CN111655121B - 微血管阻塞(mvo)和心肌梗死的冠状动脉内表征 - Google Patents
微血管阻塞(mvo)和心肌梗死的冠状动脉内表征 Download PDFInfo
- Publication number
- CN111655121B CN111655121B CN201880070198.7A CN201880070198A CN111655121B CN 111655121 B CN111655121 B CN 111655121B CN 201880070198 A CN201880070198 A CN 201880070198A CN 111655121 B CN111655121 B CN 111655121B
- Authority
- CN
- China
- Prior art keywords
- mvo
- pressure
- blood
- subject matter
- infusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02152—Measuring pressure in heart or blood vessels by means inserted into the body specially adapted for venous pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6853—Catheters with a balloon
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Business, Economics & Management (AREA)
- Medicinal Chemistry (AREA)
- General Business, Economics & Management (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Surgical Instruments (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560545P | 2017-09-19 | 2017-09-19 | |
| US62/560,545 | 2017-09-19 | ||
| PCT/US2018/051760 WO2019060421A1 (en) | 2017-09-19 | 2018-09-19 | INTRACORONARY MICROVASCULAR OBSTRUCTION CHARACTERIZATION (MVO) AND MYOCARDIAL INFARCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111655121A CN111655121A (zh) | 2020-09-11 |
| CN111655121B true CN111655121B (zh) | 2024-05-24 |
Family
ID=63998740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880070198.7A Active CN111655121B (zh) | 2017-09-19 | 2018-09-19 | 微血管阻塞(mvo)和心肌梗死的冠状动脉内表征 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11412936B2 (https=) |
| EP (1) | EP3684247A1 (https=) |
| JP (1) | JP7249672B2 (https=) |
| CN (1) | CN111655121B (https=) |
| AU (1) | AU2018336787B2 (https=) |
| CA (1) | CA3076035A1 (https=) |
| WO (1) | WO2019060421A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10315016B2 (en) | 2016-01-04 | 2019-06-11 | Corflow Therapeutics Ag | System and methods for treating MVO |
| JP7249672B2 (ja) | 2017-09-19 | 2023-03-31 | コルフロー セラピューティクス アーゲー | 微小血管閉塞(mvo)及び心筋梗塞の冠動脈内解析 |
| WO2019173758A1 (en) | 2018-03-09 | 2019-09-12 | Corflow Therapeutics Ag | System for diagnosing and treating microvascular obstructions |
| WO2019232452A1 (en) | 2018-05-31 | 2019-12-05 | Bernard Andre | Microfluidic coronary circulatory model |
| WO2020061507A1 (en) | 2018-09-21 | 2020-03-26 | Corflow Therapeutics Ag | Apparatus for assessment of microvascular dysfunction |
| WO2021035190A1 (en) | 2019-08-21 | 2021-02-25 | Corflow Therapeutics Ag | Controlled-flow infusion catheter and method |
| AU2021274173A1 (en) * | 2020-05-22 | 2022-12-22 | Corflow Therapeutics Ag | Controlled flow infusion microvascular dysfunction diagnostic and therapy |
| WO2022149106A1 (en) * | 2021-01-11 | 2022-07-14 | Corflow Therapeutics Ag | Apparatus and method for determining and/or treating microvascular obstruction |
| WO2025160126A1 (en) * | 2024-01-22 | 2025-07-31 | The Trustees Of Indiana University | Method and system for radiation-free assessment of coronary and skeletal muscle microvascular function using in-situ administration of vasoactive agents |
| CN117976155B (zh) * | 2024-04-01 | 2024-07-26 | 杭州脉流科技有限公司 | 基于造影剂示踪曲线获得冠脉功能学参数的方法、计算机设备 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596010A (zh) * | 2009-08-10 | 2012-07-18 | P2科学有限公司 | 用于诊断狭窄和其他血流受限之病症的utp |
| CN105636512A (zh) * | 2013-08-14 | 2016-06-01 | 南洋理工大学 | 用于评估血管重建的系统和方法 |
| CN105848573A (zh) * | 2013-10-25 | 2016-08-10 | 波士顿科学国际有限公司 | 利用光学传感来确定血流量的导管系统和方法 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689041A (en) | 1984-01-20 | 1987-08-25 | Eliot Corday | Retrograde delivery of pharmacologic and diagnostic agents via venous circulation |
| US5439446A (en) | 1994-06-30 | 1995-08-08 | Boston Scientific Corporation | Stent and therapeutic delivery system |
| US20050245894A1 (en) | 1996-05-20 | 2005-11-03 | Medtronic Vascular, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
| US20010041862A1 (en) | 1997-09-02 | 2001-11-15 | Morton G. Glickman | Novel apparatus and method of treating a tumor in the extremity of a patient |
| DE69725324T2 (de) | 1997-10-23 | 2004-08-05 | Schneider (Europe) Gmbh | Dichtung für eine Kathetereinrichtung mit Dilatations- und Okklusionsballon |
| US20040260333A1 (en) | 1997-11-12 | 2004-12-23 | Dubrul William R. | Medical device and method |
| US6622367B1 (en) | 1998-02-03 | 2003-09-23 | Salient Interventional Systems, Inc. | Intravascular device and method of manufacture and use |
| US6295990B1 (en) | 1998-02-03 | 2001-10-02 | Salient Interventional Systems, Inc. | Methods and systems for treating ischemia |
| US6423032B2 (en) | 1998-03-13 | 2002-07-23 | Arteria Medical Science, Inc. | Apparatus and methods for reducing embolization during treatment of carotid artery disease |
| US6488671B1 (en) | 1999-10-22 | 2002-12-03 | Corazon Technologies, Inc. | Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same |
| US6485500B1 (en) | 2000-03-21 | 2002-11-26 | Advanced Cardiovascular Systems, Inc. | Emboli protection system |
| US6616597B2 (en) | 2000-12-12 | 2003-09-09 | Datascope Investment Corp. | Intra-aortic balloon catheter having a dual sensor pressure sensing system |
| US7722596B2 (en) | 2004-02-26 | 2010-05-25 | Osprey Medical, Inc. | Regional cardiac tissue treatment |
| US7955371B2 (en) | 2004-05-12 | 2011-06-07 | Medtronic Vascular, Inc. | System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends |
| IES20040803A2 (en) | 2004-12-01 | 2006-06-14 | Medtronic Vascular Connaught | Drug delivery device |
| US7837650B1 (en) | 2004-12-30 | 2010-11-23 | Advanced Cardiovascular Systems, Inc. | Method and apparatus to prevent reperfusion injury |
| WO2007061530A1 (en) | 2005-10-14 | 2007-05-31 | Cytori Therapeutics, Inc. | Cell delivery catheters with distal tip high fidelity sensors |
| US8430861B2 (en) | 2006-08-02 | 2013-04-30 | Osprey Medical, Inc. | Microvascular obstruction detection and therapy |
| CN201058169Y (zh) | 2007-05-24 | 2008-05-14 | 席刚明 | 一种同轴球囊溶栓导管 |
| US8216209B2 (en) | 2007-05-31 | 2012-07-10 | Abbott Cardiovascular Systems Inc. | Method and apparatus for delivering an agent to a kidney |
| CN101868265B (zh) | 2007-11-19 | 2013-05-08 | 马林克罗特有限公司 | 包括具有压力监视的通畅检查的动力注射器 |
| JP5147004B2 (ja) | 2008-03-27 | 2013-02-20 | 国立大学法人鳥取大学 | 生体内温熱療法及び閉塞下動注化学療法を併用した新規治療方法に用いるバルーンカテーテル |
| BRPI0919884B8 (pt) | 2008-11-03 | 2023-04-04 | Atlanta Catheter Therapies Inc | cateter de perfusão de oclusão |
| WO2011120565A1 (en) | 2009-03-31 | 2011-10-06 | St Jude Medical Systems Ab | Sensor guide wire |
| US8706209B2 (en) | 2010-02-05 | 2014-04-22 | 3Dt Holdings, Llc | Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature |
| US8708996B2 (en) | 2010-04-30 | 2014-04-29 | Abbott Cardiovascular Systems, Inc. | Methods and device for synergistic mitigation of reperfusion injury after an ischemic event |
| US8821438B2 (en) | 2010-04-30 | 2014-09-02 | Abbott Cardiovascular Systems, Inc. | Catheter system having a fluid circuit |
| US8540669B2 (en) | 2010-04-30 | 2013-09-24 | Abbott Cardiovascular Systems Inc. | Catheter system providing step reduction for postconditioning |
| JP5922111B2 (ja) | 2010-06-23 | 2016-05-24 | ピーツー−サイエンス・エペイエス | 充血剤注入と同時に血圧測定を行う診断目的の動脈用複合カテーテル |
| US20120157913A1 (en) | 2010-12-16 | 2012-06-21 | Atherolysis Medical, Inc. | Catheter apparatus and method for atherolysis |
| US9533124B2 (en) | 2011-04-14 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Reperfusion injury devices |
| US20130035660A1 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Multidirectional microfluidic drug delivery devices with conformable balloons |
| US8177704B1 (en) | 2011-12-22 | 2012-05-15 | Miracor Medical Systems Gmbh | System and method for treating heart tissue |
| WO2014005012A1 (en) | 2012-06-28 | 2014-01-03 | Volcano Corporation | Intravascular devices, systems, and methods |
| US11219719B2 (en) | 2012-08-28 | 2022-01-11 | Osprey Medical, Inc. | Volume monitoring systems |
| US9320846B2 (en) | 2012-08-28 | 2016-04-26 | Osprey Medical, Inc. | Devices and methods for modulating medium delivery |
| US10010673B2 (en) | 2012-08-28 | 2018-07-03 | Osprey Medical, Inc. | Adjustable medium diverter |
| US9999718B2 (en) | 2012-08-28 | 2018-06-19 | Osprey Medical, Inc. | Volume monitoring device utilizing light-based systems |
| US10022497B2 (en) | 2012-08-28 | 2018-07-17 | Osprey Medical, Inc. | Reservoir for collection and reuse of diverted medium |
| JP2016507272A (ja) | 2012-12-21 | 2016-03-10 | ヴォルカノ コーポレイションVolcano Corporation | 機能的利得の測定技術及び表示 |
| WO2014182959A2 (en) | 2013-05-08 | 2014-11-13 | Embolx, Inc. | Device and methods for transvascular tumor embolization with integrated flow regulation |
| US9844383B2 (en) | 2013-05-08 | 2017-12-19 | Embolx, Inc. | Devices and methods for low pressure tumor embolization |
| US9877660B2 (en) | 2013-11-14 | 2018-01-30 | Medtronic Vascular Galway | Systems and methods for determining fractional flow reserve without adenosine or other pharmalogical agent |
| JP2016538048A (ja) | 2013-11-15 | 2016-12-08 | アシスト・メディカル・システムズ,インコーポレイテッド | マルチセンサ患部評価装置および方法 |
| US9855049B2 (en) | 2013-12-11 | 2018-01-02 | Miracor Medical Systems Gmbh | System and method for treating heart tissue |
| EP3094241B1 (en) | 2014-01-14 | 2018-07-04 | Volcano Corporation | Systems and methods for evaluating hemodialysis arteriovenous fistula maturation |
| US8876850B1 (en) | 2014-06-19 | 2014-11-04 | Aria Cv, Inc. | Systems and methods for treating pulmonary hypertension |
| WO2017004432A1 (en) | 2015-07-01 | 2017-01-05 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
| JP2016168151A (ja) | 2015-03-12 | 2016-09-23 | 株式会社東海メディカルプロダクツ | バルーンカテーテル |
| US10315016B2 (en) | 2016-01-04 | 2019-06-11 | Corflow Therapeutics Ag | System and methods for treating MVO |
| US9550046B1 (en) | 2016-02-16 | 2017-01-24 | Embolx, Inc. | Balloon catheter and methods of fabrication and use |
| WO2017160270A1 (en) | 2016-03-14 | 2017-09-21 | Sanovas, Inc. | Modulated drug delivery |
| US10492805B2 (en) | 2016-04-06 | 2019-12-03 | Walk Vascular, Llc | Systems and methods for thrombolysis and delivery of an agent |
| WO2018175485A1 (en) | 2017-03-20 | 2018-09-27 | Corflow Therapeutics Ag | Combined stent reperfusion system |
| JP7249672B2 (ja) | 2017-09-19 | 2023-03-31 | コルフロー セラピューティクス アーゲー | 微小血管閉塞(mvo)及び心筋梗塞の冠動脈内解析 |
| WO2019173758A1 (en) | 2018-03-09 | 2019-09-12 | Corflow Therapeutics Ag | System for diagnosing and treating microvascular obstructions |
| WO2019232452A1 (en) | 2018-05-31 | 2019-12-05 | Bernard Andre | Microfluidic coronary circulatory model |
| WO2020061507A1 (en) | 2018-09-21 | 2020-03-26 | Corflow Therapeutics Ag | Apparatus for assessment of microvascular dysfunction |
| US12115327B2 (en) | 2019-03-05 | 2024-10-15 | Measurement Specialties, Inc. | Sensor device and methods of operation for a catheter based treatment of myocardial microvascular obstruction |
| AU2021274173A1 (en) | 2020-05-22 | 2022-12-22 | Corflow Therapeutics Ag | Controlled flow infusion microvascular dysfunction diagnostic and therapy |
-
2018
- 2018-09-19 JP JP2020537457A patent/JP7249672B2/ja active Active
- 2018-09-19 EP EP18793291.8A patent/EP3684247A1/en active Pending
- 2018-09-19 CN CN201880070198.7A patent/CN111655121B/zh active Active
- 2018-09-19 US US16/135,987 patent/US11412936B2/en active Active
- 2018-09-19 CA CA3076035A patent/CA3076035A1/en active Pending
- 2018-09-19 WO PCT/US2018/051760 patent/WO2019060421A1/en not_active Ceased
- 2018-09-19 AU AU2018336787A patent/AU2018336787B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596010A (zh) * | 2009-08-10 | 2012-07-18 | P2科学有限公司 | 用于诊断狭窄和其他血流受限之病症的utp |
| CN105636512A (zh) * | 2013-08-14 | 2016-06-01 | 南洋理工大学 | 用于评估血管重建的系统和方法 |
| CN105848573A (zh) * | 2013-10-25 | 2016-08-10 | 波士顿科学国际有限公司 | 利用光学传感来确定血流量的导管系统和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111655121A (zh) | 2020-09-11 |
| AU2018336787B2 (en) | 2024-05-30 |
| WO2019060421A1 (en) | 2019-03-28 |
| US11412936B2 (en) | 2022-08-16 |
| CA3076035A1 (en) | 2019-03-28 |
| AU2018336787A1 (en) | 2020-04-23 |
| JP2020534132A (ja) | 2020-11-26 |
| US20190082976A1 (en) | 2019-03-21 |
| JP7249672B2 (ja) | 2023-03-31 |
| EP3684247A1 (en) | 2020-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111655121B (zh) | 微血管阻塞(mvo)和心肌梗死的冠状动脉内表征 | |
| JP6921112B2 (ja) | Mvoを治療するためのシステムおよび方法 | |
| JP2025003474A (ja) | 微小血管機能障害の査定のための装置 | |
| US11433183B2 (en) | System for diagnosing and treating microvascular obstructions | |
| JP7773483B2 (ja) | 患者に関する血管生理学的パラメータを決定するシステムまたは動脈血管を有する患者を診断または処置するためのシステム | |
| US20170296055A1 (en) | Angiogenic treatment of ischemic heart disease | |
| EP4274471B1 (en) | Apparatus and method for determining and/or treating microvascular obstruction | |
| US20220378301A1 (en) | Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction | |
| US20230381415A1 (en) | Method and apparatus for diagnosis and treatment of microvascular dysfunction | |
| Gu et al. | Treatment of right ventricular perforation during percutaneous coronary intervention | |
| Palazzo et al. | Cardiac Catheterization and Percutaneous Intervention |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |