CN111529597A - Traditional Chinese medicine composition for gout and/or hyperuricemia - Google Patents

Traditional Chinese medicine composition for gout and/or hyperuricemia Download PDF

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CN111529597A
CN111529597A CN202010473599.6A CN202010473599A CN111529597A CN 111529597 A CN111529597 A CN 111529597A CN 202010473599 A CN202010473599 A CN 202010473599A CN 111529597 A CN111529597 A CN 111529597A
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hyperuricemia
traditional chinese
chinese medicine
gout
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鲁雪梅
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Guangdong Shizhen Materia Medica Research Institute
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Guangdong Zhongyikang Biotechnology Co ltd
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/076—Poria
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
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    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for gout and/or hyperuricemia, which comprises agaricus blazei, hovenia dulcis thunb, cordyceps militaris, tea tree flower, kudzuvine root, celery seed, gardenia, hispid fig, medlar, raspberry, liquorice, chicory, sophora flower, guava, poria cocos, angelica dahurica and dark plum. The invention can fully exert the synergistic interaction among the raw materials, and effectively reduce the levels of uric acid, urea nitrogen, creatinine and xanthine oxidase in the blood serum of a mouse, thereby improving or treating gout and/or hyperuricemia.

Description

Traditional Chinese medicine composition for gout and/or hyperuricemia
Technical Field
The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for treating gout and/or hyperuricemia.
Background
Gout is a heterogeneous group of diseases in which tissue damage is caused by long-term purine metabolic disorders or elevated blood uric acid. The biochemical marker of gout is hyperuricemia, which means that urate in extracellular fluid is in a supersaturated state, and hyperuricemia is generally considered when the blood uric acid is 416 mu mol/L, and about 5-12% of patients with hyperuricemia can develop gout. The acute attack of gout is an acute inflammatory response caused by the deposition of sodium urate in crystalline form in the joints and tissues surrounding the joints. Gout not only can invade bones and joints, but also is easy to affect hyperuricemia of kidney and cardiovascular system and primary gout, and is in obvious positive correlation with diseases such as obesity, hyperlipoidemia, hypertension, diabetes, atherosclerosis and the like. Gout is therefore a serious metabolic disease that endangers human health.
At present, gout and/or hyperuricemia are mostly treated by oral medicines, and western medicine treatment medicines are mainly classified into three types according to disease conditions: 1. treatment of the acute phase: colchicine, non-steroidal anti-inflammatory drugs, glucocorticoids; 2. treatment in the intermittent period: drugs for inhibiting uric acid production and promoting uric acid excretion, such as allopurinol, probenecid, and sulpirenone. 3. Treatment of the chronic phase: diet therapy and the above drugs. However, the drugs have the side effects of gastrointestinal tract reaction, skin anaphylactic reaction, kidney damage, liver damage, leucopenia and the like, and the compliance of patients is poor.
The traditional Chinese medicine has a long history of treating gout, and has obvious curative effects on relieving pain of patients, reducing acid, removing calculus, slowing down attack frequency and the like. For example, CN103330926A discloses a toxin-expelling gout-treating medicine, which comprises the following components: 15-30 parts of cassia twig, 20-40 parts of white paeony root, 20-30 parts of ginger, 10-20 parts of Chinese date, 15-30 parts of liquorice, 20-40 parts of kudzu root, 15-30 parts of mangnolia officinalis, 15-20 parts of immature bitter orange, 10-30 parts of rhubarb, 20-30 parts of betel nut, 30-60 parts of glabrous greenbrier rhizome and 20-30 parts of clematis root.
CN108186932A discloses a traditional Chinese medicine for treating gout, which is composed of the following traditional Chinese medicine raw materials in parts by weight: 8-12 parts of wheatgrass, 10-12 parts of rhizoma panacis majoris, 20-25 parts of Chinese yam, 15-18 parts of lycopodium clavatum, 10-12 parts of sappan wood, 15-18 parts of mulberry twig, 5-7 parts of peach kernel and 3-5 parts of borneol.
Epidemiological investigation shows that along with the improvement of living standard and the acceleration of life rhythm of people, the prevalence rate of gout is increased day by day, and along with the continuous increase of the prevalence rate of gout, the demand of medicines for treating gout and/or hyperuricemia is continuously increased, but the traditional medicine composition for treating gout and/or hyperuricemia is only simple matching of a plurality of traditional Chinese medicines which are beneficial to reducing uric acid, and the synergistic promotion effect among the traditional Chinese medicines is not considered from the traditional Chinese medicine pharmacology, and meanwhile, research shows that the traditional Chinese medicine has lighter degree of liver injury compared with chemical medicines, but also has the trend of increasing year by year.
Disclosure of Invention
In order to solve the technical problems, the invention provides a safe and reliable traditional Chinese medicine composition for treating gout and/or hyperuricemia, which has high response rate and good effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine composition for gout and/or hyperuricemia, which comprises agaricus blazei, hovenia dulcis, cordyceps militaris, tea tree flower, radix puerariae, celery seeds, gardenia, hispid fig, medlar, raspberry and liquorice.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 10-100 parts of agaricus blazei murill, 10-100 parts of hovenia dulcis thunb, 10-100 parts of cordyceps militaris, 10-100 parts of tea flower, 10-50 parts of kudzu root, 10-50 parts of celery seed, 10-50 parts of gardenia, 1-30 parts of hispid fig, 1-30 parts of wolfberry fruit, 1-30 parts of raspberry and 1-30 parts of liquorice.
Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 12-95 parts of agaricus blazei murill, 15-98 parts of hovenia dulcis thunb, 11-97 parts of cordyceps militaris, 11-96 parts of tea flower, 12-48 parts of kudzu root, 11-49 parts of celery seed, 15-45 parts of gardenia, 2-28 parts of hispid fig, 2-29 parts of wolfberry fruit, 2-28 parts of raspberry and 5-25 parts of liquorice.
The technical effects of the invention can be realized by the above technical solutions, but in some preferred embodiments, the achieved technical effects are superior to other solutions.
For example:
the weight ratio of the gardenia to the hispid fig to the kudzu root to the tea flower is 2:1:4: 4; the preferable traditional Chinese medicine composition comprises the following specific components in parts by weight: 80 parts of agaricus blazei murill, 40 parts of hovenia dulcis thunb, 50 parts of cordyceps militaris, 44 parts of tea flower, 44 parts of kudzuvine root, 30 parts of celery seed, 22 parts of cape jasmine fruit, 11 parts of hispid fig root, 20 parts of medlar, 25 parts of raspberry and 20 parts of liquorice.
The traditional Chinese medicine composition also comprises chicory, sophora flower and guava; preferably comprises the following components in parts by weight: 10-100 parts of chicory, 10-50 parts of sophora flower and 1-30 parts of guava.
The traditional Chinese medicine composition also comprises poria cocos, radix angelicae and dark plum, and preferably comprises the following components in parts by weight: 10-50 parts of poria cocos, 1-30 parts of radix angelicae and 1-30 parts of dark plum.
The invention also provides application of the traditional Chinese medicine composition in preparing formula food with special medical application and/or preparing medicines for treating gout and/or hyperuricemia.
The invention also provides a preparation for treating gout and/or hyperuricemia, which comprises the traditional Chinese medicine composition for treating gout and/or hyperuricemia and medically acceptable auxiliary materials.
Compared with the prior art:
the invention provides a traditional Chinese medicine composition for gout and/or hyperuricemia, which is prepared by selecting a plurality of traditional Chinese medicine components such as agaricus blazei murill, hovenia dulcis thunb, cordyceps militaris, tea tree flower, kudzu root, celery seed, gardenia, hispid fig, medlar, raspberry, liquorice and the like, can fully play a synergistic interaction role among the raw materials, effectively reduces the levels of uric acid, urea nitrogen, creatinine and xanthine oxidase in mouse blood serum, and can improve or treat gout and/or hyperuricemia. Surprisingly, the traditional Chinese medicine composition has a good effect of reducing uric acid and uric acid nitrogen when the weight ratio of the gardenia, the hispid fig, the radix puerariae and the tea flower is 2:1:4: 4.
Meanwhile, the raw materials adopted by the invention are all natural plants, and the raw materials can be eaten, so that the medicine has the advantages of safety and no toxic or side effect compared with the known medicines for hyperuricemia and gout.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention are further described below.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
If not specifically stated, the raw materials adopted by the invention are all common commercial products, wherein the chicory is the overground part of the chicory, and the sophora flower can be sophora flower bud or sophora flower in homology of medicine and food.
Basic embodiment
A traditional Chinese medicine composition for gout and/or hyperuricemia comprises the following components in parts by weight: 10-100 parts of agaricus blazei murill, 10-100 parts of hovenia dulcis thunb, 10-100 parts of cordyceps militaris, 10-100 parts of tea flower, 10-50 parts of kudzu root, 10-50 parts of celery seed, 10-50 parts of gardenia, 1-30 parts of hispid fig, 1-30 parts of wolfberry fruit, 1-30 parts of raspberry and 1-30 parts of liquorice;
in some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 10-100 parts of chicory, 10-50 parts of sophora flower and 1-30 parts of guava.
In some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 10-50 parts of poria cocos, 1-30 parts of radix angelicae and 1-30 parts of dark plum.
Examples 1 to 14A Chinese medicinal composition for gout and/or hyperuricemia
The raw material compositions of the Chinese medicinal compositions of examples 1 to 6 are shown in Table 1, wherein "-" indicates absence.
TABLE 1 raw material composition of a Chinese medicinal composition for gout and/or hyperuricemia
Figure BDA0002515107790000041
Figure BDA0002515107790000051
The raw material compositions of a Chinese medicinal composition for gout and/or hyperuricemia of examples 7 to 9 are shown in table 2.
TABLE 2A Chinese medicinal composition for treating gout and/or hyperuricemia
Composition of Example 7 Example 8 Example 9 Example 10
Agaricus blazei Murrill/weight portion 20 20 20 20
Semen Hoveniae/part by weight 18 18 18 18
Cordyceps militaris (L.) Link/weight part 16 16 16 16
Tea flower/weight part 40 40 40 40
Kudzu root/part by weight 40 40 40 40
Celery seed/weight part 20 20 20 20
Cape jasmine/weight portion 20 20 20 20
Radix fici simplicissimae/part by weight 10 10 10 10
Wolfberry fruit/weight part 10 10 10 10
Raspberry/weight portion 15 15 15 15
Licorice root/weight part 10 10 10 10
Chicory/weight part 10 100 60 60
Flos sophorae/part by weight 10 50 40 40
Guava/weight portion 1 30 20 25
Radix Angelicae Dahuricae/weight part - - - -
Poria cocos wolf/weight portion - - - -
Dark plum in weight portion - - - -
The raw material compositions of a Chinese medicinal composition for gout and/or hyperuricemia of examples 11 to 14 are shown in table 3.
TABLE 3A Chinese medicinal composition for treating gout and/or hyperuricemia
Figure BDA0002515107790000052
Figure BDA0002515107790000061
The preparation method of the traditional Chinese medicine composition comprises the following steps: drying and crushing the traditional Chinese medicine composition with the formula amount to 5mm, and mixing the traditional Chinese medicine composition with the formula amount according to the proportion of 1: 10, adding water, decocting with slow fire for 4-5h, filtering to obtain decoction dregs and filtrate, adding water to the decoction dregs according to the weight ratio of 1:8, decocting with slow fire for 2-3h, filtering, combining the filtrates, concentrating the combined filtrate, drying, and pulverizing to obtain the traditional Chinese medicine composition.
Comparative example 1
This comparative example differs from example 5 in that it does not contain tea flowers.
Comparative example 2
This comparative example differs from example 5 in that hispid fig is not included.
Comparative example 3
This comparative example differs from example 5 in that cassia twig replaces tea flower.
Comparative example 4
This comparative example differs from example 10 in that white peony root replaces sophora flower.
Comparative example 5
This comparative example differs from example 14 in that rhubarb replaces dahurian angelica root.
Functional evaluation
1. Experimental Material
ICR mice (weight 18-22g, 5-6 weeks old): cincha Changchun city Yinshi laboratory animal technology, Inc.
Pharmaceutical compositions prepared in examples 1-14 and 1-5: taking 1g of the traditional Chinese medicine composition, and fixing the volume to 25ml by using normal saline for later use.
2. Animal modeling and grouping
Dividing 210 male Kunming mice with the weight of 22-25g into 21 groups with 10 mice in each group, dividing the mice into a model group, a blank control group and an experimental group (examples 1-14 groups and comparative examples 1-5 groups), wherein the model group and the experimental group are continuously canned for 7 days, yeast extract (15g/kg) is used for 2 times (7:00 and 19:00) per day, and ethambutol (250mg/kg) is used for 1 time (7:00) per day;
wherein, the experimental group was gavaged with the Chinese traditional medicine composition (1ml/kg) prepared in examples 1-14 and comparative examples 1-5 respectively every day (8:00), and the model group was gavaged with the same amount of physiological saline every day (8: 00).
Potassium oxonate (300mg/kg) was injected intraperitoneally for 2h after the last administration.
The blank control group was given equal dose of sterilized normal saline either intragastrically or intraperitoneally.
After the test is finished, the eyeballs of all groups of mice are picked up for blood sampling, centrifugation is carried out at 3000r/min for 15min, and serum is collected. The levels of uric acid, uric acid nitrogen, creatinine, and xanthine oxidase in serum were measured according to the kit procedures (uric acid assay kit, uric acid nitrogen assay kit, creatinine assay kit, and xanthine oxidase assay kit, all available from Nanjing, as constructed), and the results are shown in Table 4.
TABLE 4 serum-related test indexes
Figure BDA0002515107790000071
Figure BDA0002515107790000081
Note: p <0.05, indicating significant differences compared to the model group, P <0.01, indicating very significant differences compared to the model group; # P <0.05, which indicates a significant difference compared to the blank control group; # P <0.01, indicating a very significant difference compared to the blank control group.
As can be seen from the above table, compared with the blank control group, the serum uric acid, uric acid nitrogen, creatinine and xanthine oxidase of the model group mice have very significant differences (P <0.01), which indicates that the model building is successful.
Examples 1-4 mice in the group have significant differences (P <0.01) in serum levels of uric acid, uric acid nitrogen, creatinine and xanthine oxidase relative to the model group, which indicates that the traditional Chinese medicine composition of the present invention can significantly reduce serum levels of uric acid, uric acid nitrogen, creatinine and xanthine oxidase, thereby improving or treating gout and/or hyperuricemia. Meanwhile, compared with the model group, the levels of uric acid and uric acid nitrogen in the blood serum of the mice in the groups of 5 to 14 have very significant difference (P is less than 0.01), which indicates that when the weight ratio of gardenia, hispid fig, kudzu root and tea tree flower is 6:3:5:8, the traditional Chinese medicine composition has better technical effect of reducing uric acid and uric acid nitrogen.
In addition, the serum creatinine level of the mice in the examples 11-14 groups is very significant (P <0.01) compared with that of the model group, which shows that when the weight ratio of the kudzu root, the tuckahoe and the angelica dahurica is 2:1:2, the traditional Chinese medicine composition provided by the invention has a better technical effect of reducing creatinine.
Meanwhile, compared with a model group, the levels of xanthine oxidase in the sera of mice in the groups 7-14 have very poor significance (P <0.01), which indicates that when the weight ratio of the kudzu root, the chicory and the sophora flower is 2:3:2, the traditional Chinese medicine composition provided by the invention has a better technical effect of reducing xanthine oxidase.
It should be emphasized that the embodiments described herein are illustrative rather than restrictive, and thus the present invention is not limited to the embodiments described in the detailed description, but also includes other embodiments that can be derived from the technical solutions of the present invention by those skilled in the art.

Claims (10)

1. A traditional Chinese medicine composition for treating gout and/or hyperuricemia is characterized by comprising agaricus blazei, hovenia dulcis thunb, cordyceps militaris, tea tree flower, radix puerariae, celery seeds, gardenia, hispid fig, medlar, raspberry and liquorice.
2. The pharmaceutical composition according to claim 1, comprising the following components in parts by weight: 10-100 parts of agaricus blazei murill, 10-100 parts of hovenia dulcis thunb, 10-100 parts of cordyceps militaris, 10-100 parts of tea flower, 10-50 parts of kudzu root, 10-50 parts of celery seed, 10-50 parts of gardenia, 1-30 parts of hispid fig, 1-30 parts of wolfberry fruit, 1-30 parts of raspberry and 1-30 parts of liquorice.
3. The pharmaceutical composition according to claim 2, comprising the following components in parts by weight: 12-95 parts of agaricus blazei murill, 15-98 parts of hovenia dulcis thunb, 11-97 parts of cordyceps militaris, 11-96 parts of tea flower, 12-48 parts of kudzu root, 11-49 parts of celery seed, 15-45 parts of gardenia, 2-28 parts of hispid fig, 2-29 parts of wolfberry fruit, 2-28 parts of raspberry and 5-25 parts of liquorice.
4. The traditional Chinese medicine composition of claim 1, wherein the weight ratio of gardenia, hispid fig, kudzu root and tea flower is 2:1:4: 4.
5. The pharmaceutical composition of claim 1, further comprising chicory, sophora flower and guava.
6. The pharmaceutical composition of claim 5, further comprising the following components in parts by weight: 10-100 parts of chicory, 10-50 parts of sophora flower and 1-30 parts of guava.
7. The pharmaceutical composition of claim 1, further comprising Poria cocos, Angelica dahurica and Prunus mume.
8. The pharmaceutical composition of claim 7, further comprising the following components in parts by weight: 10-50 parts of poria cocos, 1-30 parts of radix angelicae and 1-30 parts of dark plum.
9. Use of a Chinese medicinal composition according to any one of claims 1 to 8 in the preparation of a food for special medical use and/or in the preparation of a medicament for the treatment of gout and/or hyperuricemia.
10. A preparation for treating gout and/or hyperuricemia, which comprises the traditional Chinese medicine composition of any one of claims 1 to 8 and medically acceptable auxiliary materials.
CN202010473599.6A 2020-05-29 2020-05-29 Traditional Chinese medicine composition for gout and/or hyperuricemia Pending CN111529597A (en)

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