CN111700196A - 一种含艾考糊精的中药解酒功能性饮料 - Google Patents
一种含艾考糊精的中药解酒功能性饮料 Download PDFInfo
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Abstract
本发明涉及食品领域，具体为一种含艾考糊精的中药解酒功能性饮料饮料。本发明的含艾考糊精的中药解酒功能性饮料包含艾考糊精，葛根提取物，葛花提取物，枸杞提取物，白砂糖，食用盐，辅助料，水。本发明的含艾考糊精的电解质饮料解酒效果好，安全，质量稳定性好，具有甜度低、口感好、保湿性好、不易结晶的优点，可在肠道中持续水解，有延长人体供能、强化机体耐力和作功能力的功效。
Description
技术领域
本发明属食品领域，具体而言，主要涉及一种含艾考糊精的中药解酒功能性饮料饮料。
技术背景
随着人们生活水平的提高，以及商业、社交活动频发，饮酒过度是人们经常会遇到的问题，这会对个人的肝脏、脾胃、中枢神经等都造成很大危害。乙醇进入体内后通过胃肠道吸收，仅有2%-10%由呼吸道、尿液和汗腺以原形排出，其余98%-90%在肝脏内氧化（很少在肝外代谢）；经肝脏代谢的乙醇约80%通过乙醇脱氢酶（ADH）转化为乙醛，约20%通过微粒体乙醇氧化酶转化为乙醛，乙醛再经过乙醛脱氢酶（ALDH）转化为乙酸，进入三羧酸循环，氧化成二氧化碳和水。乙醛的生成可刺激肾上腺激素、去甲肾上腺素等的分泌，从而引起面红耳赤、心率加快、皮肤温高等症状。酒精可以抑制抗利尿激素的产生，导致尿液增多，酒中的水又增加了尿液来源。排尿的同时人体内水分、电解质会造成相应程度的流失。
不管是肝脏代谢还是线粒体代谢，都需要能量的提供。现在市面上的解酒产品质量及疗效参次不齐，供能不持久或机理不明确。葡萄糖等作为能量供给可引起迅速的血糖与血压升高，变性淀粉、抗性糊精、低聚果糖等葡聚糖虽然可作为持续供能原料，但结构不确定，质量稳定性无法保证。
艾考糊精是由淀粉水解精制而成的一种葡聚糖，通过α(1-4)和少于 10％α(1-6)糖苷键连接，平均分子量为25000~34000道尔顿，具有良好的水溶性、安全性和生物相容性。以艾考糊精为原料的药物制剂已在36个国家和地区批准上市，可代替葡萄糖作为新一代的腹膜透析液渗透剂，具有低代谢产物、高超滤作用的特点，可有效改善代谢紊乱、降低胰岛素抵抗，对糖尿病人、心血管患者友好。
艾考糊精是一种多聚糖，具有低甜度、低热量、低渗透压的特性。它本身不能参与非酶糖基化反应，其代谢终产物为麦芽糊精，亦很难参与糖基化反应。相同时间内腹膜对艾考糊精的吸收率是葡萄糖的1/4，即人体对艾考糊精的吸收率低；但艾考糊精可在肠道中持续水解，有延长人体供能、强化机体耐力和作功能力的功效。
葛根，别名：葛条、粉葛、甘葛、葛藤。性凉，味甘、辛。功能主治：解表退热，生津、透疹，升阳止泻。用于外感发热头痛、高血压颈项强痛、口渴、消渴、麻疹不透、热痢、泄泻。《本草纲目》载：葛根，性凉、气平、味甘，具清热、降火、排毒诸功效。现代医学研究表明：葛根中的异黄酮类化合物葛根素对高血压、高血脂、高血糖和心脑血管疾病有一定疗效。
葛花，别名葛条花，其性甘、平，归胃经。《本草纲目》记载，葛花能“解酒醒脾”，故民间历史素有“千杯不醉葛藤花”之说。同时葛花具有清热解毒，分解酒精，健胃、护肝等功效。用于酒醉烦渴，解酒醒脾。治伤酒发热烦渴，不思饮食，呕逆吐酸，吐血，肠风下血。
枸杞，又称枸杞子、红耳坠，味甘性平，归肝、肺、肾经，功能为养肝滋肾润肺。枸杞药食同源的历史悠久，是驰名中外的名贵中药材，早在《神农本草经》中就被列为上品，记载：“枸杞久服能坚筋骨、耐寒暑，轻身不老，乃中药中之上品。”《本草纲目》记载“枸杞子甘平而润，性滋补……能补肾、润肺、生精、益气，此乃平补之药。”现代医学表明，枸杞子具有增强免疫，抗辐射，延缓衰老，抗肿瘤，降血脂血糖血压与保肝等功效。
发明内容
基于上述问题，本发明提供一种含艾考糊精的中药解酒功能性饮料，可维持人体疲劳时的血糖水平，避免血液浓缩和血液中乳酸的大量产生，迅速增加机体耐力和作功能力，提高工作效率；克服人体经过大量体力消耗和长时间剧烈运动后出现的盗汗、脱水等症状。对因能源储备过量消耗而出现的血糖降低、体温升高、脑功能紊乱等一系列生理上的变化，具有良好的作用。
本发明的一种含艾考糊精的中药解酒功能性饮料，其特征在于，所述解酒电解质饮料包含艾考糊精、葛根及葛花提取物和辅料。
进一步的，所述饮料包括以下组分：艾考糊精，葛根提取物，葛花提取物，枸杞提取物，白砂糖，食用盐，辅助料，水。
进一步的，所述饮料包括以下原料组分：艾考糊精0.1-20g/L，葛根5-15g/L，葛花1-15g/L，枸杞1-20g/L，白砂糖40-120/L，食用盐1-10/L，辅助料，其余为水。
进一步的，所述辅助料包括牛磺酸、氯化钾、烟酸、柠檬酸、以及柠檬酸钠。
进一步的，所述辅助料包括牛磺酸0.05-0.5 g/L、氯化钾0.02-0.5 g/L、烟酸5-100 mg/L、柠檬酸、柠檬酸钠适量。
本发明的含艾考糊精的中药解酒功能性饮料的制备方法为：
取一定量的葛根、葛花、枸杞，粉碎至粗粉，加入多功能提取罐中，90-105℃建筑回流提取两次，第一次加入10倍药材量水，回流1~2小时，第二次加入8倍药材量水，回流1~2小时。合并两次煎液，用200目筛网过滤，制成中药剂。
中药剂中依次加入艾考糊精、白砂糖、食用盐、氯化钾，搅拌至溶解。再加入烟酸、牛磺酸搅拌至溶解。加饮用水至全量定容，用柠檬酸、柠檬酸钠调节pH值为3.8~7.5。UHT杀菌后灌装，封口后包装。
本发明有益效果：艾考糊精是一种多聚糖，具有低甜度、低热量、低渗透压的特性。它本身不能参与非酶糖基化反应，其代谢终产物为麦芽糊精，亦很难参与糖基化反应。相同时间内腹膜对艾考糊精的吸收率是葡萄糖的1/4，即人体对艾考糊精的吸收率低；但是可在肠道中持续水解，有延长人体供能、强化机体耐力和作功能力的功效。且艾考糊精甜度低、口感好、保湿性好、不易结晶。所以本发明的含艾考糊精的解酒电解质饮料解酒作用明显，安全，质量稳定性好，具有甜度低、口感好、保湿性好、不易结晶的优点，可在肠道中持续水解，有延长人体供能、强化机体耐力和作功能力的功效。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述。
实施例1：
一种含艾考糊精的解酒电解质饮料I型，包括以下原料配比：艾考糊精1 g/L，葛根5g/L，葛花1g/L，枸杞1g/L，白砂糖50g/L，食用盐2g/L，辅助料（牛磺酸0.1 g/L、氯化钾0.02 g/L、烟酸 10mg/L），其余为水。用适量柠檬酸、柠檬酸钠调节pH为6.0~7.0。
按上述比例取一定量的葛根、葛花、枸杞，粉碎至粗粉，加入多功能提取罐中，90-105℃建筑回流提取两次，第一次加入10倍药材量水，回流1~2小时，第二次加入8倍药材量水，回流1~2小时。合并两次煎液，用200目筛网过滤，制成中药剂。
中药剂中依次加入艾考糊精、白砂糖、食用盐、氯化钾，搅拌至溶解。再加入烟酸、牛磺酸搅拌至溶解。加饮用水至全量定容，用柠檬酸、柠檬酸钠调节pH值为3.8~7.5。UHT杀菌后灌装，封口后包装得。
实施例2：
一种含艾考糊精的解酒电解质饮料II型，包括以下原料配比：艾考糊精20 g/L，葛根15g/L，葛根15 g/L，枸杞20 g/L，白砂糖100 g/L，食用盐9 g/L，辅助料（牛磺酸0.5 g/L、氯化钾0.5 g/L、烟酸 100mg/L），其余为水。用适量柠檬酸、柠檬酸钠调节pH为6.0~7.0。
制备方法同实施例1。
实施例3：
一种含艾考糊精的解酒电解质饮料III型，包括以下原料配比：艾考糊精10 g/L，葛根6g/L，葛花6 g/L，枸杞6 g/L，白砂糖40 g/L，食用盐4 g/L，辅助料（牛磺酸0.1 g/L、氯化钾0.2 g/L、烟酸 50 mg/L），其余为水。用适量柠檬酸、柠檬酸钠调节pH为6.0~7.0。
制备方法同实施例1。
为了进一步表明本发明提供的解酒饮料的性能，进行解酒试验。
1实验材料
1 .1动物
ICR小鼠，清洁级，18-22g，雄性。
1 .2药物与试剂
海王金樽口服液；本发明实施例1-3制备的含艾考糊精的解酒电解质饮料I型、II型、III型；56度白酒。
2实验方法
2 .1分组
空白组：未醉酒
对照组：给予生理盐水灌胃
阳性药组：给予海王金樽口服液灌胃
Y1组：给予实施例1所得含艾考糊精的解酒电解质饮料I型样品灌胃
Y2组：给予实施例2所得含艾考糊精的解酒电解质饮料II型样品灌胃
Y3组：给予实施例3所得得含艾考糊精的解酒电解质饮料III型样品灌胃
2 .2小鼠解酒试验
取60只小鼠，雄性。在实验室饲养3d后，随机分成六组，每组10只。实验前禁食一夜（12h）。空白组、对照组均用生理盐水按0.1ml/10g体重灌服；阳性组按0.1ml/10g体重灌服海王金樽口服液；Y1、Y2、Y3组分别按0.1ml/10g体重灌服本发明的解酒电解质饮料I型、II型、III型。30min后，空白组每只小鼠以0.15ml/10g体重用蒸馏水灌服，其他组小鼠均以56度白酒以0.15ml/10g体重灌服。记录各组小白鼠翻正反射消失及恢复的时间，并在灌胃后30、60、90、120、180、240min 6个时间点对小鼠进行眼眶取血。采用乙醇脱氢酶法测定小鼠血中乙醇浓度。
3实验结果
3.1小鼠耐酒精试验结果（见表1）
表1 小鼠醉酒情况及死亡率
| 组别 | 醉酒率/% | 醉酒时间/min | 醒酒时间/min | 死亡率/% |
| 空白组 | 0 | 0 | 0 | 0 |
| 对照组 | 100 | 8.9±2.5 | 408.3±45.5 | 4 |
| 阳性组 | 60 | 15.9±1.6 | 280.0±47.3 | 0 |
| Y1组 | 60 | 15.5±2.0 | 270.3±43.0 | 0 |
| Y2组 | 30 | 18.6±1.4 | 180.7±45.0 | 0 |
| Y3组 | 50 | 16.5±2.3 | 210.6±50.5 | 0 |
注：小鼠正反反射消失，证明小鼠醉酒，醉酒率指醉酒的小鼠只数与该组小鼠只数之比；醉酒时间指的是醉酒小鼠被灌服白酒到出现正反反射消失的时间；醒酒时间指的是正反反射消失到重新恢复的时间，以平均值±标准差表示。
由表1可见，在6个受试样品组中，阳性组、Y1、Y2、Y3组小鼠的醒酒时间均比对照组短， Y1、Y2、Y3组醒酒时间均比阳性组短，可见，Y1、Y2、Y3组醒酒效果明显。
3 .2对小鼠血清乙醇含量的影响
试验结果如图1所示。
由图1可知，在同一时间点，阳性组和Y1、Y2、Y3组小鼠血清乙醇含量均低于对照组，Y1组的解酒效果与阳性组相当，Y2、Y3组的解酒效果比阳性组解酒效果好。可见，Y1、Y2、Y3组醒酒效果明显。
药理试验结果表明，本发明的含艾考糊精的电解质饮料解酒效果明显，安全，质量稳定性好，具有甜度低、口感好、保湿性好、不易结晶的优点，可在肠道中持续水解，有延长人体供能、强化机体耐力和作功能力的功效。
上述实施例对本发明进行示例性描述其目的在于让熟悉此项技术的相关技术人员能够了解本发明的内容并据以实施，并不能以此限制本发明的保护范围。凡根据本发明的方法构思和技术方案进行非实质改进，或未经改进将发明的构思和技术方案直接应用于其他场合的，均在本发明的保护范围之内。
Claims (6)
1.一种含艾考糊精的中药解酒功能性饮料，其特征在于，所述解酒电解质饮料包含艾考糊精、葛根及葛花提取物和辅料。
2.如权利要求1所述的含艾考糊精的中药解酒功能性饮料，其特征在于，所述解酒电解质饮料包括以下组分：艾考糊精，葛根提取物，葛花提取物，枸杞提取物，白砂糖，食用盐，辅助料，水。
3.如权利要求1所述的含艾考糊精的中药解酒功能性饮料，其特征在于，所述解酒电解质饮料包括以下原料组分：艾考糊精0.1-20g/L，葛根5-15g/L，葛花1-15g/L，枸杞1-20g/L，白砂糖40-120/L，食用盐1-10/L，辅助料，其余为水。
4.如权利要求2所述的含艾考糊精的中药解酒功能性饮料，其特征在于，所述辅助料包括牛磺酸、氯化钾、烟酸、柠檬酸、柠檬酸钠。
5.如权利要求4所述的含艾考糊精的解酒电解质饮料，其特征在于，所述辅助料包括牛磺酸0.05-0.5 g/L、氯化钾0.02-0.5 g/L、烟酸5-100 mg/L、柠檬酸、柠檬酸钠适量。
6.如权利要求1-5所述的含艾考糊精的中药解酒功能性饮料的制备方法，其特征在于，具体步骤为：取葛根、葛花、枸杞，粉碎至粗粉，加入多功能提取罐中，90-105℃回流提取两次，第一次加入10倍药材量水，回流1~2小时，第二次加入8倍药材量水，回流1~2小时；合并两次煎液，用200目筛网过滤，制成中药剂；
中药剂中依次加入艾考糊精、白砂糖、食用盐、氯化钾，搅拌至溶解；再加入烟酸、牛磺酸搅拌至溶解；加饮用水至全量定容，用柠檬酸、柠檬酸钠调节pH值为3.8~7.5；UHT杀菌后灌装，封口后包装。
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| KR101394358B1 (ko) * | 2013-10-08 | 2014-05-13 | 주식회사 엘지생활건강 | 숙취 해소용 조성물 |
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