CN111433201A - 苯并氮杂*衍生物、其制备方法及其在医药上的应用 - Google Patents

苯并氮杂*衍生物、其制备方法及其在医药上的应用 Download PDF

Info

Publication number
CN111433201A
CN111433201A CN201880077643.2A CN201880077643A CN111433201A CN 111433201 A CN111433201 A CN 111433201A CN 201880077643 A CN201880077643 A CN 201880077643A CN 111433201 A CN111433201 A CN 111433201A
Authority
CN
China
Prior art keywords
group
groups
alkyl
cancer
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880077643.2A
Other languages
English (en)
Other versions
CN111433201B (zh
Inventor
张国宝
陈友喜
原慧卿
贺峰
陶维康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN111433201A publication Critical patent/CN111433201A/zh
Application granted granted Critical
Publication of CN111433201B publication Critical patent/CN111433201B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种苯并氮杂
Figure DDA0002516477020000012
衍生物、其制备方法及其在医药上的应用。具体而言，涉及一种通式(I)所示的新的苯并氮杂
Figure DDA0002516477020000013
衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为TLR8激动剂的用途，其中通式(I)的各取代基与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201880077643.2A 2017-12-21 2018-12-20 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 Active CN111433201B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201711396645 2017-12-21
CN2017113966451 2017-12-21
PCT/CN2018/122424 WO2019120258A1 (zh) 2017-12-21 2018-12-20 苯并氮杂草衍生物、其制备方法及其在医药上的应用

Publications (2)

Publication Number Publication Date
CN111433201A true CN111433201A (zh) 2020-07-17
CN111433201B CN111433201B (zh) 2022-05-27

Family

ID=66992517

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880077643.2A Active CN111433201B (zh) 2017-12-21 2018-12-20 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用

Country Status (3)

Country Link
CN (1) CN111433201B (zh)
TW (1) TWI700281B (zh)
WO (1) WO2019120258A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432308A (zh) * 2022-01-27 2022-05-06 华南理工大学 一种含氮螺环化合物或其药学上可接受的盐在制备抗甲型流感病毒药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329609A (zh) * 1998-10-08 2002-01-02 史密丝克莱恩比彻姆有限公司 用作多巴胺d3受体调制剂(精神抑制药)的四氢苯并氮杂䓬衍生物
CN103864765A (zh) * 2014-03-05 2014-06-18 天津药物研究院 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途
CN107148417A (zh) * 2014-12-18 2017-09-08 豪夫迈·罗氏有限公司 苯并氮杂*磺酰胺化合物
CN107344931A (zh) * 2016-05-06 2017-11-14 上海迪诺医药科技有限公司 苯并氮杂卓衍生物、其制备方法、药物组合物及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2620629T3 (es) * 2009-08-18 2017-06-29 Ventirx Pharmaceuticals, Inc. Benzoazepinas sustituidas como moduladores del receptor tipo Toll

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329609A (zh) * 1998-10-08 2002-01-02 史密丝克莱恩比彻姆有限公司 用作多巴胺d3受体调制剂(精神抑制药)的四氢苯并氮杂䓬衍生物
CN103864765A (zh) * 2014-03-05 2014-06-18 天津药物研究院 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途
CN107148417A (zh) * 2014-12-18 2017-09-08 豪夫迈·罗氏有限公司 苯并氮杂*磺酰胺化合物
CN107344931A (zh) * 2016-05-06 2017-11-14 上海迪诺医药科技有限公司 苯并氮杂卓衍生物、其制备方法、药物组合物及应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432308A (zh) * 2022-01-27 2022-05-06 华南理工大学 一种含氮螺环化合物或其药学上可接受的盐在制备抗甲型流感病毒药物中的应用
CN114432308B (zh) * 2022-01-27 2023-09-26 华南理工大学 一种含氮螺环化合物或其药学上可接受的盐在制备抗甲型流感病毒药物中的应用

Also Published As

Publication number Publication date
TWI700281B (zh) 2020-08-01
TW201927774A (zh) 2019-07-16
WO2019120258A8 (zh) 2020-06-04
CN111433201B (zh) 2022-05-27
WO2019120258A1 (zh) 2019-06-27

Similar Documents

Publication Publication Date Title
TWI760390B (zh) 吡唑並雜芳基類衍生物、其製備方法及其在醫藥上的應用
CN110177793B (zh) 杂芳基并吡唑类衍生物、其制备方法及其在医药上的应用
WO2020108590A1 (zh) 嘧啶并五元氮杂环类衍生物、其制备方法及其在医药上的应用
CN111094289B (zh) 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
CN108794486B (zh) 稠环基酮类衍生物、其制备方法及其在医药上的应用
KR20170139064A (ko) 이미다조 이소인돌 유도체, 이의 제조방법 및 이의 의학적 용도
CN112351778A (zh) 稠合三环杂环类化合物及其治疗用途
TW202140448A (zh) 並環醯亞胺類衍生物、其製備方法及其在醫藥上的應用
CN108948016B (zh) 嘌呤酮类衍生物、其制备方法及其在医药上的应用
WO2022247816A1 (zh) 含氮杂环类化合物、其制备方法及其在医药上的应用
WO2022017365A1 (zh) 含硫异吲哚啉类衍生物、其制备方法及其在医药上的应用
WO2022022489A1 (zh) 吲哚稠环类衍生物、其制备方法及其在医药上的应用
CN111433201A (zh) 苯并氮杂*衍生物、其制备方法及其在医药上的应用
CN110256446B (zh) 苯并杂环取代的环戊二烯并[4,5]吡咯并吡嗪-1-酮衍生物及其应用
CN112574212B (zh) 一种嘧啶并五元氮杂环类衍生物、其制备方法及其在医药上的应用
CN109694351B (zh) 苯并氮杂*衍生物、其制备方法及其在医药上的应用
CN114075212B (zh) 稠合三环类衍生物、其制备方法及其在医药上的应用
TW202227442A (zh) 稠合三環化合物、其製備方法及其在醫藥上的應用
CN109956903B (zh) 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用
TW202214659A (zh) 稠三環類衍生物、其製備方法及其在醫藥上的應用
CN113880833A (zh) 联苯多环类衍生物抑制剂、其制备方法和应用
TW202045493A (zh) ２－胺基嘧啶類衍生物、其製備方法及其在醫藥上的應用
CN111065636B (zh) 稠合杂芳基衍生物、其制备方法及其在医药上的应用
CN114057734B (zh) 稠合三环类衍生物、其制备方法及其在医药上的应用
CN114276351B (zh) 含氮杂环类衍生物、其制备方法及其在医药上的应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant