CA2944997C - Transdermal drug delivery apparatus and methods - Google Patents
Transdermal drug delivery apparatus and methods Download PDFInfo
- Publication number
- CA2944997C CA2944997C CA2944997A CA2944997A CA2944997C CA 2944997 C CA2944997 C CA 2944997C CA 2944997 A CA2944997 A CA 2944997A CA 2944997 A CA2944997 A CA 2944997A CA 2944997 C CA2944997 C CA 2944997C
- Authority
- CA
- Canada
- Prior art keywords
- housing
- reservoir
- microneedle assembly
- force
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title description 19
- 239000012530 fluid Substances 0.000 claims abstract description 60
- 238000004891 communication Methods 0.000 claims abstract description 31
- 239000012528 membrane Substances 0.000 claims description 93
- 230000007246 mechanism Effects 0.000 claims description 59
- 230000033001 locomotion Effects 0.000 claims description 55
- 239000000853 adhesive Substances 0.000 claims description 39
- 230000001070 adhesive effect Effects 0.000 claims description 39
- 230000004044 response Effects 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 22
- 238000012377 drug delivery Methods 0.000 claims description 17
- 210000003491 skin Anatomy 0.000 description 59
- 239000000463 material Substances 0.000 description 44
- 239000013583 drug formulation Substances 0.000 description 39
- 230000014759 maintenance of location Effects 0.000 description 21
- 238000007789 sealing Methods 0.000 description 15
- 230000002093 peripheral effect Effects 0.000 description 13
- 238000003466 welding Methods 0.000 description 10
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
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- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000012229 microporous material Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
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- 238000001020 plasma etching Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3189419A CA3189419A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461996149P | 2014-04-30 | 2014-04-30 | |
| US61/996,149 | 2014-04-30 | ||
| PCT/US2015/028150 WO2015168210A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3189419A Division CA3189419A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2944997A1 CA2944997A1 (en) | 2015-11-05 |
| CA2944997C true CA2944997C (en) | 2023-04-04 |
Family
ID=54359267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2944997A Active CA2944997C (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
| CA3189419A Pending CA3189419A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3189419A Pending CA3189419A1 (en) | 2014-04-30 | 2015-04-29 | Transdermal drug delivery apparatus and methods |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10232160B2 (enExample) |
| EP (4) | EP3581236B1 (enExample) |
| JP (3) | JP6566964B2 (enExample) |
| KR (1) | KR20160146842A (enExample) |
| CN (2) | CN106170316B (enExample) |
| AU (3) | AU2015253253B2 (enExample) |
| CA (2) | CA2944997C (enExample) |
| ES (1) | ES2943157T3 (enExample) |
| MX (2) | MX384280B (enExample) |
| RU (1) | RU2667621C2 (enExample) |
| WO (1) | WO2015168210A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106232172B (zh) * | 2014-04-30 | 2020-05-22 | 索伦托治疗有限公司 | 透皮药物递送设备的插座部分和方法 |
| EP3851153B1 (en) | 2016-04-29 | 2022-09-21 | Sorrento Therapeutics, Inc. | Microneedle array assembly and drug delivery device |
| KR102590629B1 (ko) | 2016-12-16 | 2023-10-19 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 유체 전달 장치용 어플리케이션 디바이스 및 그 이용 방법 |
| CA3046928A1 (en) | 2016-12-16 | 2018-06-21 | Sorrento Therapeutics, Inc. | Fluid delivery apparatus having a gas extraction device and method of use |
| US11213666B2 (en) | 2016-12-16 | 2022-01-04 | Sorrento Therapeutics, Inc. | Method for administering a medicament suitable for treating a migraine or cluster headache |
| CN114681787A (zh) | 2016-12-16 | 2022-07-01 | 索伦托治疗有限公司 | 具有控制器组件的流体递送装置及其使用方法 |
| EP3554619B1 (en) | 2016-12-16 | 2021-10-20 | Sorrento Therapeutics, Inc. | Fluid delivery apparatus and method of assembly |
| WO2018111609A1 (en) | 2016-12-16 | 2018-06-21 | Kimberly-Clark Worldwide, Inc. | Attachment band for a fluid delivery apparatus and method of use |
| CN108211107B (zh) * | 2018-03-01 | 2023-08-15 | 中南民族大学 | 一种针对穴位持续给药的压力可控式微泡贴及制备方法 |
| DE102019200557A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
| IL293461A (en) * | 2019-12-03 | 2022-07-01 | Sorrento Therapeutics Inc | Fluid delivery apparatus with microneedles |
| IL293479A (en) | 2019-12-05 | 2022-08-01 | Sorrento Therapeutics Inc | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic delivery device |
| WO2022029491A2 (en) * | 2020-08-03 | 2022-02-10 | Qulab Medical Ltd. | Minimally-invasive monitoring patch |
| US20240090908A1 (en) | 2021-01-22 | 2024-03-21 | Sorrento Therapeutics, Inc. | Device for microliter-scale lymphatic delivery of coronavirus vaccines and methods of use thereof |
| US20220273927A1 (en) * | 2021-02-26 | 2022-09-01 | Insulet Corporation | Drug delivery device including pump with floating microneedle assembly |
| US12377219B2 (en) | 2021-03-01 | 2025-08-05 | Deka Products Limited Partnership | Medical agent dispensing apparatuses, systems, and methods |
| US12161832B2 (en) | 2021-03-01 | 2024-12-10 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| US12357804B2 (en) | 2021-03-01 | 2025-07-15 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| WO2022192594A2 (en) | 2021-03-11 | 2022-09-15 | Sorrento Therapeutics, Inc. | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| AU2022290563A1 (en) | 2021-06-09 | 2024-01-25 | Sofusa Holdings Llc | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device |
| JP2024531337A (ja) | 2021-08-18 | 2024-08-29 | ソレント・セラピューティクス・インコーポレイテッド | リンパ系を標的化する治療剤 |
| CN114010931B (zh) * | 2021-12-01 | 2022-10-28 | 深圳市深鸿涛贸易有限公司 | 一种医疗用皮肤科烫伤皮肤敷药设备 |
| WO2023168419A2 (en) * | 2022-03-03 | 2023-09-07 | Deka Products Limited Partnership | Systems, methods, and apparatuses for medical agent administration |
| DE102023101977A1 (de) * | 2023-01-27 | 2024-08-01 | Lts Lohmann Therapie-Systeme Ag. | Applikationsvorrichtung für Mikronadeln, System zur Mikronadelapplikation und Verfahren zur Bereitstellung eines Systems zur Mikronadelapplikation |
| WO2025128670A1 (en) * | 2023-12-11 | 2025-06-19 | Tycho Speaker | Microneedle drug delivery devices and methods for using the same |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
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| DK1333880T3 (da) * | 2000-10-26 | 2009-07-20 | Alza Corp | Indretninger med coatede mikrofremspring til medikamentafgivelse gennem huden |
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| ES2393282T3 (es) * | 2001-09-12 | 2012-12-20 | Becton, Dickinson And Company | Dispositivo de pluma basado en microaguja para la administración de fármacos |
| US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
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| US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
| GB0302662D0 (en) * | 2003-02-05 | 2003-03-12 | Strakan Ltd | Transdermal granisetron |
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| KR102236575B1 (ko) * | 2012-12-21 | 2021-04-05 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 접착제 조립체 및 이를 포함하는 마이크로니들 주사 장치 |
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| CN203355122U (zh) * | 2013-06-13 | 2013-12-25 | 陈彦彪 | 一种电动微针组件 |
-
2015
- 2015-04-29 EP EP19184776.3A patent/EP3581236B1/en active Active
- 2015-04-29 ES ES21155218T patent/ES2943157T3/es active Active
- 2015-04-29 CN CN201580018929.XA patent/CN106170316B/zh not_active Expired - Fee Related
- 2015-04-29 EP EP15786061.0A patent/EP3137153A4/en not_active Withdrawn
- 2015-04-29 MX MX2016013610A patent/MX384280B/es unknown
- 2015-04-29 CN CN202010342460.8A patent/CN111420266B/zh not_active Expired - Fee Related
- 2015-04-29 CA CA2944997A patent/CA2944997C/en active Active
- 2015-04-29 CA CA3189419A patent/CA3189419A1/en active Pending
- 2015-04-29 KR KR1020167031961A patent/KR20160146842A/ko not_active Abandoned
- 2015-04-29 RU RU2016143043A patent/RU2667621C2/ru not_active IP Right Cessation
- 2015-04-29 EP EP21155218.7A patent/EP3851154B1/en active Active
- 2015-04-29 AU AU2015253253A patent/AU2015253253B2/en not_active Ceased
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- 2015-04-29 US US15/305,193 patent/US10232160B2/en active Active
- 2015-04-29 EP EP23151523.0A patent/EP4201466A3/en not_active Withdrawn
- 2015-04-29 JP JP2016562985A patent/JP6566964B2/ja not_active Expired - Fee Related
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2016
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2019
- 2019-01-29 US US16/261,095 patent/US11247033B2/en active Active
- 2019-07-30 JP JP2019139372A patent/JP7118036B2/ja active Active
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