WO2019120258A8 - 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 - Google Patents

苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
WO2019120258A8
WO2019120258A8 PCT/CN2018/122424 CN2018122424W WO2019120258A8 WO 2019120258 A8 WO2019120258 A8 WO 2019120258A8 CN 2018122424 W CN2018122424 W CN 2018122424W WO 2019120258 A8 WO2019120258 A8 WO 2019120258A8
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WO
WIPO (PCT)
Prior art keywords
application
medicine
preparation process
benzazepine derivatives
same
Prior art date
Application number
PCT/CN2018/122424
Other languages
English (en)
French (fr)
Other versions
WO2019120258A1 (zh
Inventor
张国宝
陈友喜
原慧卿
贺峰
陶维康
Original Assignee
江苏恒瑞医药股份有限公司
上海恒瑞医药有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏恒瑞医药股份有限公司, 上海恒瑞医药有限公司 filed Critical 江苏恒瑞医药股份有限公司
Priority to CN201880077643.2A priority Critical patent/CN111433201B/zh
Publication of WO2019120258A1 publication Critical patent/WO2019120258A1/zh
Publication of WO2019120258A8 publication Critical patent/WO2019120258A8/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种苯并氮杂䓬衍生物、其制备方法及其在医药上的应用。具体而言，涉及一种通式(I)所示的新的苯并氮杂䓬衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为TLR8激动剂的用途，其中通式(I)的各取代基与说明书中的定义相同。
PCT/CN2018/122424 2017-12-21 2018-12-20 苯并氮杂草衍生物、其制备方法及其在医药上的应用 WO2019120258A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201880077643.2A CN111433201B (zh) 2017-12-21 2018-12-20 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711396645.1 2017-12-21
CN201711396645 2017-12-21

Publications (2)

Publication Number Publication Date
WO2019120258A1 WO2019120258A1 (zh) 2019-06-27
WO2019120258A8 true WO2019120258A8 (zh) 2020-06-04

Family

ID=66992517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/122424 WO2019120258A1 (zh) 2017-12-21 2018-12-20 苯并氮杂草衍生物、其制备方法及其在医药上的应用

Country Status (3)

Country Link
CN (1) CN111433201B (zh)
TW (1) TWI700281B (zh)
WO (1) WO2019120258A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432308B (zh) * 2022-01-27 2023-09-26 华南理工大学 一种含氮螺环化合物或其药学上可接受的盐在制备抗甲型流感病毒药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0104280A3 (en) * 1998-10-08 2002-07-29 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them
WO2011022508A2 (en) * 2009-08-18 2011-02-24 Ventirx Pharmaceuticals, Inc. Substituted benzoazepines as toll-like receptor modulators
CN103864765B (zh) * 2014-03-05 2016-02-10 天津药物研究院 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途
WO2016096778A1 (en) * 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Benzazepine sulfonamide compounds
PT3453707T (pt) * 2016-05-06 2022-03-15 Shanghai De Novo Pharmatech Co Ltd Derivado de benzazepina, método de preparação, composição farmacêutica e a sua utilização

Also Published As

Publication number Publication date
CN111433201B (zh) 2022-05-27
TWI700281B (zh) 2020-08-01
TW201927774A (zh) 2019-07-16
WO2019120258A1 (zh) 2019-06-27
CN111433201A (zh) 2020-07-17

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