JP2010270083A - Antiseptic agent composition, use and preparation thereof, and formulation containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiseptic agent used in the field of cosmetics. <P>SOLUTION: The composition comprises: glyceryl caprylate; and a glycerol/water/sodium levulinate/sodium anisate mixture. Especially, the composition comprises: 0.25-3.0% of glycerol/water/sodium levulinate/sodium anisate mixture; and 0.5-7.0% of glyceryl caprylate. The use as an antiseptic agent and the formulation containing the same are disclosed. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a preservative composition, a process for its production, its use, and formulations containing it.

Preservatives are natural or synthetic substances that protect food, pharmaceuticals, and cosmetics from alterations caused by microorganisms and allow their long-term storage.

A number of synthetic preservatives are known and used in particular in the cosmetics field. Examples thereof include methylchloroisothiazolinone, 2-bromo-2-nitropropane-1,3-diol, sodium dehydroacetate, imidazolidinyl urea, phenoxyethanol and parabens.

However, all of these preservatives have been proven to have irritants, even if they are used in high concentrations, even if they do not actually have a toxic effect.

In particular, methyl chloroisothiazolinone and imidazolidinyl urea present in wet tissues are known as sensitizers. Groot et al. Observed in 1991 that methylchloroisothiazolinone (MI / MCI) (also known as Kathon CG) caused allergic dermatitis in five patients (De Groot et al., Contact. Dermatitis, 1991 24: 135-136). The symptoms improved after the use of wet tissue was stopped.

It is also known that parabens, preservatives widely used in the cosmetic industry, can cause intolerance, especially in sensitive skin.

In addition, 2-bromo-2-nitropropane-1,3-diol is known to cause cases of allergic contact dermatitis.

On the other hand, as natural products, Dr. Dermosoft 1388 (trade name) containing a glycerin / water / sodium levulinate / sodium anisate mixture, commercialized by Straetmans GmbH (Germany). Unfortunately, however, such mixtures are not assured of an overall preservative action in the final product and are not included in the list of preservatives approved for cosmetic use.

Therefore, at present, a search is being made for a preservative that does not have the disadvantages of known preservatives.

Accordingly, it is an object of the present invention to find natural preservatives that are superior or at least comparable to known synthetic preservatives and that do not cause side effects to end users once used.

According to the invention, such object is achieved by the composition according to claim 1, the use according to claims 5 and 6 and the production method according to claim 7. A formulation according to claim 8 is also provided.

  The preservatives of the present invention are superior or at least comparable to known synthetic preservatives and do not cause side effects to end users once used.

As used herein and in the claims, the term “glycerin / water / sodium levulinate / sodium anisate mixture” preferably refers to the product: Dermsoft 1388 (trade name), or substantially the product: Dermsoft 1388 ( It is recognized corresponding to a product having a composition corresponding to the composition of (trade name).

Advantageously, glyceryl caprylate, a substance classified as a softener / emulsifier, not classified as a preservative by the International Nomenclature Cosmetic Ingredients, is glycerin / water / sodium levulinate. When added to the / sodium anisate mixture, it has been shown to work synergistically with such ingredients to give excellent results with respect to preservatives.

Preferably, according to the present invention, the provided composition comprises:
0.25-3.0% glyceryl caprylate and 0.5-7.0% glycerin / water / sodium levulinate / sodium anisate mixture;
More preferably:
0.5-2.0% glyceryl caprylate and 1.0-5.0% glycerin / water / sodium levulinate / sodium anisate mixture.

In a preferred embodiment, the composition contains:
1% glyceryl caprylate and 4% glycerin / water / sodium levulinate / sodium anisate mixture.

The composition has proved to be particularly effective as a preservative, especially when used in the preparation of formulations, preferably cosmetics.

For example, such formulations can be as follows:
• Skin cream, emulsion, lotion, gel, and oil • Beauty mask
・ Foundation (liquid, paste, powder)
・ Makeup powder, talcum powder for bathing and personal hygiene, etc. ・ Cosmetic soap, deodorant soap, etc. ・ Perfume, eau de toilette, and cologne ・ Bathing agent and shower agent (salt, foam, oil, gel, etc.)
・ Hair removal products ・ Deodorants and antiperspirants ・ Hair treatment products ・ Hair dies and bleaches.
・ Products for curling, straightening and repairing hair ・ Hair set products ・ Hair cleaning products (lotion, powder, shampoo)
・ Hair conditioner (lotion, cream, oil)
・ Hair styling agents (lotions, sprays, brilliants)
・ Shaving agent (soap, foam, lotion, etc.).
• Face and eye makeup and makeup removers • Products intended to be applied to the lips • Teeth and oral hygiene products.
・ Nail hygiene products and nail polish ・ External intimate hygiene products ・ Suncare products ・ Sunburn products ・ Skin ・ Whitening products ・ Wrinkle removal products

The composition heats the glycerin / water / sodium levulinate / sodium anisate mixture to a temperature below 40 ° C. and then performs continuous low speed agitation until the solution thus obtained is completely clear. While adding glyceryl caprylate.

Additional features of the present invention will become apparent from the following description of some examples, which are merely illustrative and not intended to be limiting.

<Example 1>
The preservative composition according to the present invention is produced by heating a portion of the glycerin / water / sodium levulinate / sodium anisate mixture to a temperature of 40 ° C. Thereafter, the four portions of glyceryl caprylate are added with continuous low speed stirring until complete clarification.
The composition thus obtained is added to the moisturizing cream at a temperature below 40 ° C. after emulsification.

<Example 2>
The moisturizing cream produced as in Example 1 is microbiologically tested by counting the total number of bacteria, yeast, fungi and mold immediately after production and after 4 months of storage.
A series of dilutions of moisturizing cream (1:10, 1: 100, and 1: 1000) were added to soy lecithin, polysorbate 80, sodium thiosulfate pentahydrate, L-histidine hydrochloride, tryptone, sodium chloride, Manufactured in a common diluent containing sodium phosphate.12H ₂ O, monopotassium phosphate, and distilled water.
The medium used is PCA (Plate Count Agar) for detecting bacteria, and YDC (Yeast Extract Glucose Calcium Carbonate Agar) for detecting yeast and mold.
Take 1 ml from each dilution and dispense into petri dishes. Then, for each dilution, prepare plates with 15-20 ml of PCA and plates with 15-20 ml of YDC. After appropriate mixing and solidification, the plate is incubated at 30 ° C. for 72 hours (plate containing PCA) or at 24 ° C. for 5 days (plate containing YDC).
The data obtained is shown in Table I.

Table I

From the obtained results, reduction of the number of bacteria showing not only the excellent antiseptic action of the composition of the present invention but also the bactericidal action was observed.

<Example 3>
In the same manner as in Example 1, a shampoo was prepared by containing the preservative composition described in the present invention.
The shampoo was subjected to a challenge test to measure the preservative power of the mixture.
First, the shampoo sample was checked for no bacterial charge.
The samples were then inoculated with different strains: (A) Staphylococcus aureus 2.1 × 10 ⁷ , (B) Pseudomonas aeruginosa 2.1 × 10 ⁷ , (C) Escherichia coli 2.1 x 10 ⁷ , (D) Candida Albicans 2.1 x 10 ⁷ , (E) Aspergillus niger 2.1 × 10 ⁷
After 7 days, the results shown in Table II were obtained.

Table II

The results shown in Table II were compared to the results of a shampoo containing Dermosoft l388 as an antiseptic composition, which was subjected to the same challenge test. The data obtained is shown in Table III.

Table III

The data show that the preservative composition of the present invention (wherein the glycerin / water / sodium levulinate / sodium anisate mixture is added to glyceryl caprylate) is particularly relevant to fungi and yeast, It indicates how much preservative power is greater than the glycerin / water / sodium levulinate / sodium anise mixture itself.

Claims (8)

A composition comprising glyceryl caprylate and a glycerin / water / sodium levulinate / sodium anisate mixture. The composition of claim 1 containing 0.25-3.0% glyceryl caprylate and 0.5-7.0% glycerin / water / sodium levulinate / sodium anisate mixture. A composition according to claim 1 or 2 containing 0.5-2.0% glyceryl caprylate and 1.0-5.0% glycerin / water / sodium levulinate / sodium anisate mixture. A composition according to any preceding claim comprising 1% glyceryl caprylate and 4% glycerin / water / sodium levulinate / sodium anisate mixture. Use of the composition according to any one of claims 1 to 4 as a preservative. Use of the composition according to any one of claims 1 to 4 for the production of a cosmetic preparation. 2. Heating the glycerin / water / sodium levulinate / sodium anisate mixture to a temperature below 40 ° C. and adding glyceryl caprylate with continuous low speed stirring until complete clarification. The manufacturing method of the composition in any one of -4. The formulation containing the composition in any one of Claims 1-4.