 times amount water for 1st time, extract 0.5-1.5h, add 6-12 times amount water, carry for the 2nd time
Take 0.5-2h, add 3-7 times amount water for the 3rd time, extract 0.5-1h, filter every time, merge filter
Liquid, 3-6 times of g/ml of the volume concentration of filtrate to dendrobium chrysanthum weight, filter final vacuum and be dried,
Obtain Herba Dendrobii extract.
The preparation method of described Bulbus Lilii extracting solution:
Weigh Bulbus Lilii appropriate, soak 0.5-0.75h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 8-12 times of weight, extracts 0.5-2h, adds 6-10 times of weight the 2nd time
Water, extracts 0.5-2h, the water that the 3rd time adds 3-5 times of weight, extracts 0.5-2h, filter every time
Cross, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Bulbus Lilii weight, filter i.e.
?；
The preparation method of described Rhizoma Bletillae extraction solution:
Weigh the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.5-0.75h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 8-10 times of weight, extraction 0.5-2h, the water that the 2nd time adds 6-8 times of weight,
Extract 0.5-1.5h, the water that the 3rd time adds 3-5 times of weight, extract 0.5-1.5h, filter every time
Cross, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filter i.e.
?；
The preparation method of described Ganoderma extracting solution:
Weigh Ganoderma appropriate, soak 0.5-1h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 6-10 times of weight, extracts 0.5-1.5h, adds 8-12 times of weight the 2nd time
Water, extract 0.5-1.5h, the water that the 3rd time adds 2-7 times of weight, extract 0.5-2h, often
Secondary filtration, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Ganoderma weight, mistake
Filter and get final product；
The preparation method of described fructus lycii extracted solution is:
Weigh Fructus Lycii appropriate, soak 0.3-0.5h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 6-10 times of weight, extracts 0.5-1.5h, adds 6-12 times of weight the 2nd time
Water, extract 0.5-2h, the water that the 3rd time adds 3-7 times of weight, extract 0.5-1h, every time
Filter, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Fructus Lycii weight, filter
Obtain；
The preparation method of a kind of hemostasis and anti-inflammation toothpaste that the present invention provides, comprises the following steps:
(1) by the calcium hydrogen phosphate of formula ratio, deionized water, sorbic acid, hydrated silica, the moon
Cinnamic alcohol sodium sulfovinate, cellulose gum, xanthan gum, sodium pyrophosphate, saccharin sodium, sodium benzoate
Mix under the conditions of heating in water bath 80-85 DEG C with hydroxyethyl cellulose；
(2) bath temperature is reduced to 70-75 DEG C, add formula ratio Ganoderma extracting solution,
Bulbus Lilii extracting solution, Rhizoma Bletillae extraction solution and fructus lycii extracted solution, mix homogeneously；
(3) leave water-bath, add Umbillcaria esculenta extract, Herba Dendrobii extract stirring under room temperature mixed
Even；
(4) add the Mel of formula ratio, after stirring and evenly mixing, add the essence of formula ratio,
Mixing, obtains hemostasis and anti-inflammation toothpaste.
In the present invention, Umbillcaria esculenta has nourishing YIN and moistening the lung；Cooling blood for hemostasis；Effect of heat-clearing and toxic substances removing, it is possible to
Improve plasma antithrombin III activity, improve the effects such as immunity.Herba Dendrobii sweet in the mouth, cold nature,
There is reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat.In preparation process, under room temperature add Umbillcaria esculenta and
Herba Dendrobii extract, in order to avoid the loss property of medicine, Umbillcaria esculenta and the mutual compatibility of Herba Dendrobii use, significantly improves medicine
The effect of the hemostasis and anti-inflammation of cream.
The present invention with the addition of Bulbus Lilii extracting solution, Rhizoma Bletillae extraction solution, Ganoderma extracting solution and Fructus Lycii carry
Take liquid, design extraction process according to the property of medicine of every kind of Chinese medicine, make extracting solution drug effect improve.Bulbus Lilii
Heat clearing away, the Pseudobulbus Bletillae (Rhizoma Bletillae), containing bletilla mannan, have obvious anastalsis.The Pseudobulbus Bletillae (Rhizoma Bletillae) has antibacterial action,
Softening calculus, diminish inflammation the stimulation brought, and alleviates red swelling of gingiva and suppression gingival hemorrhage, changes
The microcirculation of kind gingiva.Fructus Lycii heat clearing away, raising body immunity and antioxidative effect；Ganoderma
There is antiinflammatory, antiplatelet aggregation and anti thrombotic action, and improve immunity and blood yiqi
Effect.Bulbus Lilii, the Pseudobulbus Bletillae (Rhizoma Bletillae), Ganoderma and Fructus Lycii use with Umbillcaria esculenta, Herba Dendrobii compatibility, make to be prepared into
To toothpaste there is hemostasis and anti-inflammation effect while, improve gingiva immune level, make gingiva more strong
Health, repairs the tissue wound surface of oral mucosa, improves oral health level, makes gingiva, oral cavity more
Healthy.Last in preparation process, add Mel, not only improve the mastic viscosity of toothpaste, meanwhile,
With the Chinese medicine ingredients in formula with the use of, improve toothpaste moisturizing effect.
Compared with prior art, present invention adds Bulbus Lilii extracting solution, Rhizoma Bletillae extraction solution, Ganoderma
Extracting solution, fructus lycii extracted solution and Umbillcaria esculenta, Herba Dendrobii extract, have the effect of hemostasis and anti-inflammation, anti-
Control inflammation infringement of getting angry, repair mucosal tissue wound surface, strengthen oral mucosa resistance；And carry
High gingiva, the health status in oral cavity, improve oral immunisation power；Meanwhile, toothpaste moistens degree height,
Will not dry mouth syndrome feel bad after brushing teeth.The toothpaste properties of preparation is gentle, and safety is high, makees without secondary
With.
Detailed description of the invention
Embodiment 1
A kind of hemostasis and anti-inflammation toothpaste, including the raw material of following weight portion:
The preparation method of described Umbillcaria esculenta extract is:
By Umbillcaria esculenta steep raising, clean and remove back side burr, chopping, decoct extraction 3 in 95 DEG C of heating
Secondary, add 8 times amount water for the 1st time, extract 1h, add 7 times amount water for the 2nd time, extract 1h, the
Adding 6 times amount water for 3 times, extract 1h, filter, merging filtrate every time, the volume concentration of filtrate is extremely
4 times of g/ml of Umbillcaria esculenta weight, filter final vacuum and are dried, obtain Umbillcaria esculenta extract.
The preparation method of described Herba Dendrobii extract is:
Herba Dendrobii is crushed into powder, soaks 0.5h, heat in 90 DEG C and decoct extraction 3 times, the 1st time
Add 12 times amount water, extract 1.5h, add 12 times amount water for the 2nd time, extract 1.5h, the 3rd time
Adding 5 times amount water, extract 0.5h, filter, merging filtrate every time, the volume concentration of filtrate is extremely
4 times of g/ml of dendrobium chrysanthum weight, filter final vacuum and are dried, obtain Herba Dendrobii extract.
The preparation method of described Bulbus Lilii extracting solution:
Weigh Bulbus Lilii appropriate, soak 0.5h, heat in 95 DEG C and decoct extraction 3 times, the 1st time
Add the water of 8-12 times of weight, extract 0.5-2h, the water that the 2nd time adds 7 times of weight, extract 1h,
The water that 3rd time adds 4 times of weight, extracts 1h, filters, merging filtrate, the body of filtrate every time
The long-pending 4 times of g/ml being concentrated into Bulbus Lilii weight, filter and get final product；
The preparation method of described Rhizoma Bletillae extraction solution:
Weigh the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.75h, heat in 95 DEG C and decoct extraction 3 times, the 1st time
Add the water of 9 times of weight, extract 1h, the water that the 2nd time adds 7 times of weight, extract 1.5h, the
The water that 3 times add 4 times of weight, extracts 1.5h, filters, merging filtrate, the volume of filtrate every time
It is concentrated into 5 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filters and get final product；
The preparation method of described Ganoderma extracting solution:
Weigh Ganoderma appropriate, soak 1h, decoct in 95 DEG C of heating and extract 3 times, add for the 1st time
The water of 10 times of weight, extracts 1.5h, the water that the 2nd time adds 12 times of weight, extracts 0.8h,
The water that 3rd time adds 6 times of weight, extracts 0.5h, filters, merging filtrate every time, filtrate
Volume concentration, to 4 times of g/ml of Ganoderma weight, filters and get final product；
The preparation method of described fructus lycii extracted solution is:
Weighing Fructus Lycii appropriate, soak 0.3h, heating decocts extracts 3 times, adds 7 times the 1st time
The water of weight, extraction 1.5h, the water that the 2nd time adds 12 times of weight, extraction 0.5h, the 3rd time
Adding the water of 5 times of weight, extract 0.5h, filter, merging filtrate every time, the volume of filtrate is dense
It is reduced to 4 times of g/ml of Fructus Lycii weight, filters and get final product；
The preparation method of a kind of hemostasis and anti-inflammation toothpaste, comprises the following steps:
(1) by the calcium hydrogen phosphate of formula ratio, deionized water, sorbic acid, hydrated silica, the moon
Cinnamic alcohol sodium sulfovinate, cellulose gum, xanthan gum, sodium pyrophosphate, saccharin sodium, sodium benzoate
Mix under the conditions of heating in water bath 80 DEG C with hydroxyethyl cellulose；
(2) bath temperature is reduced to 70 DEG C, adds the Ganoderma extracting solution of formula ratio, Bulbus Lilii
Extracting solution, Rhizoma Bletillae extraction solution and fructus lycii extracted solution, mix homogeneously；
(3) leave water-bath, add Umbillcaria esculenta extract, Herba Dendrobii extract stirring under room temperature mixed
Even；
(4) add the Mel of formula ratio, after stirring and evenly mixing, add the essence of formula ratio,
Mixing, obtains hemostasis and anti-inflammation toothpaste.
Embodiment 2
A kind of hemostasis and anti-inflammation toothpaste, including the raw material of following weight portion:
The preparation method of described Umbillcaria esculenta extract is:
By Umbillcaria esculenta steep raising, clean and remove back side burr, chopping, decoct extraction 3 in 90 DEG C of heating
Secondary, add 6 times amount water for the 1st time, extract 1h, add 5 times amount water for the 2nd time, extract 1.5h,
Adding 6 times amount water for 3rd time, extract 1h, filter, merging filtrate every time, the volume of filtrate is dense
It is reduced to 5 times of g/ml of Umbillcaria esculenta weight, filters final vacuum and be dried, obtain Umbillcaria esculenta extract.
The preparation method of described Herba Dendrobii extract is:
Herba Dendrobii is crushed into powder, soaks 1h, decoct in 90 DEG C of heating and extract 3 times, add for the 1st time
12 times amount water, extract 0.5h, add 7 times amount water for the 2nd time, extract 2h, add 7 times the 3rd time
Amount water, extracts 1h, filters, merging filtrate every time, and the volume concentration of filtrate is to dendrobium chrysanthum weight
6 times of g/ml of amount, filter final vacuum and are dried, obtain Herba Dendrobii extract.
The preparation method of described Bulbus Lilii extracting solution:
Weigh Bulbus Lilii appropriate, soak 0.5h, heat in 90 DEG C and decoct extraction 3 times, the 1st time
Add the water of 10 times of weight, extract 1h, the water that the 2nd time adds 8 times of weight, extract 1h, the
The water that 3 times add 4 times of weight, extracts 1h, filters, merging filtrate every time, and the volume of filtrate is dense
It is reduced to 4 times of g/ml of Bulbus Lilii weight, filters and get final product；
The preparation method of described Rhizoma Bletillae extraction solution:
Weigh the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.75h, heat in 90 DEG C and decoct extraction 3 times, the 1st time
Add the water of 9 times of weight, extract 1h, the water that the 2nd time adds 7 times of weight, extract 1.5h, the
The water that 3 times add 5 times of weight, extracts 1.5h, filters, merging filtrate, the volume of filtrate every time
It is concentrated into 5 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filters and get final product；
The preparation method of described Ganoderma extracting solution:
Weigh Ganoderma appropriate, soak 0.5h, heat in 90 DEG C and decoct extraction 3 times, the 1st time
Add the water of 6 times of weight, extract 0.5h, the water that the 2nd time adds 8 times of weight, extract 0.5h,
The water that 3rd time adds 3 times of weight, extracts 0.5h, filters, merging filtrate every time, filtrate
Volume concentration, to 3 times of g/ml of Ganoderma weight, filters and get final product；
The preparation method of described fructus lycii extracted solution is:
Weigh Fructus Lycii appropriate, soak 0.3h, heat in 90 DEG C and decoct extraction 3 times, the 1st time
Add the water of 6 times of weight, extract 0.5h, the water that the 2nd time adds 7 times of weight, extract 1h, the
The water that 3 times add 4 times of weight, extracts 0.5h, filters, merging filtrate, the volume of filtrate every time
It is concentrated into 4 times of g/ml of Fructus Lycii weight, filters and get final product；
The preparation method of a kind of hemostasis and anti-inflammation toothpaste, comprises the following steps:
(1) by the calcium hydrogen phosphate of formula ratio, deionized water, sorbic acid, hydrated silica, the moon
Cinnamic alcohol sodium sulfovinate, cellulose gum, xanthan gum, sodium pyrophosphate, saccharin sodium, sodium benzoate
Mix under the conditions of heating in water bath 85 DEG C with hydroxyethyl cellulose；
(2) bath temperature is reduced to 70 DEG C, adds the Ganoderma extracting solution of formula ratio, Bulbus Lilii
Extracting solution, Rhizoma Bletillae extraction solution and fructus lycii extracted solution, mix homogeneously；
(3) leave water-bath, add Umbillcaria esculenta extract, Herba Dendrobii extract stirring under room temperature mixed
Even；
(4) add the Mel of formula ratio, after stirring and evenly mixing, add the essence of formula ratio,
Mixing, obtains hemostasis and anti-inflammation toothpaste.
Embodiment 3
A kind of hemostasis and anti-inflammation toothpaste, including the raw material of following weight portion:
The preparation method of described Umbillcaria esculenta extract is:
By Umbillcaria esculenta steep raising, clean and remove back side burr, chopping, decoct extraction 3 in 100 DEG C of heating
Secondary, add 12 times amount water for the 1st time, extract 2h, add 10 times amount water for the 2nd time, extract 1.5h,
Add 8 times amount water for 3rd time, extract 1.5h, filter, merging filtrate, the volume of filtrate every time
It is concentrated into 6 times of g/ml of Umbillcaria esculenta weight, filters final vacuum and be dried, obtain Umbillcaria esculenta extract.
The preparation method of described Herba Dendrobii extract is:
Herba Dendrobii is crushed into powder, soaks 1h, heat in 100 DEG C and decoct extraction 3 times, the 1st time
Add 15 times amount water, extract 1.5h, add 6-12 times amount water for the 2nd time, extract 2h, the 3rd time
Adding 7 times amount water, extract 1h, filter, merging filtrate every time, the volume concentration of filtrate is to dry
6 times of g/ml of Herba Dendrobii weight, filter final vacuum and are dried, obtain Herba Dendrobii extract.
The preparation method of described Bulbus Lilii extracting solution:
Weigh Bulbus Lilii appropriate, soak 0.75h, heat in 100 DEG C and decoct extraction 3 times, the 1st
The secondary water adding 12 times of weight, extracts 2h, the water that the 2nd time adds 10 times of weight, extracts 2h,
The water that 3rd time adds 5 times of weight, extracts 2h, filters, merging filtrate, the body of filtrate every time
The long-pending 5 times of g/ml being concentrated into Bulbus Lilii weight, filter and get final product；
The preparation method of described Rhizoma Bletillae extraction solution:
Weigh the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.75h, heat in 100 DEG C and decoct extraction 3 times, the 1st
The secondary water adding 10 times of weight, extracts 2h, the water that the 2nd time adds 8 times of weight, extracts 1.5h,
The water that 3rd time adds 5 times of weight, extracts 1.5h, filters, merging filtrate every time, filtrate
Volume concentration, to 5 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filters and get final product；
The preparation method of described Ganoderma extracting solution:
Weigh Ganoderma appropriate, soak 1h, heat in 100 DEG C and decoct extraction 3 times, the 1st time
Add the water of 10 times of weight, extract 1.5h, the water that the 2nd time adds 12 times of weight, extract 1.5h,
The water that 3rd time adds 7 times of weight, extracts 2h, filters, merging filtrate, the body of filtrate every time
The long-pending 5 times of g/ml being concentrated into Ganoderma weight, filter and get final product；
The preparation method of described fructus lycii extracted solution is:
Weigh Fructus Lycii appropriate, soak 0.5h, heat in 100 DEG C and decoct extraction 3 times, the 1st time
Add the water of 10 times of weight, extract 1.5h, the water that the 2nd time adds 12 times of weight, extract 2h,
The water that 3rd time adds 7 times of weight, extracts 1h, filters, merging filtrate, the body of filtrate every time
The long-pending 5 times of g/ml being concentrated into Fructus Lycii weight, filter and get final product；
The preparation method of a kind of hemostasis and anti-inflammation toothpaste that the present invention provides, comprises the following steps:
(1) by the calcium hydrogen phosphate of formula ratio, deionized water, sorbic acid, hydrated silica, the moon
Cinnamic alcohol sodium sulfovinate, cellulose gum, xanthan gum, sodium pyrophosphate, saccharin sodium, sodium benzoate
Mix under the conditions of heating in water bath 85 DEG C with hydroxyethyl cellulose；
(2) bath temperature is reduced to 75 DEG C, adds the Ganoderma extracting solution of formula ratio, Bulbus Lilii
Extracting solution, Rhizoma Bletillae extraction solution and fructus lycii extracted solution, mix homogeneously；
(3) leave water-bath, add Umbillcaria esculenta extract, Herba Dendrobii extract stirring under room temperature mixed
Even；
(4) add the Mel of formula ratio, after stirring and evenly mixing, add the essence of formula ratio,
Mixing, obtains hemostasis and anti-inflammation toothpaste.
The physicochemical property of the hemostasis and anti-inflammation toothpaste prepared by embodiment 1-3 is as follows
1 character
This product is that viscosity is suitable, and foam is smooth suitably, fine and smooth uniform, the breast that stretchability is good
White toothpaste.
2PH value checks
Dipping a small amount of toothpaste with the PH reagent paper of moistening, PH is 6-7.
3 caloric tests
Toothpaste is packaged in transparence cosmetic bottle, in refrigerator cold-storage about week observation of 4 DEG C
Without lamination.24h is put, without layering, spoiled phenomenon in the calorstat of 55 DEG C.
4 centrifugal tests
Being packaged in by toothpaste in tool plug test tube, 3000r/min is centrifuged 20min, without lamination.
5 zests, anaphylaxis are tested
White mice back cuts off hair, smears the toothpaste by embodiment 1,2 preparation respectively in cutting off
The position of hair, and no painting position does not compares, result does not has zest and anaphylaxis.
1 gram of hemostasis and anti-inflammation toothpaste prepared by Example 1-3 be applied to volunteer (25-50 year,
80 people) in gesture and facial expression, observe after spending 30 minutes, rubescent, dermexanthesis, foaming phenomena do not occur.
6 room temperatures place experiment
Being placed in bottle for cosmetics by toothpaste made for embodiment 1-3, room temperature stands to be investigated 6 months,
Without lamination, with after feel unchanged, abnormal smells from the patient is unchanged.
7 toothpaste trial effects
Choose volunteer (25-50 year, 80 people) to brush teeth with obtained toothpaste, find foam
Smooth, it is easy to remove, generally feel breath freshening with rear volunteer, moisten the driest and the most astringent, it is possible to
Alleviate sensitivity of tooth, improve gingiva problem.Through the continuous use of month, reduce in mouth thin
The problems such as bacterium grows, dental haemorrhage, oral ulcer.
This toothpaste resultant effect is investigated
Feel to evaluate the effect of the toothpaste that embodiment 1,2 and 3 produces following with on probation.
Use public-opinion poll point system, choose 80 25-50 year age bracket people as object on probation,
Arbitrarily being divided into two groups, the toothpaste prepared by embodiment 1-3 respectively is brushed teeth.Every day uses sooner or later
Twice, the use time is two months.Every using effect total score is 5 points: 5 to be divided into best result,
Represent very well, the most satisfied；4 are divided into preferably；3 are divided into and can accept；Less than 3 points is not
Good, it is impossible to accept.It it is below every average.The results are shown in Table 1:
Table 1 resultant effect is investigated
Claims (8)
1. a hemostasis and anti-inflammation toothpaste, it is characterised in that described hemostasis and anti-inflammation toothpaste includes following
The raw material of weight portion:
Hemostasis and anti-inflammation toothpaste the most according to claim 1, it is characterised in that described Umbillcaria esculenta carries
The preparation method taking thing is:
By Umbillcaria esculenta steep raising, clean and remove back side burr, chopping, carry in 90-100 DEG C of heating decoction
Take 3 times, add 6-12 times amount water for the 1st time, extract 0.5-2h, add 4-10 times amount the 2nd time
Water, extracts 0.5-1.5h, adds 3-8 times amount water for the 3rd time, extracts 0.5-1.5h, filters every time
Crossing, merging filtrate, 3-6 times of g/ml of the volume concentration of filtrate to Umbillcaria esculenta weight, after filtration
Vacuum drying, obtains Umbillcaria esculenta extract.
Hemostasis and anti-inflammation toothpaste the most according to claim 1 and 2, it is characterised in that described stone
The preparation method of dry measure used in former times extract is:
Herba Dendrobii is crushed into powder, soaks 0.5-1h, heat in 90-100 DEG C and decoct extraction 3 times, the 1st
The secondary 8-15 times amount water that adds, extracts 0.5-1.5h, adds 6-12 times amount water for the 2nd time, extracts 0.5-2h,
Add 3-7 times amount water for 3rd time, extract 0.5-1h, filter, merging filtrate every time, filtrate
Volume concentration, to 3-6 times of g/ml of dendrobium chrysanthum weight, filters final vacuum and is dried, obtain Herba Dendrobii
Extract.
Hemostasis and anti-inflammation toothpaste the most according to claim 1 and 2, it is characterised in that described hundred
The preparation method of conjunction extracting solution:
Weigh Bulbus Lilii appropriate, soak 0.5-0.75h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 8-12 times of weight, extracts 0.5-2h, adds 6-10 times of weight the 2nd time
Water, extracts 0.5-2h, the water that the 3rd time adds 3-5 times of weight, extracts 0.5-2h, filter every time
Cross, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Bulbus Lilii weight, filter i.e.
?.
Hemostasis and anti-inflammation toothpaste the most according to claim 1 and 2, it is characterised in that described in vain
The preparation method of splendid achnatherum extracting solution:
Weigh the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.5-0.75h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 8-10 times of weight, extraction 0.5-2h, the water that the 2nd time adds 6-8 times of weight,
Extract 0.5-1.5h, the water that the 3rd time adds 3-5 times of weight, extract 0.5-1.5h, filter every time
Cross, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filter i.e.
?.
Hemostasis and anti-inflammation toothpaste the most according to claim 1 and 2, it is characterised in that described spirit
The preparation method of sesame extracting solution:
Weigh Ganoderma appropriate, soak 0.5-1h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 6-10 times of weight, extracts 0.5-1.5h, adds 8-12 times of weight the 2nd time
Water, extract 0.5-1.5h, the water that the 3rd time adds 2-7 times of weight, extract 0.5-2h, often
Secondary filtration, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Ganoderma weight, mistake
Filter and get final product.
Hemostasis and anti-inflammation toothpaste the most according to claim 1 and 2, it is characterised in that described Chinese holly
The preparation method of Qi extracting solution is:
Weigh Fructus Lycii appropriate, soak 0.3-0.5h, decoct in 90-100 DEG C of heating and extract 3 times,
The water that 1st time adds 6-10 times of weight, extracts 0.5-1.5h, adds 6-12 times of weight the 2nd time
Water, extract 0.5-2h, the water that the 3rd time adds 3-7 times of weight, extract 0.5-1h, every time
Filter, merging filtrate, 3-5 times of g/ml of the volume concentration of filtrate to Fructus Lycii weight, filter
Obtain.
8. a preparation method for the hemostasis and anti-inflammation toothpaste described in any one of claim 1-7, it is special
Levying and be, described preparation method comprises the following steps:
(1) by the calcium hydrogen phosphate of formula ratio, deionized water, sorbic acid, hydrated silica, the moon
Cinnamic alcohol sodium sulfovinate, cellulose gum, xanthan gum, sodium pyrophosphate, saccharin sodium, sodium benzoate
Mix under the conditions of heating in water bath 80-85 DEG C with hydroxyethyl cellulose；
(2) bath temperature is reduced to 70-75 DEG C, add formula ratio Ganoderma extracting solution,
Bulbus Lilii extracting solution, Rhizoma Bletillae extraction solution and fructus lycii extracted solution, mix homogeneously；
(3) leave water-bath, add Umbillcaria esculenta extract, Herba Dendrobii extract stirring under room temperature mixed
Even；
(4) add the Mel of formula ratio, after stirring and evenly mixing, add the essence of formula ratio,
Mixing, obtains hemostasis and anti-inflammation toothpaste.
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| CN109260125A (en) * | 2018-11-30 | 2019-01-25 | 俞傲然 | A kind of powder of brushing teeth that can effectively control bleeding gums, be good for tooth, permanent tooth |
| CN110917059A (en) * | 2020-01-02 | 2020-03-27 | 浙江寿仙谷健康科技有限公司 | Efficacy agent of toothpaste with anti-inflammation and hemostasis effects, toothpaste containing efficacy agent and preparation method of toothpaste |
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| CN106692755A (en) * | 2017-01-03 | 2017-05-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition |
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| CN109260125A (en) * | 2018-11-30 | 2019-01-25 | 俞傲然 | A kind of powder of brushing teeth that can effectively control bleeding gums, be good for tooth, permanent tooth |
| CN110917059A (en) * | 2020-01-02 | 2020-03-27 | 浙江寿仙谷健康科技有限公司 | Efficacy agent of toothpaste with anti-inflammation and hemostasis effects, toothpaste containing efficacy agent and preparation method of toothpaste |
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