CN102283937A - Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof - Google Patents
Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof Download PDFInfo
- Publication number
- CN102283937A CN102283937A CN2010102011021A CN201010201102A CN102283937A CN 102283937 A CN102283937 A CN 102283937A CN 2010102011021 A CN2010102011021 A CN 2010102011021A CN 201010201102 A CN201010201102 A CN 201010201102A CN 102283937 A CN102283937 A CN 102283937A
- Authority
- CN
- China
- Prior art keywords
- medicine
- preparing
- technology
- novel form
- nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a technology for preparing a novel integrated dosage form of stomach-clearing powder and a production method thereof. The novel integrated dosage form comprises the following raw materials of effective ingredients: 6 parts by weight of raw rehmannia, 6 parts by weight of Angelica body, 9 parts by weight of moutan bark, 6 parts by weight of Coptis chinensis and 9 parts by weight of cimicifugae foetidae. The production method comprises the steps including supersonic airflow pulverizing, alcohol water extraction, ultrasonic crushing extraction, water frying concentration, nano-grinding, high-pressure homogenizing, nano-particle preparation and the like. According to the novel integrated dosage form disclosed by the invention, the advantages, such as multi-cooperation, multi-targeting and the like, are embodied by utilizing a nano-carrier joint application technology; after the scale production is realized, the production cost can be greatly reduced; the product quality can be greatly increased; the targeting property and the slow controlled release property of drugs are stronger; internal and external drug deliveries can be realized at the same time; the drugs can be taken respectively during four time periods according to meridional lingers and a human blood flow law; the drugs can also be prepared into film agents and transdermal agents which can be respectively pasted on different positions of human bodies according to the meridional lingers and the human blood flow law; and the drugs can be directly absorbed through skin.
Description
Technical field
The present invention relates to the integrated novel form technology of preparing of a kind of QINGWEI SAN, the invention still further relates to integrated novel form technology of preparing of a kind of QINGWEI SAN and production method thereof.
Background technology
Chinese medicine decocting liquid compound recipe drug effect chemical reaction is too many because of chemical constituent, temporarily also not revealed its mysterious veil, but some mysterious black box drug actions are just ensconced in the Chinese medicine decocting liquid in the Chinese medicinal formulae, can not ask Chinese medicine westernization, the modernization of Chinese medicine simply most and only use monomer and effective site.The Chinese medicine water drug-decocting concentrating liquid could not be given it up! When the Chinese medicinal formulae water decocts, because prescription closes chemical environment complicated in high temperature when frying in shallow oil and the solution, reaction such as complexation, hydrolysis, oxidation, reduction between intrinsic material may take place in solution, thereby some novel substance that did not have originally in the generation solution, these novel substances produce drug actions such as potentiation, attenuation or modification to full side.New component forms the research of mechanism, stability and drug effect thereof in the reinforcement Chinese medicinal formulae decocting liquid, to improving Chinese medicine compound and new drug level, progressively dwindle Chinese medicine compound and new Chinese medicine and international gap, crucial meaning is arranged, also increased new way and new source simultaneously for the research and development new Chinese medicine.China's drug control relevant laws and regulations regulation changes dosage form and manages as new drug research.The backwardness of preparation level not only influences the performance of curative effect of medication, and cause the medicine added value low, directly influencing the market competition and industrial economy benefit, is to cause China's medical industry product quantity to occupy prostatitis, the world and the output value only is equivalent to the one of the main reasons of one or two transnational drugmaker.New drug, novel form exploitation level can embody the economy and the technical strength of the medical industry of a country.China's oral formulations accounts for 2/3 of various whole body drug-delivery preparations, and accelerating development and promoting oral sustained-release preparation is the work that current urgent need will be done.QINGWEI SAN derives from gold " secret record of the orchid chamber ", is made up of Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Moutan, Rhizoma Coptidis, Rhizoma Cimicifugae.Function: clearing stomach removing heat from blood.Cure mainly toothache due to stomach-fire, toothache traction headache, the buccal heating, its tooth is liked cold aversion to heat, or gingival atrophy is hemorrhage, or red swelling of gingiva festers, or the words cheek swells and ache, and implication heat is smelly, dry mouth and tougue, red tongue with yellow fur, slippery and rapid pulse.We are usually used in stomatitis, periodontitis, trigeminal neuralgia etc. and belong to rising up of the stomach-fire person.We card is by stomach long-pending heat to be arranged, follow through on attack due to.The stomach channel of foot-Yang-ming is followed nose and go into to be gone up tooth, passes through cheek on the large intesting channel of Hand-Yangming and goes into lower tooth, and pathogenic heat in the stomach is contained, and then implication heat is smelly to follow upper punch; Stomach is the internal organs of the many blood of many gas, and the every hyperamization of gastric heat divides also heat, injury of small vessels, so gingival atrophy is hemorrhage, and ulcer of gums very then; Dry mouth and tougue, red tongue with yellow fur, slippery and rapid pulse all are the time of gastric heat Tianjin wound.Control suitable clearing stomach removing heat from blood.The side is monarch with the Rhizoma Coptidis of bitter cold pathogenic fire purging, the heat of directly rolling over the stomach internal organs.The Rhizoma Cimicifugae that minister is slightly cold with Gan Xin, one gets its heat-clearing and toxic substances removing, to control toothache due to stomach-fire; One gets diffusing saturating the sending out of its light clear liter, but the volt that Xuan Dayu holds back is fiery, and the meaning of " dispersing fire for treating depression of fire " is arranged.Rhizoma Coptidis gets Rhizoma Cimicifugae, and residence rises in falling, then pathogenic fire purging and do not have the fraud that cold is held back; Rhizoma Cimicifugae gets Rhizoma Coptidis, then looses fire and does not have the anxiety of the flame of liter.Gastric heat is contained and has been invaded and blood system, and then consumption impairment of YIN blood, so with Radix Rehmanniae removing heat from blood YIN nourishing; The Cortex Moutan heat clearing and blood cooling is all ministerial drug.Chinese Angelica blood replonishing is invigorated blood circulation, and to help reducing swelling and alleviating pain, is adjuvant drug.Rhizoma Cimicifugae is held concurrently with tying-in to making.All medicines share, and play the effect of clearing stomach removing heat from blood altogether, so that go up scorching fiery must falling, the hot of blood system must remove, then follow through outside send out disease all, all can be because of thorough separating in the pyretic toxicity.
The QINGWEI SAN modern pharmacological research:
QINGWEI SAN mainly contains antibacterial, immunity, antiinflammatory, calmness, analgesia, effects such as hemostasis.The Radix Rehmanniae aqueous extract has obvious hypotensive effect to acute experiment hypertension, and the yellow acicular crystal of Radix Rehmanniae ethanol extraction gained can shorten the rabbit clotting time, and the existing anastalsis of Radix Rehmanniae has blood coagulation resisting function again, and its mechanism remains further to be studied.Radix Rehmanniae has obvious sedation, helps alleviating hypertensive patient's symptom, obviously improves the insomnia that the hypertensive patient causes, effective percentage reaches 94%.Someone thinks that the calm composition of Radix Rehmanniae is mainly the hydrotrope, the Radix Rehmanniae aqueous extract has obvious inhibitory action to the mouse peritoneum inflammation that vascular permeability increases and acetic acid causes that histamine causes, acute inflammation due to the Ovum Gallus domesticus album also there is antiinflammatory action, the Radix Rehmanniae water extract can significantly increase the T lymphocyte in the peripheral blood, the Radix Rehmanniae alcohol extract can obviously promote anti-SRPC antibody-hemolysin to generate, and Radix Rehmanniae water logging agent has inhibitory action to multiple fungi growth such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.Radix Rehmanniae has the effect that promotes the lymphoblastic conversion of body, increases the T lymphocyte quantity, and can strengthen the phagocytic function of reticuloendothelial system, and is more obvious to immunologic hypofunction person effect especially.
Radix Angelicae Sinensis has the protection heart, arrhythmia, and the atherosclerosis myocardial infarction suppresses smooth muscle, antiplatelet aggregation, antiinflammatory action has the enhancing human body immunity function, the protection of cerebral ischemia, antitumor makes cell proliferation, effects such as the liver protecting and kidney.
Cortex Moutan has stronger inhibitory action to dysentery bacterium, Bacillus typhi etc., and paeonol has tangible refrigeration function, experimental results show that: paeonol has central inhibitory actions such as calmness, cooling, analgesic, analgesia, spasmolytic.Cortex Moutan extract and Radix Paeoniae phenol can suppress the Cycloxygenase reaction, make the synthetic minimizing of thromboxane A2, thereby have blood coagulation resisting function.Cortex Moutan methanolic extract, paeonol, n-butyl alcohol soluble fraction and soluble fraction separate the monoterpene glycoside that obtains, and can strengthen the effect that male mouse liver Kupffer is engulfed carbon granules, strengthen the cell number of abdominal cavity leachate; The same with positive control drug reticuloendothelial system activator zymosan, can obviously shorten the interior carbon particle of body and clean up the time.
The Rhizoma Coptidis decoct has inhibitory action to various bacteria such as dysentery bacterium, shigella, Bacillus tuberculosis and multiple viruses such as influenza A virus PR8 pearl and 56-S8 pearl.Rhizoma Coptidis has function of gallbladder promoting, excited uterus and antitumaous effect.Rhizoma Coptidis decoct 100% concentration, Plating experiment show all has stronger bacteriostasis to 5 kinds of gram positive bacterias such as 7 kinds of gram negative bacterias such as dysentery dysentery bacillus, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus and staphylococcus, a-Hemolytic streptococcus, B-Hemolytic streptococcus, Diplococcus pneumoniae, bordetella pertussis.
The Rhizoma Cimicifugae water extract is injected in the effect that animal has blood pressure lowering, suppresses cardiac muscle, decreased heart rate.There is report to point out that Rhizoma Cimicifugae has stronger inhibitory action to staphylococcus aureus, anthrax bacillus.Group B streptococcus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli, dysentery bacterium also there is in various degree inhibitory action.The methanolic extract of Rhizoma Cimicifugae can prevent the animal liver damage that carbon tetrachloride brings out effectively.
Novelty and breakthrough that the present invention has essence are to have found out the key point that QINGWEI SAN modern Chinese medicine novel form Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of QINGWEI SAN " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Research and development have reached world lead level.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent data library searching.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this integrated novel form technology of preparing is to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment mass action that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to utilization nano-carrier multiple techniques development modern Chinese medicine.These will promote the development of China's Chinese medicine industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and integrated novel form technology of preparing of a kind of QINGWEI SAN and production method thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
Integrated novel form technology of preparing of a kind of QINGWEI SAN and production method thereof, wherein: this integrated novel form raw materials of effective components and weight proportion---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
Integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.Described protection domain is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
Further, integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.Described excipient substance is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
Further, integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
Again further, integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
Integrated novel form technology of preparing of a kind of QINGWEI SAN and production method thereof, it may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Moutan micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% Rhizoma Coptidis, Rhizoma Cimicifugae micropowder, adopt the ultrasonic dispersing pulverizing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, Chinese medicine extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, Chinese medical concrete or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances by latest edition " preparation part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
Integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof; wherein: the Chinese medicine of using in described step 1, step 2, the step 3 is pulverized and extracting method; described protection domain is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
Further; integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof; wherein: crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing, the described step 7, nano-emulsion; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
Further, integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: its key point 1 is different utilization nano-carrier multiple techniques different according to the nanometer particle size of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
Again further, integrated novel form technology of preparing of above-mentioned a kind of QINGWEI SAN and production method thereof, wherein: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in:
Novelty and breakthrough that the present invention has essence are to have found out the key point that the QINGWEI SAN Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of QINGWEI SAN " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent data library searching.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this integrated novel form technology of preparing and production method thereof are to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment assosting effect that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to the different nano-carrier dosage form technologies of preparing of Chinese medicine and unite use.Be to adopt Chinese medicine crude drug nano-powder, monomer, effective site, effective part group, Chinese medicine concentrated extract, water drug-decocting concentrating liquid, nano-medicament carrier etc. to unite use on the compatibility.These various Chinese traditional powder particle diameter major parts of filling a prescription are the granule of 50～1000 nanometers.Adopting different nano-medicament carriers to be prepared into nanoparticle, nanosphere, nanocapsule, solid ester matter nanoparticle, nano-emulsion, vesicle, pharmacosomes, microcapsule, nanoparticle, millimicro ball, millimicro assists etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of pharmacology, targeting, reasonable compatibility mixes, and is respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer, the drug targeting of the overall coordination therapeutical effect of this Chinese medicine compound novel form, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Broken through the traditional monarch compatibility theory of the traditional Chinese medical science, for the modern Chinese medicine development provides a practical effective novel form compatibility program.Be to have substantial technological innovation to break through.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
Integrated novel form technology of preparing of a kind of QINGWEI SAN and production method thereof, its special feature is: making the raw materials of effective components composition is by weight ratio---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Further, play the synergy of standing like the legs of a tripod on the integrated new drug formulation compatibility of QINGWEI SAN of the present invention: 1, prepare nanometer, micro-powder, the bioavailability after strengthening the QINGWEI SAN curative effect and significantly improve prepared slices of Chinese crude drugs cell wall breaking with this with the prepared slices of Chinese crude drugs; 2, with Chinese medicine extract and select suitable pharmaceutical carrier, prepare different Chemistry for Chinese Traditional Medicine monomers, effective ingredient, effective site etc., confirm and strengthen pharmacology, the efficacy of the chemical substance of QINGWEI SAN with this; 3, prepare Chinese medical concrete, water drug-decocting concentrating liquid with the prepared slices of Chinese crude drugs, the temporary transient unpredictable drug effect of bringing with this reaction such as complexation, hydrolysis, oxidation, reduction of strengthening QINGWEI SAN Chinese medicine compound uniqueness also keeps and has strengthened traditional Chinese medical science organic conception, monarch notion.More than three aspects associatings compatibility use, different according to Nano medication particle diameter and character, can reach effects such as many targeting, many collaborative, slow controlled releases, and play useful effect to strengthening the medicine pharmacologically active, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention may further comprise the steps: at first, gets each prepared slices of Chinese crude drugs pretreatment, inserts pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, and standby.Getting 30%--90% alcohol-water solution that 60% Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Moutan micropowder doubly measure with 6-12 mixes and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.Get 60% Rhizoma Coptidis, Rhizoma Cimicifugae micropowder, adopt the ultrasonic dispersing pulverizing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, Chinese medicine extract with standby.With step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50 nanometers-1000 nanometer, standby.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets Chinese medical concrete or water drug-decocting concentrating liquid with standby.With step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.Adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron." preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.In GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can make the above-mentioned end product of other type by the related preparations standard criterion.The end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
" embodiment one "
Press the following crude drug of preceding method preparation:
Extractum, nanoparticle, microcapsule, nanoparticle.
It makes the raw materials of effective components composition---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Its manufacture process is as follows:
In GMP10000 level toilet with extractum, nanoparticle, microcapsule, nanoparticle in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia hard capsule standard in 2010, do not add adjuvant, antiseptic, adopt fully-automatic capsule filling machine fill hard capsule, make hard capsule.Carry out several again, bottle, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment two "
Press the following crude drug of preceding method preparation:
Water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion.
It makes the raw materials of effective components composition---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Its manufacture process is as follows:
In GMP10000 level toilet with water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia soft capsule standard in 2010, do not add adjuvant, antiseptic, adopt full-automatic soft capsule filling machine packing soft capsule to make soft capsule.Carry out several again, bottle, seal, decals pastes, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment three "
Press the following crude drug of preceding method preparation:
Extractum, nanoparticle, nano-emulsion.
It makes the raw materials of effective components composition---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Its manufacture process is as follows:
After in the GMP10000 level toilet extractum, nanoparticle, nano-emulsion being mixed in 4: 3: 3 ratios, " a preparation part of Chinese pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, makes membrane to adopt version in 2010.Adorn box again, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.Every membrane area size is the 2-40 square centimeter, and every medicine film pasted 12-72 hour, pasted the medicine position: positions such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
By above-mentioned text description as can be seen: novelty and breakthrough that the present invention has essence are to have found out the key point that QINGWEI SAN Chinese medicine compound Chinese and western medicine theory combines, and the compound compatibility of modern Chinese medicine and technology of preparing can change the pharmacokinetic parameter of medicine monomer, effective ingredient or effective part group.This has proved the scientific meaning of Chinese medicine compound compatibility from the pharmacokinetics level." very just being harmonious; negative and positive intercommunication, coordinating water and fire, precise and tiny circle melt; greatness lies in the capacity " is the elite in the classical works such as Chinese Zhou Yi, Taoism, Huang di's Canon of Medicine, is simple philosophy doctrine thought, also is the research and development thinking and the basic guiding theory of the integrated novel form of this medicine.The traditional Chinese medical science always just has saying of the easy homology of doctor, skill of a doctor homology.This precise and tiny circle of the present invention just melts integration theoretical basis.Among the present invention: monomer, effective site, nanoparticle and carrier etc. be strange, be tiny, be cloudy.Traditional Chinese medical science organic conception, Chinese medical concrete, water drug-decocting concentrating liquid etc. be just, be grand, be the sun.Very just be harmonious then negative and positive intercommunication, the negative and positive intercommunication is then coordinating water and fire, is the optimum balance attitude.Doctor trained in Western medicine research is precise and tiny, and theory of Chinese medical science is that circle melts, and both very just are harmonious, and have just really embodied the organic conception of the combination of Chinese and Western medicine, and " close " is that " integration " is for holding.The tidemark that greatness lies in the capacity, the coordinating water and fire the present invention of being only asked most.This integrated novel form is by the reasonable compatibility of Chinese medicine monomer, effective site, active substance, Chinese medicine active substance group, extractum, water drug-decocting concentrating liquid, prepared slices of Chinese crude drugs nano-particle etc., can produce soft, hard capsule or dosage forms such as nanometer membrane, transdermal agent.Can develop simultaneously, can take four time periods respectively by interior external administration by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Can also do film former to nanometer Chinese medicine, transdermal agent is attached to the human body different parts, can directly absorb by skin.
See that further the various Chinese medicine particle diameter major parts that the present invention prepares are the granule of 50～1000 nanometers.Adopt different nano-medicament carriers and technology can be prepared into nanoparticle, nanosphere, solid ester plastid, nano-emulsion, pharmacosomes, microgranule, millimicro ball, little assist etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of medicine pharmacology, targeting, reasonable compatibility mixes, and can be respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer or Western medicine, overall coordination therapeutical effect of this integrated novel form and drug targeting, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Having broken through the traditional monarch compatibility theory of the traditional Chinese medical science, is the innovation and the model of Chinese medicine tradition compatibility theory and traditional Chinese medical science pharmaceutics, for the preparation of QINGWEI SAN modern Chinese medicine and production have proposed a practical effective novel form compatibility program.Be to have substantial preparation consolidation and innovation and technological break-through.
Claims (10)
1. integrated novel form technology of preparing of QINGWEI SAN and production method thereof is characterized in that: this novel form raw materials of effective components and weight proportion---
6 parts of Radix Rehmanniae, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Moutans, 6 parts of Rhizoma Coptidis, 9 parts of Rhizoma Cimicifugaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
2. integrated novel form technology of preparing of a kind of QINGWEI SAN according to claim 1 and production method thereof, it is characterized in that: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.The described protection domain of this claim is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
3. according to claim 1, integrated novel form technology of preparing of 2 described a kind of QINGWEI SAN and production method thereof, it is characterized in that: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.The described protection domain of this claim is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
4. according to claim 1 or 2 or 3 any integrated novel form technology of preparing of described a kind of QINGWEI SAN and production methods thereof, it is characterized in that: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
5. according to claim 1 or 2 or 3 or 4 any integrated novel form technology of preparing of described a kind of QINGWEI SAN and production methods thereof, it is characterized in that: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
6. integrated novel form technology of preparing of QINGWEI SAN and production method thereof is characterized in that may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Moutan micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% Rhizoma Coptidis, Rhizoma Cimicifugae micropowder, adopt the ultrasonic dispersing pulverizing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, get extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, extractum or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
7. integrated novel form technology of preparing of a kind of QINGWEI SAN according to claim 6 and production method thereof; it is characterized in that: pulverizing of using in described step 1, step 2, the step 3 and extracting method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
8. integrated novel form technology of preparing of a kind of QINGWEI SAN according to claim 7 and production method thereof; it is characterized in that: crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing and the described step 7, nano-emulsion; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
9. integrated novel form technology of preparing of a kind of QINGWEI SAN according to claim 8 and production method thereof, it is characterized in that: its key point 1 is different utilization nano-carrier multiple techniques different according to the nanometer particle size of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
10. integrated novel form technology of preparing of a kind of QINGWEI SAN according to claim 9 and production method thereof is characterized in that: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102011021A CN102283937A (en) | 2010-06-17 | 2010-06-17 | Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102011021A CN102283937A (en) | 2010-06-17 | 2010-06-17 | Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102283937A true CN102283937A (en) | 2011-12-21 |
Family
ID=45330873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102011021A Pending CN102283937A (en) | 2010-06-17 | 2010-06-17 | Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102283937A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257864A (en) * | 2014-10-27 | 2015-01-07 | 济南舜景医药科技有限公司 | Medicine for treating toothache, and preparation method |
| CN104740483A (en) * | 2015-04-24 | 2015-07-01 | 高元琴 | Traditional Chinese medicine used for treating recurrent oral ulceration |
| CN111419940A (en) * | 2020-04-18 | 2020-07-17 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for removing acne |
-
2010
- 2010-06-17 CN CN2010102011021A patent/CN102283937A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257864A (en) * | 2014-10-27 | 2015-01-07 | 济南舜景医药科技有限公司 | Medicine for treating toothache, and preparation method |
| CN104740483A (en) * | 2015-04-24 | 2015-07-01 | 高元琴 | Traditional Chinese medicine used for treating recurrent oral ulceration |
| CN111419940A (en) * | 2020-04-18 | 2020-07-17 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for removing acne |
| CN111419940B (en) * | 2020-04-18 | 2022-04-12 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for removing acne |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102284015A (en) | Integrated novel form preparation technology for powder with marvellous effect and production method thereof | |
| CN102283927A (en) | Technology for preparing novel integrated dosage form of windflower decoction | |
| CN102100751A (en) | Preparation technology of new integrative formulation of largetrifoliolious bugbane rhizome and kudzuvine root decoction and production method thereof | |
| CN102100813A (en) | Preparation technology of new integrative formulation of poria five powder and production method thereof | |
| CN102283937A (en) | Technology for preparing novel integrated dosage form of stomach-clearing powder and production method thereof | |
| CN102283892A (en) | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form | |
| CN102100886A (en) | Technology and method for preparing novel combined formulation of relieving-edema decoction | |
| CN102100888A (en) | Preparation technology and production method of new integrative formulation of major green-blue dragon decoction | |
| CN102283926A (en) | Preparation technology and production method for novel integrated dosage form of liver fire-purging and stomach-regulating pill | |
| CN102283944A (en) | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof | |
| CN102846746A (en) | Preparation process of integration-type novel formulation of Aconitum carmichaeli decoction and production method thereof | |
| CN102100892A (en) | Preparation technology and production method of integrated Xiaojianzhong decoction novel dosage form | |
| CN102284024A (en) | Preparation technology of integrated novel Weijing decoction dosage form | |
| CN102283990A (en) | Technology for preparing novel sweet wormwood and turtle shell decoction integrated preparation | |
| CN102895358A (en) | Preparation technology and production method for integrated new formulation of three-yellow decoction | |
| CN102100756A (en) | Preparation technology of integrated rhubarb and aconite decoction novel dosage form | |
| CN103028095A (en) | Preparation technology and production method of integrated new dosage form of dry ginger and Radix aconiti lateralis preparata decoction | |
| CN102283948A (en) | Preparation technology and production method of integrated novel Wuwei Xiaodu drink dosage form | |
| CN102895615A (en) | Preparation technology and production method for integrated new formulation of tangerine peel and bamboo shavings decoction | |
| CN102847085A (en) | Preparation process and production method for Magnolia Officinalis Seven-Ingredient Decoction preparation in an integrated new dosage form | |
| CN102526647A (en) | Preparation technology and production method of novel dual-purpose decoction integrated dosage form | |
| CN102283936A (en) | Integrated novel form preparation technology for Sisheng Wan and production method thereof | |
| CN102552412A (en) | Preparation technology and production method of integrated novel dosage form of cardamom soup | |
| CN102846985A (en) | Preparation process and production method for Ophiopogon Japonicus Decoction preparation in an integrated new dosage form | |
| CN103028069A (en) | Preparation technology and production method of integrated new dosage form of Tieshua decoction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Suzhou Zhiweitang Biotechnology Co.,Ltd. Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111221 |