CN111455045A - 系统性红斑狼疮的诊断试剂及其平台和应用 - Google Patents
系统性红斑狼疮的诊断试剂及其平台和应用 Download PDFInfo
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- CN111455045A CN111455045A CN202010557149.5A CN202010557149A CN111455045A CN 111455045 A CN111455045 A CN 111455045A CN 202010557149 A CN202010557149 A CN 202010557149A CN 111455045 A CN111455045 A CN 111455045A
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- diagnostic reagent
- lupus erythematosus
- systemic lupus
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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CN202010557149.5A CN111455045B (zh) | 2020-06-18 | 2020-06-18 | 系统性红斑狼疮的诊断试剂及其平台和应用 |
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CN202010557149.5A CN111455045B (zh) | 2020-06-18 | 2020-06-18 | 系统性红斑狼疮的诊断试剂及其平台和应用 |
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CN111455045A true CN111455045A (zh) | 2020-07-28 |
CN111455045B CN111455045B (zh) | 2020-09-29 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102140511A (zh) * | 2010-12-28 | 2011-08-03 | 中南大学 | 系统性红斑狼疮全血基因组中甲基化标记物il-2rg及其应用 |
CN103173552A (zh) * | 2013-03-21 | 2013-06-26 | 中南大学 | Foxp3基因 TSDR位点甲基化检测方法 |
WO2014036314A2 (en) * | 2012-08-31 | 2014-03-06 | Ignyta, Inc. | Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes |
CN105316404A (zh) * | 2015-02-27 | 2016-02-10 | 中南大学湘雅二医院 | 系统性红斑狼疮生物标志物及其诊断试剂盒 |
CN108315395A (zh) * | 2018-02-05 | 2018-07-24 | 南京金域医学检验所有限公司 | 一种snrpn基因启动子区甲基化的检测引物和检测系统 |
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2020
- 2020-06-18 CN CN202010557149.5A patent/CN111455045B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102140511A (zh) * | 2010-12-28 | 2011-08-03 | 中南大学 | 系统性红斑狼疮全血基因组中甲基化标记物il-2rg及其应用 |
WO2014036314A2 (en) * | 2012-08-31 | 2014-03-06 | Ignyta, Inc. | Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes |
CN103173552A (zh) * | 2013-03-21 | 2013-06-26 | 中南大学 | Foxp3基因 TSDR位点甲基化检测方法 |
CN105316404A (zh) * | 2015-02-27 | 2016-02-10 | 中南大学湘雅二医院 | 系统性红斑狼疮生物标志物及其诊断试剂盒 |
CN108315395A (zh) * | 2018-02-05 | 2018-07-24 | 南京金域医学检验所有限公司 | 一种snrpn基因启动子区甲基化的检测引物和检测系统 |
Non-Patent Citations (4)
Title |
---|
MANSOUR KARIMIFAR等: "Interferon‑induced protein 44‑like gene promoter is differentially methylated in peripheral blood mononuclear cells of systemic lupus erythematosus patients", 《J RES MED SCI》 * |
MING ZHAO等: "IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus", 《ANN RHEUM DIS》 * |
TOMASZ K. WOJDACZ等: "Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation", 《NUCLEIC ACIDS RESEARCH》 * |
廖秋燕等: "系统性红斑狼疮的诊断新方法与临床验证", 《检验医学与临床》 * |
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Application publication date: 20200728 Assignee: SHENZHEN SCIARRAY BIOTECH Co.,Ltd. Assignor: THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH University Contract record no.: X2021980003059 Denomination of invention: Diagnostic reagents, platform and application of systemic lupus erythematosus Granted publication date: 20200929 License type: Exclusive License Record date: 20210427 |
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Effective date of registration: 20220629 Address after: 518126 201a, building B6, Hezhou Hengfeng Industrial City, Xixiang street, Shenzhen, Guangdong Province Patentee after: SHENZHEN SCIARRAY BIOTECH CO.,LTD. Address before: Xiangya Second Hospital of Central South University, 139 Renmin Middle Road, Changsha City, Hunan Province, 410011 Patentee before: THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH University |
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