CN111683950B - AhR调节剂 - Google Patents
AhR调节剂 Download PDFInfo
- Publication number
- CN111683950B CN111683950B CN201980011943.5A CN201980011943A CN111683950B CN 111683950 B CN111683950 B CN 111683950B CN 201980011943 A CN201980011943 A CN 201980011943A CN 111683950 B CN111683950 B CN 111683950B
- Authority
- CN
- China
- Prior art keywords
- methyl
- trifluoromethyl
- phenyl
- quinazolin
- pyrazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Amplifiers (AREA)
- Supplying Of Containers To The Packaging Station (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862626739P | 2018-02-06 | 2018-02-06 | |
| US62/626,739 | 2018-02-06 | ||
| US201962793260P | 2019-01-16 | 2019-01-16 | |
| US62/793,260 | 2019-01-16 | ||
| PCT/US2019/016705 WO2019156987A1 (en) | 2018-02-06 | 2019-02-05 | AhR MODULATORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111683950A CN111683950A (zh) | 2020-09-18 |
| CN111683950B true CN111683950B (zh) | 2024-04-16 |
Family
ID=65494575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980011943.5A Active CN111683950B (zh) | 2018-02-06 | 2019-02-05 | AhR调节剂 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10815250B2 (https=) |
| EP (2) | EP4219495A1 (https=) |
| JP (1) | JP7382348B2 (https=) |
| CN (1) | CN111683950B (https=) |
| CA (1) | CA3090150A1 (https=) |
| DK (1) | DK3749669T6 (https=) |
| ES (1) | ES2946632T7 (https=) |
| FI (1) | FI3749669T6 (https=) |
| TW (1) | TWI840343B (https=) |
| WO (1) | WO2019156987A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018562A1 (en) * | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| ES2946632T7 (es) | 2018-02-06 | 2025-03-04 | Ideaya Biosciences Inc | Moduladores de AhR |
| EP4061484A1 (en) * | 2019-11-22 | 2022-09-28 | Senda Biosciences, Inc. | Pyridopyrimidinone derivatives as ahr antagonists |
| WO2021210970A1 (en) * | 2020-04-17 | 2021-10-21 | Dong-A St Co., Ltd. | Pyridopyrimidinone derivatives and their use as aryl hydrocarbon receptor modulators |
| WO2021236717A1 (en) | 2020-05-20 | 2021-11-25 | Senda Biosciences, Inc. | Fused imidazole derivatives as ahr antagonists |
| CN114181212B (zh) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | 哒嗪酮类AhR抑制剂 |
| CN116745622A (zh) * | 2020-10-13 | 2023-09-12 | 先达生物科技公司 | 与免疫检查点抑制剂疗法相关的生物标志物及其使用方法 |
| EP4228649A1 (en) * | 2020-10-13 | 2023-08-23 | Senda Biosciences, Inc. | Biomarkers related to immune checkpoint inhibitor therapy and methods of using the same |
| WO2023020512A1 (zh) * | 2021-08-16 | 2023-02-23 | 成都奥睿药业有限公司 | 取代的吡啶类似物、其制备方法及作为ahr调节剂的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010148350A1 (en) * | 2009-06-18 | 2010-12-23 | Cornell University | Photoproducts of tryptophan, their synthesis and uses thereof |
| WO2015197861A1 (en) * | 2014-06-27 | 2015-12-30 | Nogra Pharma Limited | Aryl receptor modulators and methods of making and using the same |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ515086A (en) | 1999-04-28 | 2003-10-31 | Aventis Pharma Gmbh | Di-aryl acid derivatives as PPAR receptor ligands |
| JP2005504047A (ja) | 2001-08-13 | 2005-02-10 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 紫外線吸収剤 |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20050256118A1 (en) | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| CR9465A (es) | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
| CA2617213C (en) | 2005-07-29 | 2014-01-28 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| WO2008054599A2 (en) | 2006-09-27 | 2008-05-08 | Surface Logix, Inc. | Rho kinase inhibitors |
| MX2010008376A (es) | 2008-02-04 | 2011-02-22 | Mercury Therapeutics Inc | Moduladores ampk. |
| EA021938B1 (ru) | 2008-05-01 | 2015-10-30 | Сертрис Фармасьютикалз, Инк. | Хинолины и их аналоги в качестве модуляторов сиртуина |
| CA2726164A1 (en) | 2008-05-27 | 2009-12-23 | The Board Of Regents Of The University Of Texas System | Wnt protein signalling inhibitors |
| US20120202793A1 (en) | 2009-03-09 | 2012-08-09 | Paul Sweetnam | Rho kinase inhibitors |
| BR112013002079B1 (pt) * | 2010-07-27 | 2021-09-14 | Trustees Of Boston University | Modificadores do receptor de aril hidrocarboneto (ahr) como novos terapêuticos contra o câncer |
| CA2813711A1 (en) | 2010-10-14 | 2012-04-19 | Immunahr Ab | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators. |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| WO2012106343A2 (en) | 2011-02-01 | 2012-08-09 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
| CA2858069C (en) | 2011-12-08 | 2020-02-11 | Novartis Ag | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| US10669528B2 (en) | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| WO2017184547A1 (en) | 2016-04-18 | 2017-10-26 | New York University | Quinoline compounds as modulators of rage activity and uses thereof |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| TW201835070A (zh) | 2017-02-21 | 2018-10-01 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| WO2018195397A2 (en) | 2017-04-21 | 2018-10-25 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| ES2946632T7 (es) | 2018-02-06 | 2025-03-04 | Ideaya Biosciences Inc | Moduladores de AhR |
| US20210254006A1 (en) | 2018-06-06 | 2021-08-19 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
-
2019
- 2019-02-05 ES ES19706135T patent/ES2946632T7/es active Active
- 2019-02-05 EP EP23160174.1A patent/EP4219495A1/en not_active Withdrawn
- 2019-02-05 EP EP19706135.1A patent/EP3749669B3/en active Active
- 2019-02-05 DK DK19706135.1T patent/DK3749669T6/da active
- 2019-02-05 WO PCT/US2019/016705 patent/WO2019156987A1/en not_active Ceased
- 2019-02-05 CA CA3090150A patent/CA3090150A1/en active Pending
- 2019-02-05 JP JP2020564046A patent/JP7382348B2/ja active Active
- 2019-02-05 FI FIEP19706135.1T patent/FI3749669T6/fi active
- 2019-02-05 CN CN201980011943.5A patent/CN111683950B/zh active Active
- 2019-02-05 US US16/268,444 patent/US10815250B2/en active Active
- 2019-02-11 TW TW108104425A patent/TWI840343B/zh active
-
2020
- 2020-09-17 US US17/023,980 patent/US11407764B2/en active Active
-
2022
- 2022-06-29 US US17/853,647 patent/US12258354B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010148350A1 (en) * | 2009-06-18 | 2010-12-23 | Cornell University | Photoproducts of tryptophan, their synthesis and uses thereof |
| WO2015197861A1 (en) * | 2014-06-27 | 2015-12-30 | Nogra Pharma Limited | Aryl receptor modulators and methods of making and using the same |
Non-Patent Citations (1)
| Title |
|---|
| RN857834-18-5;ACS;《REGISTRY》;20050801;第1页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3749669B1 (en) | 2023-03-08 |
| US12258354B2 (en) | 2025-03-25 |
| ES2946632T7 (es) | 2025-03-04 |
| US20210002297A1 (en) | 2021-01-07 |
| CA3090150A1 (en) | 2019-08-15 |
| US20230039955A1 (en) | 2023-02-09 |
| JP2021512954A (ja) | 2021-05-20 |
| EP4219495A1 (en) | 2023-08-02 |
| TWI840343B (zh) | 2024-05-01 |
| CN111683950A (zh) | 2020-09-18 |
| DK3749669T6 (da) | 2024-11-18 |
| FI3749669T6 (fi) | 2024-11-13 |
| EP3749669B3 (en) | 2024-09-04 |
| WO2019156987A1 (en) | 2019-08-15 |
| JP7382348B2 (ja) | 2023-11-16 |
| EP3749669A1 (en) | 2020-12-16 |
| US10815250B2 (en) | 2020-10-27 |
| TW201945362A (zh) | 2019-12-01 |
| DK3749669T3 (da) | 2023-06-06 |
| ES2946632T3 (es) | 2023-07-21 |
| US11407764B2 (en) | 2022-08-09 |
| US20190270754A1 (en) | 2019-09-05 |
| FI3749669T3 (fi) | 2023-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111683950B (zh) | AhR调节剂 | |
| TWI853802B (zh) | 作為a2a/a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 | |
| JP2020183397A (ja) | Ｂｔｋ活性阻害剤としてのヘテロアリールピリドン及びアザピリドン化合物 | |
| KR20220100879A (ko) | Fgfr 저해제로서의 이환식 헤테로사이클 | |
| CN114945571B (zh) | 环状化合物及其使用方法 | |
| JP2023538060A (ja) | 二環化合物、それを含む組成物、及びそれらの使用 | |
| JP2022525199A (ja) | Ｅｅｄおよびｐｒｃ２調節物質としての大環状アゾロピリジン誘導体 | |
| EP4284804A1 (en) | Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders | |
| CN119923398A (zh) | 环状化合物和其使用方法 | |
| CN117120442A (zh) | 用于治疗癌症、自身免疫性病症和炎性病症的三环化合物 | |
| HK40042159B (en) | Ahr modulators | |
| EA052528B1 (ru) | Циклические соединения и способы их применения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |