CN102283990A - Technology for preparing novel sweet wormwood and turtle shell decoction integrated preparation - Google Patents
Technology for preparing novel sweet wormwood and turtle shell decoction integrated preparation Download PDFInfo
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Abstract
The invention relates to a technology for preparing a novel sweet wormwood and turtle shell decoction integrated preparation. The preparation comprises the following effective components in parts by weight: 6 parts of sweet wormwood, 15 parts of turtle shell, 12 parts of rehmannia root, 6 parts of anemarrhena, and 9 parts of bark of tree peony. The preparation process comprises the following steps of supersonic airflow pulverizing, alcohol-water extraction, supersonic pulverizing extraction, decoction and concentration, nano-grinding, high-pressure homogenization, nano-particle preparation and the like. The technology pays attention to the application of the advantages of multi-collaboration multi-target and the like represented by a nano-carrier combination technology. After the technology is applied to production in scale, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release performance of the medicament can be stronger. The preparation can be administrated internally and externally simultaneously, can be taken in four time segments respectively according to midnight-noon ebb-flow and human body qi-blood flowing rule, also can be prepared to form a film-forming agent and transdermal agent to be applied to different positions of a human body respectively according to the midnight-noon ebb-flow and human body qi-blood flowing rule, and can be directly absorbed through skin.
Description
Technical field
The present invention relates to the integrated novel form of a kind of QINGHAOBIEJIATANG, the invention still further relates to the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG.
Background technology
Chinese medicine decocting liquid compound recipe drug effect chemical reaction is too many because of chemical constituent, temporarily also not revealed its mysterious veil, but some mysterious black box drug actions are just ensconced in the Chinese medicine decocting liquid in the Chinese medicinal formulae, can not ask Chinese medicine westernization, the modernization of Chinese medicine simply most and only use monomer and effective site.The Chinese medicine water drug-decocting concentrating liquid could not be given it up! When the Chinese medicinal formulae water decocts, because prescription closes chemical environment complicated in high temperature when frying in shallow oil and the solution, reaction such as complexation, hydrolysis, oxidation, reduction between intrinsic material may take place in solution, thereby some novel substance that did not have originally in the generation solution, these novel substances produce drug actions such as potentiation, attenuation or modification to full side.New component forms the research of mechanism, stability and drug effect thereof in the reinforcement Chinese medicinal formulae decocting liquid, to improving Chinese medicine compound and new drug level, progressively dwindle Chinese medicine compound and new Chinese medicine and international gap, crucial meaning is arranged, also increased new way and new source simultaneously for the research and development new Chinese medicine.
China's drug control relevant laws and regulations regulation changes dosage form and manages as new drug research.The backwardness of preparation level not only influences the performance of curative effect of medication, and cause the medicine added value low, directly influencing the market competition and industrial economy benefit, is to cause China's medical industry product quantity to occupy prostatitis, the world and the output value only is equivalent to the one of the main reasons of one or two transnational drugmaker.
New drug, novel form exploitation level can embody the economy and the technical strength of the medical industry of a country.China's oral formulations accounts for 2/3 of various whole body drug-delivery preparations, and accelerating development and promoting oral sustained-release preparation is the work that current urgent need will be done.
QINGHAOBIEJIATANG derives from " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ".The side is by Herba Artemisiae Annuae 6 grams, and Carapax Trionycis 15 restrains, Radix Rehmanniae 12 grams, and the Rhizoma Anemarrhenae 6 grams, Cortex Moutan 9 grams are formed.Function: yin nourishing is diathermanous.Cure mainly volt card in the pathogenic heat, show as night fever abating at dawn, heat is moved back lossless, and it is thin to eat shape, the few tongue of red tongue, rapid pulse.Card such as pulmonary tuberculosis, anemia, other Chronic consumptionss belongs to the hyperactivity of fire caused by deficiency of YIN person, the treatment of available we's plus-minus.Carapax Trionycis is directly gone into cloudy the branch in the side, salty-cold YIN nourishing, and with reducing the asthenic fever, the heat clearing away of Herba Artemisiae Annuae fragrance is poison thoroughly, draws heresy and goes out.Two share, diathermanous and impairment of YIN not, and yin nourishing and do not love heresy is main altogether.The sweet cool YIN nourishing of the Radix Rehmanniae, Rhizoma Anemarrhenae bitter cold is moistened, and helps Carapax Trionycis with reducing the asthenic fever.The Cortex Moutan removing heat from blood is diathermanous, helps the latent heat of Herba Artemisiae Annuae with the cloudy branch of expelling heat from the exterior.Modern study confirms, that we have is analgesic, calm, antibiotic, antiinflammatory, inhibition are led and turned usefulness into, nourish strong effect.Modern clinically be usually used in treating disease such as febrile disease later stage, children's's summer fever, pulmonary tuberculosis, renal tuberculosis, pyelonephritis and above-mentioned disorder is arranged.
The pharmacological action of QINGHAOBIEJIATANG: mainly contain effects such as analgesic, antiinflammatory, calmness, resisting pathogenic microbes.QINGHAOBIEJIATANG is clinical tangible refrigeration function.Herba Artemisiae Annuae, the Rhizoma Anemarrhenae, Cortex Moutan also have refrigeration function.QINGHAOBIEJIATANG can suppress organism autoimmune and allergic inflammation, and experimental arthritis is had inhibitory action.Rat is taken the plasma corticosterone determining alcohol rising that the nourishing YIN to lower pathogenic fire Chinese medicine Radix Rehmanniae, Carapax Trionycis, the Rhizoma Anemarrhenae, Cortex Moutan all can make dexamethasone suppress, and prevents the effect of atrophy of adrenal gland.QINGHAOBIEJIATANG is formed medical instrument calmness, spasmolysis, and Cortex Moutan also has inhibitory action to the excitation activity due to the caffeine.QINGHAOBIEJIATANG is formed medicine all has in various degree inhibitory action to Bacillus typhi, dysentery bacterium, diphtheria corynebacterium, staphylococcus, streptococcus pneumoniae etc.The Rhizoma Anemarrhenae also has stronger anti-mycobacterium tuberculosis effect.
The pharmacological action of Herba Artemisiae Annuae: zoopery proves that arteether extracts neutral fraction and its rare pure extractum all has remarkable malaria effect to Mus malaria, monkey malaria and people's malaria.Mouse experiment shows that arteannuin has tangible killing action to imago of blood fluke, and it impels polypide " liver moves " though the time is slower, and insecticidal action is then rapider, and is more obvious to the effect of female worm.The Herba Artemisiae Annuae water decoction disperses respectively to extract to staphylococcus epidermidis, micrococcus catarrhalis, anthrax extraction equipment, and ultrasonic power is: 800W 3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, gets extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, extractum or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Agglutination.The existing anastalsis of Radix Rehmanniae has blood coagulation resisting function again, and its mechanism remains further to be studied.Radix Rehmanniae remains further to be studied to the effect of blood glucose.Single Radix Rehmanniae hypoglycemic activity is more remarkable than Radix Puerariae; The hypoglycemic activity of Rehmanniae Bolus of Eight Ingredients is not better than the single Radix Rehmanniae.The bosom Radix Rehmanniae has obvious sedation, and its site of action may be at cerebral cortex.The sedation of Radix Rehmanniae helps alleviating hypertensive patient's symptom, obviously improves the insomnia that the hypertensive patient causes, effective percentage reaches 94%.The Radix Rehmanniae decoct is irritated stomach has tangible antagonism to rat formaldehyde arthritis and albumen arthritis, and can suppress the increase of the capillary permeability that granuloma that the Oleum Terebinthinae subcutaneous injection causes and histamine cause.Have report to think that the Radix Rehmanniae water extract can significantly increase the T lymphocyte in the peripheral blood, the Radix Rehmanniae alcohol extract can obviously promote anti-SRPC antibody-hemolysin to generate, and reduces peripheral blood T lymphocyte, and the Radix Rehmanniae Preparata water extract does not then have this effect.Radix Rehmanniae water logging agent has inhibitory action to multiple fungi growth such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.Radix Rehmanniae has the inhibitory action of antagonism dexamethasone to hypophysis-interrenal system, and can promote the synthetic of adrenocortical hormone.Clinical observation finds, Radix Rehmanniae and glucocorticoid share the side effect that can reduce the hyperactivity of YANG due to deficiency of YIN that hormone causes.It is generally acknowledged, the antitumor action of Radix Rehmanniae is relevant with the increase immunologic function, Radix Rehmanniae has the effect that promotes the lymphoblastic conversion of body, increases the T lymphocyte quantity, and can strengthen the phagocytic function of reticuloendothelial system, and is more obvious to immunologic hypofunction person effect especially.After report anesthetized dog intravenous injection Radix Rehmanniae extractum was arranged, the urine amount had increase in the unit interval, and the diuresis principle may be relevant with effects such as its heart tonifying and blood vessel dilating; But report is also arranged, and Radix Rehmanniae decocting extractum and pure extractum fail to be proved to the diuresis of rat.
The pharmacological action of the Rhizoma Anemarrhenae: Rhizoma Anemarrhenae decoct has inhibitory action to Bacillus typhi, Salmonella paratyphi, dysentery bacterium, escherichia coli, Bacillus proteus, vibrio cholera and staphylococcus etc.The decoct tube dilution method, more than 10 kind of tinea fungus such as 10%～25% pair of trichophyton has inhibitory action in various degree.The Rhizoma Anemarrhenae causes that to x-ray bombardment the mouse skin infringement has protective effect.Rhizoma Anemarrhenae polysaccharide A, B, C, D can make the blood glucose of normal mouse or hyperglycemia mice descend.The Rhizoma Anemarrhenae can delay the metabolism of liver to hydrocortisone.Chinaroot greenbrier sapogenin is concentration dependent inhibitory action to the human red blood cell sodiumpotassium pump in the Rhizoma Anemarrhenae.Zhimusaponin unit 5mg/ml, Rhizoma Anemarrhenae decoct 1g/ml irritate stomach, can obviously reduce the high thyroxin state mouse brain beta-receptor binding capacity that triiodothyronine causes.Rhizoma Anemarrhenae decoct can improve triiodothyronine and cause " hyperthyroidism " mouse brain M-receptors bind capacity, makes it to be tending towards normal.
The pharmacological action of Cortex Moutan: the paeonol lumbar injection, the over-activity due to Mus spontaneous activity and the caffeine all there is sedation, heavy dose can cause sleep; Can suppress the mouse writhing reaction, the mouse tail tenderness is had analgesic effect; Have bring down a fever, the central inhibitory actions such as convulsions due to anti-galvanic shock, anti-army tetrazolium and the nicotinamide.The intravenous injection Cortex Moutan extract has obvious protective effect to myocardial ischemia due to the dog coronary ligation.Decoct, go paeonol decoct or paeonol intravenous injection, anesthesia Canis familiaris L. and rat are all had hypotensive effect; Paeonol all has inhibitory action to zoopery arthritis, allergic inflammation.Paeonol has antiinflammatory action to experimental arthritis, otitis, and can reduce the permeability of blood capillary.Can prevent stress due to the mice Peptic Ulcers, suppress the gastric secretion of rat; Mice, isolated ileum segments in guinea pigs there are more weak anti-acetylcholine and antihistamine effect, and can suppress the autonomic movement of rat in the body uterus; To dividing a word with a hyphen at the end of a line of multiple drug-induced rat paw edema, rat pleuritis polymorphonuclear leukocyte, inhibitory action is arranged all; To Cavia porcellus Forssman cutaneous vasculitis, the reverse skin allergy of rat, rat active and passive Arthus reaction, reach allergic inflammations such as delayed hypersensitivity, inhibitory action is all arranged.The Cortex Moutan decoct is irritated stomach, and the Mice Auricle that xylol causes is swollen, and on Carrageenan, Ovum Gallus domesticus album, formaldehyde-caused rat paw edema all have inhibitory action; The models of passive skin irritability of rats reaction that Radix Trichosanthis is caused, reverse allergic inflammations such as skin allergy, Arthus reaction all have inhibitory action.The LD50 of paeonol mouse mainline, lumbar injection and filling stomach is respectively 196mg/kg, 781mg/kg and 3430mg/kg.In addition, Cortex Moutan still has antibacterial, immunological enhancement.
Novelty and breakthrough that the present invention has essence are to have found out the key point that QINGHAOBIEJIATANG modern Chinese medicine novel form Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of QINGHAOBIEJIATANG " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Research and development have reached world lead level.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent retrieval.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further: this integrated novel form technology of preparing is to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment mass action that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to utilization nano-carrier multiple techniques development modern Chinese medicine.These will promote the development of China's Chinese medicine industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, provides a kind of QINGHAOBIEJIATANG integrated novel form technology of preparing.
Purpose of the present invention is achieved through the following technical solutions:
The integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG, wherein: this integrated novel form raw materials of effective components and weight proportion---
6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
The integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.Described protection domain is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
Further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.Described excipient substance is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
Further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
Again further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
The integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG, it may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Herba Artemisiae Annuae, Carapax Trionycis, Radix Rehmanniae micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% the Rhizoma Anemarrhenae, Cortex Moutan micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, Chinese medical concrete or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances by version in 2010 " preparation part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
The integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG; wherein: the Chinese medicine of using in described step 1, step 2, the step 3 is pulverized and extracting method; described protection domain is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
Further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing and the described step 7, nano-emulsion.The described protection domain of this claim is not only described technology of preparing and method, as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
Further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
Again further, the integrated novel form technology of preparing of above-mentioned a kind of QINGHAOBIEJIATANG, wherein: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in:
Novelty and breakthrough that the present invention has essence are to have found out the key point that the QINGHAOBIEJIATANG Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of QINGHAOBIEJIATANG " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent data library searching.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this integrated novel form technology of preparing is to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment assosting effect that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to the different nano-carrier dosage form technologies of preparing of Chinese medicine and unite use.Be to adopt Chinese medicine crude drug nano-powder, monomer, effective site, effective part group, Chinese medicine concentrated extract, water drug-decocting concentrating liquid, nano-medicament carrier etc. to unite use on the compatibility.These various Chinese traditional powder particle diameter major parts of filling a prescription are the granule of 50～1000 nanometers.Adopting different nano-medicament carriers to be prepared into nanoparticle, nanosphere, nanocapsule, solid ester matter nanoparticle, nano-emulsion, vesicle, pharmacosomes, microcapsule, nanoparticle, millimicro ball, millimicro assists etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of pharmacology, targeting, reasonable compatibility mixes, and is respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer, the drug targeting of the overall coordination therapeutical effect of this Chinese medicine compound novel form, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Multichip carrier and multiple medicines thing monomer etc. are united use, have broken through the traditional monarch compatibility theory of the traditional Chinese medical science, for the modern Chinese medicine development provides a practical effective novel form compatibility program.Be to have substantial technological innovation to break through.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
The integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG, its special feature is: making the raw materials of effective components composition is by weight ratio---
6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Further, play the synergy of standing like the legs of a tripod on the integrated new drug formulation compatibility of QINGHAOBIEJIATANG of the present invention: 1, prepare nanometer, micro-powder, the bioavailability after strengthening the QINGHAOBIEJIATANG curative effect and significantly improve prepared slices of Chinese crude drugs cell wall breaking with this with the prepared slices of Chinese crude drugs; 2, with Chinese medicine extract and select suitable pharmaceutical carrier, prepare different Chemistry for Chinese Traditional Medicine monomers, effective ingredient, effective site etc., confirm and strengthen pharmacology, the efficacy of the chemical substance of QINGHAOBIEJIATANG with this; 3, prepare Chinese medical concrete, water drug-decocting concentrating liquid with the prepared slices of Chinese crude drugs, the temporary transient unpredictable drug effect of bringing with this reaction such as complexation, hydrolysis, oxidation, reduction of strengthening QINGHAOBIEJIATANG Chinese medicine compound uniqueness also keeps and has strengthened traditional Chinese medical science organic conception, monarch notion.More than three aspects associatings compatibility use, different according to Nano medication particle diameter and character, can reach effects such as many targeting, many collaborative, slow controlled releases, and play useful effect to strengthening the medicine pharmacologically active, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention may further comprise the steps:
At first, get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.Get 30%--90% alcohol-water solution that 60% Herba Artemisiae Annuae, Carapax Trionycis, Radix Rehmanniae micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times is extracted water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol, extract with standby.Get 60% the Rhizoma Anemarrhenae, Cortex Moutan micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W 3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, get extract with standby.With step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50 nanometers-1000 nanometer, standby.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets Chinese medical concrete or water drug-decocting concentrating liquid with standby.With step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.Adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron." preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.In GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can make the above-mentioned end product of other type by the related preparations standard criterion.The end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
" embodiment one "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, microcapsule, nanoparticle.
It makes the raw materials of effective components composition---6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Its manufacture process is as follows: in GMP10000 level toilet with extractum, nanoparticle, microcapsule, nanoparticle in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia hard capsule standard in 2010, do not add adjuvant, antiseptic, adopt fully-automatic capsule filling machine fill hard capsule, make hard capsule.Carry out several again, bottle, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment two "
Press the following crude drug of preceding method preparation: water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion.
It makes the raw materials of effective components composition---6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Its manufacture process is as follows: in GMP10000 level toilet with water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia soft capsule standard in 2010, do not add adjuvant, antiseptic, adopt full-automatic soft capsule filling machine packing soft capsule, make soft capsule.Carry out several again, bottle, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment three "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, nano-emulsion.
It makes the raw materials of effective components composition---6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Its manufacture process is as follows: after in 10000 grades of toilets of GMP extractum, nanoparticle, nano-emulsion being mixed in 4: 3: 3 ratios, " a preparation part of Chinese pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, makes membrane to adopt version in 2010.Adorn box again, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.Every membrane area size is the 2-40 square centimeter, and every medicine film pasted 12-72 hour, pasted the medicine position: positions such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
By above-mentioned text description as can be seen: novelty and breakthrough that the present invention has essence are to have found out the key point that QINGHAOBIEJIATANG Chinese medicine compound Chinese and western medicine theory combines, and the compound compatibility of modern Chinese medicine and technology of preparing can change the pharmacokinetic parameter of medicine monomer, effective ingredient or effective part group.This has proved the scientific meaning of Chinese medicine compound compatibility from the pharmacokinetics level." very just being harmonious; negative and positive intercommunication, coordinating water and fire, precise and tiny circle melt; greatness lies in the capacity " is the elite in the classical works such as Chinese Zhou Yi, Taoism, Huang di's Canon of Medicine, is simple philosophy doctrine thought, also is the research and development thinking and the basic guiding theory of the integrated novel form of this medicine.The traditional Chinese medical science always just has saying of the easy homology of doctor, skill of a doctor homology.This precise and tiny circle of the present invention just melts integration theoretical basis.Among the present invention: monomer, effective site, nanoparticle and carrier etc. be strange, be tiny, be cloudy.Traditional Chinese medical science organic conception, Chinese medical concrete, water drug-decocting concentrating liquid etc. be just, be grand, be the sun.Very just be harmonious then negative and positive intercommunication, the negative and positive intercommunication is then coordinating water and fire, is the optimum balance attitude.Doctor trained in Western medicine research is precise and tiny, and theory of Chinese medical science is that circle melts, and both very just are harmonious, and have just really embodied the organic conception of the combination of Chinese and Western medicine, and " close " is that " integration " is for holding.The tidemark that greatness lies in the capacity, the coordinating water and fire the present invention of being only asked most.This integrated novel form is by the reasonable compatibility of Chinese medicine monomer, effective site, active substance, Chinese medicine active substance group, extractum, water drug-decocting concentrating liquid, prepared slices of Chinese crude drugs nano-particle etc., can produce soft, hard capsule or dosage forms such as nanometer membrane, transdermal agent.Can develop simultaneously, can take four time periods respectively by interior external administration by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Can also do film former to nanometer Chinese medicine, transdermal agent is attached to the human body different parts, can directly absorb by skin.
See that further the various Chinese medicine particle diameter major parts that the present invention prepares are the granule of 50～1000 nanometers.Adopt different nano-medicament carriers and technology can be prepared into nanoparticle, nanosphere, solid ester plastid, nano-emulsion, pharmacosomes, microgranule, millimicro ball, little assist etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of medicine pharmacology, targeting, reasonable compatibility mixes, and can be respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer or Western medicine, overall coordination therapeutical effect of this integrated novel form and drug targeting, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Having broken through the traditional monarch compatibility theory of the traditional Chinese medical science, is the innovation and the model of Chinese medicine tradition compatibility theory and traditional Chinese medical science pharmaceutics, for the preparation of QINGHAOBIEJIATANG modern Chinese medicine and production have proposed a practical effective novel form compatibility program.Be to have substantial preparation consolidation and innovation and technological break-through.
Claims (10)
1. integrated novel form technology of preparing of QINGHAOBIEJIATANG is characterized in that: this novel form raw materials of effective components and weight proportion---
6 parts of Herba Artemisiae Annuaes, 15 parts of Carapax Trionycis, 12 parts in the Radix Rehmanniae, 6 parts of the Rhizoma Anemarrhenaes, 9 parts of Cortex Moutans.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
2. the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG according to claim 1, it is characterized in that: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.The described protection domain of this claim is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
3. according to claim 1, the integrated novel form technology of preparing of 2 described a kind of QINGHAOBIEJIATANG, it is characterized in that: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.The described protection domain of this claim is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
4. according to claim 1 or 2 or 3 any integrated novel form technologies of preparing of described a kind of QINGHAOBIEJIATANG, it is characterized in that: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
5. according to claim 1 or 2 or 3 or 4 any integrated novel form technologies of preparing of described a kind of QINGHAOBIEJIATANG, it is characterized in that: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
6. integrated novel form technology of preparing of QINGHAOBIEJIATANG is characterized in that may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Herba Artemisiae Annuae, Carapax Trionycis, Radix Rehmanniae micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% the Rhizoma Anemarrhenae, Cortex Moutan micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, get extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, extractum or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
7. the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG according to claim 6; it is characterized in that: pulverizing of using in described step 1, step 2, the step 3 and extracting method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
8. the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG according to claim 7; it is characterized in that: crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing and the described step 7, nano-emulsion; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
9. the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG according to claim 8, it is characterized in that: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
10. the integrated novel form technology of preparing of a kind of QINGHAOBIEJIATANG according to claim 9 is characterized in that: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
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Cited By (2)
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| CN103007011A (en) * | 2013-01-03 | 2013-04-03 | 浙江大学 | Application of sweet wormwood and turtle shell composition to preparation of drugs |
| CN105168252A (en) * | 2015-09-30 | 2015-12-23 | 河南行知专利服务有限公司 | Preparation technology and application of non-decocted preparation containing animal bone and shell type traditional Chinese medical materials |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103007011A (en) * | 2013-01-03 | 2013-04-03 | 浙江大学 | Application of sweet wormwood and turtle shell composition to preparation of drugs |
| CN105168252A (en) * | 2015-09-30 | 2015-12-23 | 河南行知专利服务有限公司 | Preparation technology and application of non-decocted preparation containing animal bone and shell type traditional Chinese medical materials |
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Application publication date: 20111221 |