CN202057599U - Micro multispectral fluorescent light receiving and processing system - Google Patents
Micro multispectral fluorescent light receiving and processing system Download PDFInfo
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- CN202057599U CN202057599U CN2011201589829U CN201120158982U CN202057599U CN 202057599 U CN202057599 U CN 202057599U CN 2011201589829 U CN2011201589829 U CN 2011201589829U CN 201120158982 U CN201120158982 U CN 201120158982U CN 202057599 U CN202057599 U CN 202057599U
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Abstract
The utility model discloses a micro multispectral fluorescent light receiving and processing system, which comprises an exciting unit, a fluorescent light collecting unit and a data processing unit. The exciting unit comprises an exciting light source, an exciting light filter and an optical gathering part. The fluorescent light collecting unit comprises a photoelectric converter and a micro light filter which is in close contact with the photoelectric converter, wherein the micro light filter is a highly integrated multichannel light filter. An object to be imaged is excited by the irradiating light of the exciting unit and gives off fluorescent light with specific wavelength, the optical gathering part gathers the fluorescent light, the fluorescent light irradiates the photoelectric converter through the micro light filter, the photoelectric converter obtains corresponding image information according to fluorescent light signals, and the data processing unit analyzes and processes the image information and outputs a result. The micro multispectral fluorescent light receiving and processing system has the advantages that multiple fluorescent light signals which are given off under excitation can be collected efficiently at low cost, the image information can be obtained, and the detection result can be reflected accurately and objectively in real time.
Description
Technical field
The utility model relates to biochemistry detection and external medical diagnostic equipment, relates in particular to a kind of little multispectral fluorescence and receives and disposal system.
Background technology
At present, the employed instrument of medical institutions' clinical diagnosis and biological detection, the fluorescence acquisition system of employing is a feature with PCR (Picymerase Chain Reaction) PCR all.In the PCR reaction system, add the primer that contains fluorescent material, fluorescent material sends the light of another feature wavelength under the excitation source irradiation of specific wavelength, detect the light intensity that fluorescent material is launched in the PCR course of reaction by photomultiplier acceptance, optical fiber optical signal transmission, discrete optical filter beam split, monitoring pcr amplification reaction process.Draw real-time analytic curve by computer software analysis, calculate the Ct value, provide the nucleic acid concentration value of sample starting template, carry out the detection and the genetic analysis of the various pathogen of DNA/RNA.
It is discrete optical filter beam split that existing clinical diagnosis, biochemical instrument adopt the method for designing of fluorescence gathering system, the optical fiber optical signal transmission, photomultiplier is accepted fluorescence signal and is carried out opto-electronic conversion, calculate original gene content and expression formula through preposition amplification and data processing post analysis, detect the situation of sample tissue element variation.This project organization cost height, the collection of light and opto-electronic conversion complexity, the poor stability that authentic specimen information is obtained, measurable number of samples is restricted.
Adopt the common photoelectric multiplier tube, be to convert faint optical signal to electric signal, but when illumination is mapped to photomultiplier, photocathode inspires photoelectron in vacuum, photoelectron enters dynode system by the focusing board electric field, obtain multiplication by further Secondary Emission and amplify, the electronics after the amplification is collected with anode and is exported as signal.Owing to adopted the Secondary Emission dynode system, so photomultiplier has higher sensitivity in the photodetection of the emittance of ultraviolet, visible light and near-infrared region, be widely used in the clinical diagnosis of carrying out optical measurement and spectral analysis and biochemical instrument.But the common photoelectric multiplier tube once can only be measured an information, and passage has only one, has limited the measurement of multi-channel information; Photomultiplier in actual use, detection sensitivity reduces because of strong illumination or because of irradiation time is long, stops after the irradiation again part and recovers, and " tired " phenomenon occurs; The sensitivity of photomultiplier photoanode surface each point is inhomogeneous.Photomultiplier also needs accessory circuit such as high-voltage power supply, amplification and Discr., cool room, magnetic shielding, base etc. in addition, and this just makes that the volume of total system is big, to the environment requirement height.
In recent years, along with development of semiconductor, multi-anode photomultiplier and silicon photomultiplier are come out one after another, and its common characteristic is to make many very thin photomultipliers form matrix, increases detection channels, reduces the volume of photomultiplier; Optical detection unit adopts the optical fiber lens arra.But the anode end of multi-anode photomultiplier is subjected to the restriction of fine wire, and it is measured passage and can only accomplish hundred at present.The optical fiber that is used for optical detection unit, for sample carriers, owing to be point measurement, the real information of the representative tested sample that the light signal of detection and transmission can not be accurately complete.Aspect the fixed form of optical fiber: optical fiber is fixed on the bottom of sample, if the location will definitely not influence the detection quality of signal; Optical fiber is fixed on the top of sample, and in the experimentation, what microwell plate can be frequent moves, and not only influences the quality of measurement but also brings inconvenience to the operator, optical fiber contaminated accuracy that also can reduce measurement in experimentation simultaneously.
Adopt discrete optical filter beam split, in a large amount of experimentations, need frequent adjustment optical filter wheel to make the discrete different wavelength of optical filter beam split, so not only can produce artificial noise, can cause the offset of obtaining image because the machinery of optical filter wheel moves simultaneously, the quality of image information is obtained in influence.
The utility model content
The technical matters that the utility model mainly solves provides a kind of little multispectral fluorescence and receives and disposal system, overcome that existing fluorescence receives and processing unit can not be in real time, the defective of the real information that obtains fluorescence signal of accurate, low cost, miniature multi-channel.
For solving the problems of the technologies described above, the technical scheme that the utility model adopts is: provide a kind of little multispectral fluorescence to receive and disposal system, comprising: be used to produce the monochromatic light uniform irradiation and treat that imaging object is to excite the data processing unit that excites the unit, is used to collect the fluorescence for the treatment of the imaging object radiation and is converted into the phosphor collection unit of image information and the image information of changing according to fluorescence is carried out analyzing and processing for the treatment of the imaging object radiofluorescence; Described phosphor collection unit comprises that optics converges parts, photoelectric commutator and is close to the micro optical filter of photoelectric commutator input end, described micro optical filter is highly integrated multi-channel filter, described micro optical filter comprises a plurality of compact arranged optical filtering infinitesimals, described optical filtering infinitesimal is arranged, and a described optical filtering infinitesimal covers a photoelectric conversion unit of described photoelectric commutator; Described optics converges parts and is arranged on the light path for the treatment of the imaging object fluorescent radiation, and described micro optical filter is arranged on the reflected light path that described optics converges parts, and the output terminal of described photoelectric commutator connects described data processing unit.
Wherein, the photoelectric commutator of described phosphor collection unit is CCD or cmos image sensor, and described micro optical filter is integrated on CCD or the cmos image sensor.
Wherein, the photoelectric commutator of described phosphor collection unit is for to press the compact arranged photomultiplier of array, and micro optical filter is integrated on the photomultiplier of little gust of arrangement.
Wherein, the described unit that excites comprises LASER Light Source and convex reflecting mirror, and described convex reflecting mirror is arranged on the emitting light path of LASER Light Source, and the described imaging object for the treatment of is arranged on the reflected light path of convex reflecting mirror.
Wherein, the described unit that excites comprises arrowband high-power LED light source and exciting light optical filter, is radiated at equably behind the emergent light process exciting light optical filter of described arrowband high-power LED light source and treats on the imaging object.
Wherein, the described unit that excites comprises arrowband high-power LED light source, exciting light optical filter and plane mirror, the emergent light of described arrowband high-power LED light source shines described plane mirror through the exciting light optical filter, and the described imaging object for the treatment of is positioned on the reflected light path of described plane mirror.
Wherein, it is concave mirror that described optics converges parts, and described micro optical filter and integrated with it photoelectric commutator are arranged on the focus of described concave mirror.
The beneficial effects of the utility model are: be different from the clinical diagnosis of prior art, fluorescence in the biochemical instrument receives and disposal system adopts photomultiplier to accept, the optical fiber optical signal transmission, discrete optical filter beam split makes image inaccurate, structure is huge, high and the testable limited amount of cost, little multispectral fluorescence of the present utility model receives and disposal system adopts miniature multispectral technology, utilize micro optical filter that the fluorescence signal of the radiation that is stimulated of collection is filtered, micro optical filter is highly integrated multi-channel filter, be close to the input end of photoelectric commutator, arrowband fluorescence signal corresponding to the primary fluorescence specific wavelength obtains corresponding image by being radiated at photoelectric commutator from the microchannel of micro optical filter, handle back output result through data processing unit.In the utility model, the fluorescence signal of the biochemical reaction process that is used for reporting that the fluorescent dye sample takes place, become real-time little multispectral image transmission on the whole, and then the photoelectric commutator that is had micro optical filter is noted, the image that is obtained accurately, sensitive, reflect the Biochemical Information of each test tube sample carrier in the micropore template objectively, improved the signal to noise ratio (S/N ratio) of image and detected the reliability of sample.Only needing to adjust miniature narrow band pass filter allows just to go for the fluorescence reception of different series and the clinical diagnosis and the biochemical instrument of processing procedure by light wavelength.For example biological detection and clinical diagnosis instruments such as fluorescent colloid detector, fluorescent polyase chain reaction instrument, immune time resolution detector, immunochemiluminescence detector.The utility model is made instrument easily, the mode of collecting fluorescence designs very compact, succinct, be easy to standardization simultaneously, reliability of products reaches high standard easily, quality in the instrument manufacture process is controlled easily, reduced cost in the manufacturing of product, the complexity of design difficulty and instrument reduces significantly.
Description of drawings
Fig. 1 is the light path principle figure of the utility model one embodiment;
Fig. 2 is the structured flowchart of embodiment among the utility model Fig. 1;
Fig. 3 is the structural representation of the utility model micro-filtration wave plate;
Fig. 4 is an A place partial enlarged drawing among Fig. 3;
Fig. 5 is the light path principle figure that the utility model uses LASER Light Source;
Fig. 6 is the index path that the utility model uses the arrowband high-power LED light source;
Fig. 7 is the index path that the utility model uses another embodiment of arrowband high-power LED light source.
Embodiment
By describing technology contents of the present utility model, structural attitude in detail, realized purpose and effect, give explanation below in conjunction with embodiment and conjunction with figs. are detailed.
See also Fig. 1 and Fig. 2, the utility model provides a kind of little multispectral fluorescence to receive and disposal system, comprise: excite unit 1, photoelectric conversion unit 2 and data processing unit 3, Sheng is loaded with fluorescent dye 4 and treats that promptly the test tube of imaging object is placed on the micropore template 5; Excite unit 1 to launch the monochromatic light uniform irradiation on the fluorescent dye 4 of micropore module 5, fluorescent dye 4 is stimulated and gives off the fluorescence of specific wavelength.Described phosphor collection unit 2 comprises that optics converges parts 23, photoelectric commutator 22 and is close to the micro optical filter 21 of photoelectric commutator 22 input ends, described micro optical filter 21 is highly integrated multi-channel filter, optics converges parts 23 and is arranged on the light path of fluorescent dye 4 fluorescent radiations, described micro optical filter 21 is arranged on the reflected light path that described optics converges parts 23, and the output terminal of described photoelectric commutator 22 connects described data processing unit 3.
In the utility model, excite rayed that unit 1 launches on fluorescent dye 4, fluorescent dye 4 is stimulated and gives off the fluorescence of intrinsic specific wavelength, fluorescence is radiated at described optics and converges on the parts 23, optics converges parts 23 fluorescence is converged on the micro optical filter 21, fluorescence signal is radiated at after by micro optical filter 21 on the photoelectric commutators of closely placing with micro optical filter 21 22, in the present embodiment, optics converges parts 23 and adopts concave mirror, micro optical filter 21 and be arranged on the focus of concave mirror with photoelectric commutators 22 that micro optical filter 21 is closely placed, the fluorescence of fluorescent dye 4 radiation is radiated on the concave mirror, concave mirror converges fluorescence according to optical principle and increases light intensity, the fluorescence that reflects impinges upon on the micro optical filter 21, described micro optical filter 21 is highly integrated multi-channel filter, only allow the fluorescence signal of specific wavelength to pass through, photoelectric commutator 22 obtains corresponding image information according to fluorescence signal, and flowing to data processing unit 3, the information that 3 pairs of described photoelectric commutators 22 of data processing unit send is demarcated, analyze and handle and export the result of analyzing and processing.Described data processing unit 3 can be Computerized image processing system, the image information that described photoelectric commutator 22 obtains is delivered to demarcation and the processing that Computerized image processing system carries out image by the computer interface circuit, fluorescent dye 4 is carried out real-time analysis and detection by quantitative, and the result of analyzing and processing is transported on the graphoscope shows.
Be different from the clinical diagnosis of prior art, fluorescence in the biochemical instrument receives and disposal system adopts photomultiplier to accept, the optical fiber optical signal transmission, discrete optical filter beam split makes image inaccurate, structure is huge, high and the testable limited amount of cost, little multispectral fluorescence of the present utility model receives and disposal system adopts miniature multispectral technology, utilize micro optical filter that the fluorescence signal of the radiation that is stimulated of collection is filtered, micro optical filter is highly integrated multi-channel filter, be close to the input end of photoelectric commutator, arrowband fluorescent signal corresponding to the primary fluorescence specific wavelength obtains corresponding image by being radiated at photoelectric commutator from the microchannel of micro optical filter, handle back output result through data processing unit.In the utility model, the fluorescence signal of the biochemical reaction process that is used for reporting that the fluorescent dye sample takes place, become real-time little multispectral image transmission on the whole, and then the photoelectric commutator that is had micro optical filter is noted, the image that is obtained accurately, sensitive, reflect the Biochemical Information of each test tube sample carrier in the micropore template objectively, improved the signal to noise ratio (S/N ratio) of image and detected the reliability of sample.Only needing to adjust miniature narrow band pass filter allows just to go for the fluorescence reception of different series and the clinical diagnosis and the biochemical instrument of processing procedure by light wavelength.For example biological detection and clinical diagnosis instruments such as fluorescent colloid detector, fluorescent polyase chain reaction instrument, immune time resolution detector, immunochemiluminescence detector.The utility model is made instrument easily, the mode of collecting fluorescence designs very compact, succinct, be easy to standardization simultaneously, reliability of products reaches high standard easily, quality in the instrument manufacture process is controlled easily, reduced cost in the manufacturing of product, the complexity of design difficulty and instrument reduces significantly.
Consult Fig. 3, micro optical filter 21 of the present utility model comprises a plurality of compact arranged optical filtering infinitesimals 211, described optical filtering infinitesimal 211 is arranged, the size of described optical filtering infinitesimal must not be significantly less than the single Pixel Dimensions of pairing described photoelectric commutator 22, and a described optical filtering infinitesimal 211 covers a photoelectric conversion unit of described photoelectric commutator 22.The arrowband fluorescent signal of primary fluorescence specific wavelength is by optical filtering infinitesimal 211 imaging on photoelectric commutator 22, between pixel and the pixel, automatically calibrating aligns between image and the image, make the image that obtained accurately, sensitive, reflect the Biochemical Information of each test tube sample carrier in the micropore template objectively, improved the signal to noise ratio (S/N ratio) of image and detected the reliability of model.The light wavelength that described optical filtering infinitesimal allows to pass through can be set to identical or different, and for example in Fig. 4, it is that the light of λ 1, λ 2, λ 3 and λ 4 passes through that four optical filtering infinitesimals can allow wavelength respectively, detects when can realize different wave length fluorescence like this.
In one embodiment, the photoelectric commutator 22 of described phosphor collection unit 2 is CCD or cmos image sensor, described micro optical filter 21 is integrated on CCD or the cmos image sensor, be specially micro optical filter 21 directly is produced on the opto-electronic conversion sensitive element of a CCD/COMS monochrome image sensor with low light level imaging capability, corresponding to the fluorescent signal of primary fluorescence specific wavelength by behind the micro optical filter 21, imaging on the imaging surface of CCD/COMS monochrome image sensor with low light level imaging capability.Described photoelectric commutator 22 adopts CCD or COMS imageing sensor, and the CCD or the cmos image sensor that are integrated with micro optical filter 21 just become multispectral CCD/COMS camera or video camera.
In another embodiment, described photoelectric commutator 22 is for to press the compact arranged photomultiplier of array, and described micro optical filter 21 is integrated in this by on the compact arranged photomultiplier of array.Described micro optical filter 21 directly is produced on the photosensor chip in micro production mode (as vacuum coating and microlithography technology etc.), and is integrated in the photomultiplier transit tube module.
Consult Fig. 5, in one embodiment, laser cell 1 comprises LASER Light Source 11 and convex reflecting mirror 14, convex reflecting mirror 14 is arranged on the emitting light path of LASER Light Source 11, the rayed that LASER Light Source 11 is sent is on convex reflecting mirror 14, and light is radiated on the fluorescent dye 4 after convex reflecting mirror 14 reflections equably.In this embodiment, the light that LASER Light Source 11 is sent expands bundle by convex reflecting mirror 14, convex reflecting mirror 14 has the characteristic to the incident light scattering, enlarged catoptrical range of exposures like this, all standing uniformly shone each fluorescent dye 4 on the micropore template 5 when reflected light shone on the micropore template 5.
Consult Fig. 6, in another embodiment, excite unit 1 to comprise arrowband high-power LED light source 11a and exciting light optical filter 12, be radiated at equably on the fluorescent dye 4 behind the emergent light process exciting light optical filter 12 of described arrowband high-power LED light source 11a.Fluorescent dye 4 gives off fluorescence and converges parts 23 through optics and converge reinforcement, again by micro optical filter 21 imaging on photoelectric commutator 22.Imaging system 40 comprises that fluorescent dye 4 and optics converge parts 23 among Fig. 6, and structure that it is concrete and light path are above existing to be specifically described, and herein to its simplification, no longer specifically describes.Hereinafter the imaging system of Chu Xianing is represented identical implication.
Fig. 7 has provided another embodiment as excitation source with arrowband high-power LED light source 11a, in this embodiment, excite unit 1 to comprise arrowband high-power LED light source 11a, exciting light optical filter 12 and plane mirror 13, the emergent light of arrowband high-power LED light source 11a incident angle with 45 ° after exciting light optical filter 12 filters is radiated on the plane mirror 13, the reflected light of plane mirror 13 shines on the imaging system 40, and the emergent light of imaging system 40 is radiated at imaging on the photoelectric commutator 22 by micro optical filter 21 again.When reality is used, reasonably adjust the angle of plane mirror 13 according to the position relation of arrowband high-power LED light source 11a, micropore module 5, make rayed that arrowband high-power LED light source 11a sends on plane mirror 13, fluorescent dye 4 is positioned on the reflected light path of plane mirror 13, and the light that arrowband high-power LED light source 11a sends can evenly cover fluorescent dye through the reflection of plane mirror 13 and get final product.
In the utility model, the light source that produces exciting light is except can be for the LASER Light Source and arrowband high-power LED light source as xenon lamp and so on, and high-pressure sodium lamp, quartz-halogen-tungsten lamp or the LED laser instrument that also can use the co-wavelength scope are as an alternative.Its embodiment repeats no more.
The above only is embodiment of the present utility model; be not so limit claim of the present utility model; every equivalent structure or equivalent flow process conversion that utilizes the utility model instructions and accompanying drawing content to be done; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present utility model.
Claims (7)
1. little multispectral fluorescence receives and disposal system, it is characterized in that, comprising:
Be used to produce the monochromatic light uniform irradiation and treat that imaging object is to excite the data processing unit that excites the unit, is used to collect the fluorescence for the treatment of the imaging object radiation and is converted into the phosphor collection unit of image information and the image information of changing according to fluorescence is carried out analyzing and processing for the treatment of the imaging object radiofluorescence;
Described phosphor collection unit comprises that optics converges parts, photoelectric commutator and is close to the micro optical filter of photoelectric commutator input end, described micro optical filter is highly integrated multi-channel filter, described micro optical filter comprises a plurality of compact arranged optical filtering infinitesimals, described optical filtering infinitesimal is arranged, and a described optical filtering infinitesimal covers a photoelectric conversion unit of described photoelectric commutator; Described optics converges parts and is arranged on the light path for the treatment of the imaging object fluorescent radiation, and described micro optical filter is arranged on the reflected light path that described optics converges parts, and the output terminal of described photoelectric commutator connects described data processing unit.
2. little multispectral fluorescence according to claim 1 receives and disposal system, and it is characterized in that: the photoelectric commutator of described phosphor collection unit is CCD or cmos image sensor, and described micro optical filter is integrated on CCD or the cmos image sensor.
3. little multispectral fluorescence according to claim 1 receives and disposal system, and it is characterized in that: the photoelectric commutator of described phosphor collection unit is for to press the compact arranged photomultiplier of array, and micro optical filter is integrated on the photomultiplier of little gust of arrangement.
4. little multispectral fluorescence according to claim 1 receives and disposal system, it is characterized in that: the described unit that excites comprises LASER Light Source and convex reflecting mirror, described convex reflecting mirror is arranged on the emitting light path of LASER Light Source, and the described imaging object for the treatment of is arranged on the reflected light path of convex reflecting mirror.
5. little multispectral fluorescence according to claim 1 receives and disposal system, it is characterized in that: the described unit that excites comprises arrowband high-power LED light source and exciting light optical filter, is radiated at equably behind the emergent light process exciting light optical filter of described arrowband high-power LED light source and treats on the imaging object.
6. little multispectral fluorescence according to claim 1 receives and disposal system, it is characterized in that: the described unit that excites comprises arrowband high-power LED light source, exciting light optical filter and plane mirror, the emergent light of described arrowband high-power LED light source shines described plane mirror through the exciting light optical filter, and the described imaging object for the treatment of is positioned on the reflected light path of described plane mirror.
7. receive and disposal system according to each described little multispectral fluorescence of claim 1-6, it is characterized in that: it is concave mirror that described optics converges parts, and described micro optical filter and integrated with it photoelectric commutator are arranged on the focus of described concave mirror.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011201589829U CN202057599U (en) | 2011-05-17 | 2011-05-17 | Micro multispectral fluorescent light receiving and processing system |
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| CN2011201589829U CN202057599U (en) | 2011-05-17 | 2011-05-17 | Micro multispectral fluorescent light receiving and processing system |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104977278A (en) * | 2014-04-04 | 2015-10-14 | 闽浪仪器科技（厦门）有限公司 | Quantitative analyzing and detecting system based on multispectral fluorescence immunochromatography |
| WO2017000701A1 (en) * | 2015-07-01 | 2017-01-05 | 上海睿钰生物科技有限公司 | Fluorescent microscopic imaging method and apparatus |
| CN106442437A (en) * | 2016-07-21 | 2017-02-22 | 贵州申科生物科技有限公司 | FDM system based on fluorescence detection |
| CN108459417A (en) * | 2018-02-05 | 2018-08-28 | 华侨大学 | A kind of monocular narrow-band multispectral stereo visual system and its application method |
-
2011
- 2011-05-17 CN CN2011201589829U patent/CN202057599U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104977278A (en) * | 2014-04-04 | 2015-10-14 | 闽浪仪器科技（厦门）有限公司 | Quantitative analyzing and detecting system based on multispectral fluorescence immunochromatography |
| WO2017000701A1 (en) * | 2015-07-01 | 2017-01-05 | 上海睿钰生物科技有限公司 | Fluorescent microscopic imaging method and apparatus |
| US10161873B2 (en) | 2015-07-01 | 2018-12-25 | Shanghai Ruiyu Biotech Co., Ltd. | Fluorescent microscopic imaging method and apparatus |
| CN106442437A (en) * | 2016-07-21 | 2017-02-22 | 贵州申科生物科技有限公司 | FDM system based on fluorescence detection |
| CN108459417A (en) * | 2018-02-05 | 2018-08-28 | 华侨大学 | A kind of monocular narrow-band multispectral stereo visual system and its application method |
| CN108459417B (en) * | 2018-02-05 | 2020-06-26 | 华侨大学 | Monocular narrow-band multispectral stereoscopic vision system and using method thereof |
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Granted publication date: 20111130 Termination date: 20180517 |