JPH08505628A - ペプチド型細胞接着阻害薬 - Google Patents
ペプチド型細胞接着阻害薬Info
- Publication number
- JPH08505628A JPH08505628A JP6516421A JP51642194A JPH08505628A JP H08505628 A JPH08505628 A JP H08505628A JP 6516421 A JP6516421 A JP 6516421A JP 51642194 A JP51642194 A JP 51642194A JP H08505628 A JPH08505628 A JP H08505628A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- ala
- phe
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K7/02—Linear peptides containing at least one abnormal peptide link
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
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Landscapes
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- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US177393A | 1993-01-08 | 1993-01-08 | |
US08/001,773 | 1993-01-08 | ||
PCT/IB1994/000026 WO1994015958A2 (fr) | 1993-01-08 | 1994-01-07 | Inhibiteurs peptidiques de l'adhesion cellulaire |
CN94115995A CN1114961A (zh) | 1993-01-08 | 1994-07-11 | 细胞粘连肽抑制剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH08505628A true JPH08505628A (ja) | 1996-06-18 |
Family
ID=37075853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6516421A Pending JPH08505628A (ja) | 1993-01-08 | 1994-01-07 | ペプチド型細胞接着阻害薬 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0677060A1 (fr) |
JP (1) | JPH08505628A (fr) |
CN (1) | CN1114961A (fr) |
CA (1) | CA2153228A1 (fr) |
SG (1) | SG52262A1 (fr) |
WO (1) | WO1994015958A2 (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE174036T1 (de) * | 1993-03-29 | 1998-12-15 | Du Pont Merck Pharma | Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern |
US5811391A (en) * | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
US6056958A (en) * | 1994-12-09 | 2000-05-02 | Dupont Pharmaceuticals | Method of treatment of arterial and venous thromboembolic disorders |
GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US7001921B1 (en) | 1995-01-23 | 2006-02-21 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
US5821329A (en) * | 1996-06-06 | 1998-10-13 | Tanabe Seiyaku Co., Ltd. | Cyclic peptide inhibitors of β1 and β2 integrin-mediated adhesion |
WO1996040781A1 (fr) * | 1995-06-07 | 1996-12-19 | Tanabe Seiyaku Co., Ltd. | INHIBITEURS PEPTIDIQUES CYCLIQUES D'ADHERENCE CELLULAIRE INDUITE PAR INTEGRINE β1 ET β¿2? |
WO1997002289A1 (fr) * | 1995-07-06 | 1997-01-23 | Zeneca Limited | Inhibiteurs peptidiques de la fibronectine |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
GB9613112D0 (en) | 1996-06-21 | 1996-08-28 | Zeneca Ltd | Chemical compounds |
US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
DK0914605T3 (da) | 1996-07-25 | 2007-09-10 | Biogen Idec Inc | Molekylemodel for VLA-4-inhibitorer |
DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
PL323130A1 (en) | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
JP2002506423A (ja) * | 1997-04-11 | 2002-02-26 | イーライ・リリー・アンド・カンパニー | ペプチド模倣型大員環のコンビナトリアルライブラリーとそのための方法 |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6511961B1 (en) | 1997-11-13 | 2003-01-28 | Toray Industries, Inc. | Cyclic peptides and medicinal use thereof |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
PL198189B1 (pl) | 1998-05-28 | 2008-06-30 | Biogen Idec Ma | (R)-N-{[4-{[(2-metylofenyloamino)-karbonylo]amino}fenylo]acetylo}-L-prolilo-3-metylo]-ß-alanina, jej zastosowanie i kompozycja farmaceutyczna ją zawierająca |
WO1999065944A1 (fr) * | 1998-06-15 | 1999-12-23 | Ixsys Incorporated | INHIBITEURS PEPTIDIQUES DE αVβ3 ET αVβ¿5? |
TR200100734T2 (tr) | 1998-09-14 | 2001-07-23 | Board Of Regents, The University Of Texas System | İntegrin antagonistlerini kullanarak multipl miyeloma ve miyeloma tarafından uyarılan kemik rezorpsiyonunun iyileştirilmesi |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
JP2003506491A (ja) | 1999-08-13 | 2003-02-18 | バイオジェン インコーポレイテッド | 細胞接着インヒビター |
EP1242118B1 (fr) | 1999-12-16 | 2009-11-11 | Biogen Idec MA Inc. | Methodes de traitement de lesion ischemique ou hemorragique du systeme nerveux central au moyen d'antagonistes anti-integrine alpha4 |
US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
AU2003211560A1 (en) | 2002-02-20 | 2003-09-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivative |
US7570871B2 (en) | 2002-11-12 | 2009-08-04 | Koninklijke Philips Electronics N.V. | Continue recording channel feature for personal video recorder |
AU2004274051A1 (en) | 2003-09-22 | 2005-03-31 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
CA2549851C (fr) | 2004-01-21 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Peptides macrocycliques actifs contre le virus de l'hepatite c |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
AU2008219007A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
CA2721093A1 (fr) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de serum humain, et ses conjugues |
US20130116184A1 (en) | 2010-04-02 | 2013-05-09 | The Regents Of The University Of Michigan | RFamide-Related Peptides and Methods Thereof |
WO2018140510A1 (fr) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Composition et méthodes de traitement d'un accident vasculaire cérébral et d'autres troubles du snc |
CN110423265A (zh) * | 2019-04-03 | 2019-11-08 | 中国药科大学 | 一种环肽类trf2抑制剂的制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5306620A (en) * | 1987-07-08 | 1994-04-26 | The Scripps Research Institute | Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation |
AU9131091A (en) * | 1990-11-07 | 1992-06-11 | Scripps Research Institute, The | Peptides that inhibit platelet binding of adhesion molecules |
CA2078817A1 (fr) * | 1991-10-18 | 1993-04-19 | Beat A. Imhof | Anticorps anti-.alpha.6-integrine |
DE69322860T2 (de) * | 1992-04-03 | 1999-07-01 | Genentech Inc | Antikörper gegen alpha v beta 3 integrin |
US5225531A (en) * | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
-
1994
- 1994-01-07 WO PCT/IB1994/000026 patent/WO1994015958A2/fr not_active Application Discontinuation
- 1994-01-07 CA CA002153228A patent/CA2153228A1/fr not_active Abandoned
- 1994-01-07 EP EP94906984A patent/EP0677060A1/fr not_active Withdrawn
- 1994-01-07 SG SG1996001553A patent/SG52262A1/en unknown
- 1994-01-07 JP JP6516421A patent/JPH08505628A/ja active Pending
- 1994-07-11 CN CN94115995A patent/CN1114961A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
SG52262A1 (en) | 1998-09-28 |
CA2153228A1 (fr) | 1994-07-21 |
WO1994015958A2 (fr) | 1994-07-21 |
CN1114961A (zh) | 1996-01-17 |
WO1994015958A3 (fr) | 1994-09-29 |
EP0677060A1 (fr) | 1995-10-18 |
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