CN102283897A - Preparation technology and production method of integrated novel Fangji Huangqi decoction dosage form - Google Patents
Preparation technology and production method of integrated novel Fangji Huangqi decoction dosage form Download PDFInfo
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Abstract
The invention relates to preparation technology and production method of an integrated novel Fangji Huangqi decoction dosage form. The integrated novel dosage form comprises the following active ingredients in parts by weight: 12 parts of radix stephaniae tetrandrae, 15 parts of radix astragali, 6 parts of liquorice and 9 parts of atractylodes macrocephala koidz. The production process comprises the following steps: supersonic jet milling, extraction in aqueous alcohol, ultrasonic milling and extraction, decoction in water and concentration, supersonic spray drying, nanoscale grinding, high-pressure homogenization, nanoparticle preparation and the like. The preparation technology and production method have the following characteristics and progresses: the advantages of multiple collaboration, multiple targets and the like embodied by utilizing a nano carrier combined technology are emphasized; after large scale production, the production cost can be substantially lowered, the product quality can be substantially improved and the targeting and slow/controlled release properties of medicaments are stronger; the dosage form can be simultaneously administrated internally and externally and can be taken in four time slots respectively according to the midnight-noon ebb-flow and the human blood flow rule; and the dosage form can be prepared into film agents and transdermal agents and then the agents are respectively stuck to different parts of human bodies according to the midnight-noon ebb-flow and the human blood flow rule and can be directly absorbed through skins.
Description
Technical field
The present invention relates to the integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction, the invention still further relates to integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction and production method thereof.
Background technology
Chinese medicine decocting liquid compound recipe drug effect chemical reaction is too many because of chemical constituent, temporarily also not revealed its mysterious veil, but some mysterious black box drug actions are just ensconced in the Chinese medicine decocting liquid in the Chinese medicinal formulae, can not ask Chinese medicine westernization, the modernization of Chinese medicine simply most and only use monomer and effective site.The Chinese medicine water drug-decocting concentrating liquid could not be given it up! When the Chinese medicinal formulae water decocts, because prescription closes chemical environment complicated in high temperature when frying in shallow oil and the solution, reaction such as complexation, hydrolysis, oxidation, reduction between intrinsic material may take place in solution, thereby some novel substance that did not have originally in the generation solution, these novel substances produce drug actions such as potentiation, attenuation or modification to full side.New component forms the research of mechanism, stability and drug effect thereof in the reinforcement Chinese medicinal formulae decocting liquid, to improving Chinese medicine compound and new drug level, progressively dwindle Chinese medicine compound and new Chinese medicine and international gap, crucial meaning is arranged, also increased new way and new source simultaneously for the research and development new Chinese medicine.China's drug control relevant laws and regulations regulation changes dosage form and manages as new drug research.The backwardness of preparation level not only influences the performance of curative effect of medication, and cause the medicine added value low, directly influencing the market competition and industrial economy benefit, is to cause China's medical industry product quantity to occupy prostatitis, the world and the output value only is equivalent to the one of the main reasons of one or two transnational drugmaker.New drug, novel form exploitation level can embody the economy and the technical strength of the medical industry of a country.China's oral formulations accounts for 2/3 of various whole body drug-delivery preparations, and accelerating development and promoting oral sustained-release preparation is the work that current urgent need will be done.Tetrandra and Astragalus Decoction side comes from Han dynasty Zhang Zhongjing " Medical Treasures of the Golden Chamber ".The side is by Radix Stephaniae Tetrandrae one or two (12g), and the Radix Astragali one or two 1 minutes (15g) goes reed, and Radix Glycyrrhizae half two (6g) fry, and the Rhizoma Atractylodis Macrocephalae seven money half (9g) are formed.Function: QI invigorating is dispeled the wind, invigorating spleen for diuresis.Cure mainly edema due to wind pathogen or rheumatism.Perspiration and aversion to wind, heavy sensation of the body, dysuria, pale tongue with white fur, floating pulse.We's treatment edema due to wind pathogen, rheumatism belong to the prescription commonly used of exterior deficiency syndrome.With perspiration and aversion to wind, dysuria, the tongue the lung-pulse is floating controls main points for demonstrate,proving.Be applicable to that chronic glomerulonephritis, cardiac edema, rheumatic arthritis etc. belong to the wet Sheng person of exterior deficiency.
The pharmacological action of Radix Stephaniae Tetrandrae: Radix stephaniae tetrandrae can obviously increase voided volume.Total alkali and fluid extract or decoct have analgesic activity.Tetrandrine has antiinflammatory action; Cardiac muscle there is protective effect, can expands coronary vasodilator, increase coronary flow, remarkable hypotensive effect is arranged, can be to arrhythmia; Obviously anticoagulant can also promote fibrinolysis, the blood coagulation process that Trombin inhibiting causes; Experimental silicosis there is the prophylactic treatment effect; Uterine contraction there is tangible relexation; The tetrandrine of low concentration can make intestinal tension force increase, and rhythmicity is shunk and strengthened, and high concentration then reduces tension force and weakens the rhythmicity contraction; The effect of antibiotic and anti-ameba is arranged; Normal rat blood glucose is obviously reduced, and serum insulin obviously raises; Certain antitumor action is arranged; Immunity there is inhibitory action; Anti-allergic effects is widely arranged.Radix Aristolochiae Fangchi can improve non-specific immunity, and phagocytosis of macrophages is strengthened; Contained Aristolochic Acid has inhibitory action to staphylococcus aureus.
The pharmacological action of the Radix Astragali: the Radix Astragali has the effect of strengthening its contraction to normal heart, and for because of poisoning or tiredly being in depleted heart, the cardiotonic of the Radix Astragali is more remarkable.To isolated frog heart, the low dose of inhibition earlier of (+)-Astragenol extracting solution back is excited, and heavy dose then produces inhibitory action.Have report to think that the Radix Astragali has tangible cardiotonic, contractive amplitude is increased, blood discharge amount increases, and under high concentration, stops for the property relaxing period between idol is visible.The Radix Astragali has hypotensive effect.Astragalus decoction gavages the rat in spontaneously hypertensive, can make the increased blood pressure amplitude obtain certain control.There is report to point out that Radix Astragali hypotensive effect mainly is the result of direct blood vessel dilating, and there is no dependence with heart, also irrelevant with cholinergic system, histamine release or adrenergic α, beta receptor effect.The Radix Astragali has the obvious anti-fatigue effect, and this effect produces by its adrenal cortex reinforcing function.The experimenter thinks that the astragalus polysaccharides I can increase spleen weight and cell number, but suppresses splenocyte to immune response, the astragalus polysaccharides II of sheep red blood cell (SRBC) are similar to I but, the astragalus polysaccharides III does not have effect.Astragalus saponin 1 is given mouse subcutaneous injection, can make the interior macrophage phagocytic function of mouse lymph knot active, secondary lysosome and residual body showed increased in the cell, the synthetic increase of primary lysosome, volume increases, enzyme content increases, and astragalus saponin 1 can obviously promote differentiation of lymph node B cell proliferation and plasma cell antibody to synthesize.Astragalus polysaccharides can resist the atrophy effect of immuning tissues such as spleen due to the immunosuppressant meticortelone, thymus, colic lymph nodes and to the effect of periphery leukopenia; Can strengthen cytophagous phagocytic function.Astragalus decoction can promote the lymhocyte transformation rate of normal person and tumour patient, and the Radix Astragali can promote the body cell immunologic function.Radix Astragali decocting liquid can make thymocyte cell glucocorticoid receptor (GR) concentration reduce by 40%, shows that it has the T cell differentiation of promotion and sophisticated effect.The Radix Astragali all has antibacterial action to shigella, anthrax bacillus, Diplococcus pneumoniae, alpha-Hemolytic streptococcus, beta hemolytic streptococcus, diphtheria and bacillus pseudodiphthericus, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus, bacillus subtilis etc.Astragalus polysaccharides has tangible antagonism to tubercle bacillus affection.Radix Astragali injection has the effect that suppresses virus to mouse mainline.And the mice of I type influenza infection there is the obvious treatment effect.Other compositions of the Radix Astragali such as aminoacid, alkaloid, flavone and glycoside all have the effect of remarkable anti-folliculus stomatitis virus.
The pharmacological action of Radix Glycyrrhizae: flavonoid glycosides has obvious protective effect to the rat experiment ulcer in Radix Glycyrrhizae extractum and the Radix Glycyrrhizae.Radix Glycyrrhizae extractum, glycyrrhizin and enoxolone all have promotion sodium to healthy people and animal, the effect of water retention; Low dose of glycyrrhizin (every 100ug) can make rat chest gland atrophy and adrenal gland's weight increase, and produces the effect of glucocorticoid cortisone sample.Then the effect of glucocorticoid sample is not obvious when heavy dose of, only presents the effect of mineralocorticoid sample.Radix Glycyrrhizae extractum and glycyrrhizin all have certain detoxification ability to some drugs poisoning, alimentary toxicosis, interior metabolism product poisoning.The effective ingredient of Detoxication is a glycyrrhizin, detoxification machine is made as glycyrrhizin has adsorption to poisonous substance, glycyrrhizin hydrolyzate glucuronic acid can combine with poisonous substance, and glycyrrhizin have the effect of adrenocortical hormone sample, the result of the aspect combined factors effects such as detoxification ability of enhancing liver.Enoxolone has tangible central antitussive effect, and heavy dose of enoxolone can make mouse breathing suppress.Glycyrrhizin, glycyrrhetate still have anti-inflammatory and antiallergic, anti-liver injury, anti-promoting, antibiotic, anti AIDS virus (glycyrrhizin) effect in addition.
The pharmacological action of the Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae not only increases the drainage of water, also promote the particularly discharge of sodium of electrolyte, and the drainage of sodium also is better than the drainage of water.Rabbit is irritated stomach decoct or extractum, and blood glucose has reduction slightly.The rat oral gavage decoct has the assimilation thereby the blood sugar lowering of glucose in the acceleration bodies.Mice decoct for oral administration has the liver protecting, prevents the liver glycogen minimizing effect that carbon tetrachloride causes.Rhizoma Atractylodis Macrocephalae decoct is irritated stomach 1mol or 6g/kg, can promote the mice weight increase and strengthen swimming endurance, the Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system, the mice reticuloendothelial system is activation, promote the phagocytic function of Turnover of Mouse Peritoneal Macrophages, make the phagocytic percentage of macrophage, phagocytic index and lysosome digestion thereof on average significantly increase than matched group.When leukopenia, the Rhizoma Atractylodis Macrocephalae has leukogenic effect.The Rhizoma Atractylodis Macrocephalae can also improve lymhocyte transformation rate and natural Flos Rosae Rugosae formation rate, promotes cellular immune function, and obviously increases IgG.Illustrate that the Rhizoma Atractylodis Macrocephalae has the effect of strengthening the spleen and stomach, strong health and disease resistance enhancemen.The Rhizoma Atractylodis Macrocephalae has the obvious suppression effect to platelet aggregation, and Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg irritates stomach 1-4 week, the time of energy significant prolongation rat prothrombing.In vitro tests shows that the neutral oil in the Rhizoma Atractylodis Macrocephalae volatile oil has obvious inhibitory action to esophageal cancer cell.Rhizoma Atractylodis Macrocephalae volatile oil is to the inhibitory action of murine sarcoma-180 the strongest (suppression ratio is 31-49%).The Rhizoma Atractylodis Macrocephalae has tangible antagonism to the tetanic property of the isolated small intestines of rabbits contraction due to acetylcholine, the dichloride barium, and to adding the active inhibition of isolated rabbit small intestinal due to the epinephrine, the Rhizoma Atractylodis Macrocephalae can this effect of antagonism.Infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.Nearly report Rhizoma Atractylodis Macrocephalae decoct and decoction of four noble drugs all have in various degree bacteriostasis to Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus etc., and do not have bactericidal action.The tender white muscle skin of Rhizoma Atractylodis Macrocephalae energy, slow down aging, whitening and speckle dispelling.Air making-up and spleen enlivening is also arranged, effect such as defying age, antioxidation, anticoagulation, blood fat reducing, blood sugar lowering, antibacterial, diuresis.Rhizoma Atractylodis Macrocephalae powder is mixed well with vinegar, evenly smeared on the face, can control freckle and black speck.
Novelty and breakthrough that the present invention has essence are to have found out the key point that Tetrandra and Astragalus Decoction modern Chinese medicine novel form Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of Tetrandra and Astragalus Decoction " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Research and development have reached world lead level.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent retrieval.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this integrated novel form technology of preparing is to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment mass action that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to utilization nano-carrier multiple techniques development modern Chinese medicine.These will promote the development of China's Chinese medicine industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction and production method thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
Integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: this integrated novel form raw materials of effective components and weight proportion---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
Integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.Described protection domain is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.Further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.Described excipient substance is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
Further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
Again further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
Integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction and production method thereof, it may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Radix Stephaniae Tetrandrae, Radix Astragali micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, Chinese medical concrete or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances by version in 2010 " preparation part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
Integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof; wherein: the Chinese medicine of using in described step 1, step 2, the step 3 is pulverized and extracting method; described protection domain is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
Further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing and the described step 7, nano-emulsion.The described protection domain of this claim is not only described technology of preparing and method, as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
Further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
Again further, integrated novel form technology of preparing of above-mentioned a kind of Tetrandra and Astragalus Decoction and production method thereof, wherein: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be made into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in:
Novelty and breakthrough that the present invention has essence are to have found out the key point that the Tetrandra and Astragalus Decoction Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of Tetrandra and Astragalus Decoction " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, and does not have identical or similar bibliographical information both at home and abroad.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent data library searching.Utilize domestic and international data base to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains to draw a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano-powder that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. go out the nanosphere of different-grain diameter size with the different pharmaceutical preparing carriers, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, the immune nano grain, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, the millimicro ball, millimicro is assisted etc., and mixing is respectively charged into soft then, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) utilization nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product have characteristics such as targeting distributes extensively, slow controlled release properties is strong; Do not see open report at home in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this integrated novel form technology of preparing and production method thereof are to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, with the organic conception of theory of Chinese medical science and collaborative idea and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of paying attention between medicine is the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to the effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer treatment, pay attention to Chinese medicine active substance, effective site and active substance group the treatment assosting effect that disease played.Pay attention to the contained trace element of Chinese medicine to the treatment assosting effect that disease played.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to the different nano-carrier dosage form technologies of preparing of Chinese medicine and unite use.Be to adopt Chinese medicine crude drug nano-powder, monomer, effective site, effective part group, Chinese medicine concentrated extract, water drug-decocting concentrating liquid, nano-medicament carrier etc. to unite use on the compatibility.These various Chinese traditional powder particle diameter major parts of filling a prescription are the granule of 50～1000 nanometers.Adopting different nano-medicament carriers to be prepared into nanoparticle, nanosphere, nanocapsule, solid ester matter nanoparticle, nano-emulsion, vesicle, pharmacosomes, microcapsule, nanoparticle, millimicro ball, millimicro assists etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of pharmacology, targeting, reasonable compatibility mixes, and is respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer, the drug targeting of the overall coordination therapeutical effect of this Chinese medicine compound novel form, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Multichip carrier and multiple medicines thing monomer etc. are united use, have broken through the traditional monarch compatibility theory of the traditional Chinese medical science, for the modern Chinese medicine development provides a practical effective novel form compatibility program.Be to have substantial technological innovation to break through.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
Integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction and production method thereof, its special feature is: making the raw materials of effective components composition is by weight ratio---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Further, play the synergy of standing like the legs of a tripod on the integrated new drug formulation compatibility of Tetrandra and Astragalus Decoction of the present invention: 1, prepare nanometer, micro-powder, the bioavailability after strengthening the Tetrandra and Astragalus Decoction curative effect and significantly improve prepared slices of Chinese crude drugs cell wall breaking with this with the prepared slices of Chinese crude drugs; 2, with Chinese medicine extract and select suitable pharmaceutical carrier, prepare different Chemistry for Chinese Traditional Medicine monomers, effective ingredient, effective site etc., confirm and strengthen pharmacology, the efficacy of the chemical substance of Tetrandra and Astragalus Decoction with this; 3, prepare Chinese medical concrete, water drug-decocting concentrating liquid with the prepared slices of Chinese crude drugs, the temporary transient unpredictable drug effect of bringing with this reaction such as complexation, hydrolysis, oxidation, reduction of strengthening Tetrandra and Astragalus Decoction Chinese medicine compound uniqueness also keeps and has strengthened traditional Chinese medical science organic conception, monarch notion.More than three aspects associatings compatibility use, different according to Nano medication particle diameter and character, can reach effects such as many targeting, many collaborative, slow controlled releases, and play useful effect to strengthening the medicine pharmacologically active, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention may further comprise the steps:
At first, get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.Get 30%--90% alcohol-water solution that 60% Radix Stephaniae Tetrandrae, Radix Astragali micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times is extracted water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol, extract with standby.Get 60% Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, get extract with standby.With step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50 nanometers-1000 nanometer, standby.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets Chinese medical concrete or water drug-decocting concentrating liquid with standby.With step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.Adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron." preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.In GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can make the above-mentioned end product of other type by the related preparations standard criterion.The end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
" embodiment one "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, microcapsule, nanoparticle.
It makes the raw materials of effective components composition---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Its manufacture process is as follows: in GMP10000 level toilet with extractum, nanoparticle, microcapsule, nanoparticle in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia hard capsule standard in 2010, do not add adjuvant, antiseptic, adopt fully-automatic capsule filling machine fill hard capsule, make hard capsule.Carry out several again, bottle, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment two "
Press the following crude drug of preceding method preparation: water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion.
It makes the raw materials of effective components composition---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Its manufacture process is as follows: in GMP10000 level toilet with water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia soft capsule standard in 2010, do not add adjuvant, antiseptic, adopt full-automatic soft capsule filling machine packing soft capsule, make soft capsule.Carry out several again, bottle, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment three "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, nano-emulsion.
It makes the raw materials of effective components composition---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Its manufacture process is as follows: after in the GMP10000 level toilet extractum, nanoparticle, nano-emulsion being mixed in 4: 3: 3 ratios, " a preparation part of Chinese pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, makes membrane to adopt version in 2010.Adorn box again, seal, paste labeling, play exterior and interior packings such as sign indicating number, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.Every membrane area size is the 2-40 square centimeter, and every medicine film pasted 12-72 hour, pasted the medicine position: positions such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
By above-mentioned text description as can be seen: novelty and breakthrough that the present invention has essence are to have found out the key point that Tetrandra and Astragalus Decoction Chinese medicine compound Chinese and western medicine theory combines, and the compound compatibility of modern Chinese medicine and technology of preparing can change the pharmacokinetic parameter of medicine monomer, effective ingredient or effective part group.This has proved the scientific meaning of Chinese medicine compound compatibility from the pharmacokinetics level." very just being harmonious; negative and positive intercommunication, coordinating water and fire, precise and tiny circle melt; greatness lies in the capacity " is the elite in the classical works such as Chinese Zhou Yi, Taoism, Huang di's Canon of Medicine, is simple philosophy doctrine thought, also is the research and development thinking and the basic guiding theory of the integrated novel form of this medicine.The traditional Chinese medical science always just has saying of the easy homology of doctor, skill of a doctor homology.This precise and tiny circle of the present invention just melts integration theoretical basis.Among the present invention: monomer, effective site, nanoparticle and carrier etc. be strange, be tiny, be cloudy.Traditional Chinese medical science organic conception, Chinese medical concrete, water drug-decocting concentrating liquid etc. be just, be grand, be the sun.Very just be harmonious then negative and positive intercommunication, the negative and positive intercommunication is then coordinating water and fire, is the optimum balance attitude.Doctor trained in Western medicine research is precise and tiny, and theory of Chinese medical science is that circle melts, and both very just are harmonious, and have just really embodied the organic conception of the combination of Chinese and Western medicine, and " close " is that " integration " is for holding.The tidemark that greatness lies in the capacity, the coordinating water and fire the present invention of being only asked most.This integrated novel form is by the reasonable compatibility of Chinese medicine monomer, effective site, active substance, Chinese medicine active substance group, extractum, water drug-decocting concentrating liquid, prepared slices of Chinese crude drugs nano-particle etc., can produce soft, hard capsule or dosage forms such as nanometer membrane, transdermal agent.Can develop simultaneously, can take four time periods respectively by interior external administration by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Can also do film former to nanometer Chinese medicine, transdermal agent is attached to the human body different parts, can directly absorb by skin.
See that further the various Chinese medicine particle diameter major parts that the present invention prepares are the granule of 50～1000 nanometers.Adopt different nano-medicament carriers and technology can be prepared into nanoparticle, nanosphere, solid ester plastid, nano-emulsion, pharmacosomes, microgranule, millimicro ball, little assist etc.Its particle size distribution is between 10 microns of 10 nanometers----.According to difference, the difference and the traditional Chinese medical science monarch theory of slow controlled release time of medicine pharmacology, targeting, reasonable compatibility mixes, and can be respectively charged among hard capsule and the soft capsule then.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into targeted systems such as RE targeted system, stomach mucosa absorption system, small intestinal absorption system, colon absorption system respectively.Compare Chinese medicine and medicine monomer or Western medicine, overall coordination therapeutical effect of this integrated novel form and drug targeting, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Having broken through the traditional monarch compatibility theory of the traditional Chinese medical science, is the innovation and the model of Chinese medicine tradition compatibility theory and traditional Chinese medical science pharmaceutics, for the preparation of Tetrandra and Astragalus Decoction modern Chinese medicine and production have proposed a practical effective novel form compatibility program.Be to have substantial preparation consolidation and innovation and technological break-through.
Claims (10)
1. integrated novel form technology of preparing of Tetrandra and Astragalus Decoction and production method thereof is characterized in that: this novel form raw materials of effective components and weight proportion---
12 parts of Radixs Stephaniae Tetrandrae, 15 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, 9 parts of the Rhizoma Atractylodis Macrocephalaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
2. integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction according to claim 1 and production method thereof, it is characterized in that: medicine is become medicine support material medicine with preparing carriers, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, the microcapsule etc., and can as required one or more be mixed.The described protection domain of this claim is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not influence its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
3. according to claim 1, integrated novel form technology of preparing of 2 described a kind of Tetrandra and Astragalus Decoctions and production method thereof, it is characterized in that: the drug carrier material that this novel form is selected for use, activating agent, help Emulsion, excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.The described protection domain of this claim is not only the said medicine adjuvant in the described scope, and other do not influence its disease of controlling to be also included within its basic upward interpolation, and just make the excipient substance of its better efficacy.
4. according to claim 1 or 2 or 3 any integrated novel form technology of preparing of described a kind of Tetrandra and Astragalus Decoction and production methods thereof, it is characterized in that: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active substance group, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
5. according to claim 1 or 2 or 3 or 4 any integrated novel form technology of preparing of described a kind of Tetrandra and Astragalus Decoction and production methods thereof, it is characterized in that: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
6. integrated novel form technology of preparing of Tetrandra and Astragalus Decoction and production method thereof is characterized in that may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, adopt supersonic airstream to be crushed to the 1-10 micron then, get different Chinese medicine micropowder, standby.
Step 2: get 30%--90% alcohol-water solution that 60% Radix Stephaniae Tetrandrae, Radix Astragali micropowder doubly measure with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility simultaneously, recovered alcohol gets extract with standby.
Step 3: get 60% Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae micropowder, adopt the ultrasonic dispersing extraction equipment of independent research to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, get extract with standby.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt the nanon ball-mill of independent research to grind 4-16 hour, get particle size distribution and be the nano powder of 50-1000 nanometer, standby.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, extractum or water drug-decocting concentrating liquid with standby.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared respectively, obtain medicine materials such as different medicine monomers, effective site, active substance group.
Step 7: adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " requirement of version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " in 2005 in waiting adopts the high pressure breast to spare method respectively in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanometer suspension liquid, crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with above-mentioned mixed raw materials medicine adopt the fully-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out several respectively, bottles, adorns box, seals, pastes labeling, plays exterior and interior packings such as sign indicating number, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
7. integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction according to claim 6 and production method thereof; it is characterized in that: pulverizing of using in described step 1, step 2, the step 3 and extracting method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
8. integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction according to claim 7 and production method thereof; it is characterized in that: the medicine monomer in the described step 6; active substance; the dissimilar nanoparticle that adopts the different pharmaceutical adjuvant to be prepared in effective site technology of preparing and the described step 7; crude drug such as nano-emulsion; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if; more economical; upgrade; more advanced; the more preparation method of environmental protection and technology.
9. integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction according to claim 8 and production method thereof, it is characterized in that: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targeting.
10. integrated novel form technology of preparing of a kind of Tetrandra and Astragalus Decoction according to claim 9 and production method thereof is characterized in that: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be made into membrane, transdermal agent is attached to the human body different parts respectively by the energy and blood of human body flowing law, can directly absorb by skin.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716330A (en) * | 2012-06-25 | 2012-10-10 | 李良 | Astragalus root traditional Chinese medicine decoction for treating edema and preparation method thereof |
| CN102846714A (en) * | 2012-08-06 | 2013-01-02 | 李承平 | Radix stephaniae tetrandrae and astragalus mongholicus tablet for treating arthralgia |
| CN104857374A (en) * | 2015-06-12 | 2015-08-26 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicinal composition for treating pig rheumatism and preparation method thereof |
| CN109394908A (en) * | 2018-10-08 | 2019-03-01 | 湖北省中医院 | A kind of drug and preparation method thereof for treating chronic primary glomerulus diseases |
-
2010
- 2010-06-17 CN CN2010102010207A patent/CN102283897A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716330A (en) * | 2012-06-25 | 2012-10-10 | 李良 | Astragalus root traditional Chinese medicine decoction for treating edema and preparation method thereof |
| CN102846714A (en) * | 2012-08-06 | 2013-01-02 | 李承平 | Radix stephaniae tetrandrae and astragalus mongholicus tablet for treating arthralgia |
| CN104857374A (en) * | 2015-06-12 | 2015-08-26 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicinal composition for treating pig rheumatism and preparation method thereof |
| CN109394908A (en) * | 2018-10-08 | 2019-03-01 | 湖北省中医院 | A kind of drug and preparation method thereof for treating chronic primary glomerulus diseases |
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