TWI831764B - 眼科疾病之治療 - Google Patents

眼科疾病之治療 Download PDF

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Publication number
TWI831764B
TWI831764B TW108104518A TW108104518A TWI831764B TW I831764 B TWI831764 B TW I831764B TW 108104518 A TW108104518 A TW 108104518A TW 108104518 A TW108104518 A TW 108104518A TW I831764 B TWI831764 B TW I831764B
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TW
Taiwan
Prior art keywords
weeks
treatment
vegf
seq
antibody
Prior art date
Application number
TW108104518A
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English (en)
Chinese (zh)
Other versions
TW202000700A (zh
Inventor
羅柏特 詹姆士 威克特
亞倫 奧斯本
嘉亞許瑞 沙尼
Original Assignee
美商建南德克公司
瑞士商赫孚孟拉羅股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 美商建南德克公司, 瑞士商赫孚孟拉羅股份公司 filed Critical 美商建南德克公司
Publication of TW202000700A publication Critical patent/TW202000700A/zh
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Publication of TWI831764B publication Critical patent/TWI831764B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW108104518A 2018-02-06 2019-02-11 眼科疾病之治療 TWI831764B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862627103P 2018-02-06 2018-02-06
US62/627,103 2018-02-06
US201862729333P 2018-09-10 2018-09-10
US62/729,333 2018-09-10

Publications (2)

Publication Number Publication Date
TW202000700A TW202000700A (zh) 2020-01-01
TWI831764B true TWI831764B (zh) 2024-02-11

Family

ID=65352014

Family Applications (3)

Application Number Title Priority Date Filing Date
TW108104518A TWI831764B (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW113103154A TWI885720B (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW114116623A TW202535932A (zh) 2018-02-06 2019-02-11 眼科疾病之治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW113103154A TWI885720B (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW114116623A TW202535932A (zh) 2018-02-06 2019-02-11 眼科疾病之治療

Country Status (12)

Country Link
US (2) US20210139576A1 (https=)
EP (1) EP3749359A1 (https=)
JP (5) JP7005772B2 (https=)
KR (3) KR20250166355A (https=)
CN (4) CN111699004A (https=)
AU (3) AU2019219004B2 (https=)
CA (1) CA3088355A1 (https=)
IL (1) IL276383B2 (https=)
MX (1) MX2020007527A (https=)
SG (1) SG11202006712XA (https=)
TW (3) TWI831764B (https=)
WO (1) WO2019154776A1 (https=)

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AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
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MY195550A (en) 2018-10-29 2023-01-31 Hoffmann La Roche Antibody Formulation
EP3886946A1 (en) 2019-06-05 2021-10-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
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CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
TW202216761A (zh) 2020-07-16 2022-05-01 瑞士商諾華公司 抗β細胞素抗體、其片段及多特異性結合分子
EP4208201A1 (en) * 2020-09-04 2023-07-12 F. Hoffmann-La Roche AG Antibody that binds to vegf-a and ang2 and methods of use
WO2022057888A1 (zh) * 2020-09-17 2022-03-24 江苏恒瑞医药股份有限公司 特异性结合vegf和ang-2的双特异性抗原结合分子
JP2024512701A (ja) * 2021-03-30 2024-03-19 アブプロ コーポレーション 抗ａｎｇ２×ｖｅｇｆ多重特異性抗体を用いて脈絡膜新生血管形成を治療するための方法
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
CN118139628A (zh) * 2021-08-23 2024-06-04 阿维麦克思生物制药公司 用于转基因表达的组合物和方法
CN117100845A (zh) * 2022-10-24 2023-11-24 景泽生物医药(合肥)股份有限公司 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途
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Citations (1)

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Also Published As

Publication number Publication date
CN119770646A (zh) 2025-04-08
WO2019154776A1 (en) 2019-08-15
MX2020007527A (es) 2020-09-09
AU2019219004A1 (en) 2020-07-16
TW202419464A (zh) 2024-05-16
CN111699004A (zh) 2020-09-22
JP2021506947A (ja) 2021-02-22
IL276383B1 (en) 2023-09-01
JP7005772B2 (ja) 2022-02-10
KR20250166355A (ko) 2025-11-27
JP7852107B2 (ja) 2026-04-27
JP7646727B2 (ja) 2025-03-17
JP2025084976A (ja) 2025-06-03
US20210139576A1 (en) 2021-05-13
JP2022046738A (ja) 2022-03-23
AU2025220841A1 (en) 2025-09-11
TW202535932A (zh) 2025-09-16
AU2019219004B2 (en) 2025-06-05
CN119733046A (zh) 2025-04-01
IL276383B2 (en) 2024-01-01
TWI885720B (zh) 2025-06-01
KR20200119274A (ko) 2020-10-19
JP2023099094A (ja) 2023-07-11
US20230416353A1 (en) 2023-12-28
CN119909169A (zh) 2025-05-02
JP2025084977A (ja) 2025-06-03
KR20240093772A (ko) 2024-06-24
JP7273204B2 (ja) 2023-05-12
EP3749359A1 (en) 2020-12-16
SG11202006712XA (en) 2020-08-28
AU2025220842A1 (en) 2025-09-11
TW202000700A (zh) 2020-01-01
IL276383A (en) 2020-09-30
CA3088355A1 (en) 2019-08-15
JP7852108B2 (ja) 2026-04-27

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