CN111686196A - Traditional Chinese medicine composition for improving immunity and preparation method thereof - Google Patents
Traditional Chinese medicine composition for improving immunity and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for improving immunity and a preparation method thereof, and belongs to the field of preparation of Chinese herbal medicines. A traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 15-40 parts of pseudo-ginseng stem leaves, 1-20 parts of ginseng, 8-32 parts of rhizoma polygonati, 2-25 parts of gordon euryale seed and 8-32 parts of wolfberry fruit, and a traditional Chinese medicine composition for improving immunity and a preparation method thereof, wherein the preparation method comprises the following steps: the method comprises the following steps: weighing the ginseng according to the amount, placing the ginseng into a percolation cylinder, repeatedly extracting ginseng percolate at normal temperature by using a heavy percolation method for multiple times until the percolate becomes colorless, and performing the following steps: weighing stem and leaf of Notoginseng radix, rhizoma Polygonati, semen euryales, and fructus Lycii; the preparation method is simple, convenient to implement and popularize, suitable for wide crowds, good in effect, and capable of effectively improving the gastrointestinal function of a human body, tonifying qi and improving the immunity of the human body, and adverse reactions are not found in a large number of clinical tests.
Description
Technical Field
The invention relates to the technical field of Chinese herbal medicine preparation, in particular to a traditional Chinese medicine composition for improving immunity and a preparation method thereof.
Background
The immunity is the defense mechanism of the human body, is the process of identifying and eliminating the invasion of foreign matters, such as viruses, bacteria and the like, by the body, and is the physiological reaction of identifying and eliminating the abnormal self of the human body. Modern medical science finds that immunity is a factor closely related to aging, hypoimmunity is one of the most important reasons of aging, but the body immune function begins to decline in the age of about 30 years, and the change is performed silently, slowly and continuously. The reduction of immunity results in the body being more susceptible to foreign substances, thereby making the body vulnerable to infectious diseases.
Modern Chinese medicine theory considers that human body is an organic unified whole, and in order to enhance immunity, the problem of yin-yang balance should be solved, the effect of the body on keeping healthy qi is emphasized, and the purpose of treating diseases is achieved by adjusting the functional state of the body, so that not only the treatment but also the prevention is emphasized. Along with the improvement of the living standard of people, the attention on health is correspondingly improved, and more people begin to pay attention to the health status of the people. At present, the existing health care products for enhancing the immunity of human bodies on the market are various in types, but the effects are different.
Disclosure of Invention
The invention aims to solve the problems of various health-care products for enhancing the immunity of human bodies but different effects in the prior art, and provides a traditional Chinese medicine composition for enhancing the immunity and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 15-40 parts of pseudo-ginseng stem leaves, 1-20 parts of ginseng, 8-32 parts of rhizoma polygonati, 2-25 parts of gordon euryale seeds and 8-32 parts of wolfberry fruits.
Preferably, the traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 27 parts of pseudo-ginseng stem and leaf, 7 parts of ginseng, 20 parts of rhizoma polygonati, 13 parts of gordon euryale seed and 20 parts of wolfberry fruit.
Preferably, the traditional Chinese medicine composition for improving immunity comprises the following auxiliary materials in parts by weight:
5-8 parts of theanine, 11-15 parts of inulin, 28-42 parts of pectin and 32-46 parts of xylitol, wherein the weight ratio of theanine: the inulin content is 1: 2.
Preferably, the traditional Chinese medicine composition for improving immunity and the preparation method thereof are characterized in that the preparation method comprises the following steps:
the method comprises the following steps: weighing Ginseng radix, placing into a percolating cylinder, and repeatedly extracting Ginseng radix percolate at room temperature by heavy percolation method until the percolate turns colorless.
Step two: weighing the stem and leaf of pseudo-ginseng, the rhizome of Siberian solomonseal, the gordon euryale seed and the fruit of Chinese wolfberry according to the amount, respectively putting the medicinal materials into an ultramicro pulverizer for pulverization, then pouring the pulverized raw materials into a boiling extraction pot, adding water for soaking for 24 hours, then adding purified water with the amount of 6-8 times of the medicinal materials, boiling and extracting for 3-3.5 hours, taking the boiling extract a and standing for later use.
Step three: and (3) soaking the dregs in the step one in water for 24 hours again, adding 2-4 times of purified water, boiling and extracting for 3-3.5 hours, and taking the boiling extract b and standing for later use.
Step four: filtering the decoction solution a, the decoction solution b and the ginseng percolate respectively, placing the filtered liquid in a stirrer, stirring for 20 minutes, and uniformly mixing to obtain a mixed liquid c.
Step five: and (3) placing the mixed solution c in a concentration tank to be concentrated to 1:1, then adding 95% ethanol, adjusting the ethanol concentration in the solution to be 45%, placing the solution at 0 ℃ for cold soaking for 12 hours, centrifuging, taking supernate, recovering ethanol, and concentrating to obtain a thick extract d with the ratio of 10: 1.
Step six: adding 2 times of adjuvants into the soft extract d, mixing, oven drying, pulverizing, micronizing, irradiating, granulating, and packaging.
Preferably, the stem and leaf of panax notoginseng are air-dried at normal temperature for a long time.
Preferably, in the ginseng percolate in the first step, the weight ratio of water to the ginseng percolate is 2-3:1, and the percolation time is 1.5-2 hours.
Preferably, the superfine powder in the second step is processed into superfine powder with the size of 0.1-500 microns by a superfine pulverizer, wherein the pulverized particle size of the medicinal material containing volatile oil is 20-500 microns, and the pulverized particle size of the medicinal material containing more sugar is 0.5-200 microns.
Preferably, the boiling in the second step and the third step is boiling at 80-100 ℃, and then boiling for 2.5-3 hours at 30-50 ℃.
Preferably, the filtration in the fourth step is a broad-spectrum macroporous resin adsorption column, after the adsorption is finished, the column is eluted by 60 to 70 percent of ethanol, the eluent is collected, and the ethanol is recovered.
Preferably, the relative specific gravity of the concentrated traditional Chinese medicine in the step five is 1.180-1.200 g/ml.
Compared with the prior art, the invention provides a traditional Chinese medicine composition for improving immunity and a preparation method thereof, and the traditional Chinese medicine composition has the following beneficial effects:
1. the traditional Chinese medicine composition for improving the immunity has the advantages that the ginseng is used as a monarch drug, the heart channel is benefited, the heart is monarch drug, other visceral organs are ministerial drug, and various saponins, ginseng polysaccharide and ginseng volatile oil contained in the ginseng are all easy to enable the traditional Chinese medicine composition to have the effects of improving the human immunity and resisting cancers.
2. The traditional Chinese medicine composition for improving the immunity is prepared by taking the stem and leaf of the pseudo-ginseng and the rhizoma polygonati as ministerial medicines to assist the ginseng and respectively regulate blood and qi in the body. The panax notoginseng saponins which are main active ingredients in panax notoginseng saponins are used for improving functions of a blood system and a cardiovascular system, nourishing and strengthening, improving phagocytic function of macrophages and phagocytic and bactericidal capacity of granulocytes, and promoting specific rosette formation cell assay (SRFC) and hemolytic plaque formation cell assay (PFC), wherein the SRFC reflects the early state of the immune function of an organism, and the PFC sensitively reflects the specific humoral immune function and the final state of immune response of the organism, so that the panax notoginseng saponins have the immune enhancement function in the early stage of the immune function and the final stage of the immune response and can promote the specific humoral immune function; rhizoma Polygonati has effects of improving organism immunity and promoting synthesis of DNA, RNA and protein, and polysaccharide extract has effects of promoting lymphocyte transformation, and enhancing activity of natural killer cell and cytolytic T lymphocyte. Research proves that the sealwort can enhance the humoral immunity of the organism and obviously reduce the contents of CAMP and CGMP in blood plasma.
3. The Chinese medicinal composition for improving the immunity has the effects of respectively tonifying spleen and protecting liver by taking the gordon euryale seed and the barbary wolfberry fruit as the auxiliary medicaments so as to comprehensively and integrally improve the immunity of a human body.
4. The traditional Chinese medicine composition for improving the immunity is prepared by connecting a plurality of percolating cylinders in series, recycling the percolating liquid as the solvent of new medicine powder repeatedly, and improving the concentration of the percolating liquid through multiple percolating, wherein the use ratio of the solvent in the double percolating method is high, the leaching efficiency is high, the concentration of the effective components in the percolating liquid is high, the heating and the concentration are not needed, and the thermal decomposition or the volatilization loss of the effective components are avoided.
The device has the advantages that the manufacturing method is simple, the implementation and the popularization are convenient, the device is suitable for wide crowds, adverse reactions are not found in a large number of clinical tests, the effect is good, the gastrointestinal functions of the human body can be effectively improved, qi is supplemented, and the immunity of the human body is improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations and positional relationships only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Example 1:
a traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 15 parts of pseudo-ginseng stem and leaf, 1 part of ginseng, 8 parts of rhizoma polygonati, 2 parts of gordon euryale seed and 8 parts of wolfberry fruit.
Example 2:
a traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 40 parts of pseudo-ginseng stem leaves, 20 parts of ginseng, 32 parts of rhizoma polygonati, 25 parts of gordon euryale seeds and 32 parts of wolfberry fruits.
Example 3:
a traditional Chinese medicine composition for improving immunity comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 27 parts of pseudo-ginseng stem and leaf, 7 parts of ginseng, 20 parts of rhizoma polygonati, 13 parts of gordon euryale seed and 20 parts of wolfberry fruit.
Further, the traditional Chinese medicine composition for improving immunity comprises the following auxiliary materials in parts by weight:
5-8 parts of theanine, 11-15 parts of inulin, 28-42 parts of pectin and 32-46 parts of xylitol, wherein the weight ratio of theanine: the inulin content is 1: 2.
Further, a traditional Chinese medicine composition for improving immunity and a preparation method thereof, wherein the preparation method comprises the following steps:
the method comprises the following steps: weighing Ginseng radix, placing into a percolating cylinder, and repeatedly extracting Ginseng radix percolate at room temperature by heavy percolation method until the percolate turns colorless.
Step two: weighing the stem and leaf of pseudo-ginseng, the rhizome of Siberian solomonseal, the gordon euryale seed and the fruit of Chinese wolfberry according to the amount, respectively putting the medicinal materials into an ultramicro pulverizer for pulverization, then pouring the pulverized raw materials into a boiling extraction pot, adding water for soaking for 24 hours, then adding purified water with the amount of 6-8 times of the medicinal materials, boiling and extracting for 3-3.5 hours, taking the boiling extract a and standing for later use.
Step three: and (3) soaking the dregs in the step one in water for 24 hours again, adding 2-4 times of purified water, boiling and extracting for 3-3.5 hours, and taking the boiling extract b and standing for later use.
Step four: filtering the decoction solution a, the decoction solution b and the ginseng percolate respectively, placing the filtered liquid in a stirrer, stirring for 20 minutes, and uniformly mixing to obtain a mixed liquid c.
Step five: and (3) placing the mixed solution c in a concentration tank to be concentrated to 1:1, then adding 95% ethanol, adjusting the ethanol concentration in the solution to be 45%, placing the solution at 0 ℃ for cold soaking for 12 hours, centrifuging, taking supernate, recovering ethanol, and concentrating to obtain a thick extract d with the ratio of 10: 1.
Step six: adding 2 times of adjuvants into the soft extract d, mixing, oven drying, pulverizing, micronizing, irradiating, granulating, and packaging.
Further, the stem and leaf of the pseudo-ginseng are processed and prepared at normal temperature for a long time.
Further, in the ginseng percolate in the first step, the weight ratio of water to the ginseng percolate is 2-3:1, and the percolation time is 1.5-2 hours.
Further, the superfine powder in the second step is processed into superfine powder with the size of 0.1-500 mu m by a superfine pulverizer, wherein the pulverized particle size of the medicinal material containing the volatile oil is 20-500 mu m, and the pulverized particle size of the medicinal material containing more sugar is 0.5-200 mu m.
Furthermore, the boiling in the second step and the third step is firstly boiling at 80-100 ℃, and then boiling for 2.5-3 hours at 30-50 ℃.
Further, the fourth step is that the filtration is carried out by a broad-spectrum macroporous resin adsorption column, 60-70% ethanol is used for elution after the adsorption is finished, the eluent is collected, and the ethanol is recovered.
Further, the relative specific gravity of the concentrated traditional Chinese medicine in the fifth step is more than 1.15 g/ml.
Stem and leaf of pseudo-ginseng: has the effects of reducing blood fat, resisting inflammation and delaying senility. The record of the compendium of materia Medica is Shi Yi: ginseng, radix Ginseng and Notoginseng are the most valuable Chinese herbs, because it tonifies qi the first time and tonifies blood the first time, and its flavor is the same and powerful. ";
ginseng: sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Tonify qi, secure collapse, promote fluid production, induce tranquilization, and promote intelligence. Many traditional Chinese medical literature records the efficacy of ginseng, such as Rihuazi Bencao: regulate middle energizer and control qi, promote digestion and stimulate appetite. "(Yunnan Ben Cao >): treat yin and yang deficiency and lung qi deficiency. "materia Medica Mongolian fish pot: relieving asthma and cough, smoothing blood vessels, purging yin fire and nourishing primordial yang. ";
rhizoma polygonati: sweet in taste and neutral in nature, and has the effects of tonifying spleen, moistening lung, tonifying qi and nourishing yin. The Shenxianziao Jing records the functions of rhizoma polygonati as follows: to strengthen the middle energizer and replenish qi, harmonize the five zang organs and enrich the muscles. ";
gorgon fruit: sweet and astringent taste, mild in nature. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia. The herbal Zhenzhen: how Gorgon fruit tonifies the spleen, so its taste is sweet; qian Shi can strengthen kidney because of its astringent taste. Only its flavor is sweet and can tonify spleen, so it can induce diuresis, and diarrhea abdominal pain can be treated; but it is astringent in flavor and astringes kidney, so it can stop qi and cure enuresis, leukorrhagia and urinary incontinence. The effect is similar to that of yam, but the yin of yam is too much gordon euryale seed, and the astringent of gordon euryale seed is better than that of yam; yam also tonifies lung yin, while Qian Shi ends in spleen and kidney but not in lung. ";
wolfberry fruit: sweet and neutral. Nourish kidney, moisten lung, tonify liver, improve vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. Dietary therapy Ben Cao: strengthen tendons and resist aging, dispel wind, tonify tendons and bones, benefit people and relieve consumptive disease.
In the invention, ginseng is used as a monarch drug, which benefits the heart channel, the heart is the monarch drug, other visceral organs are the ministers, and various saponins, ginseng polysaccharide and ginseng volatile oil contained in ginseng are all easy to cause the invention to have the functions of improving human immunity and resisting cancer; the stem and leaf of pseudo-ginseng and the rhizoma polygonati are used as ministerial drugs to assist the ginseng and respectively regulate the blood and qi in the body. The panax notoginseng saponins which are main active ingredients in panax notoginseng saponins are used for improving functions of a blood system and a cardiovascular system, nourishing and strengthening, improving phagocytic function of macrophages and phagocytic and bactericidal capacity of granulocytes, and promoting specific rosette formation cell assay (SRFC) and hemolytic plaque formation cell assay (PFC), wherein the SRFC reflects the early state of the immune function of an organism, and the PFC sensitively reflects the specific humoral immune function and the final state of immune response of the organism, so that the panax notoginseng saponins have the immune enhancement function in the early stage of the immune function and the final stage of the immune response and can promote the specific humoral immune function; rhizoma Polygonati has effects of improving organism immunity and promoting synthesis of DNA, RNA and protein, and polysaccharide extract has effects of promoting lymphocyte transformation, and enhancing activity of natural killer cell and cytolytic T lymphocyte. Research proves that the sealwort can enhance the humoral immunity of the organism and obviously reduce the content of CAMP and CGMP in blood plasma; by taking the gordon euryale seed and the barbary wolfberry fruit as the auxiliary medicines, the spleen is respectively tonified and the liver is protected, so that the effect of comprehensively and integrally improving the immunity of a human body is achieved; by connecting a plurality of percolating barrels in series, the percolate is recycled and repeatedly used as a solvent of new medicinal powder, the concentration of the percolate is improved by multiple percolating, the utilization rate of the solvent in the double percolating method is high, the leaching efficiency is high, the concentration of effective components in the percolate is high, the effective components can be concentrated without heating, and the thermal decomposition or volatilization loss of the effective components is avoided; the preparation method is simple, convenient to implement and popularize, suitable for wide crowds, good in effect, and capable of effectively improving the gastrointestinal function of a human body, tonifying qi and improving the immunity of the human body, and adverse reactions are not found in a large number of clinical tests.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for improving immunity is characterized by comprising Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 15-40 parts of pseudo-ginseng stem leaves, 1-20 parts of ginseng, 8-32 parts of rhizoma polygonati, 2-25 parts of gordon euryale seeds and 8-32 parts of wolfberry fruits.
2. The traditional Chinese medicine composition for improving immunity according to claim 1, which comprises Chinese herbal medicines and auxiliary materials, wherein the Chinese herbal medicines are prepared from the following raw materials in parts by weight: 27 parts of pseudo-ginseng stem and leaf, 7 parts of ginseng, 20 parts of rhizoma polygonati, 13 parts of gordon euryale seed and 20 parts of wolfberry fruit.
3. The traditional Chinese medicine composition for improving immunity according to claim 1, wherein the auxiliary materials comprise the following raw materials in parts by weight:
5-8 parts of theanine, 11-15 parts of inulin, 28-42 parts of pectin and 32-46 parts of xylitol, wherein the weight ratio of theanine: the inulin content is 1: 2.
4. The traditional Chinese medicine composition for improving immunity and the preparation method thereof according to claim 1 are characterized in that the preparation method comprises the following steps:
the method comprises the following steps: weighing Ginseng radix, placing into a percolating cylinder, and repeatedly extracting Ginseng radix percolate at room temperature by heavy percolation method until the percolate turns colorless.
Step two: weighing the stem and leaf of pseudo-ginseng, the rhizome of Siberian solomonseal, the gordon euryale seed and the fruit of Chinese wolfberry according to the amount, respectively putting the medicinal materials into an ultramicro pulverizer for pulverization, then pouring the pulverized raw materials into a boiling extraction pot, adding water for soaking for 24 hours, then adding purified water with the amount of 6-8 times of the medicinal materials, boiling and extracting for 3-3.5 hours, taking the boiling extract a and standing for later use.
Step three: and (3) soaking the dregs in the step one in water for 24 hours again, adding 2-4 times of purified water, boiling and extracting for 3-3.5 hours, and taking the boiling extract b and standing for later use.
Step four: filtering the decoction solution a, the decoction solution b and the ginseng percolate respectively, placing the filtered liquid in a stirrer, stirring for 20 minutes, and uniformly mixing to obtain a mixed liquid c.
Step five: and (3) placing the mixed solution c in a concentration tank to be concentrated to 1:1, then adding 95% ethanol, adjusting the ethanol concentration in the solution to be 45%, placing the solution at 0 ℃ for cold soaking for 12 hours, centrifuging, taking supernate, recovering ethanol, and concentrating to obtain a thick extract d with the ratio of 10: 1.
Step six: adding 2 times of adjuvants into the soft extract d, mixing, oven drying, pulverizing, micronizing, irradiating, granulating, and packaging.
5. The traditional Chinese medicine composition for improving immunity and the preparation method thereof according to claim 1 are characterized in that the stem leaves of panax notoginseng are processed and prepared by air drying at normal temperature for a long time.
6. The traditional Chinese medicine composition for improving immunity and the preparation method thereof according to claim 1, wherein in the ginseng percolate in the first step, the weight ratio of water to ginseng liquid is 2-3:1, and the percolation time is 1.5-2 hours.
7. The composition as claimed in claim 1, wherein the superfine powder in step two is processed into superfine powder of 0.1-500 μm size by superfine pulverizer, wherein the pulverized particle size of the volatile oil-containing material is 20-500 μm, and the pulverized particle size of the sugar-rich material is 0.5-200 μm.
8. The traditional Chinese medicine composition for improving immunity as claimed in claim 1, wherein the decoction in the second step and the third step is firstly decocting at 80-100 ℃ until boiling, and then decocting at 30-50 ℃ for 2.5-3 hours.
9. The traditional Chinese medicine composition for improving immunity according to claim 1 and the preparation method thereof, wherein the filtration in the fourth step is a broad-spectrum macroporous resin adsorption column, and after the adsorption is finished, 60-70% ethanol is used for elution, and the eluent is collected and the ethanol is recovered.
10. The traditional Chinese medicine composition for improving immunity and the preparation method thereof according to claim 1, wherein the relative specific gravity of the traditional Chinese medicine concentrated in the fifth step is more than 1.15 g/ml.
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2019
- 2019-05-24 CN CN201910436753.XA patent/CN111686196A/en active Pending
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