CN111686060A

CN111686060A - Oil-control and bacteriostatic moisturizing skin care lotion and preparation method thereof

Info

Publication number: CN111686060A
Application number: CN202010739398.6A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-28
Filing date: 2020-07-28
Publication date: 2020-09-22

Abstract

The invention discloses an oil-control and bacteriostatic moisturizing skin care lotion and a preparation method thereof, wherein the skin care lotion comprises the following raw materials: by weight, 5-8 parts of traditional Chinese medicine additive, 4-8 parts of skin care particles, 2-3 parts of ascorbic acid, 5-8 parts of ethylene diamine tetraacetic acid, 4-6 parts of carbomer, 15-25 parts of glycerol, 10-20 parts of 1, 2-pentanediol, 80-90 parts of water, 3-5 parts of polyvinyl alcohol and 3-5 parts of gelatin; the traditional Chinese medicine additive comprises the following raw materials: 6-10 parts of liquorice, 10-12 parts of turmeric, 6-8 parts of salvia miltiorrhiza, 8-10 parts of scutellaria baicalensis, 8-10 parts of sophora flavescens and 10-15 parts of golden cypress. The invention discloses an oil-control and bacteriostatic moisturizing skin moisturizer and a preparation method thereof, the process design is reasonable, the operation is simple, the prepared skin moisturizer has excellent moisturizing and whitening effects, can effectively inhibit and sterilize microorganisms on the surface of skin, avoids the occurrence of pockmarks, acnes and the like, can repair the skin, has an excellent acne-removing effect, and is high in practicability.

Description

Oil-control and bacteriostatic moisturizing skin care lotion and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a moisturizing skin care lotion capable of controlling oil and inhibiting bacteria and a preparation method thereof.

Background

With the continuous progress of social economy and the abundance of material life, the skin care product is no longer a thing which is only used by abundant people in the past. Skin care products are now moving into the homes of ordinary people. It plays a great role in improving the spirit and the image of people. The skin care lotion can be used after face cleaning, has effects of moisturizing skin, reducing irritation of sebaceous gland, preventing vicious circulation secretion of oil, and improving skin surface dryness.

Acne occurs in close relation to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reactions. After the skin care product enters the youth period, the grease secretion of teenagers is greatly increased, the hair follicles are easy to block, a plurality of microorganisms in the hair follicles are propagated in a large quantity, and are induced and generate inflammatory reaction to form whelks, the existing skin care product has single performance, and the effect on the aspects of acne removal and bacteriostasis cannot meet the requirements of consumers.

Aiming at the problem, a moisturizing skin care lotion for controlling oil and inhibiting bacteria and a preparation method thereof are designed, which are technical problems to be urgently solved.

Disclosure of Invention

The invention aims to provide a moisturizing skin care lotion capable of controlling oil and inhibiting bacteria and a preparation method thereof, and aims to solve the problems in the prior art.

In order to achieve the purpose, the invention provides the following technical scheme:

the moisturizing skin care lotion capable of controlling oil and inhibiting bacteria comprises the following raw materials: by weight, 5-8 parts of traditional Chinese medicine additive, 4-8 parts of skin care particles, 2-3 parts of ascorbic acid, 5-8 parts of ethylene diamine tetraacetic acid, 4-6 parts of carbomer, 15-25 parts of glycerol, 10-20 parts of 1, 2-pentanediol, 80-90 parts of water, 3-5 parts of polyvinyl alcohol and 3-5 parts of gelatin.

According to an optimized scheme, the traditional Chinese medicine additive comprises the following raw materials: 6-10 parts of liquorice, 10-12 parts of turmeric, 6-8 parts of salvia miltiorrhiza, 8-10 parts of scutellaria baicalensis, 8-10 parts of sophora flavescens and 10-15 parts of golden cypress.

According to an optimized scheme, the skin care particles comprise the following raw materials: 10-12 parts of modified particles, 8-10 parts of tetrabutylammonium iodide, 10-20 parts of dimethyl sulfoxide and 5-7 parts of dimethylchlorosilane by weight.

According to an optimized scheme, the modified particles comprise the following raw materials in parts by weight: 10-20 parts of chitosan, 3-7 parts of diammonium glycyrrhizinate, 4-8 parts of sodium sulfosuccinate, 2-3 parts of epichlorohydrin, 8-10 parts of sodium hyaluronate, 10-15 parts of buffer, 1-2 parts of sodium tripolyphosphate and 5-8 parts of epidermal growth factor.

In an optimized scheme, the buffer solution is PBS buffer solution.

According to an optimized scheme, the preparation method of the moisturizing and skin-care lotion with oil control and bacteriostasis functions comprises the following steps:

1) preparing materials;

2) preparation of the traditional Chinese medicine additive:

a) pulverizing Glycyrrhrizae radix, Curcuma rhizome, Saviae Miltiorrhizae radix, Scutellariae radix, radix Sophorae Flavescentis and cortex Phellodendri, sieving, soaking in 95% ethanol solution, slowly percolating with 95% ethanol solution as solvent, collecting filtrate, and filtering to obtain primary filtrate and primary residue; taking the primary filtrate, carrying out centrifugal filtration, and carrying out reduced pressure concentration to obtain a first extracting solution;

b) soaking the primary filter residue in 75% ethanol solution, slowly percolating with 75% ethanol solution as solvent, collecting, and filtering to obtain secondary filtrate and secondary filter residue; soaking the secondary filter residue in 50% ethanol solution, slowly percolating with 50% ethanol solution as solvent, collecting, and filtering to obtain tertiary filtrate;

c) mixing and stirring the secondary filtrate and the tertiary filtrate, centrifuging and filtering, and concentrating under reduced pressure to obtain a second extracting solution;

3) preparing skin care particles:

a) dissolving chitosan in acetic acid to obtain a chitosan solution; dissolving sodium sulfosuccinate in distilled water to obtain an aqueous solution of sodium sulfosuccinate;

b) dissolving sodium hyaluronate in PBS buffer solution, stirring, adding sodium tripolyphosphate and epidermal growth factor, mixing and stirring to obtain solution A;

c) taking a chitosan solution, adjusting pH, adding the solution A, stirring for reacting for 2-3h, adding diammonium glycyrrhizinate, stirring for reacting for 15-25min, then adding an aqueous solution of sodium sulfosuccinate, mixing and stirring, standing, adjusting pH, adding epichlorohydrin, performing crosslinking reaction for 2-3h, dialyzing with distilled water after the reaction is finished, and freeze-drying to obtain modified particles;

d) taking modified particles, adding tetrabutylammonium iodide and dimethyl sulfoxide, performing ultrasonic dispersion in the dark, continuing stirring at 0-5 ℃, adding a triethylamine solution of dimethylchlorosilane and dimethyl sulfoxide under the protection of nitrogen, performing stirring reaction, filtering, precipitating with ethyl acetate, continuing filtering, freeze-drying, crushing, grinding, and sieving with a 200-mesh sieve to obtain skin-care particles;

4) dissolving ascorbic acid and isopropanol, and stirring to obtain a solution B; adding ethylene diamine tetraacetic acid and water into carbomer, heating to 80-85 ℃, adding glycerol, performing ultrasonic dispersion, adding the first extracting solution and the second extracting solution, continuing stirring, adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion, continuing adding the solution B, polyvinyl alcohol and gelatin, and stirring to obtain the skin care lotion.

The optimized scheme comprises the following steps:

1) preparing materials;

2) preparation of the traditional Chinese medicine additive:

a) pulverizing Glycyrrhrizae radix, Curcuma rhizome, Saviae Miltiorrhizae radix, Scutellariae radix, radix Sophorae Flavescentis and cortex Phellodendri, sieving, soaking in 95% ethanol solution for 24-28 hr, slowly percolating with 95% ethanol solution, collecting filtrate and residue; taking the primary filtrate, centrifuging, filtering, and concentrating under reduced pressure at 60-65 deg.C to obtain a first extractive solution;

b) soaking the primary filter residue in 75% ethanol solution for 6-8h, slowly percolating with 75% ethanol solution as solvent, collecting, and filtering to obtain secondary filtrate and secondary filter residue; soaking the secondary filter residue in 50% ethanol solution for 6-8h, slowly percolating with 50% ethanol solution as solvent, collecting filtrate, and filtering to obtain third filtrate;

c) mixing the secondary filtrate and the third filtrate, stirring for 10-15min, centrifuging, filtering, and concentrating under reduced pressure at 60-65 deg.C to obtain second extractive solution;

3) preparing skin care particles:

a) dissolving chitosan in acetic acid, and stirring for 10-20min to obtain chitosan solution; dissolving sodium sulfosuccinate in distilled water, and stirring for 10-20min to obtain sodium sulfosuccinate water solution;

b) dissolving sodium hyaluronate in PBS buffer solution, stirring for 10-20min, adding sodium tripolyphosphate and epidermal growth factor, mixing and stirring for 10-12min to obtain solution A;

c) taking a chitosan solution, adjusting the pH value to 4-5 by sodium hydroxide, adding the solution A, stirring for reacting for 2-3h, adding diammonium glycyrrhizinate, stirring for reacting for 15-25min, then adding an aqueous solution of sodium sulfosuccinate, mixing and stirring for 30-40min, standing for 20-24h, adjusting the pH value to 8-9, adding epoxy chloropropane, carrying out crosslinking reaction for 2-3h at the reaction temperature of 48-50 ℃, dialyzing for 10 days by using distilled water after the reaction is finished, and freeze-drying for 48h to obtain modified particles;

d) taking modified particles, adding tetrabutylammonium iodide and dimethyl sulfoxide, carrying out ultrasonic dispersion for 10-15min in the dark, continuing stirring at 0-5 ℃, adding a triethylamine solution of dimethylchlorosilane and dimethyl sulfoxide under the protection of nitrogen, stirring for reaction for 48-50h, wherein the reaction temperature is 25-28 ℃, filtering, precipitating with ethyl acetate, continuing filtering, freeze-drying, crushing and grinding, and sieving with a 200-mesh sieve to obtain skin-care particles;

4) dissolving ascorbic acid and isopropanol, and stirring for 10-15min to obtain solution B; adding ethylene diamine tetraacetic acid and water, heating to 80-85 ℃, adding glycerol, performing ultrasonic dispersion for 5-10min, adding the first extracting solution and the second extracting solution, continuing to stir for 10-15min, adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion for 5-8min, continuing to add the solution B, polyvinyl alcohol and gelatin, stirring for 2-2.5h at 25-30 ℃, and adjusting the pH value to obtain the skin care lotion.

In an optimized scheme, in the step 4), the mass ratio of the first extracting solution to the second extracting solution is 1: (1-1.5).

In the optimized scheme, in the steps a) and c) of the step 2), the centrifugation rate is 2000-2200r/min, and the centrifugation time is 5-10 min.

In an optimized scheme, in the step 4), the pH value of the skin moisturizer is 6.5-7.

Compared with the prior art, the invention has the beneficial effects that:

in daily skin care, the effect of bacteria on the skin is very great, seborrheic dermatitis is caused when malassezia furfur hyperproliferates, and acne, comedones and skin surface inflammation are caused when propionibacterium acnes hyperproliferates; when bacteria such as escherichia coli, pseudomonas aeruginosa and the like excessively propagate, allergy, infection and the like easily appear on the surface of the skin, so the traditional Chinese medicine additive is added, malassezia furfur and propionibacterium acnes can be effectively killed, the proliferation and propagation of the escherichia coli and the pseudomonas aeruginosa are inhibited, the situations of allergy, infection and the like caused by the proliferation of microorganisms on the surface of the skin are avoided, and the formation of acne, comedo and pockmpox is inhibited.

The liquorice can effectively improve the moisturizing capability of the skin care product, has the functions of histamine resistance and vasodilation resistance, can relieve the inflammatory reaction of subacute and chronic skin diseases, and can promote the repair of wounds caused by pox, sunburn and the like; meanwhile, the liquorice can also inhibit the activity of tyrosinase and dopachrome tautomerase, inhibit the polymerization of 5,6 dihydroxyindole, prevent the formation of melanin and play a role in whitening. The turmeric contains curcumin as an active ingredient, can be used as an anti-aging ingredient, can effectively resist inflammation and treat photodamage skin, can improve skin texture and glossiness while whitening the skin, treats symptoms such as skin inflammation and pox, inhibits phosphorylase kinase secretion caused by injury and prevents subsequent inflammation formation; the salvia miltiorrhiza and the scutellaria baicalensis can realize the effects of clearing heat and reducing noise, can remove color spots on the surface of skin, and treat acnes and comedo, and have excellent acne removing and freckle removing effects.

The traditional Chinese medicine additive is prepared by compounding the traditional Chinese medicine components, not only can perform the functions of whitening and moisturizing the skin, but also can inhibit and kill bacteria, reduce the occurrence of pockmarks, acnes and skin allergy, and improve the skin quality; meanwhile, when the traditional Chinese medicine additive is prepared, each traditional Chinese medicine material is treated by a gradient percolation method, 95% ethanol is used as a percolation solvent to extract components such as alkaloid, volatile oil and resin chlorophyll in the Chinese herbal medicine components, 75% ethanol is used for percolating primary filter residue to extract glycosides in the Chinese herbal medicine components, and 50% ethanol solution is used for percolating secondary filter residue to extract components such as tannin and bitter substances contained in the secondary filter residue, so that the components in the traditional Chinese medicine additive can be effectively utilized, and the skin can be effectively whitened, moisturized and moistened.

The skin care particles are also prepared, when the skin care particles are prepared, sodium hyaluronate, sodium tripolyphosphate and epidermal growth factor are used as raw materials, the nano microspheres loaded with the epidermal growth factor are prepared by an ionic gel method, the nano microspheres can slowly release the epidermal growth factor when in actual use, the epidermal growth factor can promote the proliferation and differentiation of fibroblasts and keratinocyte, accelerate the update of skin cuticle, and realize the whitening effect; meanwhile, the component can also stimulate the production of extracellular matrixes such as collagen and the like, hyaluronic acid and glycoprotein, realize the skin moisturizing effect and slow down the generation of wrinkles; meanwhile, when verification and acne appear on the skin surface of people, most people can treat the acne in a squeezing and piercing mode, so that wounds are easily formed on the skin surface, and bacterial infection further causes inflammation; when the product is implemented, the traditional Chinese medicine additive is used for inhibiting bacteria and killing bacteria around acnes, and the skin care particles are used for promoting wound healing, so that the acne removing capability of the product can be effectively improved.

The modified particles can have certain oil absorption performance, can adsorb oil secreted on the surface of the skin, avoid the situation of skin acne growth caused by excessive oil, and are also beneficial to removing acne and allergic inflammation; and diammonium glycyrrhizinate is added during preparation, has excellent anti-inflammatory performance, and can further improve the acne removing effect of the product.

According to the invention, the modified particles are treated, and the silanized hyaluronic acid is prepared by using the sodium hyaluronate in the modified particles as a raw material, so that the skin care particles are prepared, and the substance has a strong moisturizing effect on skin, can repair skin injury and further improves the skin care and moisturizing effects of the skin care lotion.

The invention discloses an oil-control and bacteriostatic moisturizing skin moisturizer and a preparation method thereof, the process design is reasonable, the operation is simple, the prepared skin moisturizer has excellent moisturizing and whitening effects, can effectively inhibit and sterilize microorganisms on the surface of skin, avoids the occurrence of pockmarks, acnes and the like, can repair the skin, has an excellent acne-removing effect, and is high in practicability.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

s1: preparing materials;

s2: preparation of the traditional Chinese medicine additive:

pulverizing Glycyrrhrizae radix, Curcuma rhizome, Saviae Miltiorrhizae radix, Scutellariae radix, radix Sophorae Flavescentis and cortex Phellodendri, sieving, soaking in 95% ethanol solution for 24 hr, slowly percolating with 95% ethanol solution, collecting filtrate and residue; taking the primary filtrate, centrifuging at the speed of 2000r/min for 5min, filtering, and concentrating under reduced pressure at 60 deg.C to obtain a first extractive solution;

soaking the primary filter residue in 75% ethanol solution for 6h, slowly percolating with 75% ethanol solution as solvent, collecting, and filtering to obtain secondary filtrate and secondary filter residue; soaking the secondary filter residue in 50% ethanol solution for 6h, slowly percolating with 50% ethanol solution as solvent, collecting, and filtering to obtain third filtrate;

mixing the secondary filtrate and the third filtrate under stirring for 10min at a centrifugation rate of 2000r/min for 5min, filtering, and concentrating under reduced pressure at 60 deg.C to obtain a second extractive solution;

s3: preparing skin care particles:

dissolving chitosan in acetic acid, and stirring for 10min to obtain chitosan solution; dissolving sodium sulfosuccinate in distilled water, and stirring for 10min to obtain sodium sulfosuccinate water solution;

dissolving sodium hyaluronate in PBS buffer solution, stirring for 10min, adding sodium tripolyphosphate and epidermal growth factor, mixing and stirring for 10min to obtain solution A;

taking a chitosan solution, adjusting the pH value to 4 by using sodium hydroxide, adding the solution A, stirring for reacting for 2 hours, adding diammonium glycyrrhizinate, stirring for reacting for 15 minutes, then adding an aqueous solution of sodium sulfosuccinate, mixing and stirring for 30 minutes, standing for 20 hours, adjusting the pH value to 8, adding epichlorohydrin, performing crosslinking reaction for 2 hours at the reaction temperature of 48 ℃, dialyzing for 10 days by using distilled water after the reaction is finished, and freeze-drying for 48 hours to obtain modified particles;

taking modified particles, adding tetrabutylammonium iodide and dimethyl sulfoxide, carrying out ultrasonic dispersion in the dark for 10min, continuing stirring at 0 ℃, adding a triethylamine solution of dimethylchlorosilane and dimethyl sulfoxide under the protection of nitrogen, stirring for reaction for 48h, wherein the reaction temperature is 25 ℃, filtering, precipitating with ethyl acetate, continuing filtering, freeze-drying, grinding, and sieving with a 200-mesh sieve to obtain skin-care particles;

s4: dissolving ascorbic acid and isopropanol, and stirring for 10min to obtain solution B; adding carbomer into disodium ethylene diamine tetraacetate and water, heating to 80 ℃, adding glycerol, performing ultrasonic dispersion for 5min, then adding the first extracting solution and the second extracting solution, continuing stirring for 10min, then adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion for 5min, continuing adding the solution B, polyvinyl alcohol and gelatin, stirring for 2h at 25 ℃, and adjusting the pH to 6.5 to obtain a skin care solution; wherein the mass ratio of the first extracting solution to the second extracting solution is 1: 1.

in this embodiment, the skin lotion comprises the following raw materials: by weight, 5 parts of traditional Chinese medicine additive, 4 parts of skin care particles, 2 parts of ascorbic acid, 5 parts of ethylene diamine tetraacetic acid, 4 parts of carbomer, 15 parts of glycerol, 10 parts of 1.2-pentanediol, 80 parts of water, 3 parts of polyvinyl alcohol and 3 parts of gelatin.

The traditional Chinese medicine additive comprises the following raw materials: 6 parts of liquorice, 10 parts of turmeric, 6 parts of salvia miltiorrhiza, 8 parts of scutellaria baicalensis, 8 parts of sophora flavescens and 10 parts of phellodendron; the skin care particle comprises the following raw materials: 10 parts of modified particles, 8 parts of tetrabutylammonium iodide, 10 parts of dimethyl sulfoxide and 5 parts of dimethylchlorosilane by weight.

The modified particles comprise the following raw materials in parts by weight: by weight, 10 parts of chitosan, 3 parts of diammonium glycyrrhizinate, 4 parts of sodium sulfosuccinate, 2 parts of epichlorohydrin, 8 parts of sodium hyaluronate, 10 parts of buffer, 1 part of sodium tripolyphosphate and 5 parts of epidermal growth factor; the buffer solution is PBS buffer solution.

Example 2:

s1: preparing materials;

s2: preparation of the traditional Chinese medicine additive:

pulverizing Glycyrrhrizae radix, Curcuma rhizome, Saviae Miltiorrhizae radix, Scutellariae radix, radix Sophorae Flavescentis and cortex Phellodendri, sieving, soaking in 95% ethanol solution for 26 hr, slowly percolating with 95% ethanol solution, collecting filtrate and residue; taking the primary filtrate, centrifuging at the speed of 2100r/min for 8min, filtering, and concentrating under reduced pressure at 63 deg.C to obtain a first extractive solution;

soaking the primary filter residue in 75% ethanol solution for 7h, slowly percolating with 75% ethanol solution as solvent, collecting, and filtering to obtain secondary filtrate and secondary filter residue; soaking the secondary filter residue in 50% ethanol solution for 7h, slowly percolating with 50% ethanol solution as solvent, collecting, and filtering to obtain third filtrate;

mixing the secondary filtrate and the tertiary filtrate for 12min under stirring at a centrifugation rate of 2100r/min for 8min, filtering, and concentrating under reduced pressure at 63 deg.C to obtain a second extractive solution;

s3: preparing skin care particles:

dissolving chitosan in acetic acid, and stirring for 15min to obtain chitosan solution; dissolving sodium sulfosuccinate in distilled water, and stirring for 15min to obtain sodium sulfosuccinate water solution;

dissolving sodium hyaluronate in PBS buffer solution, stirring for 15min, adding sodium tripolyphosphate and epidermal growth factor, mixing and stirring for 11min to obtain solution A;

taking a chitosan solution, adjusting the pH value to 4.5 by using sodium hydroxide, adding the solution A, stirring and reacting for 2.5 hours, adding diammonium glycyrrhizinate, stirring and reacting for 20 minutes, then adding an aqueous solution of sodium sulfosuccinate, mixing and stirring for 35 minutes, standing for 22 hours, adjusting the pH value to 8.5, adding epichlorohydrin, carrying out crosslinking reaction for 2.5 hours at the reaction temperature of 49 ℃, dialyzing for 10 days by using distilled water after the reaction is finished, and carrying out freeze drying for 48 hours to obtain modified particles;

taking modified particles, adding tetrabutylammonium iodide and dimethyl sulfoxide, carrying out ultrasonic dispersion for 12min in the dark, continuing stirring at 3 ℃, adding a triethylamine solution of dimethylchlorosilane and dimethyl sulfoxide under the protection of nitrogen, carrying out stirring reaction for 49h at the reaction temperature of 27 ℃, filtering, precipitating with ethyl acetate, continuing filtering, carrying out freeze drying, grinding, and sieving with a 200-mesh sieve to obtain skin-care particles;

s4: dissolving ascorbic acid and isopropanol, and stirring for 13min to obtain solution B; adding ethylene diamine tetraacetic acid and water, adding carbomer, heating to 82 ℃, adding glycerol, performing ultrasonic dispersion for 8min, then adding the first extracting solution and the second extracting solution, continuing stirring for 12min, then adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion for 7min, continuing adding the solution B, polyvinyl alcohol and gelatin, stirring for 2.2h at 28 ℃, and adjusting the pH to 6.5 to obtain a skin care solution; wherein the mass ratio of the first extracting solution to the second extracting solution is 1: 1.2.

in this embodiment, the skin lotion comprises the following raw materials: by weight, 7 parts of traditional Chinese medicine additive, 6 parts of skin care particles, 2.5 parts of ascorbic acid, 7 parts of ethylene diamine tetraacetic acid, 5 parts of carbomer, 20 parts of glycerol, 15 parts of 1.2-pentanediol, 85 parts of water, 4 parts of polyvinyl alcohol and 4 parts of gelatin.

The traditional Chinese medicine additive comprises the following raw materials: 8 parts of liquorice, 11 parts of turmeric, 7 parts of salvia miltiorrhiza, 9 parts of scutellaria baicalensis, 9 parts of sophora flavescens and 12 parts of phellodendron; the skin care particle comprises the following raw materials: 11 parts of modified particles, 9 parts of tetrabutylammonium iodide, 15 parts of dimethyl sulfoxide and 6 parts of dimethylchlorosilane by weight.

The modified particles comprise the following raw materials in parts by weight: by weight, 15 parts of chitosan, 5 parts of diammonium glycyrrhizinate, 6 parts of sodium sulfosuccinate, 2.5 parts of epichlorohydrin, 9 parts of sodium hyaluronate, 12 parts of buffer, 1.5 parts of sodium tripolyphosphate and 7 parts of epidermal growth factor; the buffer solution is PBS buffer solution.

Example 3:

s1: preparing materials;

s2: preparation of the traditional Chinese medicine additive:

pulverizing Glycyrrhrizae radix, Curcuma rhizome, Saviae Miltiorrhizae radix, Scutellariae radix, radix Sophorae Flavescentis and cortex Phellodendri, sieving, soaking in 95% ethanol solution for 28 hr, slowly percolating with 95% ethanol solution, collecting filtrate and residue; taking primary filtrate, centrifuging at the speed of 2200r/min for 10min, filtering, and concentrating under reduced pressure at 65 deg.C to obtain first extractive solution;

soaking the primary filter residue in 75% ethanol solution for 8h, slowly percolating with 75% ethanol solution as solvent, collecting, and filtering to obtain secondary filtrate and secondary filter residue; soaking the secondary filter residue in 50% ethanol solution for 8h, slowly percolating with 50% ethanol solution as solvent, collecting, and filtering to obtain third filtrate;

mixing the secondary filtrate and the tertiary filtrate, stirring for 15min at the centrifugation rate of 2200r/min for 10min, filtering, and concentrating under reduced pressure at 65 deg.C to obtain second extractive solution;

s3: preparing skin care particles:

dissolving chitosan in acetic acid, and stirring for 20min to obtain chitosan solution; dissolving sodium sulfosuccinate in distilled water, and stirring for 20min to obtain sodium sulfosuccinate water solution;

dissolving sodium hyaluronate in PBS buffer solution, stirring for 20min, adding sodium tripolyphosphate and epidermal growth factor, mixing and stirring for 12min to obtain solution A;

taking a chitosan solution, adjusting the pH value to 5 by using sodium hydroxide, adding the solution A, stirring and reacting for 3 hours, adding diammonium glycyrrhizinate, stirring and reacting for 25 minutes, then adding an aqueous solution of sodium sulfosuccinate, mixing and stirring for 40 minutes, standing for 24 hours, adjusting the pH value to 9, adding epichlorohydrin, carrying out a crosslinking reaction for 3 hours at the reaction temperature of 50 ℃, dialyzing for 10 days by using distilled water after the reaction is finished, and freeze-drying for 48 hours to obtain modified particles;

taking modified particles, adding tetrabutylammonium iodide and dimethyl sulfoxide, carrying out ultrasonic dispersion in the dark for 15min, continuing stirring at 5 ℃, adding a triethylamine solution of dimethylchlorosilane and dimethyl sulfoxide under the protection of nitrogen, carrying out stirring reaction for 50h at the reaction temperature of 28 ℃, filtering, precipitating with ethyl acetate, continuing filtering, carrying out freeze drying, crushing and grinding, and sieving with a 200-mesh sieve to obtain skin-care particles;

s4: dissolving ascorbic acid and isopropanol, and stirring for 15min to obtain solution B; adding ethylene diamine tetraacetic acid and water into carbomer, heating to 85 ℃, adding glycerol, performing ultrasonic separation for 10min, adding the first extracting solution and the second extracting solution, continuing stirring for 15min, adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion for 8min, continuing adding the solution B, polyvinyl alcohol and gelatin, stirring for 2.5h at 30 ℃, and adjusting the pH to 7 to obtain a skin care solution; wherein the mass ratio of the first extracting solution to the second extracting solution is 1: 1.5.

in this embodiment, the skin lotion comprises the following raw materials: by weight, 8 parts of traditional Chinese medicine additive, 8 parts of skin care particles, 3 parts of ascorbic acid, 8 parts of ethylene diamine tetraacetic acid, 6 parts of carbomer, 25 parts of glycerol, 20 parts of 1.2-pentanediol, 90 parts of water, 5 parts of polyvinyl alcohol and 5 parts of gelatin.

The traditional Chinese medicine additive comprises the following raw materials: 10 parts of liquorice, 12 parts of turmeric, 8 parts of salvia miltiorrhiza, 10 parts of scutellaria baicalensis, 10 parts of sophora flavescens and 15 parts of phellodendron; the skin care particle comprises the following raw materials: the modified particle comprises, by weight, 12 parts of modified particles, 10 parts of tetrabutylammonium iodide, 20 parts of dimethyl sulfoxide and 7 parts of dimethylchlorosilane.

The modified particles comprise the following raw materials in parts by weight: by weight, 20 parts of chitosan, 7 parts of diammonium glycyrrhizinate, 8 parts of sodium sulfosuccinate, 3 parts of epichlorohydrin, 10 parts of sodium hyaluronate, 15 parts of buffer, 2 parts of sodium tripolyphosphate and 8 parts of epidermal growth factor; the buffer solution is PBS buffer solution.

Comparative example 1:

s1: preparing materials;

s2: preparing skin care particles:

s3: dissolving ascorbic acid and isopropanol, and stirring for 13min to obtain solution B; adding ethylene diamine tetraacetic acid and water into carbomer, heating to 82 ℃, adding glycerol, performing ultrasonic dispersion for 8min, adding 1.2-pentanediol and skin care particles, performing ultrasonic dispersion for 7min, continuously adding the solution B, polyvinyl alcohol and gelatin, stirring for 2.2h at 28 ℃, and adjusting the pH to 6.5 to obtain skin care liquid;

in this embodiment, the skin lotion comprises the following raw materials: by weight, 6 parts of skin care particles, 2.5 parts of ascorbic acid, 7 parts of ethylene diamine tetraacetic acid, 5 parts of carbomer, 20 parts of glycerol, 15 parts of 1.2-pentanediol, 85 parts of water, 4 parts of polyvinyl alcohol and 4 parts of gelatin.

The skin care particle comprises the following raw materials: 11 parts of modified particles, 9 parts of tetrabutylammonium iodide, 15 parts of dimethyl sulfoxide and 6 parts of dimethylchlorosilane by weight.

Comparative example 2:

s1: preparing materials;

s2: dissolving ascorbic acid and isopropanol, and stirring for 13min to obtain solution B; adding carbomer into disodium ethylene diamine tetraacetate and water, heating to 82 ℃, adding glycerol, performing ultrasonic dispersion for 8min, adding 1.2-pentanediol, performing ultrasonic dispersion for 7min, continuously adding the solution B, polyvinyl alcohol and gelatin, stirring for 2.2h at 28 ℃, and adjusting the pH value to 6.5 to obtain the skin moisturizer;

in this embodiment, the skin lotion comprises the following raw materials: by weight, 2.5 parts of ascorbic acid, 7 parts of ethylene diamine tetraacetic acid, 5 parts of carbomer, 20 parts of glycerol, 15 parts of 1.2-pentanediol, 85 parts of water, 4 parts of polyvinyl alcohol and 4 parts of gelatin.

Detection experiment:

1. and (3) testing the acne removing effect:

selecting 50 adult female volunteers as testers, wherein the ages of the volunteers are 25-30 years old, and 2 testers give up the test due to body discomfort, and the specific test process is as follows:

the products prepared in examples 1-3, comparative example 1 and comparative example 2 (i.e. test groups 1-5), 10 in test group 1, 9 in test group 2, 9 in test group 3 and 10 in test groups 4-5) were distributed among 48 testers, and each tester used a skin lotion sample with a size of 1 yuan of coin for 2 times per day (once in the morning and evening and after cleaning) and tested the change of acne on the skin surface by a skin rapid optical imaging method after continuously using for 3 weeks, with the results shown in the following table:

item	Test set 1	Test set 2	Test group 3	Test set 4	Test set 5
						Removal rate of skin acne	70.1％	70.4％	69.8％	54.7％	35.1％
Skin acne mark removing rate	71.2％	71.1％	71.2％	64.2％	28.3％

In the detection process, all testers do not have the stimulation phenomena of allergy, red and swollen skin and the like.

As can be seen from the above table, the skin moisturizers prepared according to the embodiments 1 to 3 have excellent acne removing effect, while the skin moisturizer in the comparative example 1 has no traditional Chinese medicine additive, and the skin moisturizer in the comparative example 2 has no traditional Chinese medicine additive and skin moisturizer particles, and after the skin moisturizers are tested, the acne removing effect of the skin moisturizers in the two prepared types is obviously reduced.

2. And (3) testing the antibacterial performance:

taking skin moisturizer samples prepared in examples 1-3, comparative example 1 and comparative example 2, respectively carrying out bacteriostasis tests by using escherichia coli, malassezia furfur, propionibacterium acnes and pseudomonas aeruginosa, and carrying out tests according to a microorganism test method of cosmetic safety and health specifications (2015 edition), wherein the specific data are as follows:

item	Example 1	Example 2	Example 3	Example 4	Example 5
						Rate of inhibition of bacteria	99％	99％	99％	64％	47％

As can be seen from the above table, the skin moisturizers prepared according to the embodiments 1 to 3 have excellent bacteriostatic and bactericidal effects on escherichia coli, malassezia furfur, propionibacterium acnes and pseudomonas aeruginosa, while the traditional Chinese medicine additive is not added in the comparative example 1, and the traditional Chinese medicine additive and skin care particles are not added in the comparative example 2, and after the test, the bacteriostatic effects of the two skin moisturizers prepared are found to be obviously reduced.

And (4) conclusion: the skin care lotion has the advantages of reasonable process design and simple operation, has excellent moisturizing and whitening effects, can effectively inhibit and sterilize microorganisms on the surface of the skin, avoids occurrence of pockmarks, acnes and the like, can repair the skin, has excellent acne removal effect, and is high in practicability.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims

1. The oil-control bacteriostatic moisturizing skin care lotion is characterized by comprising the following components in parts by weight: the skin lotion comprises the following raw materials: by weight, 5-8 parts of traditional Chinese medicine additive, 4-8 parts of skin care particles, 2-3 parts of ascorbic acid, 5-8 parts of ethylene diamine tetraacetic acid, 4-6 parts of carbomer, 15-25 parts of glycerol, 10-20 parts of 1, 2-pentanediol, 80-90 parts of water, 3-5 parts of polyvinyl alcohol and 3-5 parts of gelatin.

2. The oil-control and bacteriostatic moisturizing skin care lotion according to claim 1, which is characterized in that: the traditional Chinese medicine additive comprises the following raw materials: 6-10 parts of liquorice, 10-12 parts of turmeric, 6-8 parts of salvia miltiorrhiza, 8-10 parts of scutellaria baicalensis, 8-10 parts of sophora flavescens and 10-15 parts of golden cypress.

3. The oil-control and bacteriostatic moisturizing skin care lotion according to claim 1, which is characterized in that: the skin care particles comprise the following raw materials: 10-12 parts of modified particles, 8-10 parts of tetrabutylammonium iodide, 10-20 parts of dimethyl sulfoxide and 5-7 parts of dimethylchlorosilane by weight.

4. The oil-control and bacteriostatic moisturizing skin care lotion according to claim 3, which is characterized in that: the modified particles comprise the following raw materials in parts by weight: 10-20 parts of chitosan, 3-7 parts of diammonium glycyrrhizinate, 4-8 parts of sodium sulfosuccinate, 2-3 parts of epichlorohydrin, 8-10 parts of sodium hyaluronate, 10-15 parts of buffer, 1-2 parts of sodium tripolyphosphate and 5-8 parts of epidermal growth factor.

5. The oil-control and bacteriostatic moisturizing skin care lotion according to claim 4, which is characterized in that: the buffer solution is PBS buffer solution.

6. A preparation method of the moisturizing skin care lotion with oil control and bacteriostasis functions is characterized by comprising the following steps: the method comprises the following steps:

1) preparing materials;

2) preparation of the traditional Chinese medicine additive:

3) preparing skin care particles:

7. The preparation method of the oil-control and bacteriostatic moisturizing skin care lotion according to claim 6, which is characterized by comprising the following steps of: the method comprises the following steps:

1) preparing materials;

2) preparation of the traditional Chinese medicine additive:

3) preparing skin care particles:

8. The preparation method of the oil-control and bacteriostatic moisturizing skin care lotion according to claim 7, which is characterized by comprising the following steps of: in the step 4), the mass ratio of the first extracting solution to the second extracting solution is 1: (1-1.5).

9. The preparation method of the oil-control and bacteriostatic moisturizing skin care lotion according to claim 7, which is characterized by comprising the following steps of: in the steps a) and c) of the step 2), the centrifugation speed is 2000-2200r/min, and the centrifugation time is 5-10 min.

10. The preparation method of the oil-control and bacteriostatic moisturizing skin care lotion according to claim 7, which is characterized by comprising the following steps of: in the step 4), the pH value of the skin care lotion is 6.5-7.