CN111690031B - 糖皮质激素受体抑制剂 - Google Patents

糖皮质激素受体抑制剂 Download PDF

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Publication number
CN111690031B
CN111690031B CN202010567003.9A CN202010567003A CN111690031B CN 111690031 B CN111690031 B CN 111690031B CN 202010567003 A CN202010567003 A CN 202010567003A CN 111690031 B CN111690031 B CN 111690031B
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optionally substituted
alkyl
group
independently
carbocyclyl
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Chinese (zh)
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CN111690031A (zh
Inventor
孙大庆
劳伦斯·R·麦吉
杜晓慧
朱柳生
闫雪蕾
柳曜燮
约翰·埃克斯特洛维奇
胡里奥·C·麦迪纳
瓦莱里娅·R·凡廷
周海英
明娜·德拉拉·巴尔巴斯
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Oric Pharmaceuticals Inc
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Oric Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202010567003.9A 2016-10-07 2017-10-06 糖皮质激素受体抑制剂 Active CN111690031B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662405801P 2016-10-07 2016-10-07
US62/405,801 2016-10-07
US201762526331P 2017-06-28 2017-06-28
US62/526,331 2017-06-28
CN201780075818.1A CN110099915A (zh) 2016-10-07 2017-10-06 糖皮质激素受体抑制剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780075818.1A Division CN110099915A (zh) 2016-10-07 2017-10-06 糖皮质激素受体抑制剂

Publications (2)

Publication Number Publication Date
CN111690031A CN111690031A (zh) 2020-09-22
CN111690031B true CN111690031B (zh) 2021-06-01

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010567003.9A Active CN111690031B (zh) 2016-10-07 2017-10-06 糖皮质激素受体抑制剂
CN201780075818.1A Pending CN110099915A (zh) 2016-10-07 2017-10-06 糖皮质激素受体抑制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780075818.1A Pending CN110099915A (zh) 2016-10-07 2017-10-06 糖皮质激素受体抑制剂

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US (5) US10472387B2 (enExample)
EP (2) EP3523315B1 (enExample)
JP (2) JP6801093B2 (enExample)
KR (2) KR20210039001A (enExample)
CN (2) CN111690031B (enExample)
AU (3) AU2017339510B2 (enExample)
BR (1) BR112019006987B1 (enExample)
CA (1) CA3039636C (enExample)
DK (1) DK3523315T3 (enExample)
ES (1) ES2867853T3 (enExample)
HU (1) HUE054542T2 (enExample)
IL (2) IL265835B (enExample)
MX (2) MX385658B (enExample)
NZ (1) NZ753142A (enExample)
PL (1) PL3523315T3 (enExample)
PT (1) PT3523315T (enExample)
SG (1) SG11201903055UA (enExample)
SI (1) SI3523315T1 (enExample)
WO (1) WO2018068021A1 (enExample)
ZA (1) ZA202004440B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108699102A (zh) 2015-12-23 2018-10-23 欧瑞克制药公司 糖皮质激素受体抑制剂
US11110103B2 (en) 2015-12-23 2021-09-07 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
AU2016379417B2 (en) 2015-12-23 2020-09-24 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
DK3523315T3 (da) 2016-10-07 2021-05-03 Oric Pharmaceuticals Inc Inhibitor af glucocorticoidreceptor
EP3773515A4 (en) * 2018-04-11 2022-03-23 Oric Pharmaceuticals, Inc. SOLID FORMS AND FORMULATIONS COMPRISING A GLUCOCORTICOID RECEPTOR ANTAGONIST AND THEIR USES
WO2021163273A1 (en) * 2020-02-12 2021-08-19 Oric Pharmaceuticals, Inc. Uses of glucocorticoid receptor antagonists
US20230212215A1 (en) * 2020-05-08 2023-07-06 Trustees Of Dartmouth College Glucocorticoid receptor modulators
CN115915529A (zh) 2021-09-30 2023-04-04 赛万特科技有限责任公司 发光控制方法、发光控制装置及发光装置
CN114230627B (zh) * 2021-12-31 2023-09-15 湖南新合新生物医药有限公司 一种倍他米松环氧水解物中间体的制备方法

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US4386085A (en) * 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
CN1048219A (zh) * 1989-06-23 1991-01-02 先灵公司 11β-芳基-4-雌烯药物组合物的制备方法
CN1065070A (zh) * 1990-12-22 1992-10-07 舍林股份公司 6,7-变性的11β-芳基-4-雌烯
US5405979A (en) * 1990-06-01 1995-04-11 Schering Aktiengesellschaft Process for the production of 10β-H-steroids
EP0763541A1 (en) * 1995-08-17 1997-03-19 Akzo Nobel N.V. 11-(Substituted phenyl)-estra-4,9-diene derivatives
EP1285927A2 (de) * 2001-08-16 2003-02-26 Jenapharm GmbH & Co. KG Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
WO2015089338A2 (en) * 2013-12-11 2015-06-18 Sloan-Kettering Institute For Cancer Research Glucocorticoid inhibitors for treatment of prostate cancer
CN105530943A (zh) * 2013-06-05 2016-04-27 伊万斯彻有限公司 咪唑基孕酮拮抗剂

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FR2528434B1 (fr) 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
JP2785023B2 (ja) 1987-12-30 1998-08-13 ルセル―ユクラフ １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物
JPH02188599A (ja) 1988-11-16 1990-07-24 Roussel Uclaf ３―ケト―デルタ―４，９―１９―ノルステロイドから誘導される新物質及びそれらよりなる薬剤
FR2651435A1 (fr) 1989-09-07 1991-03-08 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques.
US5741787A (en) 1993-08-04 1998-04-21 Akzo Nobel N.V. Antiglucocorticoid steroids for the treatment of anxiety disorders
WO1995017192A1 (en) 1993-12-22 1995-06-29 The Salk Institute For Biological Studies Methods for reducing multidrug resistance
SK282570B6 (sk) 1995-02-02 2002-10-08 Schering Aktiengesellschaft Antagonisty progesterónu na výrobu liekov na ošetrenie dysfunkčného maternicového krvácania
IL122740A (en) * 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
CN1085078C (zh) * 1998-01-07 2002-05-22 沈志华 用于大月份引产的复合药物
US6512130B1 (en) * 2000-09-05 2003-01-28 Council Of Scientific And Industrial Research Mifepristone analogue, process for the preparation thereof and use thereof
US7250408B2 (en) * 2002-12-16 2007-07-31 Bayer Schering Pharma Ag Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
DK1989218T3 (da) 2006-02-17 2010-04-26 Janssen Pharmaceutica Nv 17-phosphor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer
MX2008012492A (es) 2006-03-29 2008-12-12 Univ California Compuestos de diariltiohidantoina.
PT2148681E (pt) 2007-04-20 2016-06-17 Preglem Sa Moduladores seletivos da progesterona no tratamento da hemorragia uterina
US8658128B2 (en) 2011-02-03 2014-02-25 Pop Test Cortisol Llc System and method for diagnosis and treatment
EP2545922A1 (en) 2011-07-12 2013-01-16 PregLem S.A. Treatment of excessive menstrual bleeding associated with uterine fibroids
US20130029953A1 (en) 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
US9289436B2 (en) 2012-02-24 2016-03-22 The University Of Chicago Method of treatment of prostate cancer with androgen receptor and glucocorticoid receptor antagonists
EP2641602A1 (en) 2012-03-23 2013-09-25 PregLem S.A. Method for treating gynecological diseases
CN104530166B (zh) 2014-12-04 2016-08-24 陕西汉江药业集团股份有限公司 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法
CN108699102A (zh) * 2015-12-23 2018-10-23 欧瑞克制药公司 糖皮质激素受体抑制剂
US11110103B2 (en) 2015-12-23 2021-09-07 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
AU2016379417B2 (en) 2015-12-23 2020-09-24 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
DK3523315T3 (da) 2016-10-07 2021-05-03 Oric Pharmaceuticals Inc Inhibitor af glucocorticoidreceptor
US12233073B2 (en) 2017-06-09 2025-02-25 Regents Of The University Of Minnesota Skin care formulations and skin cancer treatment
EP3773515A4 (en) 2018-04-11 2022-03-23 Oric Pharmaceuticals, Inc. SOLID FORMS AND FORMULATIONS COMPRISING A GLUCOCORTICOID RECEPTOR ANTAGONIST AND THEIR USES

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386085A (en) * 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
CN1048219A (zh) * 1989-06-23 1991-01-02 先灵公司 11β-芳基-4-雌烯药物组合物的制备方法
US5405979A (en) * 1990-06-01 1995-04-11 Schering Aktiengesellschaft Process for the production of 10β-H-steroids
CN1065070A (zh) * 1990-12-22 1992-10-07 舍林股份公司 6,7-变性的11β-芳基-4-雌烯
EP0763541A1 (en) * 1995-08-17 1997-03-19 Akzo Nobel N.V. 11-(Substituted phenyl)-estra-4,9-diene derivatives
EP1285927A2 (de) * 2001-08-16 2003-02-26 Jenapharm GmbH & Co. KG Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
CN105530943A (zh) * 2013-06-05 2016-04-27 伊万斯彻有限公司 咪唑基孕酮拮抗剂
WO2015089338A2 (en) * 2013-12-11 2015-06-18 Sloan-Kettering Institute For Cancer Research Glucocorticoid inhibitors for treatment of prostate cancer

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DK3523315T3 (da) 2021-05-03
IL265835B (en) 2021-06-30
PL3523315T3 (pl) 2021-10-18
AU2021202016B2 (en) 2022-01-06
EP3851444A1 (en) 2021-07-21
SG11201903055UA (en) 2019-05-30
AU2017339510A1 (en) 2019-05-23
HUE054542T2 (hu) 2021-09-28
BR112019006987A2 (pt) 2019-06-25
EP3523315A4 (en) 2020-04-15
KR20210039001A (ko) 2021-04-08
JP2021046409A (ja) 2021-03-25
CA3039636C (en) 2023-04-11
EP3523315B1 (en) 2021-03-24
IL265835A (en) 2019-06-30
US20200055892A1 (en) 2020-02-20
US20210017219A1 (en) 2021-01-21
BR112019006987B1 (pt) 2021-05-04
KR20190083651A (ko) 2019-07-12
CN110099915A (zh) 2019-08-06
PT3523315T (pt) 2021-04-29
CA3039636A1 (en) 2018-04-12
AU2020213316B2 (en) 2021-03-11
MX2021010252A (es) 2021-09-21
WO2018068021A1 (en) 2018-04-12
SI3523315T1 (sl) 2021-08-31
US20200291058A1 (en) 2020-09-17
AU2021202016A1 (en) 2021-04-29
EP3523315A1 (en) 2019-08-14
ES2867853T3 (es) 2021-10-21
US20230096870A1 (en) 2023-03-30
US20190218246A1 (en) 2019-07-18
KR102237916B1 (ko) 2021-04-09
AU2021202016C1 (en) 2022-06-09
AU2017339510B2 (en) 2020-07-30
CN111690031A (zh) 2020-09-22
ZA202004440B (en) 2022-07-27
US10723759B2 (en) 2020-07-28
US10472387B2 (en) 2019-11-12
AU2020213316A1 (en) 2020-08-27
NZ753142A (en) 2020-08-28
IL284005A (en) 2021-07-29
JP2019533651A (ja) 2019-11-21
US10836789B2 (en) 2020-11-17
MX2019004030A (es) 2019-09-16
MX385658B (es) 2025-03-18
JP6801093B2 (ja) 2020-12-16

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