CN111413306A - Fluorescence detector, detection array and method for manufacturing fluorescence detector - Google Patents
Fluorescence detector, detection array and method for manufacturing fluorescence detector Download PDFInfo
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- CN111413306A CN111413306A CN202010265090.2A CN202010265090A CN111413306A CN 111413306 A CN111413306 A CN 111413306A CN 202010265090 A CN202010265090 A CN 202010265090A CN 111413306 A CN111413306 A CN 111413306A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
- G02B6/06—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres the relative position of the fibres being the same at both ends, e.g. for transporting images
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
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Abstract
The invention relates to the technical field of fluorescence detection, in particular to a fluorescence detector, a detection array and a method for preparing the fluorescence detector. The fluorescence signal after gathering with the detection end is surveyed through fluorescence detection circuit and is converted into corresponding signal of telecommunication again, and the fluorescence detector of this application has sensitivity height, the wide and short advantage of response time of collection angle. The fluorescence detection array provided by the application can detect fluorescence signals in a wide angle and a wide range, and can collect the fluorescence signals in various wavelength ranges.
Description
Technical Field
The invention relates to the technical field of fluorescence detection, in particular to a fluorescence detector, a detection array and a method for preparing the fluorescence detector.
Background
Fluorescence, a photoluminescence, is a property of luminescent materials. When a certain normal temperature substance is irradiated by incident light (usually ultraviolet rays or X rays) with a certain wavelength, the absorbed light energy enters an excited state, and immediately excites and emits emergent light with the wavelength of the incident light, which is called 'fluorescence', and the wavelength is usually in the visible light band, i.e. the wavelength range is 400-760 nm.
The application of fluorescence in our daily life is very wide, such as fluorescent lamps used for illumination, fluorescent pens used for marking, fluorescent markers in DNA detection and the like. Fluorescence detection is also one of the important detection methods in many fields, such as oil and gas exploration by using fluorescence analysis to identify whether a rock sample contains oil; in immunofluorescence examination, antibodies are fluorescently labeled and detected to determine the distribution positions of antigens, so that the fluorescence detection technology is a very practical and promising optical detection means, and has important influence on the research fields of biology, medicine, materials science and the like and the clinical medical diagnosis.
At present, two types of fluorescence detectors in the market mainly exist, one type is that a camera is adopted to detect fluorescence information with different wavelengths, the space range of the detection of the camera is large, but the sensitivity is low, and as the fluorescence signal is weak and the service life is short, the response process of the detection and the receiving of the camera is slow, and the acquisition time is long. The other method is a detection method adopting multi-fiber conduction, the response is faster, but the detection space range is smaller, namely the acquisition angle is small, the acquired intensity is small, and the requirement on the photoelectric detector is higher.
Disclosure of Invention
In order to solve the technical problems of small acquisition angle, long response time and low sensitivity of a fluorescence detector in the prior art, the application provides the following technical scheme.
A fluorescence detector, comprising a fluorescence collector for collecting fluorescence, made of a plurality of optical fibers;
the fluorescence collector comprises a collecting end and a detecting end, the fluorescence collector is in a tapered shape from the collecting end to the detecting end, the area of the end face of the collecting end is larger than that of the end face of the detecting end, the collecting end is used for collecting fluorescence signals, and the collected fluorescence signals are collected to the detecting end when being transmitted in the fluorescence detector.
Preferably, the fluorescence detector is conical or truncated cone-shaped.
In one embodiment, the fluorescence detector further comprises a filter disposed on the end face of the detection end for filtering the interference light signal used for passing through fluorescence.
In one embodiment, the fluorescence detector further comprises a fluorescence detection circuit disposed at the detection end of the fluorescence collector, and is configured to detect the fluorescence signal collected by the detection end of the fluorescence collector and convert the fluorescence signal into a corresponding electrical signal.
In one embodiment, the fluorescence detection circuit includes a sensing element and an acquisition circuit electrically connected to the sensing element;
the sensing element is arranged at the detection end of the fluorescence collector and used for converting the fluorescence signal into an electric signal, and the acquisition circuit is used for acquiring the electric signal.
In one embodiment, the sensing element is positioned 0.5mm from the detection end of the fluorescence collector.
In one embodiment, the fluorescent light collector further comprises a sealed housing surrounding the fluorescent light collector and the sensing element.
A fluorescence detection array comprises a plurality of fluorescence detectors as described above, wherein the fluorescence detectors are closely arranged, so that the collection ends of the fluorescence collectors of the fluorescence detectors are on the same plane, and the side faces of two adjacent fluorescence collectors are closely contacted.
A fluorescence detection array, comprising six fluorescence detectors as described above, wherein the six fluorescence detectors are closely arranged, so that the collection ends of the fluorescence collectors of the six fluorescence detectors are on the same plane, and the side faces of two adjacent fluorescence collectors are closely contacted;
the filters with the wavelength ranges of 430 +/-30 nm, 490 +/-30 nm, 550 +/-30 nm, 610 +/-30 nm, 670 +/-30 nm and 730 +/-30 nm are respectively selected for the filters on the detection ends of the six fluorescence collectors.
A method for preparing a fluorescence detector as described above, the method comprising: a plurality of optical fibers are sequentially subjected to regular arrangement, heating, pressure fusion, torsion and stretching to form a tapered fluorescence collector, so that the area of the end face of the collection end of the fluorescence collector is larger than that of the end face of the detection end of the fluorescence collector.
According to the fluorescence detector of the embodiment, the area of the collecting end of the fluorescence collector is large, the fluorescence signals in a large range and a large angle can be collected, the collected signals are transmitted through the optical fiber and collected at the detecting end, and the collected signals are detected by the fluorescence detection circuit to convert the fluorescence signals collected by the detecting end into corresponding electric signals. In addition, the fluorescence detection array of the embodiment can detect fluorescence signals in a wide angle and a wide range, can acquire the fluorescence signals in various wavelength ranges, and has the advantages of high acquisition precision and wide coverage range.
Drawings
FIG. 1 is a front view of a fluorescence collector according to an embodiment of the present application;
FIG. 2 is a top view of a fluorescent collector according to an embodiment of the present application;
FIG. 3 is a schematic structural diagram of a fluorescence detector according to an embodiment of the present application;
FIG. 4 is a top view of a fluorescence detection array according to an embodiment of the present application;
FIG. 5 is a front view of a fluorescence detection array according to an embodiment of the present application;
FIG. 6 is a rear view of a fluorescence detection array according to an embodiment of the present application.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The fluorescence detector provided by the embodiment of the invention comprises the fluorescence collector for collecting fluorescence, and the fluorescence collector is made of a plurality of optical fibers and has the advantages of high transmission speed, high sensitivity and small signal loss during transmission. This its fluorescence collector's collection end area is great, can gather on a large scale and the wide-angle fluorescence signal, and the signal that passes through of gathering collects at the detection end through optical fiber transmission and collection, surveys through fluorescence detection circuit again and convert the fluorescence signal that the detection end collected into corresponding signal of telecommunication, and the fluorescence detector of this embodiment has sensitivity height, gathers the advantage that the angle is wide and response time period with prior art's comparison. In addition, the fluorescence detection array comprises a plurality of fluorescence detectors, can detect fluorescence signals in a wide angle and a wide range, can acquire the fluorescence signals in various wavelength ranges, and has the advantages of high acquisition precision and wide coverage range.
The first embodiment is as follows:
referring to fig. 1 and 2, the fluorescence detector of the present embodiment includes a fluorescence collector 01 for collecting fluorescence, which is made of a plurality of optical fibers, the fluorescence collector 01 includes a collection end 011 and a detection end 012, the collection end 011 to the detection end 012 of the fluorescence collector 01 are tapered, so that the cross-sectional area of the collection end 011 is larger than that of the detection end, the collection end 011 is used for collecting fluorescence signals in a large angle and a large range, when the fluorescence irradiates on the cross-sectional area of the collection end 011, the collected fluorescence signals are collected to the detection end 012 when transmitted in the fluorescence detector, and thus the fluorescence signals transmitted in the optical fibers follow the full emission principle, so that the fluorescence detector has no loss, high transmittance and fast response during transmission, and is collected to the detection end 012.
The fluorescence collector 01 in this embodiment is in a truncated cone shape (may also be considered as a cone shape), the cross-sectional area of the collection end 011 is larger than that of the detection end 012, and the collection end 011 is substantially cylindrical near the end, and then gradually tapers to form the detection end 012, the collection end 011 and the end face of the detection end 012. In other embodiments, the fluorescence collector 01 can be configured in a polygon terrace shape or other tapered shapes, and can also realize the collection of large-angle and large-area fluorescence signals.
Wherein, this fluorescence detector is still including setting up filter 11 on the terminal surface of detection end 012, and filter 11 is used for the filtering to adopt other interference light signals for only fluorescence passes through, makes the precision of gathering higher like this. The filter 11 has the same size as the end face of the probe 012, and is attached to the end face of the probe 012.
Further, the fluorescence detector of the present embodiment further includes a fluorescence detection circuit 21 disposed at the detection end 012 of the fluorescence collector 01, and the fluorescence detection circuit 21 is configured to detect a fluorescence signal collected by the detection end of the fluorescence collector and convert the fluorescence signal into a corresponding electrical signal.
Specifically, as shown in fig. 3, the fluorescence detection circuit 21 of the present embodiment includes a sensing element 211 and an acquisition circuit electrically connected to the sensing element 211, the sensing element is disposed at the detection end 012 of the fluorescence collector 01 and is configured to convert a fluorescence signal into an electrical signal, and the acquisition circuit is configured to acquire the converted electrical signal and send the signal to a computer for processing.
Specifically, the sensing element 211 in this embodiment is disposed at a position 0.5mm below the detection end 012 of the fluorescent collector 01, the acquisition circuit includes a circuit board (not shown), the positive pin 212 and the negative pin 213 are led out from the circuit board, and the positive pin 212 and the negative pin 213 are electrically connected to the sensing element 211, and are configured to supply power to the sensing element and receive an electrical signal.
Further, the fluorescence detector further comprises a sealing shell 31 surrounding the fluorescence collector 01 and the sensing element 211, and since the fluorescence collector 01 and the sensing element 211 are both made of materials which are easily damaged and affected, the fluorescence collector 01 and the sensing element 211 are sealed by the sealing shell 31 to prevent dust from entering, and the sealing shell 31 of the embodiment adopts a glass shell.
After the fluorescence detector is powered on, the fluorescence detection circuit 21 works, and the sensitive element 211 converts the optical signal collected by the fluorescence collector 01 into an electric signal. The detection end 012 of the fluorescence collector 01 is attached to the filter 11, the fluorescence detection circuit 21 is arranged at a position of about 0.5mm below the filter 11, and the fluorescence collector 01 and the sensitive element 211 are sealed by the sealing shell 31 to form the fluorescence detector. The sealed shell 31 is tightly attached to the fluorescent collector 01 and the fluorescent detection circuit 21 through glue or a heat source, so that the working stability of the system is ensured. The fluorescence collector 01 collects the fluorescence signal in the space, and transmits the fluorescence signal to the filter 11 attached to the detection end 012 through the total reflection of the optical fiber, the filter 11 filters out the unwanted fluorescence, the fluorescence with the wavelength range of 430 +/-30 nm is selected to pass through, then the fluorescence signal is converted into an electric signal through the sensitive element 211 of the fluorescence detection circuit 21, and finally the electric signal is processed by the computer, so the work of the fluorescence cone detector is completed.
Example two
The present embodiment provides a fluorescence detection array, which includes a plurality of fluorescence detectors as provided in the first embodiment, and the plurality of fluorescence detectors are closely and neatly arranged, so that the collecting ends of the fluorescence collectors of the plurality of fluorescence detectors are on the same plane, and the side surfaces of two adjacent fluorescence collectors are in close contact, so that the fluorescence detection array can detect fluorescence signals at a wide angle and in a wide range, and can collect fluorescence signals in various wavelength ranges, and has the advantages of high collecting precision and wide coverage.
The filter wavelength ranges of the filter plates arranged on the detection ends of the fluorescence collectors of the fluorescence detectors are different, so that fluorescence in different wavelength ranges can be collected, the light intensity of each light wave can be increased, and the size of the probe can be reduced.
It should be noted that the arrangement of the plurality of fluorescence collectors in the fluorescence detection array may have various forms according to the requirement, for example, one of the fluorescence collectors is used as a center, and the others are arranged circumferentially around the center, or arranged in several rows, each row having a plurality of arrangements.
EXAMPLE III
The present embodiment provides a fluorescence detection array, as shown in fig. 4-6, which includes six fluorescence detectors provided in the first embodiment, wherein the fluorescence collectors of the six fluorescence detectors are respectively indicated by reference numerals 01, 02, 03, 04, 05 and 06 in fig. 3, the six fluorescence detectors are closely arranged, such that the collecting ends of the fluorescence collectors of the six fluorescence detectors are on the same plane, the six fluorescence detectors are arranged in two rows, each row is three, and the side surfaces of two adjacent fluorescence collectors are closely contacted. The filters with the wavelength ranges of 430 +/-30 nm, 490 +/-30 nm, 550 +/-30 nm, 610 +/-30 nm, 670 +/-30 nm and 730 +/-30 nm are respectively selected for the filters on the detection ends of the six fluorescence collectors, so that the fluorescence in a larger wavelength range can be collected. As shown in FIG. 5 and FIG. 6, the filters with reference numbers 11, 12, 13, 14, 15, and 16 have wavelengths of 430 + -30 nm, 490 + -30 nm, 550 + -30 nm, 610 + -30 nm, 670 + -30 nm, and 730 + -30 nm, respectively.
Example four
This embodiment provides a method of making a fluorescence detector according to the first embodiment, comprising: a plurality of optical fibers are sequentially subjected to regular arrangement, heating, pressure fusion, torsion and stretching to form a tapered fluorescence collector, the molded fluorescence detector is conical, the area of the end face of the collection end of the fluorescence detector is larger than that of the end face of the detection end of the fluorescence detector, and the fluorescence detector has the advantages of wide collection angle, high transmittance and low loss.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.
Claims (10)
1. A fluorescence detector, characterized in that, the fluorescence detector comprises a fluorescence collector for collecting fluorescence, which is made of a plurality of optical fibers;
the fluorescence collector comprises a collecting end and a detecting end, the fluorescence collector is in a tapered shape from the collecting end to the detecting end, the area of the end face of the collecting end is larger than that of the end face of the detecting end, the collecting end is used for collecting fluorescence signals, and the collected fluorescence signals are collected to the detecting end when being transmitted in the fluorescence detector.
2. The fluorescence detector of claim 1, wherein said fluorescence detector is cone-shaped or truncated cone-shaped.
3. The fluorescence detector of claim 1, further comprising a filter disposed on an end face of said detection end for filtering interfering light signals received therein to allow fluorescence to pass therethrough.
4. The fluorescence detector of claim 3, further comprising a fluorescence detection circuit disposed at the detection end of the fluorescence collector for detecting the fluorescence signal collected by the detection end of the fluorescence collector and converting the fluorescence signal into a corresponding electrical signal.
5. The fluorescence detector of claim 4, wherein said fluorescence detection circuitry comprises a sensing element and acquisition circuitry electrically connected to the sensing element;
the sensing element is arranged at the detection end of the fluorescence collector and used for converting the fluorescence signal into an electric signal, and the acquisition circuit is used for acquiring the electric signal.
6. The fluorescence detector of claim 5, wherein said sensing element is positioned 0.5mm from the detection end of said fluorescence collector.
7. The fluorescence probe of claim 5, further comprising a sealed housing surrounding the fluorescence collector and sensing element.
8. A fluorescence detection array comprising a plurality of fluorescence detectors according to any of claims 1-7, the plurality of fluorescence detectors being closely arranged such that the collection ends of the fluorescence collectors of the plurality of fluorescence detectors are in the same plane and the sides of two adjacent fluorescence collectors are in close contact.
9. A fluorescence detection array comprising six fluorescence detectors according to any of claims 3 to 7, wherein the six fluorescence detectors are closely arranged such that the collection ends of the fluorescence collectors of the six fluorescence detectors are on the same plane and the sides of two adjacent fluorescence collectors are in close contact;
the filters with the wavelength ranges of 430 +/-30 nm, 490 +/-30 nm, 550 +/-30 nm, 610 +/-30 nm, 670 +/-30 nm and 730 +/-30 nm are respectively selected for the filters on the detection ends of the six fluorescence collectors.
10. A method for preparing a fluorescence detector according to any of claims 1-7, comprising: a plurality of optical fibers are sequentially subjected to regular arrangement, heating, pressure fusion, torsion and stretching to form a tapered fluorescence collector, so that the area of the end face of the collection end of the fluorescence collector is larger than that of the end face of the detection end of the fluorescence collector.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010265090.2A CN111413306A (en) | 2020-04-07 | 2020-04-07 | Fluorescence detector, detection array and method for manufacturing fluorescence detector |
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| CN202010265090.2A CN111413306A (en) | 2020-04-07 | 2020-04-07 | Fluorescence detector, detection array and method for manufacturing fluorescence detector |
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| US4654532A (en) * | 1985-09-09 | 1987-03-31 | Ord, Inc. | Apparatus for improving the numerical aperture at the input of a fiber optics device |
| US6103535A (en) * | 1996-05-31 | 2000-08-15 | University Of Maryland | Optical fiber evanescent field excited fluorosensor and method of manufacture |
| US20060194334A1 (en) * | 2005-02-28 | 2006-08-31 | The State of Oregon Acting by and through the State Board of Higher Education | Probes for optical micromanipulation |
| CN103278183A (en) * | 2013-05-28 | 2013-09-04 | 福州英诺电子科技有限公司 | Single-fiber fluorescent fiber sensing head and optical path structure thereof |
| CN104251848A (en) * | 2013-06-28 | 2014-12-31 | 天津奇谱光电技术有限公司 | Fluorescence method optical fiber sensor |
| CN105115955A (en) * | 2015-09-16 | 2015-12-02 | 北京首量科技有限公司 | Optical fiber detection device for biological detection |
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2020
- 2020-04-07 CN CN202010265090.2A patent/CN111413306A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4573761A (en) * | 1983-09-14 | 1986-03-04 | The Dow Chemical Company | Fiber-optic probe for sensitive Raman analysis |
| US4654532A (en) * | 1985-09-09 | 1987-03-31 | Ord, Inc. | Apparatus for improving the numerical aperture at the input of a fiber optics device |
| US6103535A (en) * | 1996-05-31 | 2000-08-15 | University Of Maryland | Optical fiber evanescent field excited fluorosensor and method of manufacture |
| US20060194334A1 (en) * | 2005-02-28 | 2006-08-31 | The State of Oregon Acting by and through the State Board of Higher Education | Probes for optical micromanipulation |
| CN103278183A (en) * | 2013-05-28 | 2013-09-04 | 福州英诺电子科技有限公司 | Single-fiber fluorescent fiber sensing head and optical path structure thereof |
| CN104251848A (en) * | 2013-06-28 | 2014-12-31 | 天津奇谱光电技术有限公司 | Fluorescence method optical fiber sensor |
| CN105115955A (en) * | 2015-09-16 | 2015-12-02 | 北京首量科技有限公司 | Optical fiber detection device for biological detection |
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