CN111574730A - 一种聚环氧丙酸水凝胶的制备方法 - Google Patents
一种聚环氧丙酸水凝胶的制备方法 Download PDFInfo
- Publication number
- CN111574730A CN111574730A CN202010517098.3A CN202010517098A CN111574730A CN 111574730 A CN111574730 A CN 111574730A CN 202010517098 A CN202010517098 A CN 202010517098A CN 111574730 A CN111574730 A CN 111574730A
- Authority
- CN
- China
- Prior art keywords
- polyepoxy
- hydrogel
- propionic acid
- aqueous solution
- steps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000002253 acid Substances 0.000 title claims description 14
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims abstract description 52
- 235000019260 propionic acid Nutrition 0.000 claims abstract description 26
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims abstract description 26
- 239000007864 aqueous solution Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000243 solution Substances 0.000 claims abstract description 20
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 18
- 238000004132 cross linking Methods 0.000 claims abstract description 13
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 6
- GYPZFDNQZCSGND-UHFFFAOYSA-N propanoic acid;hydrate Chemical compound O.CCC(O)=O GYPZFDNQZCSGND-UHFFFAOYSA-N 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 17
- 229920002125 Sokalan® Polymers 0.000 claims description 11
- 239000004584 polyacrylic acid Substances 0.000 claims description 9
- 239000001263 FEMA 3042 Substances 0.000 claims description 6
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- OTGHWLKHGCENJV-UHFFFAOYSA-N glycidic acid Chemical compound OC(=O)C1CO1 OTGHWLKHGCENJV-UHFFFAOYSA-N 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 2
- 150000002924 oxiranes Chemical class 0.000 claims 7
- 239000000463 material Substances 0.000 abstract description 17
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract description 5
- 238000010438 heat treatment Methods 0.000 description 10
- 238000003756 stirring Methods 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 125000004430 oxygen atom Chemical group O* 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 4
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 4
- 229920002258 tannic acid Polymers 0.000 description 4
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 4
- 229940033123 tannic acid Drugs 0.000 description 4
- 235000015523 tannic acid Nutrition 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 238000003898 horticulture Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002557 polyglycidol polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 238000010618 wire wrap Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2371/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/16—Halogen-containing compounds
- C08K2003/162—Calcium, strontium or barium halides, e.g. calcium, strontium or barium chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/01—Use of inorganic substances as compounding ingredients characterized by their specific function
- C08K3/011—Crosslinking or vulcanising agents, e.g. accelerators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0025—Crosslinking or vulcanising agents; including accelerators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/07—Aldehydes; Ketones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/15—Heterocyclic compounds having oxygen in the ring
- C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
- C08K5/1545—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epoxy Resins (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
本发明公开了一种聚环氧丙酸水凝胶的制备方法,包括如下步骤:(1)在一定温度下将聚环氧丙酸溶解,配制成聚环氧丙酸水溶液;(2)配制交联剂水溶液;(3)在一定温度下将交联剂水溶液以一定比例与聚环氧丙酸水溶液进行混合,交联反应一定时间;(4)将交联后的溶液倒入模具冷却至室温,或直接冷却至室温,得到聚环氧丙酸水凝胶。本发明采用聚环氧丙烯酸为水凝胶基材,它是一种新型的水凝胶材料,生物相容性好,使用后能自然降解,能减轻对环境的影响。
Description
技术领域
本发明属于精细化工领域,具体涉及一种可容易自然降解的聚环氧丙酸水凝胶的制备方法。
背景技术
水凝胶是一种迅速发展的新型功能高分子材料,是一类具有三维网络结构的聚合物,在水中能够吸收大量水分而溶胀,并在溶胀之后能够继续保持其原有结构而不被溶解。
水凝胶作为一种高吸水性材料,广泛地应用于降温贴、卫生巾、尿布、生理卫生用品、香料载体以及纸巾等方面;水凝胶可用于油水分离、废水处理、空气过滤、电线包裹材料、防静电、密封材料、蓄冷剂、溶剂脱水、金属离子浓集、包装材料等诸多方面;水凝胶还可用在农用薄膜、农业园艺用保水材料、污泥固化、泥水添加剂、墙壁顶棚材料等方面。绿化沙漠是高吸水性水凝胶材料极有潜力的用途之一,可通过制成保水剂的方式实施。
水凝胶材料直接用于与人体组织接触,可防止体外微生物的感染,抑制体液的损失,传输氧到伤口,一般说来能促进伤口的愈合。当水凝胶被移植或注射到生物体后,水凝胶能够维持或向体液控制释放包埋在水凝胶中的药物,特别是智能型水凝胶问世以来,水凝胶在该领域的应用研究更为深入。
水凝胶可分为合成高分子水凝胶和天然高分子水凝胶。天然高分子水凝胶具有更好的生物相容性、对环境的敏感性以及丰富的来源、低廉的价格,但是稳定性较差,易降解、持久性差。合成高分子水凝胶主要有聚乙烯醇、聚丙烯酸盐类、聚酰胺类、聚氨酯、聚吡咯烷酮等,这些物质稳定性好,生产技术成熟,但生物相容性不太好,在环境中很难自然降解,使用后对环境容易造成污染,而且由于一定的毒性也限制了它们在一些民用、医用领域的应用。近些年,水凝胶是全世界科技研究的热点之一,人们针对不同用途开发出许许多多性能各异的水凝胶材料,但是寻求高性能、环境友好、可降解、生物相容的高分子合成水凝胶材料一直是国内外众多研究者努力追求的目标。
聚环氧丙酸是一种潜在的环境友好的水凝胶基材,与聚丙烯酸类、聚酰胺类等不同的是其分子主链每隔两个碳原子就连着一个氧原子。聚环氧丙酸与聚丙烯酸结构对比如下:
聚环氧丙酸主链中大量氧原子的存在必定会导致凝胶性能与聚丙烯酸类不同,在一些方面前者要优于后者。首先,氧原子可以形成更多的氢键从而提高制品的机械强度;同时氧原子与水分子的结合性好,可以推断聚环氧丙酸比相同链长的聚丙烯酸具有更强的吸水、保水性能;另外氧原子会使高分子链段更加自由的转动,能增加凝胶的柔韧性;碳氧键的能量比较大,碳氧键比碳碳键断裂的几率要大,聚合物降解要容易。
发明内容
发明目的:针对现有水凝胶材料的不足,本发明的目的在于提供一种新型的水凝胶材料,它的原料安全易得,具有较好的机械强度、良好的吸水性和保水性,特别是它可以在自然条件下较容易地降解。
技术方案:为了解决上述技术问题,本发明是通过以下技术方案实现的:一种聚环氧丙酸水凝胶的制备方法,包括以下步骤:
(1)在一定温度下将聚环氧丙酸溶解,配制成聚环氧丙酸水溶液;
(2)配制交联剂水溶液;
(3)在一定温度下将交联剂水溶液以一定比例与聚环氧丙酸水溶液进行混合,交联反应一定时间;
(4)将交联后的溶液倒入模具冷却至室温,或直接冷却至室温,得到聚环氧丙酸水凝胶。
进一步的,所述的聚环氧丙酸水溶液的质量百分比浓度为2-10%。
进一步的,所述的聚环氧丙酸水溶液的质量百分比浓度为6%。
进一步的,溶解所述的聚环氧丙酸水溶液的温度为45-90℃。
进一步的,所述的交联剂为CaCl2、单宁酸、戊二醛。
进一步的,所述的交联剂水溶液的质量百分比浓度为2-6%。
进一步的,所述的交联反应中,交联剂水溶液与聚环氧丙酸水溶液的体积比为;10:90-25:75。
进一步的,所述的交联反应中,反应温度为50-80℃。
进一步的,所述的交联反应中,交联反应时间为40-180分钟。
有益效果:本发明通过聚环氧丙酸在一定温度下经交联剂交联后形成水凝胶制品。较之现有的技术,聚环氧丙酸可以由丙烯酸为基本原料制得,原料丙烯酸安全、易得,价格便宜;聚环氧丙酸是一种新型的水凝胶基材,制备的水凝胶具有机械强度好、吸水能力大,自然条件下容易降解。因此,本发明提供的技术方法非常实用,可以提供一种新型的水凝胶材料。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,以使本领域的技术人员能够更好的理解本发明的优点和特征,从而对本发明的保护范围做出更为清楚的界定。本发明所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例,基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。
具体实施例一:
(1)称取6g聚环氧丙酸,加入到94g去离子水,电磁搅拌下加热至75℃,将聚环氧丙酸完全溶解;
(2)称取5g固体CaCl2,溶解于95g去离子水中,制成交联剂溶液;
(3)取上述(1)中聚环氧丙酸水溶液88mL、上述(2)中氯化钙水溶液12mL,混合后水浴升温至60℃,边升温边电磁搅拌;
(4)上述混合液保持60℃继续电磁搅拌40分钟;
(5)趁热将上述交联后的溶液倒入模具冷却至室温,便可得到经Ca2+交联的聚环氧丙酸水凝胶。
具体实施例二:
(1)称取6g聚环氧丙酸,加入到94g去离子水,电磁搅拌下加热至75℃,将聚环氧丙酸完全溶解;
(2)称取4g单宁酸粉末置于96g去离子水中,稍微加热溶解,不溶物经中速滤纸过滤除去,制成交联剂溶液;
(3)取上述(1)中聚环氧丙酸水溶液80mL、上述(2)中单宁酸水溶液20mL,混合后水浴升温至75℃,边升温边电磁搅拌;
(4)上述混合液保持75℃继续电磁搅拌60分钟;
(5)趁热将上述交联后的溶液倒入模具冷却至室温,便可得到经单宁酸交联的聚环氧丙酸水凝胶。
具体实施例三:
(1)称取6g聚环氧丙酸,加入到94g去离子水,电磁搅拌下加热至75℃,将聚环氧丙酸完全溶解;
(2)称取6g交联剂戊二醛,溶解于94g去离子水中,制成交联剂溶液;
(3)取上述(1)中聚环氧丙酸水溶液85mL、上述(2)中戊二醛水溶液15mL,混合后水浴升温至55℃,边升温边电磁搅拌;
(4)上述混合液保持55℃继续电磁搅拌180分钟;
(5)趁热将上述交联后的溶液倒入模具冷却至室温,便可得到经戊二醛交联的聚环氧丙酸水凝胶。
本发明通过聚环氧丙酸在一定温度下经交联剂交联后形成水凝胶制品。较之现有的技术,聚环氧丙酸可以由丙烯酸为基本原料制得,原料丙烯酸安全、易得,价格便宜;聚环氧丙酸是一种新型的水凝胶基材,制备的水凝胶具有机械强度好、吸水能力大,自然条件下容易降解。因此,本发明提供的技术方法非常实用,可以提供一种新型的水凝胶材料。
Claims (9)
1.一种聚环氧丙酸水凝胶的制备方法,其特征在于:包括以下步骤:
(1)在一定温度下将聚环氧丙酸溶解,配制成聚环氧丙酸水溶液;
(2)配制交联剂水溶液;
(3)在一定温度下将交联剂水溶液以一定比例与聚环氧丙酸水溶液进行混合,交联反应一定时间;
(4)将交联后的溶液倒入模具冷却至室温,或直接冷却至室温,得到聚环氧丙酸水凝胶。
2.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的聚环氧丙酸水溶液的质量百分比浓度为2-10%。
3.根据权利要求2所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的聚环氧丙酸水溶液的质量百分比浓度为6%。
4.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:溶解所述的聚环氧丙酸水溶液的温度为45-90℃。
5.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的交联剂为CaCl2、单宁酸、戊二醛。
6.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的交联剂水溶液的质量百分比浓度为2-6%。
7.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的交联反应中,交联剂水溶液与聚环氧丙酸水溶液的体积比为;10:90-25:75。
8.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的交联反应中,反应温度为50-80℃。
9.根据权利要求1所述的聚环氧丙酸水凝胶的制备方法,其特征在于:所述的交联反应中,交联反应时间为40-180分钟。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010517098.3A CN111574730A (zh) | 2020-06-09 | 2020-06-09 | 一种聚环氧丙酸水凝胶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010517098.3A CN111574730A (zh) | 2020-06-09 | 2020-06-09 | 一种聚环氧丙酸水凝胶的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111574730A true CN111574730A (zh) | 2020-08-25 |
Family
ID=72121736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010517098.3A Pending CN111574730A (zh) | 2020-06-09 | 2020-06-09 | 一种聚环氧丙酸水凝胶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111574730A (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4026738A (en) * | 1975-05-08 | 1977-05-31 | Canadian Industries, Ltd. | Stabilized, foamed water gel explosives and method |
CN106831657A (zh) * | 2017-02-23 | 2017-06-13 | 江苏工程职业技术学院 | 一种环氧丙酸钾的制备方法 |
CN108816062A (zh) * | 2018-06-27 | 2018-11-16 | 苏州市贝克生物科技有限公司 | 聚酰胺-海藻纤维透析膜及其制备方法 |
CN109021431A (zh) * | 2018-06-22 | 2018-12-18 | 苏州市贝克生物科技有限公司 | 一种增强型医用薄膜材料 |
WO2019172509A1 (ko) * | 2018-03-06 | 2019-09-12 | 비엘테크 주식회사 | 하이드로겔의 제조방법 |
CN110746615A (zh) * | 2019-10-25 | 2020-02-04 | 扬州大学 | 一种pH响应型高强度导电水凝胶的制备方法及用途 |
-
2020
- 2020-06-09 CN CN202010517098.3A patent/CN111574730A/zh active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4026738A (en) * | 1975-05-08 | 1977-05-31 | Canadian Industries, Ltd. | Stabilized, foamed water gel explosives and method |
CN106831657A (zh) * | 2017-02-23 | 2017-06-13 | 江苏工程职业技术学院 | 一种环氧丙酸钾的制备方法 |
WO2019172509A1 (ko) * | 2018-03-06 | 2019-09-12 | 비엘테크 주식회사 | 하이드로겔의 제조방법 |
CN109021431A (zh) * | 2018-06-22 | 2018-12-18 | 苏州市贝克生物科技有限公司 | 一种增强型医用薄膜材料 |
CN108816062A (zh) * | 2018-06-27 | 2018-11-16 | 苏州市贝克生物科技有限公司 | 聚酰胺-海藻纤维透析膜及其制备方法 |
CN110746615A (zh) * | 2019-10-25 | 2020-02-04 | 扬州大学 | 一种pH响应型高强度导电水凝胶的制备方法及用途 |
Non-Patent Citations (1)
Title |
---|
孟立山等: "聚丙烯酸水凝胶的制备研究", 《应用化工》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Kundu et al. | Cellulose hydrogels: Green and sustainable soft biomaterials | |
CN113577377B (zh) | 一种活性氧消除抗菌消炎水凝胶皮肤敷料及其制备方法 | |
CN109942905B (zh) | 一种复合水凝胶材料及其制备方法 | |
CN101664563B (zh) | 一种抗菌水凝胶敷料的制备方法 | |
WO2019062024A1 (zh) | 一种土壤调理剂的制备方法 | |
CN113004543B (zh) | 一种纳米木质素/聚乙烯醇复合医用水凝胶及其制备方法 | |
CN114949324B (zh) | 一种生物相容性抗菌凝胶膜的制备方法 | |
CN111303449A (zh) | 可降解的电活性细菌纤维素/MXene复合水凝胶及制备与应用 | |
CN112745515A (zh) | 一种载银单宁多酚交联聚乙烯醇抗菌水凝胶及其制备方法 | |
CN111214695A (zh) | 一种共价反应制备的新型的3d结构生物高分子材料及其合成方法 | |
CN107955188B (zh) | 一种改性羟乙基纤维素超吸水凝胶及其制备方法和应用 | |
CN112353754B (zh) | 一种导电聚吡咯/中药复合水凝胶及其制备方法与应用 | |
CN111574730A (zh) | 一种聚环氧丙酸水凝胶的制备方法 | |
Yang et al. | Research Advances in Superabsorbent Polymers | |
CN114479204B (zh) | 一种复合交联医用高分子材料及其制备方法与应用 | |
CN103301504A (zh) | 一种γ-聚谷氨酸/丝胶水凝胶敷料的制备方法 | |
CN109529099B (zh) | 一种基于三维打印技术的双网络负载壳聚糖酶水凝胶敷料及其制备方法 | |
CN116376123A (zh) | 可注射葡聚糖基水凝胶、负载重楼皂苷i的葡聚糖基水凝胶及制备方法与应用 | |
WO2012147255A1 (ja) | 吸水性および吸液性高分子 | |
CN114437371A (zh) | 一种基于双交联机制的酪蛋白基纳米杂化水凝胶的制备方法 | |
CN114702695A (zh) | 一种pha水凝胶及其制备方法及其应用 | |
CN114478831A (zh) | 一种新型高分子材料及其制备方法与应用 | |
JP3999823B2 (ja) | 架橋多糖類及びその製造法並びにこれによる複合材料 | |
CN101831723A (zh) | 一种三价铈改性的明胶抑菌纤维及其制备方法和用途 | |
CN111333870A (zh) | 一种可自修复壳聚糖水凝胶及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200825 |
|
RJ01 | Rejection of invention patent application after publication |