CN111635406A - 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式 - Google Patents

用于药物制剂中的PI3Kδ选择性抑制剂的改良形式 Download PDF

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Publication number
CN111635406A
CN111635406A CN202010471226.5A CN202010471226A CN111635406A CN 111635406 A CN111635406 A CN 111635406A CN 202010471226 A CN202010471226 A CN 202010471226A CN 111635406 A CN111635406 A CN 111635406A
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salt
disease
tgr
ptsa
ptsa salt
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CN202010471226.5A
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Chinese (zh)
Inventor
斯瓦鲁普·库马尔·文卡塔·萨蒂亚·瓦卡拉恩卡
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Lisen Pharmaceutical Co ltd
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Lisen Pharmaceutical Co ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202010471226.5A 2014-05-27 2015-05-26 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式 Pending CN111635406A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2597/CHE/2014 2014-05-27
IN2597CH2014 2014-05-27
IN2596/CHE/2014 2014-05-27
IN2596CH2014 2014-05-27
CN201580034288.7A CN106661030B (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3K δ选择性抑制剂的改良形式

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CN201580034288.7A Division CN106661030B (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3K δ选择性抑制剂的改良形式

Publications (1)

Publication Number Publication Date
CN111635406A true CN111635406A (zh) 2020-09-08

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CN202010471226.5A Pending CN111635406A (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式
CN201580034288.7A Expired - Fee Related CN106661030B (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3K δ选择性抑制剂的改良形式

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US (4) US9969740B2 (enExample)
EP (2) EP3149000B1 (enExample)
JP (3) JP6987501B2 (enExample)
KR (1) KR20170007480A (enExample)
CN (2) CN111635406A (enExample)
AU (1) AU2015265542B2 (enExample)
BR (1) BR112016027674A2 (enExample)
CA (1) CA2949932C (enExample)
CY (1) CY1124316T1 (enExample)
DK (1) DK3149000T3 (enExample)
EA (1) EA032506B1 (enExample)
ES (1) ES2880999T3 (enExample)
HR (1) HRP20211151T1 (enExample)
HU (1) HUE054916T2 (enExample)
IL (1) IL249058B2 (enExample)
LT (1) LT3149000T (enExample)
PL (1) PL3149000T3 (enExample)
PT (1) PT3149000T (enExample)
RS (1) RS62136B1 (enExample)
SI (1) SI3149000T1 (enExample)
SM (1) SMT202100532T1 (enExample)
WO (1) WO2015181728A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3149000T1 (sl) * 2014-05-27 2021-09-30 Rhizen Pharmaceuticals S.A. Kristalinična tosilatna sol selektivnega inhibitorja PI3K delta za uporabo v farmacevtskih oblikah
MX2018014577A (es) 2016-05-27 2019-05-20 Tg Therapeutics Inc Combinacion de anticuerpo anti-cd20, inhibidor selectivo de quinasa p13-delta, e inhibidor de btk para tratar trastornos proliferativos de celulas b.
EP3509634A1 (en) 2016-09-09 2019-07-17 TG Therapeutics Inc. Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers
CN114127074A (zh) * 2019-07-15 2022-03-01 庄信万丰股份有限公司 无定形乌帕拉尼单甲苯磺酸盐
US20220143026A1 (en) 2020-11-12 2022-05-12 Tg Therapeutics, Inc. Triple combination to treat b-cell malignancies
US11814439B1 (en) 2022-06-01 2023-11-14 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11807689B1 (en) 2022-06-01 2023-11-07 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11965032B1 (en) 2022-06-01 2024-04-23 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11884740B1 (en) 2022-06-01 2024-01-30 Tg Therapeutics, Inc. Anti-CD20 antibody compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440408A (zh) * 2000-04-25 2003-09-03 艾科斯有限公司 人磷脂酰肌醇3-激酶δ的抑制剂
WO2014006572A1 (en) * 2012-07-04 2014-01-09 Rhizen Pharmaceuticals Sa Selective pi3k delta inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103833854B (zh) 2002-12-16 2017-12-12 健泰科生物技术公司 免疫球蛋白变体及其用途
US20050043239A1 (en) 2003-08-14 2005-02-24 Jason Douangpanya Methods of inhibiting immune responses stimulated by an endogenous factor
ES2674719T3 (es) 2008-11-13 2018-07-03 Gilead Calistoga Llc Terapias para neoplasias hematológicas
CA2756347A1 (en) 2009-03-24 2010-09-30 Gilead Calistoga Llc Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
MX2011011036A (es) 2009-04-20 2012-01-20 Gilead Calistoga Llc Metodos de tratamiento para tumores solidos.
SI3149000T1 (sl) * 2014-05-27 2021-09-30 Rhizen Pharmaceuticals S.A. Kristalinična tosilatna sol selektivnega inhibitorja PI3K delta za uporabo v farmacevtskih oblikah

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440408A (zh) * 2000-04-25 2003-09-03 艾科斯有限公司 人磷脂酰肌醇3-激酶δ的抑制剂
WO2014006572A1 (en) * 2012-07-04 2014-01-09 Rhizen Pharmaceuticals Sa Selective pi3k delta inhibitors

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Publication number Publication date
HUE054916T2 (hu) 2021-10-28
RS62136B1 (sr) 2021-08-31
AU2015265542A1 (en) 2016-12-08
DK3149000T3 (da) 2021-08-30
EP3149000B1 (en) 2021-06-30
HRP20211151T1 (hr) 2021-10-15
PL3149000T3 (pl) 2021-11-02
EA201692255A1 (ru) 2017-04-28
US20190016725A1 (en) 2019-01-17
PT3149000T (pt) 2021-07-27
ES2880999T3 (es) 2021-11-26
JP2022082680A (ja) 2022-06-02
SMT202100532T1 (it) 2021-11-12
CN106661030A (zh) 2017-05-10
IL249058B (en) 2022-11-01
AU2015265542B2 (en) 2019-05-09
CA2949932A1 (en) 2015-12-03
US10947244B2 (en) 2021-03-16
US20190382411A1 (en) 2019-12-19
US9969740B2 (en) 2018-05-15
US20170121336A1 (en) 2017-05-04
US10414773B2 (en) 2019-09-17
CN106661030B (zh) 2020-06-30
EA032506B1 (ru) 2019-06-28
JP6987501B2 (ja) 2022-01-05
US20210269446A1 (en) 2021-09-02
CA2949932C (en) 2021-08-10
IL249058B2 (en) 2023-03-01
KR20170007480A (ko) 2017-01-18
EP3971188A1 (en) 2022-03-23
SI3149000T1 (sl) 2021-09-30
WO2015181728A1 (en) 2015-12-03
BR112016027674A2 (pt) 2017-08-15
JP2017516785A (ja) 2017-06-22
JP2020122022A (ja) 2020-08-13
EP3149000A1 (en) 2017-04-05
LT3149000T (lt) 2021-09-10
CY1124316T1 (el) 2022-07-22
IL249058A0 (en) 2017-01-31

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Application publication date: 20200908