CN111630187A - 鉴定结直肠癌状态的方法和试剂盒 - Google Patents
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Abstract
提供了一种在受试者中鉴定结直肠癌状态的方法，包括：1)从所述受试者采集生物样品；2)检测所述生物样品中生物标志物基因的甲基化水平，其中所述生物标志物基因选自如下基因的一种或多种：ALX4、BCAT1、BMP3、IKZF1、NDRG4、NPTX2、RARB、SDC2、Septin9和VIM；以及3)将步骤2)检测的甲基化水平与群体中相应生物标志物基因的正常甲基化水平进行比较，以确定所述受试者中的结直肠癌状态。还提供了用于鉴定受试者中结直肠癌状态的试剂盒。
Description
PCT国内申请，说明书已公开。
Claims (34)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2018/073821 WO2019144277A1 (zh) | 2018-01-23 | 2018-01-23 | 鉴定结直肠癌状态的方法和试剂盒 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111630187A true CN111630187A (zh) | 2020-09-04 |
Family
ID=67395234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880087486.3A Pending CN111630187A (zh) | 2018-01-23 | 2018-01-23 | 鉴定结直肠癌状态的方法和试剂盒 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20210032703A1 (zh) |
| EP (1) | EP3792362A4 (zh) |
| CN (1) | CN111630187A (zh) |
| WO (1) | WO2019144277A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113249477A (zh) * | 2021-05-19 | 2021-08-13 | 北京艾克伦医疗科技有限公司 | 结直肠癌早期诊断的方法和试剂盒 |
| CN116482367A (zh) * | 2023-05-04 | 2023-07-25 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230242990A1 (en) * | 2019-10-16 | 2023-08-03 | Xiamen Sciendox Biological Technology Co., Ltd. | Primer set, reagent, and kit for methylation of specific regions of human colorectal cancer-related genes, and application of the kit |
| CN114207153A (zh) * | 2020-03-20 | 2022-03-18 | 上海鹍远健康科技有限公司 | 筛查结直肠瘤的方法和试剂盒 |
| CN112159844B (zh) * | 2020-05-25 | 2022-05-03 | 浙江中创生物医药有限公司 | 结直肠癌dna甲基化的检测方法及试剂 |
| CN111748636B (zh) * | 2020-08-31 | 2020-11-17 | 圣湘生物科技股份有限公司 | 辅助诊断结直肠癌的组合物、试剂盒及其用途 |
| GB2620255A (en) * | 2022-05-09 | 2024-01-03 | Oxford Simcell Ltd | Method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011126768A2 (en) * | 2010-03-29 | 2011-10-13 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal cancer and adenoma |
| CN106574303A (zh) * | 2014-06-04 | 2017-04-19 | 奎斯特诊断投资股份有限公司 | 用于结肠直肠癌的甲基化的标志物 |
| CN106893777A (zh) * | 2017-03-02 | 2017-06-27 | 武汉艾米森生命科技有限公司 | 用于检测结直肠癌相关基因多位点甲基化试剂盒及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2630669C1 (ru) * | 2016-07-21 | 2017-09-11 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Способ определения метилирования сайтов PuCGPy регуляторных областей генов-онкомаркеров колоректального рака методом GLAD-ПЦР-анализа и набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для осуществления указанного способа |
| WO2018087129A1 (en) * | 2016-11-08 | 2018-05-17 | Region Nordjylland, Aalborg University Hospital | Colorectal cancer methylation markers |
-
2018
- 2018-01-23 CN CN201880087486.3A patent/CN111630187A/zh active Pending
- 2018-01-23 US US16/964,154 patent/US20210032703A1/en not_active Abandoned
- 2018-01-23 EP EP18902067.0A patent/EP3792362A4/en active Pending
- 2018-01-23 WO PCT/CN2018/073821 patent/WO2019144277A1/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011126768A2 (en) * | 2010-03-29 | 2011-10-13 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal cancer and adenoma |
| CN106574303A (zh) * | 2014-06-04 | 2017-04-19 | 奎斯特诊断投资股份有限公司 | 用于结肠直肠癌的甲基化的标志物 |
| CN106893777A (zh) * | 2017-03-02 | 2017-06-27 | 武汉艾米森生命科技有限公司 | 用于检测结直肠癌相关基因多位点甲基化试剂盒及应用 |
Non-Patent Citations (3)
| Title |
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| RASMUSSEN SL.等: "Hypermethylated DNA, a circulating biomarker for colorectal canc", 《PLOS ONE》 * |
| RASMUSSEN SL.等: "Hypermethylated DNA, a circulating biomarker for colorectal cancer detection", 《PLOS ONE》 * |
| YOUNG GP.等: "A cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumor-derived DNA with CEA for detection of recurrent colorectal cancer", 《CANCER MED.》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113249477A (zh) * | 2021-05-19 | 2021-08-13 | 北京艾克伦医疗科技有限公司 | 结直肠癌早期诊断的方法和试剂盒 |
| CN116482367A (zh) * | 2023-05-04 | 2023-07-25 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3792362A4 (en) | 2021-11-17 |
| EP3792362A8 (en) | 2021-05-12 |
| WO2019144277A1 (zh) | 2019-08-01 |
| EP3792362A1 (en) | 2021-03-17 |
| US20210032703A1 (en) | 2021-02-04 |
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