CN1114961A - 细胞粘连肽抑制剂 - Google Patents
细胞粘连肽抑制剂 Download PDFInfo
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- CN1114961A CN1114961A CN94115995A CN94115995A CN1114961A CN 1114961 A CN1114961 A CN 1114961A CN 94115995 A CN94115995 A CN 94115995A CN 94115995 A CN94115995 A CN 94115995A CN 1114961 A CN1114961 A CN 1114961A
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000008010 sperm capacitation Effects 0.000 description 1
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- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB1994/000026 WO1994015958A2 (fr) | 1993-01-08 | 1994-01-07 | Inhibiteurs peptidiques de l'adhesion cellulaire |
| CA002153228A CA2153228A1 (fr) | 1993-01-08 | 1994-01-07 | Inhibiteurs peptidiques de l'adhesion cellulaire |
| JP6516421A JPH08505628A (ja) | 1993-01-08 | 1994-01-07 | ペプチド型細胞接着阻害薬 |
| SG1996001553A SG52262A1 (en) | 1993-01-08 | 1994-01-07 | Peptide inhibitors of cell adhesion |
| EP94906984A EP0677060A1 (fr) | 1993-01-08 | 1994-01-07 | Inhibiteurs peptidiques de l'adhesion cellulaire |
| CN94115995A CN1114961A (zh) | 1993-01-08 | 1994-07-11 | 细胞粘连肽抑制剂 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US177393A | 1993-01-08 | 1993-01-08 | |
| CN94115995A CN1114961A (zh) | 1993-01-08 | 1994-07-11 | 细胞粘连肽抑制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1114961A true CN1114961A (zh) | 1996-01-17 |
Family
ID=37075853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94115995A Pending CN1114961A (zh) | 1993-01-08 | 1994-07-11 | 细胞粘连肽抑制剂 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0677060A1 (fr) |
| JP (1) | JPH08505628A (fr) |
| CN (1) | CN1114961A (fr) |
| CA (1) | CA2153228A1 (fr) |
| SG (1) | SG52262A1 (fr) |
| WO (1) | WO1994015958A2 (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0691986B1 (fr) * | 1993-03-29 | 1998-12-02 | The Du Pont Merck Pharmaceutical Company | NOUVEAU PROCEDE ET COMPOSES INTERMEDIAIRES SERVANT A LA PREPARATION D'INHIBITEURS DE LA GLYCOPROTEINE PLAQUETTAIRE IIb/IIIa |
| US5811391A (en) * | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| US6056958A (en) * | 1994-12-09 | 2000-05-02 | Dupont Pharmaceuticals | Method of treatment of arterial and venous thromboembolic disorders |
| GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US7001921B1 (en) | 1995-01-23 | 2006-02-21 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| WO1996040781A1 (fr) * | 1995-06-07 | 1996-12-19 | Tanabe Seiyaku Co., Ltd. | INHIBITEURS PEPTIDIQUES CYCLIQUES D'ADHERENCE CELLULAIRE INDUITE PAR INTEGRINE β1 ET β¿2? |
| US5821329A (en) * | 1996-06-06 | 1998-10-13 | Tanabe Seiyaku Co., Ltd. | Cyclic peptide inhibitors of β1 and β2 integrin-mediated adhesion |
| WO1997002289A1 (fr) * | 1995-07-06 | 1997-01-23 | Zeneca Limited | Inhibiteurs peptidiques de la fibronectine |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| US6037324A (en) | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| GB9613112D0 (en) | 1996-06-21 | 1996-08-28 | Zeneca Ltd | Chemical compounds |
| US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
| US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
| CA2261974A1 (fr) | 1996-07-25 | 1998-02-05 | Biogen, Inc. | Modele moleculaire pour inhibiteurs vl4-4 |
| DE19647382A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| WO1998046631A1 (fr) * | 1997-04-11 | 1998-10-22 | Eli Lilly And Company | Echantillotheques combinatoires de macrocycles peptidomimetiques et procedes correspondants |
| DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6511961B1 (en) | 1997-11-13 | 2003-01-28 | Toray Industries, Inc. | Cyclic peptides and medicinal use thereof |
| DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
| DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| SI1082302T1 (en) | 1998-05-28 | 2004-06-30 | Biogen, Inc. | A vla-4 inhibitor: omepupa-v |
| WO1999065944A1 (fr) * | 1998-06-15 | 1999-12-23 | Ixsys Incorporated | INHIBITEURS PEPTIDIQUES DE αVβ3 ET αVβ¿5? |
| JP2002524529A (ja) | 1998-09-14 | 2002-08-06 | ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム | インテグリンアンタゴニストを用いて多発性骨髄腫および骨髄腫誘導骨吸収を治療する方法 |
| US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PL354063A1 (en) | 1999-08-13 | 2003-12-15 | Biogen, Inc.Biogen, Inc. | Cell adhesion inhibitors |
| AU783110B2 (en) | 1999-12-16 | 2005-09-22 | Biogen Ma Inc. | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
| US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
| DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| JP4470219B2 (ja) | 2002-02-20 | 2010-06-02 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| US7570871B2 (en) | 2002-11-12 | 2009-08-04 | Koninklijke Philips Electronics N.V. | Continue recording channel feature for personal video recorder |
| UY28525A1 (es) | 2003-09-22 | 2005-04-29 | Boehringer Ingelheim Int | Péptidos macrociclicos activos contra en virus de la hepatitis c |
| RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
| WO2005070955A1 (fr) | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Peptides macrocycliques actifs contre le virus de l'hepatite c |
| US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| CA2714335A1 (fr) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methodes de traitement de la sclerose en plaques par administration d'une alpha-foetoproteine combinee a un antagoniste de l'integrine |
| AU2009234253C1 (en) | 2008-04-11 | 2015-05-07 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| WO2011123652A1 (fr) | 2010-04-02 | 2011-10-06 | The Regents Of The University Of Michigan | Peptides de type rf-amide et procédés les utilisant |
| WO2018140510A1 (fr) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Composition et méthodes de traitement d'un accident vasculaire cérébral et d'autres troubles du snc |
| CN110423265A (zh) * | 2019-04-03 | 2019-11-08 | 中国药科大学 | 一种环肽类trf2抑制剂的制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5306620A (en) * | 1987-07-08 | 1994-04-26 | The Scripps Research Institute | Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation |
| WO1992008476A1 (fr) * | 1990-11-07 | 1992-05-29 | The Scripps Research Institute | Peptides inhibant la liaison plaquettaire de molecules d'ashesion |
| CA2078817A1 (fr) * | 1991-10-18 | 1993-04-19 | Beat A. Imhof | Anticorps anti-.alpha.6-integrine |
| EP0633945B1 (fr) * | 1992-04-03 | 1998-12-30 | Genentech, Inc. | ANTICORPS DE L'INTEGRINE ALPHA v BETA 3 |
| US5225531A (en) * | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
-
1994
- 1994-01-07 EP EP94906984A patent/EP0677060A1/fr not_active Withdrawn
- 1994-01-07 SG SG1996001553A patent/SG52262A1/en unknown
- 1994-01-07 WO PCT/IB1994/000026 patent/WO1994015958A2/fr not_active Application Discontinuation
- 1994-01-07 JP JP6516421A patent/JPH08505628A/ja active Pending
- 1994-01-07 CA CA002153228A patent/CA2153228A1/fr not_active Abandoned
- 1994-07-11 CN CN94115995A patent/CN1114961A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2153228A1 (fr) | 1994-07-21 |
| EP0677060A1 (fr) | 1995-10-18 |
| WO1994015958A2 (fr) | 1994-07-21 |
| WO1994015958A3 (fr) | 1994-09-29 |
| SG52262A1 (en) | 1998-09-28 |
| JPH08505628A (ja) | 1996-06-18 |
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