CN110934977A - Tabletting candy with uric acid reducing function and preparation method thereof - Google Patents
Tabletting candy with uric acid reducing function and preparation method thereof Download PDFInfo
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- CN110934977A CN110934977A CN201911423491.XA CN201911423491A CN110934977A CN 110934977 A CN110934977 A CN 110934977A CN 201911423491 A CN201911423491 A CN 201911423491A CN 110934977 A CN110934977 A CN 110934977A
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- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 34
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- 238000002360 preparation method Methods 0.000 title abstract description 9
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 32
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Images
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
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Abstract
The invention provides a tablet candy with uric acid reducing function and a preparation method thereof, the tablet candy is prepared by medicinal and edible traditional Chinese medicinal materials/active ingredients and auxiliary materials, and is prepared by 8 traditional Chinese medicinal materials/active ingredients, namely sunflower powder, tuckahoe, liquorice, chicory, gardenia, cassia seed, fructus amomi, medlar, auxiliary materials, maltodextrin and magnesium stearate according to a certain mass ratio. The formula of the invention is scientific and reasonable, the efficacies of the raw materials play a synergistic effect of mutual root of yin and yang and mutual promotion, aiming at the gout problem caused by hyperuricemia, the invention mainly takes dispelling wind and dredging collaterals, promoting diuresis and discharging turbidity, takes heat clearing and detoxifying, activating blood and dissolving stasis as assistance, and simultaneously takes the functions of tonifying spleen and kidney to achieve the aim of reducing uric acid. The product of the invention can be used for reducing uric acid and assisting in treating a series of diseases caused by gout and the like, and is convenient to carry, store, take and absorb in the form of candy tablets.
Description
Technical Field
The invention relates to the technical field of biological medicines, and particularly relates to a tablet candy with a uric acid reducing function and a preparation method thereof.
Background
With the development of economy in China and the improvement of living standard of people, more and more people begin to have high uric acid at the side of the people. According to the '2017 Chinese gout status report white paper', the number of hyperuricemia patients in China reaches 1.7 hundred million, wherein the number of gout patients exceeds 8000 ten thousand, and the annual growth rate is rapidly increased by 9.7% every year. In 2020, the number of gout people is estimated to reach 1 hundred million. Gout prevalence is continuously increasing in developed or developing countries. There is increasing evidence that gout not only affects the joints themselves, but also has a close relationship with the cardiovascular and renal functions, and it has become a non-negligible aspect in treating gout.
The traditional Chinese medicine holds that the pathological basis of gout is 'damp phlegm and blood stasis' mutual accumulation. According to the theory of traditional Chinese medicine, the main diseases of gout are caused by dysfunction of spleen and kidney, exogenous pathogenic wind, cold and damp heat, over-exertion, emotional disorder, or addiction to alcohol, fat and sweet wine, or joint trauma, etc., aggravate and promote phlegm-dampness to flow into joints, muscles or bones, cause unsmooth circulation of qi and blood, and cause pain due to obstruction[1]. Modern medicine proves that gout is related to hyperuricemia formation and sodium urate crystal accumulation, and is a repeated inflammatory metabolic disease[2]. Two causes of hyperuricemia are the first cause that uric acid generation is increased due to purine metabolic disorder, and the second cause that uric acid excretion is reduced, and long-term hyperuricemia can cause urate crystals to deposit on joints, kidneys and other parts, so that long-term acute or chronic inflammation of the joints and the kidneys is caused, and gouty arthritis and gouty nephropathy are caused. The key point of the treatment is to control the level of the hematuria, and the gout arthritis can be fundamentally treated only by reducing the level of the hematuria within a normal range and generally requiring less than 360 micromoles per liter.
Reference documents:
[1] plum blossom, yangbo, chun Heng fei, etc. research overview of traditional Chinese medicine for treating gout [ J ] rheumatism and arthritis, 2017, 6 (10): 72-76.
[2] Wang Yi, Zhang Zhuo Li 2016 European Union on treatment of gout recommendation: based on evidence of evidence-based medicine [ J ]. journal of chinese clinical immunity and allergy, 2017, 11 (1): 95-98.
Disclosure of Invention
The invention aims to provide a tablet candy with a function of reducing uric acid and a preparation method thereof, the tablet candy is prepared from 8 medicinal and edible traditional Chinese medicinal materials/active ingredients and auxiliary materials, and aims at solving the gout problem caused by hyperuricemia, mainly aims at dispelling wind and dredging collaterals, promoting diuresis and discharging turbidity, and assists in clearing away heat and toxic materials, promoting blood circulation and removing blood stasis, and simultaneously, benefits the spleen and kidney, so as to achieve the purposes of reducing uric acid and treating a series of diseases caused by gout and the like.
In order to achieve the purpose, the invention adopts the technical scheme that:
a tablet candy with uric acid reducing function is composed of 8 traditional Chinese medicinal materials/active ingredients and 2 auxiliary materials, wherein the ratio of each component in percentage by mass is as follows:
the Chinese medicinal materials/active ingredients comprise: 20 to 40 percent of sunflower powder, 10 to 20 percent of tuckahoe, 5 to 18 percent of liquorice, 5 to 15 percent of chicory, 1 to 10 percent of gardenia, 1 to 10 percent of cassia seed, 5 to 15 percent of amomum villosum, 5 to 15 percent of medlar, 0.1 to 3 percent of maltodextrin and 0.1 to 3 percent of magnesium stearate.
Further, the tablet candy with the function of reducing uric acid comprises the following components in percentage by mass:
the Chinese medicinal materials/active ingredients comprise: 32% of sunflower powder, 12% of poria cocos, 7% of liquorice, 14% of chicory, 9% of gardenia, 5% of semen cassiae, 10% of fructus amomi, 10% of wolfberry fruit, 0.3% of maltodextrin and 0.7% of magnesium stearate.
The preparation method of the tabletting candy with the uric acid reducing function comprises the following steps:
1) weighing the components, and respectively drying and sterilizing the sunflower powder, the poria cocos, the liquorice, the chicory, the gardenia, the cassia seed, the fructus amomi and the wolfberry fruit;
2) pulverizing Poria, Glycyrrhrizae radix, herba Cichorii, fructus Gardeniae, semen Cassiae, fructus Amomi, and fructus Lycii respectively with coarse pulverizer, and sieving with 80-140 mesh sieve to obtain 7 kinds of coarse powder; respectively carrying out superfine grinding on the 7 coarse powders to obtain 7 superfine powders; mixing and ball-milling the 7 kinds of ultrafine powder, the sunflower powder and the auxiliary material maltodextrin, and sieving with a 160-mesh and 200-mesh sieve to obtain medicinal powder;
3) soaking the medicinal powder obtained in the step 2) with ethanol to prepare a soft material;
in step 3), the concentration of ethanol may be 50% to 90%, preferably 75%, and the amount of ethanol may be 20% to 30%, preferably 25%, of the powder.
4) Cutting the soft material obtained in the step 3) into granules, and performing aseptic drying to obtain whole granules;
5) mixing the granules obtained in the step 4) with magnesium stearate, and tabletting with a grinding tool to obtain tablets, namely the tabletting candy with the function of reducing uric acid.
And removing unqualified products from the obtained tablet candy with the function of reducing uric acid, sampling and inspecting, packaging after qualified detection, then externally packaging, and warehousing for quality inspection.
The main effects of the above 8 Chinese medicinal materials/active ingredients are introduced as follows:
sunflower powder: dispel wind, pacify liver, induce diuresis, manifest dizziness, tinnitus, and stranguria with urine.
Tuckahoe, poria cocos: induce diuresis to alleviate edema, invigorate spleen and regulate qi, nourish yin and benefit marrow.
Licorice root: invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, relieving spasm and pain, clearing heat and detoxicating, and harmonizing the other drugs.
Chicory: clearing liver-fire, promoting bile flow, invigorating stomach, resolving food stagnation, inducing diuresis, and relieving swelling. Can be used for treating jaundice due to damp-heat pathogen, stomach ache, anorexia, edema, and oliguria.
Gardenia: purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and removing toxicity.
Cassia seed: clear heat, improve eyesight, moisten intestines and relax bowels.
Amomum fruit: resolving dampness, promoting appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage; can be used for treating damp stagnation, abdominal distention, inappetence, deficiency-cold of spleen and stomach, emesis, and diarrhea.
Wolfberry fruit: nourishing liver and kidney, strengthening tendons and bones, moistening lung, improving eyesight, and prolonging life.
The formula of the invention is scientific and reasonable, the efficacies of the raw materials play the synergistic effect of mutual root and mutual promotion of yin and yang, the traditional Chinese medicine is used for treatment based on syndrome differentiation, the modern medical pharmacology is fully used, and the purposes of regulating the internal organs of liver, spleen and kidney and dispelling wind, eliminating phlegm and dissipating blood stasis are achieved.
The invention has the following outstanding technical effects: aiming at the gout problem caused by hyperuricemia, the traditional Chinese medicine composition mainly has the effects of dispelling wind, dredging collaterals, promoting diuresis and discharging turbidity, and has the effects of clearing away heat and toxic materials, promoting blood circulation and removing blood stasis as auxiliary materials, and simultaneously has the effects of tonifying spleen and kidney, so as to achieve the purpose of reducing uric acid. The product of the invention can be used for reducing uric acid and assisting in treating a series of diseases caused by gout and the like, and is convenient to carry, store, take and absorb in the form of candy tablets.
Drawings
FIG. 1 is a flow chart of the preparation of the present invention.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A tablet candy with uric acid reducing function and a preparation method thereof comprise the following steps:
(1) metering and weighing: accurately weighing the components, and respectively drying and sterilizing 32% of sunflower powder, 12% of poria cocos, 7% of liquorice, 14% of chicory, 9% of gardenia, 5% of semen cassiae, 10% of fructus amomi, 10% of wolfberry fruit, 0.3% of maltodextrin and 0.7% of magnesium stearate;
(2) grinding and sieving: pulverizing Poria, Glycyrrhrizae radix, herba Cichorii, fructus Gardeniae, semen Cassiae, fructus Amomi, and fructus Lycii respectively with coarse pulverizer, and sieving with 80-140 mesh sieve to obtain 7 kinds of coarse powder; respectively carrying out superfine grinding on the 7 coarse powders to obtain 7 superfine powders; mixing and ball-milling the 7 kinds of ultrafine powder, the sunflower powder and the auxiliary material maltodextrin, and sieving with a 160-mesh and 200-mesh sieve to obtain medicinal powder;
(3) material preparation and mixing: soaking the medicinal powder with 75% ethanol to obtain soft material, wherein the ethanol content is about 25% of the medicinal powder;
(4) granulating and drying: cutting the soft material into granules, and then performing aseptic drying to obtain whole granules;
(5) tabletting: mixing the whole granules with the auxiliary material magnesium stearate, and tabletting by using a grinding tool to obtain tablets;
(6) packaging: and removing unqualified products from the pressed candy tablets, performing sampling inspection, performing internal packaging after the candy tablets are detected to be qualified, then performing external packaging, and performing quality inspection and warehousing.
The obtained tablet candy comprises the following components in percentage by mass: 32% of sunflower powder, 12% of poria cocos, 7% of liquorice, 14% of chicory, 9% of gardenia, 5% of semen cassiae, 10% of fructus amomi, 10% of wolfberry fruit, 0.3% of maltodextrin and 0.7% of magnesium stearate.
Example 2
The method of making a tabletted candy according to this example can be seen in example 1 with the following differences:
weighing the following raw materials in percentage by mass: 30% of sunflower powder, 15% of poria cocos, 15% of liquorice, 10% of chicory, 8% of gardenia, 10% of semen cassiae, 5% of fructus amomi, 5% of wolfberry fruit, 1% of maltodextrin and 1% of magnesium stearate;
the obtained tablet candy comprises the following components in percentage by mass: 30% of sunflower powder, 15% of poria cocos, 15% of liquorice, 10% of chicory, 8% of gardenia, 10% of semen cassiae, 5% of fructus amomi, 5% of wolfberry fruit, 1% of maltodextrin and 1% of magnesium stearate.
Example 3
The method of making a tabletted candy according to this example can be seen in example 1 with the following differences:
weighing the following raw materials in percentage by mass: 35% of sunflower powder, 10% of poria cocos, 6% of liquorice, 15% of chicory, 6% of gardenia, 11% of semen cassiae, 7% of fructus amomi, 8% of wolfberry fruit, 1% of maltodextrin and 1% of magnesium stearate;
the obtained tablet candy comprises the following components in percentage by mass: 35% of sunflower powder, 10% of poria cocos, 6% of liquorice, 15% of chicory, 6% of gardenia, 11% of semen cassiae, 7% of fructus amomi, 8% of fructus lycii, 1% of maltodextrin and 1% of magnesium stearate.
Example 4
The method of making a tabletted candy according to this example can be seen in example 1 with the following differences:
weighing the following raw materials in percentage by mass: 34% of sunflower powder, 10% of poria cocos, 7% of liquorice, 12% of chicory, 7% of gardenia, 12% of semen cassiae, 9% of fructus amomi, 8% of wolfberry fruit, 0.5% of maltodextrin and 0.5% of magnesium stearate;
the obtained tablet candy comprises the following components in percentage by mass: 34% of sunflower powder, 10% of poria cocos, 7% of liquorice, 12% of chicory, 7% of gardenia, 12% of semen cassiae, 9% of fructus amomi, 8% of wolfberry fruit, 0.5% of maltodextrin and 0.5% of magnesium stearate.
The experiment of the tablet candy with uric acid reducing function of the invention for patients with hyperuricemia is given below.
30 hyperuricemia patients are randomly divided into two groups, namely a treatment group and a control group, wherein each group comprises 15 patients, and the two groups take 45 days as 1 treatment course and treat 1 treatment course. During the treatment period, two groups of patients are ordered to strictly abstain from alcohol, and the patients are prevented from eating high-purine food and drink water in sufficient quantity; avoid overwork, emotional tension and long-term wet and cold environment.
Control group: allopurinol tablet is orally administered for 15 people, 0.1g each time, 2 times daily.
Treatment groups: 15 persons took the tabletted confectionery product prepared in example 1 of the present invention 2 times a day (1 time each in the morning and evening), 4g (8 tablets) per time.
And (3) observation indexes are as follows: changes in blood Uric Acid (UA), Triacylglycerol (TG), and Erythrocyte Sedimentation Rate (ESR) before and after treatment were observed in both groups.
The therapeutic effect judgment standard is as follows: according to the standard of curative effect of diagnosis of traditional Chinese medicine diseases. The effect is shown: the total symptoms disappear or the main symptoms disappear, the joint function is basically recovered, and the blood uric acid and erythrocyte sedimentation rate are obviously reduced. The method has the following advantages: the main symptoms basically disappear, the main joint function is improved, and the blood uric acid and erythrocyte sedimentation rate are slightly reduced. And (4) invalidation: all aspects are not improved.
The two efficacy comparisons and the UA, TG, ESR comparisons before and after treatment are shown in table 1 and table 2, respectively. It can be seen from the table that the tabletted candy prepared by taking the tabletted candy in the embodiment 1 of the invention has the effects of reducing the sedimentation rate of uric acid, triacylglycerol and red blood cells, can improve the clinical symptoms of gout patients, recover the joint function, and has a good effect on adjuvant therapy of gout.
Claims (7)
1. A tablet candy with uric acid reducing function is characterized by comprising 8 traditional Chinese medicinal materials/active ingredients and 2 auxiliary materials, wherein the components are respectively mixed according to the mass percentage as follows:
20 to 40 percent of sunflower powder, 10 to 20 percent of tuckahoe, 5 to 18 percent of liquorice, 5 to 15 percent of chicory, 1 to 10 percent of gardenia, 1 to 10 percent of cassia seed, 5 to 15 percent of amomum villosum, 5 to 15 percent of medlar, 0.1 to 3 percent of maltodextrin and 0.1 to 3 percent of magnesium stearate.
2. The tabletted candy with the uric acid reducing function of claim 1, wherein the traditional Chinese medicinal materials/active ingredients and the auxiliary materials comprise the following components in percentage by mass: 32% of sunflower powder, 12% of poria cocos, 7% of liquorice, 14% of chicory, 9% of gardenia, 5% of semen cassiae, 10% of fructus amomi, 10% of wolfberry fruit, 0.3% of maltodextrin and 0.7% of magnesium stearate.
3. The method for preparing the tabletting candy with uric acid lowering function according to claim 2, which comprises the following steps:
1) weighing the components, and respectively drying and sterilizing the sunflower powder, the poria cocos, the liquorice, the chicory, the gardenia, the cassia seed, the fructus amomi and the wolfberry fruit;
2) pulverizing Poria, Glycyrrhrizae radix, herba Cichorii, fructus Gardeniae, semen Cassiae, fructus Amomi, and fructus Lycii respectively with coarse pulverizer, and sieving with 80-140 mesh sieve to obtain 7 kinds of coarse powder; respectively carrying out superfine grinding on the 7 coarse powders to obtain 7 superfine powders; mixing and ball-milling the 7 kinds of ultrafine powder, the sunflower powder and the auxiliary material maltodextrin, and sieving with a 160-mesh and 200-mesh sieve to obtain medicinal powder;
3) soaking the medicinal powder obtained in the step 2) with ethanol to prepare a soft material;
4) cutting the soft material obtained in the step 3) into granules, and performing aseptic drying to obtain whole granules;
5) mixing the granules obtained in the step 4) with magnesium stearate, and tabletting with a grinding tool to obtain tablets, namely the tabletting candy with the function of reducing uric acid.
4. The method for preparing a tabletted candy with the uric acid lowering effect as claimed in claim 3, wherein in the step 2), the pulverization is performed by using a coarse pulverizer.
5. The method for preparing a tabletted candy with the uric acid lowering function as claimed in claim 3, wherein in the step 2), the 1 st sieving is performed by using a 80-140 mesh sieve.
6. The method for preparing a tabletted candy with uric acid lowering effect as claimed in claim 3, wherein in step 2), the 2 nd sieving is performed with 160-200 mesh sieve.
7. The method for preparing a tabletted candy with uric acid lowering effect according to claim 3, wherein in step 3), the concentration of ethanol may be 50% -90%, preferably 75%, and the amount of ethanol may be 20% -30%, preferably 25%, of the medicinal powder.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529597A (en) * | 2020-05-29 | 2020-08-14 | 广东众益康生物科技有限公司 | Traditional Chinese medicine composition for gout and/or hyperuricemia |
| CN112189747A (en) * | 2020-10-12 | 2021-01-08 | 王同河 | Radix puerariae and liquorice tablet candy |
| CN112425677A (en) * | 2020-11-20 | 2021-03-02 | 上海问茶健康科技有限公司 | Tablet candy with liver-protecting, spleen-invigorating and anti-tumor effects and preparation method thereof |
| CN113424895A (en) * | 2021-07-16 | 2021-09-24 | 安徽天凯生物科技有限公司 | Formula of tablet candy with function of assisting in reducing uric acid |
| CN115518132A (en) * | 2022-10-24 | 2022-12-27 | 北京擎天数康科技有限公司 | Chinese medicinal compound composition for preventing and treating hyperuricemia |
| CN116036226A (en) * | 2023-02-15 | 2023-05-02 | 武双平 | Radix puerariae, chicory and poria cocos tablet candy for regulating high uric acid and preparation method thereof |
| CN116850244A (en) * | 2023-08-10 | 2023-10-10 | 深圳市一宝通食品技术有限公司 | Traditional Chinese medicine composition for preventing and treating gout and reducing uric acid, preparation method thereof and beverage containing traditional Chinese medicine composition |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529597A (en) * | 2020-05-29 | 2020-08-14 | 广东众益康生物科技有限公司 | Traditional Chinese medicine composition for gout and/or hyperuricemia |
| CN112189747A (en) * | 2020-10-12 | 2021-01-08 | 王同河 | Radix puerariae and liquorice tablet candy |
| CN112425677A (en) * | 2020-11-20 | 2021-03-02 | 上海问茶健康科技有限公司 | Tablet candy with liver-protecting, spleen-invigorating and anti-tumor effects and preparation method thereof |
| CN113424895A (en) * | 2021-07-16 | 2021-09-24 | 安徽天凯生物科技有限公司 | Formula of tablet candy with function of assisting in reducing uric acid |
| CN115518132A (en) * | 2022-10-24 | 2022-12-27 | 北京擎天数康科技有限公司 | Chinese medicinal compound composition for preventing and treating hyperuricemia |
| CN116036226A (en) * | 2023-02-15 | 2023-05-02 | 武双平 | Radix puerariae, chicory and poria cocos tablet candy for regulating high uric acid and preparation method thereof |
| CN116850244A (en) * | 2023-08-10 | 2023-10-10 | 深圳市一宝通食品技术有限公司 | Traditional Chinese medicine composition for preventing and treating gout and reducing uric acid, preparation method thereof and beverage containing traditional Chinese medicine composition |
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