CN111419940A - Chinese herbal medicine composition for removing acne - Google Patents

Chinese herbal medicine composition for removing acne Download PDF

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Publication number
CN111419940A
CN111419940A CN202010308752.XA CN202010308752A CN111419940A CN 111419940 A CN111419940 A CN 111419940A CN 202010308752 A CN202010308752 A CN 202010308752A CN 111419940 A CN111419940 A CN 111419940A
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acne
herbal medicine
medicine composition
chinese herbal
extraction
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CN111419940B (en
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侯占军
张云丰
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Beiwencao Biotechnology Shanghai Co ltd
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Beiwencao Biotechnology Shanghai Co ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract

The invention discloses a Chinese herbal medicine composition for removing acne, which contains rehmannia root, mulberry root bark, tree peony bark, Chinese angelica, wrinkled gianthyssop herb, liquorice, coptis root and cimicifuga foetida, and the solvents are as follows: caprylyl glycol, ethylhexyl glycerin, 1, 3-propanediol; the combined extract has the effects of clearing heat and removing toxicity, and reducing swelling and resolving masses, and researches show that the combined extract has the effects of diminishing inflammation and resisting bacteria and has a treatment effect on acne. The natural extract is from Chinese classical Chinese medicinal components, and has effects of dispelling pathogenic wind, dredging collaterals, resisting bacteria, relieving inflammation, promoting blood circulation, relieving pain, cooling blood and resolving carbuncle. It also has antiallergic and antiviral effects.

Description

Chinese herbal medicine composition for removing acne
Technical Field
The invention relates to a Chinese herbal medicine composition for removing acnes, and in particular relates to a preparation method and application of an extract of the Chinese herbal medicine composition for removing acnes.
Background
Acne, commonly known as whelk, is a chronic inflammation of pilosebaceous glands caused by multiple factors, is commonly generated in various groups, particularly adolescent men and women, and mainly forms acne, papule, pustule, nodule, cyst and the like on the face, chest and back of a patient, thereby bringing negative influence on the psychological and social interaction of the patient.
One of the important causes for acne is the massive proliferation of propionibacterium acnes and other microorganisms, the production of lysolipases, the breakdown of sebum to produce free acids, the rupture of the damage of the hair follicle wall, the entry of the accumulated sebum into the surrounding dermal tissue, and the clinical manifestations of lesions ranging from inflammatory papules to cysts. The traditional Chinese medicine theory considers that the acne is formed by heat in the lung channel, the spleen channel and the stomach channel, blood heat stagnation and skin stagnation caused by external infection of toxic factors, or heat generation in the spleen and the stomach caused by overeating fat, sweet, pungent and spicy food, and dampness generation and skin fumigation.
The existing methods for treating acne are various, and western medicine treatment mainly comprises antibiotics, hormones, external tretinoin and the like; the traditional Chinese medicine mainly comprises an oral administration and external application method of traditional Chinese medicines such as salvia miltiorrhiza, saffron crocus, radix scutellariae, coptis chinensis, honeysuckle and the like. The long-term use of hormones and antibiotic chemicals by patients may cause serious toxic and side effects, resulting in chronic skin injury.
With the improvement of living standard of people, the efficacy, safety and quality of the cosmetics are more and more concerned, and the herbal cosmetics are more and more favored by consumers due to small natural toxic and side effects. The acne-removing cosmetic adopts natural Chinese herbal medicines as raw materials, is extracted, purified, analyzed and developed by using a modern technology, provides a novel herbal compound acne-removing scheme, and provides a basic basis for developing high-safety acne-removing cosmetics.
In the prior art:
the rehmanniae extract has effect in promoting fibrin growth, enhancing skin metabolism, changing sebum composition, and inhibiting oil, softening skin and caring skin by combining its moisture absorption capacity in low humidity environment; the rehmannia glutinosa extract promotes the activity of cathepsin D and shows dermatitis treatment; it can also be used in weight reducing, hair growth promoting and hair blackening products.
The mulberry root bark extract contains reducing sugar, pentosan, galactoside, tannin, flavone, etc. Can inhibit elastase, and has antiaging effect; promoting the synthesis of fiber bud cell brain amide and softening and moistening skin; can well prevent and treat acne caused by high androgen; has contraction effect on collagen fiber, and can be used for reducing weight; has promoting effect on the activation of luciferase, and shows that the product has anti-inflammatory effect.
Peony root has anti-inflammatory and antiallergic effects. Can prevent melanin generation and freckle. And can be used for resisting skin aging caused by peroxidation.
The radix Angelicae sinensis extract can be used in many cosmetics for promoting blood circulation, such as promoting hair growth, regulating skin secretion, supplementing nutrition, and relieving black eye, based on the effects of radix Angelicae sinensis in promoting blood circulation, removing blood stasis, and improving skin microcirculation; the proliferation of the angelica on vascular endothelial cells shows that the angelica has the function of solidifying capillary vessels while promoting blood circulation; the angelica has good SOD-like activity, inhibits membrane lipid peroxidation and free radical reaction caused by superoxide radical, protects the damage of membrane lipid and other mechanisms to tissues by combining with biological membrane phospholipid to antagonize free radicals, and has special effects on dark complexion or sore swelling caused by free radical retardation; has anti-aging effect on the activation rate of fluorescent enzyme and the proliferation effect on stem cells.
The patchouli essential oil can effectively inhibit the secretion of inflammatory factors I L-1 β in THP-1 induced by P.acnes, remarkably reduce the transcription of T L R2 mRNA in THP-1 induced by P.acnes, and play a role in inhibiting inflammatory signal transduction and generation of secondary inflammatory mediators.
Research on proliferation of muscle cells, proliferation promotion of vascular endothelial cells, collagen-4 type generation promotion, NO generation inhibition and the like of the liquorice extract shows that the liquorice extract has promotion effect on improving activity of skin and the like, and can be used for anti-aging cosmetics; the licorice extract has the effects of inhibiting melanin and whitening skin; has obvious inhibiting effect on some bacteria, and can be used as anti-inflammatory agent.
The coptis chinensis has various pharmacological activities, wherein the coptis chinensis has a wide antibacterial effect and is known as a Chinese medicinal antibiotic, the coptis chinensis contains various isoquinoline alkaloids, and the main antibacterial components of the coptis chinensis are berberine, coptisine and jateorhizine.
Cimicifugae rhizoma is first recorded in Shen nong Ben Cao Jing (Shen nong's herbal Jing), which says: sweet and pungent in flavor. Mainly relieves the toxin, kills the drug Podophyllum, and avoids warm diseases, pathogen obstruction and poison venomous. The pharmacopoeia of the people's republic of China records cimicifuga foetida: pungent, slightly sweet and slightly cold. It enters lung, spleen, stomach and large intestine meridians. Releasing exterior and promoting eruption, clearing heat and removing toxicity, and lifting yang qi. Can be used for treating headache due to wind-heat evil, toothache, aphtha, sore throat, measles without adequate eruption, and macula due to yang toxin.
Disclosure of Invention
The invention aims to provide a Chinese herbal medicine composition for removing acne and also provides application of the composition.
The invention provides a Chinese herbal medicine composition for removing acne, which comprises the following components in part by weight: rehmannia root, mulberry root bark, tree peony bark, Chinese angelica, wrinkled gianthyssop herb, liquorice, coptis root and cimicifuga foetida, and the solvent comprises: octyl glycol, ethylhexyl glycerol, 1, 3-propanediol.
The Chinese herbal medicine composition for removing acnes comprises the following components in percentage by mass: 10-30% of rehmannia root, 10-30% of mulberry root bark, 10-30% of tree peony bark, 10-30% of Chinese angelica, 10-30% of wrinkled gianthyssop herb, 5-20% of liquorice, 3-10% of coptis root and 3-10% of cimicifuga foetida.
The extraction and preparation method of the Chinese herbal medicine composition for removing the acne comprises the following steps:
washing, drying and pulverizing the composition of claim 1;
the extraction solvent is 75% ethanol;
the extraction process comprises leaching, extracting to obtain extract, adding octyl glycol, ethylhexyl glycerol, and 1, 3-propylene glycol, and dissolving.
The extraction and preparation method of the Chinese herbal medicine composition for removing the acne comprises the following steps:
twice leaching;
primary leaching: adding the mixture into an extraction tank for leaching for 2 hours at the temperature of 50-60 ℃ when the ratio of material to liquid is 1: 5;
secondary leaching: taking out the primary extraction filtrate, adding 75% ethanol into the filter cake according to the material-liquid ratio of 1:3 for secondary extraction, and extracting for 2 hours at the temperature of 50-60 ℃;
mixing the two filtrates, performing plate filtration, and settling to remove impurities;
evaporating the obtained extract to obtain extract;
the dissolving solvent is octyl glycol, ethylhexyl glycerol and 1, 3-propylene glycol in a ratio of 2:3: 5;
and uniformly dissolving the extract and the solvent according to the ratio of 3: 7.
An application of a Chinese herbal medicine composition for removing acne is applied to preparing skin care products for removing acne, including facial masks, water, essence, skin moistening cream, cream and washing products, and the addition amount is 1-5%.
Compared with the prior art, the invention has the following beneficial effects:
the combined extract has the effects of clearing heat and removing toxicity, and reducing swelling and resolving masses, and researches show that the combined extract has the effects of diminishing inflammation and resisting bacteria and has a treatment effect on acne. The natural extract is from Chinese classical Chinese medicinal components, and has effects of dispelling pathogenic wind, dredging collaterals, resisting bacteria, relieving inflammation, promoting blood circulation, relieving pain, cooling blood and resolving carbuncle. It also has antiallergic and antiviral effects.
In addition, the long-term use of hormones and antibiotic chemicals by patients may cause serious toxic and side effects, resulting in chronic skin injury. The herbal extract is applied to cosmetics, has small natural toxic and side effects, and can be used for a long time.
The biochemical experiment proves that: the composition has obvious inhibition effect on escherichia coli and staphylococcus aureus, and has good effect of removing DPPH and free radicals.
Detailed Description
The present invention will be further described with reference to the following examples.
Effect verification experiment 1 inhibitory experiment of the combined extracts on escherichia coli and staphylococcus aureus.
The method comprises the following steps of respectively measuring extract samples of different combinations by 2 mu L, adding the extract samples to a sterilized paper sheet, taking out a solid culture medium, adding bacterial liquid of 10 mu L escherichia coli by using a pipette gun, uniformly coating the bacterial liquid on the solid culture medium by using an applicator, taking a paper sheet by using tweezers, placing the paper sheet on the solid culture medium with the bacterial liquid, marking, preparing staphylococcus aureus by using the same method, respectively making three parallel controls on two kinds of bacterial liquid, observing the size of a bacteriostatic circle around the paper sheet, and obtaining the total bacteriostatic circle of the paper sheet according to the following table 1:
TABLE 1 Effect of Combined extracts on Escherichia coli and Staphylococcus aureus
Figure BDA0002456822720000041
Figure BDA0002456822720000051
Effect verification experiment 2 DPPH free radical scavenging experiment.
Adding a DPPH solution and a sample solution into a 96-well plate according to a volume ratio of 1: 1, shaking for 30s, and observing the absorbance (OD value) measured at 517nm after the dark reaction time is 15 min, 30 min and 45min respectively, wherein the absorbance of the sample solution added into the DPPH solution is A1(100 mu L DPPH solution +100 mu L sample solution), the absorbance of the sample solution is A2(100 mu L absolute ethyl alcohol +100 mu L sample solution), the absorbance of the DPPH solution added into a blank solvent is A3(100 mu L DPPH solution +100 mu L absolute ethyl alcohol), and the DPPH clearance (%) is calculated according to a formula, the DPPH free radical removal absorbance of the sample solution is A3- (A1-A2), and the DPPH clearance/% (1- (A1-A2)/A3) × 100%, and the detection results are shown in Table 2:
TABLE 2 DPPH & free radical scavenging ability of the combined extracts
Figure BDA0002456822720000052
Example 1A herbal composition for removing acne
Washing rehmanniae radix, cortex Mori, cortex moutan, radix Angelicae sinensis, herba Agastaches, Glycyrrhrizae radix, Coptidis rhizoma, and cimicifugae rhizoma, placing into forced air drying oven, and drying thoroughly.
Weighing 10Kg of dried rehmannia, 10Kg of mulberry root bark, 10Kg of tree peony bark, 10Kg of angelica, 10Kg of wrinkled gianthyssop herb, 5Kg of liquorice, 3Kg of coptis root and 3Kg of cimicifuga foetida.
Placing the pulverized Chinese herbal medicines into a constant-temperature extraction tank.
Primary leaching: adding 75% ethanol 305KG, and leaching in an extraction tank at 50-60 deg.C for 2 hr.
Secondary leaching: taking out the primary extraction filtrate, adding 183kg of 75% ethanol into the filter cake according to the feed liquid, and leaching for 2 hours at 50-60 ℃.
And combining the two filtrates, performing plate filtration, and settling to remove impurities.
Evaporating the obtained extractive solution to obtain extract 4.7 kg.
The dissolving solvent is octyl glycol, ethylhexyl glycerol and 1, 3-propylene glycol in a ratio of 2:3: 5.
Adding the extract and a solvent according to the proportion of 3: 7: 10.9Kg of the product is dissolved evenly to obtain the required product.
Example 2 application of a Chinese herbal medicine composition for removing acne in facial mask
The components and contents (%) of the mask are as follows:
a Chinese herbal medicine composition for removing acne comprises: 1
Water: TO100
Glycerol: 3
EDTA：0.05
Sodium hyaluronate: 0.05
Xanthan gum: 0.1
Carbomer: 0.15
Betaine: 1.5
Arginine: 0.12
The preparation method of the facial mask comprises the following steps:
94.33Kg of water, 3Kg of glycerin, 0.05Kg of EDTA, 0.05Kg of sodium hyaluronate, 0.1Kg of xanthan gum, 0.15Kg of carbomer and 1.5Kg of betaine are put into a water pot, heated to 85 ℃, stirred for 30 minutes, homogenized for 3 minutes and uniformly dispersed.
Cooling to 40 ℃, adding 0.12Kg of arginine, and stirring uniformly.
Cooling to room temperature, adding a Chinese herbal medicine composition for removing acne: 1Kg, and stirring the mixture evenly.
The prepared facial mask essence can be used as an acne-removing facial mask for daily use by people by adding a mask cloth.
Example 3 application of a Chinese herbal medicine composition for removing acne in cream
The cream comprises the following components in percentage by weight:
a Chinese herbal medicine composition for removing acne comprises: 3
Water: TO100
Glycerol: 3
EDTA：0.05
Sodium hyaluronate: 0.05
Acrylamide dimethyl ammonium taurate/VP copolymer: 1
Betaine: 1.5
Cetearyl glucoside, sorbitan olivate, cetearyl alcohol: 1.5
Caprylic/capric triglyceride: 8
The preparation method of the cream comprises the following steps:
82.9Kg of water, 3Kg of glycerin, 0.05Kg of EDTA, 0.05Kg of sodium hyaluronate, 1Kg of acrylamide dimethyl ammonium taurate/VP copolymer and 1.5Kg of betaine are put into an emulsifying pot, heated to 85 ℃, stirred for 30 minutes, homogenized for 3 minutes and uniformly dispersed. Adding cetearyl glucoside, sorbitan olivate, cetearyl alcohol 1.5Kg, caprylic/capric triglyceride 8Kg into oil pan, and dissolving at 85 deg.C.
Cooling to room temperature, adding 3Kg of a Chinese herbal medicine composition for removing freckles, and stirring uniformly.
The preparation of the natural acne-removing face cream is completed.

Claims (5)

1. A Chinese herbal medicine composition for removing acne is characterized by comprising the following components: rehmannia root, mulberry root bark, tree peony bark, Chinese angelica, wrinkled gianthyssop herb, liquorice, coptis root and cimicifuga foetida, and the solvent comprises: octyl glycol, ethylhexyl glycerol, 1, 3-propanediol.
2. The Chinese herbal medicine composition for removing acne according to claim 1, wherein the content of the composition comprises the following mass percent: 10-30% of rehmannia root, 10-30% of mulberry root bark, 10-30% of tree peony bark, 10-30% of Chinese angelica, 10-30% of wrinkled gianthyssop herb, 5-20% of liquorice, 3-10% of coptis root and 3-10% of cimicifuga foetida.
3. The extraction preparation method of the Chinese herbal medicine composition for removing the acne according to any one of claims 1 and 2, which is characterized by comprising the following steps:
(1) washing, drying and pulverizing the composition of claim 1;
(2) the extraction solvent is 75% ethanol;
(3) the extraction process comprises leaching, extracting to obtain extract, adding octyl glycol, ethylhexyl glycerol, and 1, 3-propylene glycol, and dissolving.
4. The extraction and preparation method of the Chinese herbal medicine composition for removing acne according to claim 3,
twice leaching;
primary leaching: adding the mixture into an extraction tank for leaching for 2 hours at the temperature of 50-60 ℃ when the ratio of material to liquid is 1: 5;
secondary leaching: taking out the primary extraction filtrate, adding 75% ethanol into the filter cake according to the material-liquid ratio of 1:3 for secondary extraction, and extracting for 2 hours at the temperature of 50-60 ℃;
mixing the two filtrates, performing plate filtration, and settling to remove impurities;
evaporating the obtained extract to obtain extract;
the dissolving solvent is octyl glycol, ethylhexyl glycerol and 1, 3-propylene glycol in a ratio of 2:3: 5;
and uniformly dissolving the extract and the solvent according to the ratio of 3: 7.
5. The application of the Chinese herbal medicine composition for removing the acne according to claim 4 is used for preparing acne-removing skin care products, including facial masks, water, essences, skin moisturizing creams, creams and washing products, and the addition amount is 1-5%.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569152A (en) * 2020-12-22 2021-03-30 山东花物堂生物科技有限公司 Oil-control anti-inflammatory plant combined extract and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102247473A (en) * 2011-08-15 2011-11-23 成都绿迪科技有限公司 Chinese medicinal formula for treating whelk
CN102283937A (en) * 2010-06-17 2011-12-21 苏州知微堂生物科技有限公司 Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof
CN106511218A (en) * 2016-12-28 2017-03-22 广州市聚吉科绿色化学共性技术研究院有限公司 Emulsion capable of removing acne
CN109528506A (en) * 2018-12-14 2019-03-29 安徽大学 A kind of multiple-effect blemish clearing gel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102283937A (en) * 2010-06-17 2011-12-21 苏州知微堂生物科技有限公司 Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof
CN102247473A (en) * 2011-08-15 2011-11-23 成都绿迪科技有限公司 Chinese medicinal formula for treating whelk
CN106511218A (en) * 2016-12-28 2017-03-22 广州市聚吉科绿色化学共性技术研究院有限公司 Emulsion capable of removing acne
CN109528506A (en) * 2018-12-14 2019-03-29 安徽大学 A kind of multiple-effect blemish clearing gel

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
崔珏等: "桑白皮总黄酮的抗氧化与镇痛活性研究", 《食品科学》 *
王晓林等: "藿香、葫芦巴总黄酮的体外抗氧化活性研究", 《中国调味品》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569152A (en) * 2020-12-22 2021-03-30 山东花物堂生物科技有限公司 Oil-control anti-inflammatory plant combined extract and preparation method and application thereof

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