CN111616987A - Artemisia apiacea wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and preparation method thereof - Google Patents
Artemisia apiacea wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention provides sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and a preparation method thereof, wherein the sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer comprises A, B, C three-phase components in parts by weight (100 parts), wherein the phase A is as follows: 60-75 parts of medical alcohol, 0.1-3 parts of sweet wormwood wax oil, 0.1-0.5 part of carbomer 501E, 0.1-1 part of propylene glycol and 0.01-0.5 part of rosemary essential oil; the phase B is as follows: 0.01-0.1 part of barbaloin, 0.01-0.1 part of geniposide, 0.05-0.2 part of kasong and 18-30 parts of deionized water; the phase C is as follows: 0.1-0.5 part of triethanolamine, 3-10 parts of deionized water and 0.2-0.5 part of gardenia essence. The method fully utilizes the byproduct sweet wormwood wax oil extracted from the artemisinin, improves the resource utilization rate, utilizes the mosquito repelling, bacteriostasis and disinfection effects, has simple and easy operation process, fast volatilization of the product, bacteriostasis, disinfection and skin care, no toxic or side effect, safety and reliability.
Description
Technical Field
The invention relates to the field of washing products, in particular to sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and a preparation method thereof.
Background
Artemisia apiacea, Artemisia annua (A. Merr.), (Artemisia annuaLinn.), is an annual herb plant of the genus Artemisia of the family Compositae, the class Dicotyledoneae, and mainly contains volatile oil, and contains artemisinin, flavonoid compounds, etc. Wherein, the artemisinin is a compound containing peroxy bridge sesquiterpene lactone, and is a main effective component for antimalarial. During the extraction of artemisinin, a byproduct, namely artemisia apiacea wax oil, is produced, about five tons of artemisia apiacea wax oil are produced as a byproduct when one ton of artemisinin is produced, and about 500 tons of artemisia apiacea wax oil are roughly estimated to be produced by artemisinin enterprises per year. The herba Artemisiae Annuae wax oil is semisolid at room temperature, has dark color and heavy medicinal taste, and contains a large amount of chlorophyll, volatile oil, fatty acid, vegetable wax and other active ingredients. Wherein, the chlorophyll has a plurality of functions of hematopoiesis, vitamin supply, detoxification, disease resistance and the like; the volatile oil has antiinflammatory, antiallergic, antimicrobial, antimutagenic and anticancer, anthelmintic, enzyme inhibiting, central nervous system, and respiratory system effects; the fatty acid can be used for producing high-grade soap, transparent soap, stearic acid and intermediates of various surfactants; the vegetable wax can be used for preparing medicines, cosmetics, etc., and these components have been developedThe utilization value is high.
The Chinese patent CN 110105195A 'a method for extracting dihydroartemisinic acid from artemisia apiacea wax oil', introduces that the artemisia apiacea wax oil is extracted and filtered by various solvents, and then is subjected to chromatography, concentration, extraction and impurity removal, and then the crude product is refined for multiple times to obtain the dihydroartemisinic acid. Chinese patent CN 110591821 a, "a method for extracting sweet wormwood essential oil", describes that sweet wormwood wax oil is extracted by twice hot reflux, and then is subjected to vacuum centrifugal filtration and further concentration to obtain sweet wormwood essential oil. Chinese patent CN 110623002A "a method for preparing insect repellent from wax oil of Artemisia annua" introduces an insect repellent prepared by mixing and stirring wax oil of Artemisia annua, polysorbate 65, ethanol, water, etc., and is mainly used in the technical field of deinsectization.
Disclosure of Invention
The invention provides the sweet wormwood wax oil mosquito-repellent, antibacterial, disinfecting and skin-care water-free hand sanitizer and the preparation method thereof, the process is simple, the scale-up production is easy, the resource utilization rate is improved, the production cost is reduced, the environmental pollution is avoided, and the wide requirements in the field of washing and care products are met.
The technical scheme for realizing the invention is as follows:
a sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer comprises A, B, C three-phase components in parts by weight (100 parts), wherein the phase A is as follows: 60-75 parts of medical alcohol, 0.1-3 parts of sweet wormwood wax oil, 0.1-0.5 part of carbomer 501E, 0.1-1 part of propylene glycol and 0.01-0.5 part of rosemary essential oil; the phase B is as follows: 0.01-0.1 part of barbaloin, 0.01-0.1 part of geniposide, 0.05-0.2 part of kasong and 18-30 parts of deionized water; the phase C is as follows: 0.1-0.5 part of triethanolamine, 3-10 parts of deionized water and 0.2-0.5 part of gardenia essence.
The preparation method of the sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer comprises the following steps:
(1) mixing carbomer 501E, propylene glycol, rosemary oil and herba Artemisiae Annuae wax oil alcohol solution, stirring at room temperature for 5-10min, standing for 4-48h, and stirring for 1-6h to obtain phase A mixed solution;
(2) mixing barbaloin, geniposide, kasong, and deionized water, stirring at room temperature for 15-60min to obtain phase B mixed solution;
(3) mixing triethanolamine, deionized water and Gardenia essence, and stirring at room temperature for 5-30min to obtain C phase mixed solution;
(4) and (3) mixing the phase A mixed solution and the phase B mixed solution obtained in the steps (1) and (2) with each other, stirring at room temperature for 30-60min, slowly adding the phase C mixed solution obtained in the step (3) into the solution, stirring for 30-60min, and standing for 1-72h to obtain the antibacterial, disinfectant and skin-care hand sanitizer.
The preparation of the sweet wormwood wax oil alcohol solution in the step (1) is as follows: mixing sweet wormwood wax oil and 95% medical alcohol in proportion, stirring at room temperature for 10-60min or performing ultrasonic treatment for 5-30min, refrigerating in a refrigerator for 4-24h, and filtering to obtain clear solution to obtain sweet wormwood wax oil alcohol solution.
According to the invention, the sweet wormwood wax oil is prepared into the alcohol-containing water-free hand sanitizer, so that the utilization rate of sweet wormwood resources is fully improved, and the value of the sweet wormwood wax oil is maximized. Traditional liquid soap can not leave the boiling water source, does not have the water condition in many environmental occasions, and during daily life, trip, outdoor recreation, everywhere bacterium virus etc. threatened human health again, this problem of water source restriction just can fine solution of water-free liquid soap, under anhydrous condition, also can accomplish disinfection sanitation and hygiene. The active ingredients in the sweet wormwood wax oil are mainly dissolved in ethanol, and the main solvent for preparing the water-free hand sanitizer is medical alcohol, so that the sweet wormwood wax oil can be dissolved more completely. Meanwhile, the aloin and geniposide with high purity are added, so that the effects and advantages of anti-inflammation, mosquito repelling, bacteriostasis, skin care and the like can be fully exerted.
The invention has the following advantages and beneficial effects:
(1) according to the invention, the artemisinin extraction byproduct sweet wormwood wax oil is fully utilized, the resource utilization rate is improved, the addition of a small amount of high-purity impurity-free aloin and geniposide is assisted, the antibacterial, disinfecting and mosquito-repellent effects of the sweet wormwood wax oil are improved, and meanwhile, the antioxidant rosemary essential oil is added, so that the active ingredients in the sweet wormwood wax oil are more stable;
(2) the invention has simple process, can stir and dissolve components such as alcohol soluble and water soluble in groups, greatly shortens the operation time, improves the efficiency, can fully and uniformly mix without high-end production equipment such as a homogenizer, and reduces the production cost;
(3) the pH value (5.5-7.9) of the product is adjusted by triethanolamine, so that the product is closer to human skin, and is safe and non-irritant;
(4) the invention realizes no water washing, can effectively inhibit bacteria and disinfect, has quick solvent volatilization, can inhibit bacteria, disinfect, repel mosquitoes and preserve moisture of residual substances, and has moist and not tight skin.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
All the raw materials are calculated by 100 parts by weight:
mixing 3 parts of sweet wormwood wax oil and 95% medical alcohol, stirring at room temperature for 1h or performing ultrasonic treatment for 30min, then placing in a refrigerator for cold storage for 24h, and performing suction filtration to obtain a clear solution, namely the sweet wormwood wax oil alcohol solution.
Mixing 0.5 part of carbomer 501E, 0.3 part of propylene glycol, 0.5 part of rosemary oil and 65 parts of the sweet wormwood wax oil-alcohol solution, stirring at room temperature for 10min, standing for 48h, and continuously stirring for 6h after the carbomer is fully swelled to obtain a phase A mixed solution; mixing barbaloin 0.1 part, geniposide 0.1 part, Kathon 0.2 part, and deionized water 20 parts, and stirring at room temperature for 30min to obtain phase B mixed solution; mixing triethanolamine 0.4 parts, fructus Gardeniae essence 0.5 parts, and deionized water (balance), and stirring at room temperature for 30min to obtain C phase mixed solution; mixing the obtained A, B two-phase mixed solution, stirring at room temperature for 60min, slowly adding the C-phase mixed solution, stirring for 60min, and standing for 12h to obtain the mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer.
In this embodiment 1, the product sterilization performance, bacteriostatic performance and stability test method in appendix C of GB 15979-2002 hygienic products for disposable use of the national standard shows that the bacteriostatic rates of the test items such as Escherichia coli, Staphylococcus aureus and Candida albicans are all 100%, and the product has a strong bacteriostatic action.
Example 2
All the raw materials are calculated by 100 parts by weight:
mixing 1 part of sweet wormwood wax oil and 95% medical alcohol, stirring at room temperature for 30min or performing ultrasonic treatment for 10min, refrigerating in a refrigerator for 12h, and performing suction filtration to obtain a clear solution to obtain the sweet wormwood wax oil alcohol solution.
Mixing carbomer 501E 0.45 part, propylene glycol 0.4 part, rosemary oil 0.1 part and herba Artemisiae Annuae wax oil solution 70 parts, stirring at room temperature for 10min, standing for 48 hr until carbomer is fully swelled, and stirring for 2 hr to obtain phase A mixed solution; mixing barbaloin 0.01 parts, geniposide 0.01 parts, Kathon 0.1 parts, and deionized water 20 parts, and stirring at room temperature for 30min to obtain phase B mixed solution; mixing triethanolamine 0.3 parts, fructus Gardeniae essence 0.4 parts, and deionized water (balance), and stirring at room temperature for 30min to obtain C phase mixed solution; mixing the obtained A, B two-phase mixed solution, stirring at room temperature for 30min, slowly adding the C-phase mixed solution, stirring for 60min, and standing for 1h to obtain the mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer.
In this embodiment 2, the product sterilization performance, bacteriostatic performance and stability test method in appendix C of GB 15979-2002 hygienic products for disposable use of the national standard shows that the bacteriostatic rates of the test items such as Escherichia coli, Staphylococcus aureus and Candida albicans are all 100%, and the product has a strong bacteriostatic action.
Example 3
All the raw materials are calculated by 100 parts by weight:
mixing 0.1 part of sweet wormwood wax oil and 95% medical alcohol, stirring at room temperature for 30min or performing ultrasonic treatment for 5min, placing in a refrigerator for cold storage for 4h, and performing suction filtration to obtain a clarified liquid to obtain the sweet wormwood wax oil alcohol solution.
Mixing carbomer 501E 0.1 part, propylene glycol 0.1 part, rosemary oil 0.01 part and herba Artemisiae Annuae wax oil solution 75 parts, stirring at room temperature for 5min, standing for 4 hr until carbomer is fully swelled, and stirring for 1 hr to obtain phase A mixed solution; mixing barbaloin 0.01 parts, geniposide 0.01 parts, Kathon 0.05 parts, and deionized water 18 parts, and stirring at room temperature for 30min to obtain phase B mixed solution; mixing triethanolamine 0.1 part, fructus Gardeniae essence 0.2 part, and deionized water (balance), and stirring at room temperature for 30min to obtain C phase mixed solution; mixing the obtained A, B two-phase mixed solution, stirring at room temperature for 30min, slowly adding the C-phase mixed solution, stirring for 30min, and standing for 2h to obtain the mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer.
In this embodiment 3, the product sterilization performance, bacteriostatic performance and stability test method in appendix C of GB 15979-2002 hygienic products for disposable use of the national standard shows that the bacteriostatic rates of the test items such as Escherichia coli, Staphylococcus aureus and Candida albicans are all 100%, and the product has a strong bacteriostatic action.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (3)
1. The sweet wormwood wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer is characterized by comprising A, B, C three-phase components in parts by weight, wherein the phase A is as follows: 60-75 parts of medical alcohol, 0.1-3 parts of sweet wormwood wax oil, 0.1-0.5 part of carbomer HV-501E, 0.1-1 part of propylene glycol and 0.01-0.5 part of rosemary essential oil; the phase B is as follows: 0.01-0.1 part of barbaloin, 0.01-0.1 part of geniposide, 0.05-0.2 part of kasong and 18-30 parts of deionized water; the phase C is as follows: 0.1-0.5 part of triethanolamine, 3-10 parts of deionized water and 0.2-0.5 part of gardenia essence.
2. The preparation method of the sweet wormwood wax oil mosquito-repellent, bacteriostatic, disinfectant and skin-care water-free hand sanitizer according to claim 1 is characterized by comprising the following steps:
(1) mixing carbomer HV-501E, propylene glycol, rosemary essential oil and sweet wormwood wax oil alcohol solution, stirring at room temperature for 5-10min, standing for 4-48h, and continuously stirring for 1-6h to obtain phase A mixed solution;
(2) mixing barbaloin, geniposide, kasong, and deionized water, stirring at room temperature for 15-60min to obtain phase B mixed solution;
(3) mixing triethanolamine, deionized water and Gardenia essence, and stirring at room temperature for 5-30min to obtain C phase mixed solution;
(4) and (3) mixing the A-phase mixed solution and the B-phase mixed solution obtained in the steps (1) and (2), stirring at room temperature for 30-60min, slowly adding the C-phase mixed solution obtained in the step (3) into the solution, stirring for 30-60min, and standing for 1-72h to obtain the antibacterial, disinfectant and skin-care hand sanitizer.
3. The preparation method of the sweet wormwood wax oil mosquito-repellent, bacteriostatic, disinfectant and skin-care water-free hand sanitizer according to claim 2, wherein the preparation of the sweet wormwood wax oil alcoholic solution in the step (1) is as follows: mixing sweet wormwood wax oil and 95% medical alcohol in proportion, stirring at room temperature for 10-60min or performing ultrasonic treatment for 5-30min, refrigerating in a refrigerator for 4-24h, and filtering to obtain clear solution to obtain sweet wormwood wax oil alcohol solution.
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| CN202010465632.0A CN111616987A (en) | 2020-05-28 | 2020-05-28 | Artemisia apiacea wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and preparation method thereof |
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| CN202010465632.0A CN111616987A (en) | 2020-05-28 | 2020-05-28 | Artemisia apiacea wax oil mosquito-repellent, antibacterial, disinfectant and skin-care water-free hand sanitizer and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623002A (en) * | 2019-09-18 | 2019-12-31 | 禹州市天源生物科技有限公司 | Preparation method of sweet wormwood wax oil insect repellent |
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| CN105779129A (en) * | 2016-04-22 | 2016-07-20 | 四川蓝伯特生物科技有限责任公司 | Method for preparing Artemisia apiacea volatile oil from Artemisia apiacea waste mother liquor, method for preparing byproduct and obtained byproduct |
| CN105886166A (en) * | 2016-04-22 | 2016-08-24 | 四川蓝伯特生物科技有限责任公司 | Artemisia annua wax handmade soap and production method thereof |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
| CN110623002A (en) * | 2019-09-18 | 2019-12-31 | 禹州市天源生物科技有限公司 | Preparation method of sweet wormwood wax oil insect repellent |
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- 2020-05-28 CN CN202010465632.0A patent/CN111616987A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105779129A (en) * | 2016-04-22 | 2016-07-20 | 四川蓝伯特生物科技有限责任公司 | Method for preparing Artemisia apiacea volatile oil from Artemisia apiacea waste mother liquor, method for preparing byproduct and obtained byproduct |
| CN105886166A (en) * | 2016-04-22 | 2016-08-24 | 四川蓝伯特生物科技有限责任公司 | Artemisia annua wax handmade soap and production method thereof |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
| CN110623002A (en) * | 2019-09-18 | 2019-12-31 | 禹州市天源生物科技有限公司 | Preparation method of sweet wormwood wax oil insect repellent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623002A (en) * | 2019-09-18 | 2019-12-31 | 禹州市天源生物科技有限公司 | Preparation method of sweet wormwood wax oil insect repellent |
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