CN111699004A - 眼科疾病的治疗 - Google Patents

眼科疾病的治疗 Download PDF

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Publication number
CN111699004A
CN111699004A CN201980011416.4A CN201980011416A CN111699004A CN 111699004 A CN111699004 A CN 111699004A CN 201980011416 A CN201980011416 A CN 201980011416A CN 111699004 A CN111699004 A CN 111699004A
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CN
China
Prior art keywords
weeks
bispecific antibody
treatment
vegf
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201980011416.4A
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English (en)
Chinese (zh)
Inventor
亚伦·奥斯本
贾亚什里·萨尼
罗伯特·詹姆斯·威克特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Priority to CN202411926524.3A priority Critical patent/CN119770646A/zh
Priority to CN202510108289.7A priority patent/CN119909169A/zh
Priority to CN202411925146.7A priority patent/CN119733046A/zh
Publication of CN111699004A publication Critical patent/CN111699004A/zh
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980011416.4A 2018-02-06 2019-02-05 眼科疾病的治疗 Withdrawn CN111699004A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202411926524.3A CN119770646A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202510108289.7A CN119909169A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411925146.7A CN119733046A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862627103P 2018-02-06 2018-02-06
US62/627,103 2018-02-06
US201862729333P 2018-09-10 2018-09-10
US62/729,333 2018-09-10
PCT/EP2019/052704 WO2019154776A1 (en) 2018-02-06 2019-02-05 Treatment of ophthalmologic diseases

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN202510108289.7A Division CN119909169A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411925146.7A Division CN119733046A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411926524.3A Division CN119770646A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗

Publications (1)

Publication Number Publication Date
CN111699004A true CN111699004A (zh) 2020-09-22

Family

ID=65352014

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201980011416.4A Withdrawn CN111699004A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411925146.7A Pending CN119733046A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202510108289.7A Pending CN119909169A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411926524.3A Pending CN119770646A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202411925146.7A Pending CN119733046A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202510108289.7A Pending CN119909169A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗
CN202411926524.3A Pending CN119770646A (zh) 2018-02-06 2019-02-05 眼科疾病的治疗

Country Status (12)

Country Link
US (2) US20210139576A1 (https=)
EP (1) EP3749359A1 (https=)
JP (5) JP7005772B2 (https=)
KR (3) KR20250166355A (https=)
CN (4) CN111699004A (https=)
AU (3) AU2019219004B2 (https=)
CA (1) CA3088355A1 (https=)
IL (1) IL276383B2 (https=)
MX (1) MX2020007527A (https=)
SG (1) SG11202006712XA (https=)
TW (3) TWI831764B (https=)
WO (1) WO2019154776A1 (https=)

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WO2024088156A1 (zh) * 2022-10-24 2024-05-02 景泽生物医药(合肥)有限公司 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途

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AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
EP3758737A4 (en) 2018-03-02 2022-10-12 Kodiak Sciences Inc. IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
MY195550A (en) 2018-10-29 2023-01-31 Hoffmann La Roche Antibody Formulation
EP3886946A1 (en) 2019-06-05 2021-10-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
TWI785360B (zh) * 2019-08-06 2022-12-01 美商建南德克公司 眼科疾病之個人化治療
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
TW202216761A (zh) 2020-07-16 2022-05-01 瑞士商諾華公司 抗β細胞素抗體、其片段及多特異性結合分子
EP4208201A1 (en) * 2020-09-04 2023-07-12 F. Hoffmann-La Roche AG Antibody that binds to vegf-a and ang2 and methods of use
WO2022057888A1 (zh) * 2020-09-17 2022-03-24 江苏恒瑞医药股份有限公司 特异性结合vegf和ang-2的双特异性抗原结合分子
JP2024512701A (ja) * 2021-03-30 2024-03-19 アブプロ コーポレーション 抗ａｎｇ２×ｖｅｇｆ多重特異性抗体を用いて脈絡膜新生血管形成を治療するための方法
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
CN118139628A (zh) * 2021-08-23 2024-06-04 阿维麦克思生物制药公司 用于转基因表达的组合物和方法
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024088156A1 (zh) * 2022-10-24 2024-05-02 景泽生物医药(合肥)有限公司 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途

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CN119770646A (zh) 2025-04-08
WO2019154776A1 (en) 2019-08-15
MX2020007527A (es) 2020-09-09
AU2019219004A1 (en) 2020-07-16
TW202419464A (zh) 2024-05-16
JP2021506947A (ja) 2021-02-22
IL276383B1 (en) 2023-09-01
JP7005772B2 (ja) 2022-02-10
KR20250166355A (ko) 2025-11-27
JP7852107B2 (ja) 2026-04-27
TWI831764B (zh) 2024-02-11
JP7646727B2 (ja) 2025-03-17
JP2025084976A (ja) 2025-06-03
US20210139576A1 (en) 2021-05-13
JP2022046738A (ja) 2022-03-23
AU2025220841A1 (en) 2025-09-11
TW202535932A (zh) 2025-09-16
AU2019219004B2 (en) 2025-06-05
CN119733046A (zh) 2025-04-01
IL276383B2 (en) 2024-01-01
TWI885720B (zh) 2025-06-01
KR20200119274A (ko) 2020-10-19
JP2023099094A (ja) 2023-07-11
US20230416353A1 (en) 2023-12-28
CN119909169A (zh) 2025-05-02
JP2025084977A (ja) 2025-06-03
KR20240093772A (ko) 2024-06-24
JP7273204B2 (ja) 2023-05-12
EP3749359A1 (en) 2020-12-16
SG11202006712XA (en) 2020-08-28
AU2025220842A1 (en) 2025-09-11
TW202000700A (zh) 2020-01-01
IL276383A (en) 2020-09-30
CA3088355A1 (en) 2019-08-15
JP7852108B2 (ja) 2026-04-27

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