CN111449999A - A hand sanitizer containing folium Artemisiae Argyi extract, and its preparation method - Google Patents
A hand sanitizer containing folium Artemisiae Argyi extract, and its preparation method Download PDFInfo
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- CN111449999A CN111449999A CN202010261099.6A CN202010261099A CN111449999A CN 111449999 A CN111449999 A CN 111449999A CN 202010261099 A CN202010261099 A CN 202010261099A CN 111449999 A CN111449999 A CN 111449999A
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- folium artemisiae
- artemisiae argyi
- wormwood extract
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- 239000001522 artemisia absinthium l. herb extract Substances 0.000 claims abstract description 34
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- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
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- RZJRJXONCZWCBN-NJFSPNSNSA-N octadecane Chemical group CCCCCCCCCCCCCCCCC[14CH3] RZJRJXONCZWCBN-NJFSPNSNSA-N 0.000 description 1
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention belongs to the technical field of sanitary cleaning products, and particularly relates to a no-wash hand disinfection preparation containing a wormwood extract and a preparation method thereof. The invention relates to a washing-free hand disinfection preparation containing wormwood extract, which comprises the following raw materials in percentage by mass: 85 to 97 percent of wormwood extract; 1 to 5 percent of water; 1% -3% of glycerol; 0.05 to 0.5 percent of sodium hyaluronate; 0 to 1.5 percent of thickening agent; 0.02-5% of pH regulator. The no-wash hand disinfection preparation containing the wormwood extract can be used for hand disinfection, has good disinfection effect and long disinfection duration, and can keep hands moist.
Description
Technical Field
The invention belongs to the technical field of sanitary cleaning products, and particularly relates to a no-wash hand disinfection preparation containing a wormwood extract and a preparation method thereof.
Background
In daily life, the most frequent part of a human body contacting the outside is the hand, various bacteria are easily infected, the bacteria on the hand are divided into two types according to different parasitic depths of the hand, one type is a temporary living bacterium, one part of the temporary living bacterium is pathogenic bacteria or conditional pathogenic bacteria, the breeding and contact transmission of the bacteria cause a plurality of diseases, but the survival time of the temporary living bacterium on the skin is less than 24 hours, about 98 percent of the temporary living bacterium can be eliminated by using bacteriostatic hand sanitizer or disinfectant, the other type is a common living bacterium, the type and the quantity are relatively fixed, and most of the bacteria are non-pathogenic bacteria. Therefore, effectively disinfecting hands is advantageous to prevent the occurrence of diseases.
At present, the disinfectant used for hand disinfection is various in types, the components and the performance of the disinfectant are different, and the disinfection effect of the product is considered in most of the products sold in the market for washing-free hand disinfection, if the products are not used for timely and correct nursing and moisture preservation, the skin injury is easily caused after long-term and frequent use, and the skin aging is accelerated. The folium artemisiae argyi has complex chemical components, and the medicinal effect of the folium artemisiae argyi is known to be derived from various rich chemical substances according to research and related documents, and the folium artemisiae argyi mainly contains volatile oil, flavonoids, tannins, terpenes, polysaccharides, trace elements and the like, and the components have pharmacological activities of inhibiting microorganisms, resisting allergy, resisting inflammation, relieving pain, regulating immunity, stopping bleeding, resisting aging and the like, and can relieve the side effect of alcohol on skin irritation. The residue is obtained after the wormwood is subjected to supercritical extraction of essential oil, after the inventor analyzes the residue, the residue is found to contain a large amount of unextracted effective components such as flavonoid components, tannin components and the like, and if the effective components in the residue are fully extracted, the use efficiency of the wormwood can be increased, and high efficiency and environmental protection are achieved.
Disclosure of Invention
The invention aims to provide a no-clean hand disinfection preparation containing wormwood extract and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a washing-free hand disinfection preparation containing wormwood extract comprises the following raw materials in percentage by mass:
85 to 97 percent of wormwood extract;
1 to 5 percent of water;
1% -3% of glycerol;
0.05 to 0.5 percent of sodium hyaluronate;
0 to 1.5 percent of thickening agent;
0.02-5% of pH regulator.
Preferably, the raw materials comprise the following mass fractions:
95.33 percent of wormwood extract;
1.5 percent of water;
2.5% of glycerol;
0.05% of sodium hyaluronate;
0.6 percent of thickening agent;
0.02 percent of pH regulator.
Preferably, the thickening agent is one or more of carbomer, acryloyl dimethyl ammonium taurate/VP copolymer and xanthan gum.
Preferably, the mass ratio of the xanthan gum to the carbomer is 1: (5-8) or the mass ratio of the xanthan gum to the ammonium acryloyl dimethyl taurate/VP copolymer is 1: (5-8).
Preferably, the pH adjusting agent is triethanolamine or aminomethyl propanol.
Preferably, the preparation method of the wormwood extract comprises the following steps:
s1) pulverizing folium Artemisiae Argyi, performing supercritical extraction to obtain folium Artemisiae Argyi residue, and drying to obtain folium Artemisiae Argyi residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into a 60-90% ethanol solution, soaking and filtering to obtain the mugwort extract.
Preferably, the soaking time in the step S2 is 0.5h to 4 h.
Preferably, the preparation type of the non-washing hand disinfection preparation containing the wormwood extract is one of liquid agent, gel agent and spray.
The invention also provides a preparation method of the non-washing hand disinfection preparation containing the wormwood extract, which comprises the following steps:
uniformly mixing glycerol, sodium hyaluronate and a thickening agent according to the formula ratio to obtain a mixture; adding folium Artemisiae Argyi extract into the mixture, and stirring to obtain preparation; mixing water and a pH regulator to obtain the pH regulator; and measuring the pH value of the preparation, adding a pH regulator to regulate the pH value of the preparation to 4.5-6.5, filling, and performing quality inspection to obtain the product.
Compared with the prior art, the invention has the following beneficial effects:
(1) the moxa extract in the no-wash hand disinfection preparation containing the moxa extract is prepared by performing supercritical extraction on the moxa to obtain the moxa residue, so that the utilization rate of the moxa can be improved, the effective components of the moxa residue are close to those of the moxa, and the no-wash hand disinfection preparation has strong economic benefits.
(2) The invention discloses a washing-free hand disinfection preparation containing wormwood extract, which can be used for hand disinfection.
(3) The wormwood extract, the glycerin, the sodium hyaluronate and the thickening agent added into the wormwood extract-containing no-clean hand disinfection preparation can act together to nourish the skin and keep hands moist. After the fifth experiment, the addition of the wormwood extract reduces the irritation to the skin.
Drawings
FIG. 1 is a diagram showing the UV absorption spectra of mugwort powder in different extraction solvents.
FIG. 2 is a diagram showing the ultraviolet absorption spectra of the moxa slag powder of the present invention in different extraction solvents.
FIG. 3 shows the UV absorption spectra of mugwort grass powder and mugwort slag powder at different leaching times.
FIG. 4 is a graph showing the ultraviolet absorption spectra of mugwort grass powder and mugwort slag powder of the present invention after leaching with 75% ethanol for 24 hours.
FIG. 5 is a 280nm HPLC chromatogram of mugwort slag powder and mugwort grass powder according to the present invention.
FIG. 6 is a graph showing the antibacterial effect of the disinfectant formulation of the present invention against Escherichia coli.
FIG. 7 is a graph showing the antibacterial effect of the disinfectant formulation of the present invention against Staphylococcus aureus.
FIG. 8 is a graph showing the antibacterial effect of the disinfectant formulation of the present invention against Candida albicans.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
Experiment I, the influence of different leaching agents on mugwort grass powder and mugwort slag powder
1.1 test subjects
Mugwort powder (mugwort leaf): drying folium Artemisiae Argyi and pulverizing;
moxa residue powder: pulverizing folium Artemisiae Argyi, performing supercritical extraction to obtain folium Artemisiae Argyi residue, and drying to obtain folium Artemisiae Argyi residue powder.
1.2 Experimental methods: respectively placing 2.5g folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder in 100ml conical flask, respectively adding 50ml 75% ethanol solution, 80% ethanol solution, and anhydrous ethanol solution, leaching for 24 hr, filtering with 0.45 μm microporous membrane, and scanning with ultraviolet-visible spectrophotometer.
The parameters of the ultraviolet-visible spectrophotometer device are set as follows: the cuvette is 1 cm; scanning range: 190nm-800 nm; scanning speed: medium speed; scanning interval: 0.5nm, response time: 0.2 s.
1.3 conclusion: FIG. 1 is a UV absorption spectrum of folium Artemisiae Argyi powder in different extraction solvents, and FIG. 2 is a UV absorption spectrum of folium Artemisiae Argyi powder in different extraction solvents. The tannin can absorb at the wavelength of 400-1000nm, wherein the maximum absorption wavelength of the tannin content is 760 nm. The flavonoid component mainly comprises 300-400nm (absorption band I) and 240-280nm (absorption band II) in the ultraviolet absorption spectrum. As can be seen from fig. 1 and 2, the wormwood powder and the wormwood residue powder are extracted most effectively when 75% ethanol solution is used as the extracting agent.
Experiment II, influence of different leaching time on wormwood powder and wormwood residue powder
2.1 subjects: folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder
2.2 Experimental methods: respectively putting 2.5g folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder into 100ml conical flask, respectively adding 50ml 75% ethanol, and soaking in contrast for 15min, 30min, 60min, 90min, 120min, and 24h to obtain solution with ultraviolet spectrum change within 190-800 nm range.
2.3 conclusion: FIG. 3 shows the UV absorption spectra of mugwort grass powder and mugwort slag powder at different leaching times. As can be seen from FIG. 3, the contents of flavonoids and tannins in the moxa slag powder after 15min of extraction were superior to those in the moxa powder.
Experiment III, comparative experiment of mugwort grass powder and mugwort slag powder
3.1 ultraviolet spectral comparison
3.1.1 subjects: folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder
3.1.2 putting 2.5g of folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder in 50ml conical flask, adding 50ml of 75% ethanol, leaching for 24h, filtering the solution to be tested with 0.45 μm microporous membrane, setting the parameters of UV-visible spectrophotometer as follows: the cuvette is 1 cm; scanning range: 190-; scanning speed: medium speed; scanning interval: 0.5nm, response time: 0.2 s. The absorption spectrum is contrasted with changes.
3.2 high Performance liquid chromatography comparison
3.2.1 subjects: folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder
3.2.2 Experimental methods: respectively placing 2.5g folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder into 100ml conical flask, adding 50ml 75% ethanol solution, weighing, shaking and soaking for 24 hr, weighing again, adding 75% ethanol solution to reduce weight loss, shaking for 5min, standing, and filtering to obtain filtrate to obtain the final product. Octadecane bonded silica gel is used as a filling agent, the following methanol-water ratio is used as a mobile phase, and the detection wavelength is 280 nm. Precisely absorbing 10 μ l each of folium Artemisiae Argyi leach liquor and folium Artemisiae Argyi leach liquor, injecting into liquid chromatograph, and measuring.
Mobile phase ratio:
3.3 conclusion: FIG. 4 is a graph of ultraviolet absorption spectrum of folium Artemisiae Argyi powder and folium Artemisiae Argyi residue powder after leaching with 75% ethanol for 24h, and FIG. 5 is a graph of 280nm high performance liquid chromatogram of folium Artemisiae Argyi residue powder and folium Artemisiae Argyi powder. As can be seen from fig. 4 and 5, the difference between the components of the mugwort slag powder and the mugwort grass powder in 75% ethanol after the volatile components are extracted by supercritical extraction is not obvious, and the content of part of the components in the mugwort grassland plant is slightly low. Therefore, the moxa slag powder after the supercritical extraction of the volatile components has great economic benefit.
EXAMPLES 1-5 No-clean hand sanitizer containing Artemisia argyi extract
Table 1: formulations of examples 1 to 5
The preparation method of the wormwood extract in example 1 comprises the following steps:
s1) taking 2.5g of wormwood, crushing, performing supercritical extraction to obtain wormwood residue, and drying to obtain wormwood residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into a 70% ethanol solution, soaking for 1h, and filtering to obtain the mugwort extract.
The preparation method of the wormwood extract of example 2 is:
s1) taking 2.5g of wormwood, crushing, performing supercritical extraction to obtain wormwood residue, and drying to obtain wormwood residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into a 75% ethanol solution, soaking for 1h, and filtering to obtain the mugwort extract.
The preparation method of the wormwood extract of example 3 is:
s1) taking 2.5g of wormwood, crushing, performing supercritical extraction to obtain wormwood residue, and drying to obtain wormwood residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into a 75% ethanol solution, soaking for 2 hours, and filtering to obtain the mugwort extract.
The preparation method of the wormwood extract of example 4 is:
s1) taking 2.5g of wormwood, crushing, performing supercritical extraction to obtain wormwood residue, and drying to obtain wormwood residue powder;
s2) adding the wormwood residue powder obtained in the step S2 into an 80% ethanol solution, soaking for 1.5h, and filtering to obtain the wormwood extract.
The preparation method of the wormwood extract of example 5 is:
s1) taking 2.5g of wormwood, crushing, performing supercritical extraction to obtain wormwood residue, and drying to obtain wormwood residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into an 80% ethanol solution, soaking for 2h, and filtering to obtain the mugwort extract.
The preparation method of the non-washing hand disinfection preparation containing the wormwood extract comprises the following steps: uniformly mixing glycerol, sodium hyaluronate and a thickening agent according to the formula ratio to obtain a mixture; adding folium Artemisiae Argyi extract into the mixture, and stirring to obtain preparation; mixing water and a pH regulator to obtain the pH regulator; measuring pH value of the preparation, adding pH regulator to adjust pH to 6.3, bottling, and inspecting quality.
Comparative example 1 No-clean hand sanitizer containing Artemisia princeps Pampanini extract
The difference compared to example 2 is that the wormwood extract was replaced by a 75% ethanol solution.
Comparative example 2 No-clean hand sanitizer containing Artemisia princeps Pampanini extract
The difference compared to example 2 is that no xanthan gum was added.
Comparative example 3 No-clean hand sanitizer containing Artemisia princeps Pampanini extract
The difference compared to example 2 is that the mass ratio of xanthan gum to the ammonium acryloyldimethyltaurate/VP copolymer is 1: 1.
Comparative example 4 No-clean hand sanitizer containing Artemisia princeps Pampanini extract
The difference compared to example 2 is that the mass ratio of xanthan gum to the ammonium acryloyldimethyltaurate/VP copolymer is 1: 15.
Experiment four, disinfection effect experiment
1) Evaluation of Sterilization Effect
1.1 Experimental methods:
A. culturing Escherichia coli, Staphylococcus aureus and Candida albicans (Escherichia coli 8099, Staphylococcus aureus ATCC6538 and Candida albicans ATCC10231) in enrichment culture and streaking separation culture, selecting a single typical colony, inoculating to a common agar culture medium (Saburg agar culture medium for Candida albicans) inclined plane, culturing at 37 deg.C in an oven for 24h, diluting with phosphate buffer solution containing peptone 10 g/L to prepare test bacterial suspension, and recovering bacteria with the number of 1 × 104cfu/mL~9×104cfu/mL;
B. Heating hydrolyzed enzyme protein agar (or Saburg agar) with distilled water to melt, sterilizing at 118 deg.C for 13min, cooling to 60 deg.C, pouring into sterile culture dish, and cooling to obtain plate.
C. Placing 5m L of the disinfectant preparation in example 2 in a sterilization test tube, forming a three-tube structure, keeping the temperature at 20 ℃ for 5min, taking three kinds of suspension liquid in the step A, respectively dripping 100 microliters in the three test tubes, starting timing after uniform mixing, respectively sucking 0.5m L and adding the mixture into a test tube containing 4.5m L sterile PBS for acting for 1min to be fully mixed, standing for 10mi, sucking 0.1m L (or 2-3 dilutions), uniformly mixing the sample liquid, coating an agar plate, culturing for 24 h-48 h, counting at least 2 plates per dilution, replacing a tested sample with PBS, repeating the operation to serve as a control sample, performing two parallel tests, and calculating the average value.
Calculating the formula: the sterilization rate is as follows:
bactericidal ratio (%) - (a-b)/a × 100 … … … … … … … … … … … … … … … … (1)
In the formula:
a-average colony number of control samples;
b-average number of colonies of test sample.
1.2 Experimental results Table 1 antibacterial plate count of tested samples on Candida albicans, Staphylococcus aureus and Escherichia coli
Note: the symbol "-" in the table indicates the number of the plural numbers.
As can be seen from table 1 in conjunction with fig. 5, 6 and 7, the disinfectant has 100% sterilization rate against escherichia coli, 100% sterilization rate against staphylococcus aureus, and 100% sterilization rate against candida albicans. The hand sanitizer without washing containing the wormwood extract has good bactericidal effect.
2) Evaluation of bacteriostatic Effect
2.1 Experimental methods:
A. carrying out enrichment culture and streaking separation culture on escherichia coli, staphylococcus aureus and candida albicans (escherichia coli 8099, staphylococcus aureus ATCC6538 and candida albicans ATCC10231), selecting a single typical colony, inoculating a common agar culture medium (a sandburg agar culture medium for candida albicans) inclined plane, carrying out oven culture at 37 ℃ for 24 hours, and diluting with a phosphate buffer solution containing 10 g/L of peptone to prepare a test bacterium suspension;
B. heating hydrolyzed enzyme protein agar (or Saburg agar) with distilled water to melt, sterilizing at 118 deg.C for 13min, cooling to 60 deg.C, pouring into sterile culture dish, and cooling to obtain plate.
C. And (2) respectively taking 5m L of the disinfectant preparations of the examples and the comparative examples, placing the disinfectant preparations in sterile test tubes in a three-tube mode, respectively dropwise adding 100 microliters of the three suspension liquid in the step A, starting timing after uniform mixing, respectively sucking 0.5m L and adding the suspension liquid into a test tube containing 4.5m L PBS for sufficient mixing when acting for 15min, 60min and 240min, performing live bacteria culture counting by using a column pouring method, controlling the temperature of the experimental environment to be 19-25 ℃, repeating 3 times of experiments, and calculating the average bacteriostasis rate, sucking 100 microliters of the suspension liquid in a positive control group, adding the suspension liquid into 5m L PBS, sucking 0.5m L and adding the suspension liquid into a test tube containing 4.5m L PBS after acting for 240min, performing live bacteria culture counting by using a column pouring method, and taking a blank nutrient agar plate as a negative control group.
2.2 results of the experiment
Table 2: experimental results of sterilizing effects of examples and comparative examples
Note that the average colony number recovered after the positive control group is acted for 240min is 39500cfu/m L, and the negative control group has no colony of Escherichia coli.
Staphylococcus aureus, the average colony number recovered by the positive control group after 240min is 36700cfu/m L, and the negative control group has no staphylococcus aureus colony.
The average colony number recovered by the positive control group after 240min of action is 38200cfu/m L, and the negative control group has no colony of the candida albicans.
As can be seen from table 3, the bacteriostatic effect of the examples and the comparative examples is similar in 15min, and the bacteriostatic effect of the comparative examples is changed when the time is prolonged to 60min and 240min, so that the bacteriostatic effect of the comparative examples is reduced, the examples still maintain a good bacteriostatic effect, and the bacteriostatic effect of the examples 1 and 2 is optimal.
Fifth experiment, investigation and comparison of skin sensation
The experimental method comprises the following steps: 30 persons were randomly selected from social volunteers, and the average age was 25 to 40 years, wherein 11 men and 19 women were divided into 6 groups and the leave-on hand sanitizer containing the wormwood extract of example 2 and comparative examples 1 to 4 were used, and after use, the appearance, the presence or absence of irritation, the presence or absence of tightness, and the comfort after use were evaluated at 25 points of each full scale, and the average was obtained.
Table 3: survey scoring standard table
Table 4: skin feel investigation results
As can be seen from table 4, example 2 has a good appearance and a comfortable skin feel.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (8)
1. A hand-washing-free hand disinfection preparation containing a wormwood extract is characterized by comprising the following raw materials in percentage by mass:
85 to 97 percent of wormwood extract;
1 to 5 percent of water;
1% -3% of glycerol;
0.05 to 0.5 percent of sodium hyaluronate;
0 to 1.5 percent of thickening agent;
0.02-5% of pH regulator.
2. The wormwood extract-containing hand sanitizer according to claim 1, comprising the following raw materials in parts by mass:
95.33 percent of wormwood extract;
1.5 percent of water;
2.5% of glycerol;
0.05% of sodium hyaluronate;
0.6 percent of thickening agent;
0.02 percent of pH regulator.
3. The hand sanitizer according to claim 1 or 2, wherein the thickener is one or more of carbomer, ammonium acryloyldimethyltaurate/VP copolymer, xanthan gum.
4. The hand sanitizer according to claim 3, wherein the mass ratio of xanthan gum to carbomer is from 1: (5-8) or the mass ratio of the xanthan gum to the ammonium acryloyl dimethyl taurate/VP copolymer is 1: (5-8).
5. The hand sanitizer according to claim 1 or 2, wherein the wormwood extract is prepared by the method comprising:
s1) pulverizing folium Artemisiae Argyi, performing supercritical extraction to obtain folium Artemisiae Argyi residue, and drying to obtain folium Artemisiae Argyi residue powder;
s2) adding the mugwort slag powder obtained in the step S2 into a 60-90% ethanol solution, soaking and filtering to obtain the mugwort extract.
6. The hand sanitizer according to claim 5, wherein the soaking time in step S2 is 0.5 to 4 hours.
7. The wormwood extract-containing no-clean hand sanitizer according to any one of claims 1 to 6, wherein the wormwood extract-containing no-clean hand sanitizer is in the form of one of a liquid, a gel and a spray.
8. The method for preparing a no-wash hand sanitizer containing wormwood extract according to claim 7, comprising the steps of:
uniformly mixing glycerol, sodium hyaluronate and a thickening agent according to the formula ratio to obtain a mixture; adding folium Artemisiae Argyi extract into the mixture, and stirring to obtain preparation; mixing water and a pH regulator to obtain the pH regulator; and measuring the pH value of the preparation, adding a pH regulator to regulate the pH value of the preparation to 4.5-6.5, filling, and performing quality inspection to obtain the product.
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