KR20150062394A - Skin external composition having excellent bactericidal activities - Google Patents

Abstract

The present invention relates to a skin preparation composition for external use having excellent antiseptic ability without using chemical antiseptics and, more particularly, to a skin preparation composition for external use, comprising: xylityl caprylate with excellent antiseptic ability; and one or more mixtures of ethylhexylglycerin, glyceryl caprylate, p-anisic acid, and a citrus mixed extract, thus improving antiseptic ability through the increased effects of antiseptic abilities of the materials.

Description

[0001] The present invention relates to a skin external composition having excellent buoyancy,

The present invention relates to a composition for external application for skin having excellent repellency without using a chemical preservative, and more particularly to a composition for external application for skin, which comprises Xylityl caprylate having excellent buoyancy; And at least one substance selected from the group consisting of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid, and citric mixed extracts, and thus has a superior anti- will be.

The composition for external application for skin is not particularly limited as long as it is contaminated by a microorganism adhered to a dropping bacteria in a manufacturing plant, a product water or a raw material transfer pipe, contamination by bacteria on the surface of a user's finger, palm, Contamination of microorganisms may occur due to contamination of foreign materials during use. For this reason, in the composition for external application, for the purpose of suppressing the proliferation of contaminated microorganisms and improving the repelling force for destroying the contaminated microorganisms, there are used paraffinic acid esters (parabens), imidazolidinyl urea, phenoxyethanol, , Benzoic acid, sorbic acid, and dehydroacetic acid. However, such a chemical preservative is effective as a preservative used in a composition for external application for skin, but it has disadvantages such as toxicity, skin irritation, irritation and allergy. Therefore, it is necessary to reduce the use of a chemical preservative, There is a demand for.

It is of course possible to produce a composition for external application for skin which is not formulated with a conventional chemical preservative by using a diol which has recently been known to have antibacterial activity or to pack it in a container which prevents the incorporation of microorganisms in the manufacturing process and inhibits the contamination of bacteria It is also possible to produce a skin external preparation which does not use a preservative or has a lower preservative content than usual. However, in the case of diol, skin irritation affects safety, solubilization, and stability of emulsified formulations. When a container that inhibits aseptic production or bacterial inflow is used, the manufacturing process is complicated, Economic generality falls.

Japanese Patent Application Laid-Open No. 2010-270083 (published on December 22, 2010)

Accordingly, the present inventors have made it possible to provide a composition for skin external application having a safe repelling force against harmful microorganisms, which is equal to or more than that of a composition for external application using a chemical preservative without using a conventional chemical preservative. Hexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract, it is possible to provide an excellent repelling force owing to the synergistic effect on the repelling force of these substances Thereby completing the present invention.

Accordingly, it is an object of the present invention to provide a composition for external application for skin having excellent repelling force without using a conventional chemical preservative.

In order to accomplish the above object, And at least one substance selected from ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract.

The present invention provides a repelling force equal to or greater than that obtained by using a chemical preservative without using a conventional chemical preservative and does not cause toxicity, skin irritation, irritation, and allergy due to the use of a chemical preservative, .

FIG. 1 is a flowchart showing a procedure for evaluating the buoyant force.

The present invention relates to a composition comprising xylityl caprylate; And at least one substance selected from the group consisting of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract.

In the present invention, xylitylcaprylate having an antibacterial effect; And at least one substance selected from the group consisting of glyceryl caprylate, p-anisic acid and citrus mixture, is used in combination to provide a synergistic effect, thereby providing excellent repelling force even with a small amount of use.

The composition of the present invention comprises 0.01 to 4.0% by weight of xylityl caprylate, 0.01 to 1.0% by weight of ethylhexyl glycerin, 0.01 to 1.0% by weight of glyceryl caprylate, 0.01 to 1.0% by weight of p- 1.0% by weight, and the citrus mixed extract in an amount of 0.01 to 1.0% by weight.

In addition, the composition of the present invention preferably contains 1.0% by weight of xylitylcaprylate, 0.05 to 0.1% by weight of ethylhexyl glycerin, 0.1 to 0.2% by weight of glyceryl caprylate, 0.1 to 0.2% by weight of p- 0.1 to 0.2% by weight and the citrus mixture extract in an appropriate amount in the range of 0.05 to 0.2% by weight. However, the range of the mixing ratio is not limited.

The citrus mixed extract used in the present invention is an extract of citrus plants. Citrus plants that can be used include, but are not limited to, Citrus Paradisi, Citrus Aurantium Bergamia, Sweet Orange, Citrus Tangerina, And the like. In the present invention, extracts from all parts of citrus fruits such as stem, leaf, flower, and fruit can be used, and the extract is not limited to any specific part. In addition, the extract includes not only the leached liquid obtained by leaching and transferring from the citrus plants but also the concentrate obtained by partially or completely concentrating the leaching solution, or the one prepared by drying the concentrate again, Used in combination with vegetable glycerin. In addition, the extract of the present invention may be obtained by compressing fruit, leaves and stem of a citrus plant, mixing and fermenting the fermented product, centrifuging the fermentation product to obtain a liquid fermentation extract, heat-treating the fermented extract, and mixing with vegetable glycerin .

As described above, the present invention can also be used in combination with xylityl caprylate and at least one substance selected from ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extracts, It is possible to provide a composition for external application for skin which has sufficient chemical repellency without containing chemical preservatives, conventional diols that may cause skin irritation or irritation, and the like.

Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples and test examples are presented only for understanding the contents of the present invention, and the scope of the present invention is not limited thereto.

[Reference Example 1] Production of Examples 1 to 11 and Comparative Examples 1 to 7

The formulation of lotion was prepared in a conventional manner according to the composition of the following Tables 1 and 2 (unit: wt%). At this time, Citrus Mix Extract was a product of Bio Citro liquid (Quinabra), which contains grapefruit juice extract, bergamot fruit extract, citrus aurantium dulcis fruit extract, tangerine fruit extract and glycerin.

Raw material name Example One 2 3 4 5 6 7 8 9 10 11 Purified water Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Cyclopentasiloxane 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipropylene glycol 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 Dimethicone / Vinyl Dimethicone Crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Hydrolized milk protein / PIPE crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Beta-glucan 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 FAGE -100 stearate 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 Cetyl ethyl hexanoate 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Dimethicone 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Silica 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Sorbitan sesquioleate 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 Carbomer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Pigment Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Xylitylcaprylate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Ethylhexyl glycerin 0.1 - - - 0.05 0.05 0.05 - - 0.04 0.025 Glyceryl caprylate - 0.1 - - 0.05 - - 0.05 0.05 0.03 0.025 p-Anisan - - 0.1 - - 0.05 - 0.05 - 0.03 0.025 Citrus mixed extract - - - 0.1 - - 0.05 - 0.05 - 0.025 1.2-Nucleic acid diol - - - - - - - - - - - Phenoxyethanol - - - - - - - - - - -

Raw material name Comparative Example One 2 3 4 5 6 7 Purified water Balance Balance Balance Balance Balance Balance Balance Cyclopentasiloxane 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipropylene glycol 2.50 2.50 2.50 2.50 2.50 2.50 2.50 Dimethicone / Vinyl Dimethicone Crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Hydrolized milk protein / PIPE crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Beta-glucan 1.30 1.30 1.30 1.30 1.30 1.30 1.30 FAGE -100 stearate 1.20 1.20 1.20 1.20 1.20 1.20 1.20 Cetyl ethyl hexanoate 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Dimethicone 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Silica 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Ammonium acryloyldimethyltaurate /
V-picopolymer 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Sorbitan sesquioleate 0.30 0.30 0.30 0.30 0.30 0.30 0.30 Carbomer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.14 0.14 0.14 0.14 0.14 0.14 0.14 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Pigment Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Xylitylcaprylate - 1.00 - - - - - Ethylhexyl glycerin - - 0.2 - - - - Glyceryl caprylate - - - 0.4 - - - p-Anisan - - - - 0.4 - - Citrus mixed extract - - - - - 0.4 - 1.2-Nucleic acid diol - - - - - - 1.0 Phenoxyethanol - - - - - - 0.4

 [Test Example 1] Flotation test

In order to evaluate the buoyant force, the test was basically carried out according to the procedure shown in Fig.

20 to 30 g of the cosmetics of Examples 1 to 11 and Comparative Examples 1 to 7, from which the initial microorganisms were removed, were added to Escherichia coli coli ; ATCC 8739), Staphlyococcus aureus ; ATCC 6538), Pseudomonas aeruginosa ; ATCC 99027) and Candida albicans ATCC 10231) was added and mixed at an initial concentration of ⁵ × 10 ⁵ cfu (colony forming unit) / g per sample. 1 g of each cosmetic was taken at intervals of 7, 14, and 28 days while the cells were cultured in a 32 ° C thermostatic chamber for 4 weeks, and the viable cell counts were measured. The results are shown in Table 3 below.

In the case of fungi, 20 to 30 g of the cosmetic compositions of Examples 1 to 11 and Comparative Examples 1 to 7 were mixed with an initial concentration of 1 x 10 ⁵ cfu / g of Aspergillus niger (ATCC 16404) And 1 g of each cosmetic was taken at intervals of 7, 14 and 28 days while culturing in a constant temperature bath at 25 ° C. The viable cell counts were measured and the hyphae and spore formation on the surface of the samples were observed. Respectively.

Cosmetics Bacteria (cfu / g) Initial number of bacteria Day 7 Day 14 Day 28 Lotion Example 1 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 2 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 3 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 4 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 5 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 6 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 7 5 × 10 ⁵ 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 8 5 × 10 ⁵ 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 9 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 10 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 11 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Comparative Example 1 5 × 10 ⁵ > 1 × 10 ⁶ > 1 × 10 ⁶ > 1 × 10 ⁶ Comparative Example 2 5 × 10 ⁵ > 1 × 10 ⁶ > 1 × 10 ⁶ > 1 × 10 ⁶ Comparative Example 3 5 × 10 ⁵ 4.5 × 10 ⁵ 1 × 10 ⁵ 2 x 10 ³ Comparative Example 4 5 × 10 ⁵ 3.5 × 10 ⁵ 1 × 10 ⁵ 3 x 10 ⁴ Comparative Example 5 5 × 10 ⁵ 3.5 × 10 ⁵ 1 × 10 ⁵ 1 x 10 ⁴ Comparative Example 6 5 × 10 ⁵ 4 × 10 ⁵ 4 × 10 ⁵ 4 × 10 ⁵ Comparative Example 7 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ²

Cosmetics Mold (cfu / g) Initial number of bacteria Day 7 Day 14 Day 28 Visual observation Lotion Example 1 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ² 1 x 10 ² clear Example 2 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ³ 1 x 10 ³ clear Example 3 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ² clear Example 4 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 5 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 6 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 7 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 8 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 9 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 10 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Example 11 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Comparative Example 1 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ Spore development Comparative Example 2 1 × 10 ⁵ 2.3 x 10 ⁴ 3.6 × 10 ⁴ 1 x 10 ³ clear Comparative Example 3 1 × 10 ⁵ 3 x 10 ⁴ 2.1 x 10 ⁴ 1 x 10 ³ clear Comparative Example 4 1 × 10 ⁵ 3 x 10 ⁴ 2.1 x 10 ⁴ 1 x 10 ³ clear Comparative Example 5 1 × 10 ⁵ 1 x 10 ³ 1 x 10 ² 1 x 10 ² clear Comparative Example 6 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ Spore development Comparative Example 7 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ³ 1 x 10 ³ clear

As shown in Tables 3 and 4, in the case of Examples 1 to 11 according to the present invention, in Comparative Example 2 where xylitylcaprylate, ethylhexylglycerin glyceryl caprylate, p-anisic acid and citrus mixed extracts were used, It can be observed that the use of less than ~ 6 amount of better anti-buoyancy is possible and the lower amount of use compared to the case of Comparative Example 7 using 1,2-hexanediol and phenoxyethanol It is possible to confirm that the buoyant force is superior to that of the second embodiment.

[Test Example 2] Skin irritation test

To evaluate the skin safety of xylityl caprylate, ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extracts in the human body, a patch test was conducted on 40 subjects for 24 hours. The patch was attached to the upper part of the subject's back, and 20 μl of the prepared test material was applied using an IQ chamber (chemotechique, Sweeden). Twenty - four hours after removing the patch, the first reading was performed 30 minutes later, and the second reading was performed after 24 hours. In order to examine the intensity of the skin irritation of the sample, weights were assigned according to the degree of the positive reaction of the skin, and skin irritation of the sample was determined according to the following equation (1) to determine skin irritation of the sample.

<Criteria>

score Less than 1 (Grade I): No stimulation range

1 to less than 3 (grade II): light stimulus

3 to less than 5 (grade III): moderate irritation

5 or more (grade IV): Strong stimulus

Test substance score Xylityl caprylate 10% 0.90 Ethylhexyl glycerin 3% 0.31 Glyceryl caprylate 5% 0.94 p-Anisan 1% 0.94 Citrus Mixture Extract 1% 0.00

From the results in Table 5, it can be confirmed that xylityl caprylate, ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extracts are all at a non-stimulating level.

Therefore, even if the composition containing these substances is used as an external preparation for skin, it can be safely used without irritating the skin.

Claims (4)

Xylityl caprylate; And at least one substance selected from ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract. The composition according to claim 1, wherein the xylitol caprylate is 0.01 to 4.0 wt%, the ethylhexyl glycerin is 0.01 to 1.0 wt%, the glyceryl caprylate is 0.01 to 1.0 wt%, the p- 1.0% by weight, and the citrus mixed extract is contained in an amount of 0.01 to 1.0% by weight. The composition according to claim 1 or 2, wherein the xylitol caprylate, ethylhexyl glycerin, and glyceryl caprylate are 1.0 wt%, 0.05-0.1 wt%, 0.1-0.2 wt%, p-anisic acid, 0.1 to 0.2% by weight and citrus mixed extracts are mixed in the range of 0.05 to 0.2% by weight. The composition for external application for skin according to claim 1, wherein the composition is improved in buoyancy.

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