CN111420266B - 透皮药物递送设备和方法 - Google Patents
透皮药物递送设备和方法 Download PDFInfo
- Publication number
- CN111420266B CN111420266B CN202010342460.8A CN202010342460A CN111420266B CN 111420266 B CN111420266 B CN 111420266B CN 202010342460 A CN202010342460 A CN 202010342460A CN 111420266 B CN111420266 B CN 111420266B
- Authority
- CN
- China
- Prior art keywords
- reservoir
- force
- microneedle assembly
- response
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461996149P | 2014-04-30 | 2014-04-30 | |
| US61/996149 | 2014-04-30 | ||
| PCT/US2015/028150 WO2015168210A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
| CN201580018929.XA CN106170316B (zh) | 2014-04-30 | 2015-04-29 | 透皮药物递送设备和方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580018929.XA Division CN106170316B (zh) | 2014-04-30 | 2015-04-29 | 透皮药物递送设备和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111420266A CN111420266A (zh) | 2020-07-17 |
| CN111420266B true CN111420266B (zh) | 2022-05-27 |
Family
ID=54359267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010342460.8A Expired - Fee Related CN111420266B (zh) | 2014-04-30 | 2015-04-29 | 透皮药物递送设备和方法 |
| CN201580018929.XA Expired - Fee Related CN106170316B (zh) | 2014-04-30 | 2015-04-29 | 透皮药物递送设备和方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580018929.XA Expired - Fee Related CN106170316B (zh) | 2014-04-30 | 2015-04-29 | 透皮药物递送设备和方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10232160B2 (enExample) |
| EP (4) | EP3581236B1 (enExample) |
| JP (3) | JP6566964B2 (enExample) |
| KR (1) | KR20160146842A (enExample) |
| CN (2) | CN111420266B (enExample) |
| AU (3) | AU2015253253B2 (enExample) |
| CA (2) | CA2944997C (enExample) |
| ES (1) | ES2943157T3 (enExample) |
| MX (2) | MX384280B (enExample) |
| RU (1) | RU2667621C2 (enExample) |
| WO (1) | WO2015168210A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20220026606A (ko) * | 2014-04-30 | 2022-03-04 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 경피 약물 전달 장치 및 방법의 수용기 부분 |
| CN113198101B (zh) | 2016-04-29 | 2023-06-09 | 索伦托治疗有限公司 | 微针阵列组件、药物递送装置和用于大面积低压输注液体的方法 |
| KR20190088077A (ko) | 2016-12-16 | 2019-07-25 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 편두통 또는 군발두통을 치료하기에 적합한 투약 방법 |
| ES2898083T3 (es) | 2016-12-16 | 2022-03-03 | Sorrento Therapeutics Inc | Aparato de suministro de líquidos y procedimiento de montaje |
| EP4023281A1 (en) | 2016-12-16 | 2022-07-06 | Sorrento Therapeutics, Inc. | Attachment band for a fluid delivery apparatus and method of use |
| AU2017378040B2 (en) | 2016-12-16 | 2023-06-08 | Vivasor, Inc. | Application device for a fluid delivery apparatus and method of use |
| CA3046928A1 (en) | 2016-12-16 | 2018-06-21 | Sorrento Therapeutics, Inc. | Fluid delivery apparatus having a gas extraction device and method of use |
| CN110300612B (zh) | 2016-12-16 | 2022-04-22 | 索伦托治疗有限公司 | 具有控制器组件的流体递送装置及其使用方法 |
| CN108211107B (zh) * | 2018-03-01 | 2023-08-15 | 中南民族大学 | 一种针对穴位持续给药的压力可控式微泡贴及制备方法 |
| DE102019200557A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
| KR20220110542A (ko) * | 2019-12-03 | 2022-08-08 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 마이크로니들을 갖는 유체 전달 기구 |
| KR20220110273A (ko) | 2019-12-05 | 2022-08-05 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 항-pd-1 또는 항-pd-l1 치료제를 림프 전달 장치를 통해 투여하여 암을 치료하는 방법 |
| CN116367770A (zh) * | 2020-08-03 | 2023-06-30 | 曲莱博医疗有限公司 | 微创监测贴片 |
| CN117813128A (zh) | 2021-01-22 | 2024-04-02 | 索伦托药业有限公司 | 用于微升级淋巴递送冠状病毒疫苗的装置 |
| EP4297820A1 (en) * | 2021-02-26 | 2024-01-03 | Insulet Corporation | Drug delivery device including pump with floating microneedle assembly |
| US12161832B2 (en) | 2021-03-01 | 2024-12-10 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| US12357804B2 (en) | 2021-03-01 | 2025-07-15 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| IL322176A (en) | 2021-03-01 | 2025-09-01 | Deka Products Lp | Medical material dispensing device, system and method |
| WO2022192594A2 (en) | 2021-03-11 | 2022-09-15 | Sorrento Therapeutics, Inc. | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| CA3221925A1 (en) | 2021-06-09 | 2022-12-15 | Sorrento Therapeutics, Inc. | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device |
| US20250120905A1 (en) | 2021-08-18 | 2025-04-17 | Vivasor, Inc | Therapeutic agents targeting the lymphatic system |
| CN114010931B (zh) * | 2021-12-01 | 2022-10-28 | 深圳市深鸿涛贸易有限公司 | 一种医疗用皮肤科烫伤皮肤敷药设备 |
| CA3245155A1 (en) * | 2022-03-03 | 2023-09-07 | Deka Products Lp | SYSTEMS, METHODS AND APPARATUS FOR ADMINISTRATING MEDICAL AGENTS |
| DE102023101977A1 (de) * | 2023-01-27 | 2024-08-01 | Lts Lohmann Therapie-Systeme Ag. | Applikationsvorrichtung für Mikronadeln, System zur Mikronadelapplikation und Verfahren zur Bereitstellung eines Systems zur Mikronadelapplikation |
| WO2025128670A1 (en) * | 2023-12-11 | 2025-06-19 | Tycho Speaker | Microneedle drug delivery devices and methods for using the same |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101616709A (zh) * | 2007-02-22 | 2009-12-30 | 厄弗翁简易股份公司 | 用于医疗用途的微型注射装置 |
| CN102497909A (zh) * | 2009-07-31 | 2012-06-13 | 3M创新有限公司 | 中空微针阵列 |
| CN102753225A (zh) * | 2009-12-16 | 2012-10-24 | 贝克顿·迪金森公司 | 自注射装置 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| EP1341442B1 (en) * | 2000-10-13 | 2005-06-29 | Alza Corporation | Microblade array impact applicator |
| BR0114909A (pt) | 2000-10-26 | 2004-02-03 | Alza Corp | Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas |
| US7850663B2 (en) * | 2001-01-12 | 2010-12-14 | Becton, Dickinson And Company | Medicament microdevice delivery system, cartridge and method of use |
| JP4383168B2 (ja) * | 2001-09-12 | 2009-12-16 | ベクトン・ディキンソン・アンド・カンパニー | マイクロ針投与デバイスおよび薬物投与デバイス |
| US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
| US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
| GB0302662D0 (en) | 2003-02-05 | 2003-03-12 | Strakan Ltd | Transdermal granisetron |
| US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
| WO2006015299A2 (en) | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| EP1790375A4 (en) | 2004-08-12 | 2009-06-17 | Hisamitsu Pharmaceutical Co | TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL |
| US20080009801A1 (en) | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
| JPWO2007091608A1 (ja) | 2006-02-10 | 2009-07-02 | 久光製薬株式会社 | マイクロニードル付き経皮薬物投与装置 |
| CA2536845C (en) * | 2006-02-16 | 2009-10-27 | Pka Softtouch Corp. | Drug delivery device |
| EP2255841A1 (en) * | 2008-03-24 | 2010-12-01 | Olympus Corporation | Medicine administration device |
| US9370621B2 (en) * | 2008-12-16 | 2016-06-21 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| US8337466B2 (en) * | 2009-03-30 | 2012-12-25 | Lifemedix, Llc | Manual pump for intravenous fluids |
| WO2010126174A1 (en) | 2009-05-01 | 2010-11-04 | Nanbu Plastics Co., Ltd. | Transdermal administration device |
| JP5558047B2 (ja) * | 2009-08-13 | 2014-07-23 | 深江化成株式会社 | 物質供給装置 |
| CA2936768C (en) * | 2009-10-13 | 2019-01-08 | Valeritas, Inc. | Fluid delivery device |
| US20110144591A1 (en) | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
| WO2011075100A1 (en) * | 2009-12-16 | 2011-06-23 | Becton, Dickinson And Company | Self-injection device |
| US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| US8328757B2 (en) | 2010-01-08 | 2012-12-11 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
| US20110172609A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| US20110172639A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Device and method for delivery of microneedle to desired depth within the skin |
| US10245421B2 (en) | 2010-04-28 | 2019-04-02 | Sorrento Therapeutics, Inc. | Nanopatterned medical device with enhanced cellular interaction |
| WO2012012541A2 (en) * | 2010-07-21 | 2012-01-26 | Allergan, Inc. | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY |
| US9173994B2 (en) | 2010-08-20 | 2015-11-03 | Purdue Research Foundation | Touch-actuated micropump for transdermal drug delivery and method of use |
| US9017289B2 (en) * | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
| US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
| EP2460553A1 (fr) * | 2010-12-02 | 2012-06-06 | Debiotech S.A. | Dispositif pour l'insertion d'aiguilles |
| EP2654582B1 (en) * | 2010-12-22 | 2017-05-31 | Valeritas, Inc. | Microneedle patch applicator |
| US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
| US20130345638A1 (en) * | 2012-06-25 | 2013-12-26 | Flugen, Inc. | Multiple drug delivery device |
| EP2906285B1 (en) * | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
| EP3513833A1 (en) * | 2012-12-21 | 2019-07-24 | 3M Innovative Properties Co. | Adhesive assemblies and microneedle injection apparatus comprising same |
| EP3003459B1 (en) * | 2013-05-31 | 2018-06-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
| CN203355122U (zh) * | 2013-06-13 | 2013-12-25 | 陈彦彪 | 一种电动微针组件 |
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2015
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2016
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2022
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101616709A (zh) * | 2007-02-22 | 2009-12-30 | 厄弗翁简易股份公司 | 用于医疗用途的微型注射装置 |
| CN102497909A (zh) * | 2009-07-31 | 2012-06-13 | 3M创新有限公司 | 中空微针阵列 |
| CN102753225A (zh) * | 2009-12-16 | 2012-10-24 | 贝克顿·迪金森公司 | 自注射装置 |
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