CN111405865A - 用于光可调节眼内晶状体辐照系统的患者接口 - Google Patents
用于光可调节眼内晶状体辐照系统的患者接口 Download PDFInfo
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Abstract
在实施例中,一种用于光可调节辐照系统的光可调节晶状体辐照系统,包括辐照光源,用于产生UV光束;光学系统,用于将UV光束引向植入在患者的眼球内的光可调节眼内晶状体;和患者接口,耦合到光学系统,用于使眼球相对于光学系统稳定,以实现光可调节眼内晶状体和UV光束的对准。
Description
技术领域
本专利文献涉及光可调节晶状体的辐照系统。更为详细的是,它是针对用于光可调节眼内辐照系统的患者接口。
背景技术
老年性白内障常发生在老年性眼球上。目前的治疗标准是通过摘除不透明的天然晶状体并将人工眼内晶状体植入到囊袋内来进行白内障手术,从而恢复健康的视力。然而,手术完成后,眼内晶状体(IOL)有时会发生移位,或偏离手术植入到眼球囊袋内的位置。这种移动会使IOL的焦点偏离预定位置,通常是在视网膜上,从而导致IOL的光学性能下降。此外,眼球愈合过程中的不确定性、手术前对眼球的测量误差以及医生在选择和放置IOL时的错误也会导致非最佳的手术结果。这种光学性能的恶化或降低往往决定了患者术后是否需要戴眼镜,因此也是影响术后患者满意度的关键因素。
轻度可调节眼内晶状体(LAL)为解决这一问题提供了一种解决方案。如果患者在术后回访医生时,因LAL的位置错位、移位或不是最佳选择而对光学效果不满意,医生可以通过非侵入性地调节LAL光学性能来缓解患者的不满。详细来说,医生可以进行诊断,确定LAL光学性能不佳的原因、性质和程度。然后,医生可以计算出LAL的光学特性有哪些变化可以弥补LAL的光学性能不足。最后,医生可以对LAL进行光照过程,以带来所计算出的变化。
这种调节是通过将LAL由可光聚合的大分子材料制成,中间穿插有光引发剂来实现的。当医生用空间调制光源辐照LAL时,典型的是发射紫外光,吸收紫外光的光引发剂会诱导大分子的光聚合。所选择的辐照UV光的径向强度轮廓诱导光聚合具有相应的径向强度轮廓。具有径向轮廓的光聚合会改变LAL的形状,从而改变LAL的光学特性。因此,用强度轮廓辐照LAL以改变LAL,以达到医生计算的光学特性,以补偿LAL植入后的性能不足。在J.Jethmalani等人的共同拥有的美国专利6,450,642"Lenses capable of post-fabrication power modification"中已经广泛地描述了LAL系统和装置,在此通过引用的方式将其全部纳入其中。
图1A-D示意性地说明了本发明的光调节步骤的各个方面。图1A说明,当LAL轴与LAL辐照系统的光轴对准时,则UV光束的光束强度轮廓与LAL对准并居中。图1B说明,在这样对准的情况下,UV光束在LAL中引起的形状变化与LAL的轴线对准并居中。
图1C示出了当LAL不与辐照系统对准的情况,并且因此LAL轴与辐照系统轴不对准。在这种情况下,UV光束的辐照光束强度轮廓相对于LAL轴不居中。图1D说明了在这种未对准的LAL中,由UV光束引起的形状变化将与LAL轴不对准。具有这种不对准的形状变化的LAL的光学特性和性能可能与医生的计算和计划有很大的差异。具有未对准的形状改变的LAL通常不能达到医生计划的补偿效果,因此不能减轻患者的不满。因此,使LAL轴与LAL辐照系统轴对准,对晶状体调节手术的成功与否具有重要意义,是LAL辐照系统设计中的重中之重。
在目前的LAL辐照手术中,通过外科医生手动固定LAL,使眼球及其中的LAL与LAL辐照系统对准。虽然这是一种有效的方法,但这种对准方式可能不完美,外科医生的手轻微的抖动可能会使LAL中形成的辐照模式变得模糊不清。基于上述原因,如果能使LAL辐照系统和LAL本身更好、更稳定地对准,将进一步改善白内障手术的视觉效果,提高患者的满意度。
发明内容
在本发明的实施例中,一种光可调节晶状体辐照系统包括辐照光源,用于产生UV光束;光学系统,用于将UV光束引向植入患者的眼球内的光可调节眼内晶状体;以及患者接口,耦合至光学系统,用于使眼球相对于光学系统稳定,以实现光可调节眼内晶状体和UV光束的对准。
附图说明
图1A-D示出了对准和未对准的光线调节过程。
图2A-C示出了光可调节晶状体辐照系统的实施例。
图3A-C示出了光可调节晶状体辐照系统的实施例。
图4示出了具有真空吸力的患者接口。
图5A-B示出了了两件式患者接口。
图6示出了光可调节晶状体辐照系统的可穿戴式实施例。
具体实施方式
本发明的实施例解决了前述的医疗需求。特别是,这些实施例改善了植入的光可调节晶状体(LAL)与LAL辐照系统的对准性。
实施例通过将患者的眼球与辐照系统机械地连接,从而使光束强度轮廓与患者眼球内的LAL对准,来实现这种改进的对准。该机械连接大幅提高了LAL辐照系统、辐照光束和植入的LAL之间的相对对准精度。具有良好对准的光束的光调节过程带来了更加精准的计划中的LAL光学特性改变,并且因此更有效地补偿LAL性能不足。
图2A-C示出了光可调节晶状体辐照系统100的实施例,该系统100包括辐照光源110,用于产生UV光束;光学系统120,用于将UV光束引向植入在患者的眼球1内的光可调节眼内晶状体10,或简单地说是光可调节晶状体(LAL)10;以及患者接口130,耦合到光学系统120,用于相对于光学系统120稳定眼球1,以实现光可调节眼内晶状体10和UV光束的对准。
辐照光源110可以发射出波长为320-400nm的紫外光束。例如,可以使用工作在325nm处的氦镉(HeCd)激光器,或对334和365nm处的发射线进行光谱过滤的汞(Hg)电弧灯作为辐照光源110。其他的实施例可以包括工作在355nm处的三倍频率激光二极管泵浦固态YAG激光器、工作在350-360nm范围内的氩离子激光器、放电灯、宽频氙:具有光谱过滤器的汞灯、或UV LED、或LED阵列。
光学系统120可以通过采用数字镜装置(DMD)、空间光调制器(SLM),例如液晶显示器(LCD)或可变形镜等来调制紫外光束以实现径向强度轮廓。
在一些实施例中,光学系统120可以包括作为面向患者的物镜121,作为最远端的光学元件。在这样的实施例中,患者接口130可以耦合到光学系统120的物镜121。
图2A示出了光可调节晶状体(LAL)辐照系统100的这些实施例的的侧视图。LAL辐照系统100的一些实施例可以包括患者啮合框架131。该患者啮合框架131可安装在与光学系统120共享的刚性底座上,例如诊断台。患者可以将其头部靠在患者啮合框架131的下巴托上,并将其额头压在头带上。由下巴托和头带施加的力可以使患者的头部相对于光学系统120定位和固定。一旦头部被固定,患者接口130可向前移动以相对于光学系统120啮合并固定眼球1。
图2B示出了患者接口130和眼球1之间的接触区域的一些细节。光学系统120可以包括调节器122,该调节器122可以移动患者接口130,以在其被患者啮合框架131固定后,在患者接口130与患者眼球1之间残留的最终气隙之间架起桥梁。医生可以调节调节器122以使患者接口130向前移动,直到它与眼球1的角膜5对接。许多其他方案可以提供这种相同的对接功能:整个光学系统120可以相对于其底座可移动,或者患者接口130可以具有可伸缩的、可扩展的构件,或者患者啮合框架131可以具有自己的调节器122。
患者接口130可以包括最远端的隐形眼镜132,以与眼球1的角膜5形成清晰的光学接口。该隐形眼镜132的硬度可以是不同的,可以是硬的玻璃体或PMMA晶状体,也可以是软的、水凝胶状的隐形眼镜,类似于放置在角膜5上的用于矫正视力的一次性隐形眼镜。
患者接口130可以包括弹性裙部133,该弹性裙部133可以通过轴向机械压力和横向摩擦力有效地固定住眼球1。患者接口130的压力和力可以防止眼球1自愿或不自愿的转动。
一旦患者的头部被患者接触架131固定住,并且眼球1被患者接口130进一步固定或稳定后,光学系统120可以以高精度和对准将UV光束引向位于眼球1的囊袋7中的光可调节晶状体10。该对准可以通过各种方式进行微调。一旦患者接口130将眼球1固定,从而将LAL 10固定在眼球1内,医生或自动对准系统可以通过横向地并且可能轴向地调节光学系统120的瞄准系统来调节UV光束的对准。在其他实施例中,患者接口130可以包括横向调节构件。在另一个实施例中,患者啮合框架131可以具有横向调节构件。
图2C从透视图示出了LAL辐照系统100。在一些实施例中,光学系统120可包括双目显微镜123,或瞄准光学系统123,该瞄准光学系统123可协助医生执行患者接口130与眼球1的对准和最终对接。双目显微镜123可以具有各种瞄准和对准系统的任意组合。它可以包括各种目标照明源、眼球固定灯、以及在其光学系统中的瞄准图形,如十字发、瞄准圈等。双目显微镜123,或瞄准光学系统123,可以是模拟或视频/数字的,并且可以包括一个或多个视频屏幕或显示器。它也可以是模拟和视频/数字双目显微镜123的组合体。它可以具有自己的光路,或者可以至少部分地共享光学系统120的光路。这可以通过例如分光器来实现。
图3A-C示出了光可调节晶状体辐照系统100的相关实施例。该LAL辐照系统100基本上类似于图2A-C的实施例。不同之处在于,患者接口130被耦合或贴附在患者啮合框架131上,而不是光学系统120。在一些实施例中,在患者的头部被患者啮合框架131固定后,调节器122可以将患者接口130推进到与患者的眼球1对接。这样的实施例使患者的头部与患者啮合框架131固定,并使患者的眼球1及其中的LAL 10与患者接口130固定。由于患者啮合框架131与光学系统120共用刚性基座,因此,相对于患者啮合框架131固定和稳定光可调节晶状体10,也使光可调节晶状体10相对于光学系统120稳定。因此,这样的实施例还可以使由光学系统120产生的UV光束与光可调节晶状体10高精度对准。
图4示出了通过在LAL辐照系统100中包括用于产生真空吸力的真空泵142;以及用于将真空泵142与患者接口130耦合的吸力头144,以通过流体连接传递真空吸力,可以提高患者接口130与眼球1之间的耦合和机械连接的强度。患者接口130可以包括弹性裙部133,该弹性裙部133环形地设置在患者接口130的周边,用于将真空吸力通过一个或多个环形和同心的凹槽施加到眼球1上以稳定眼球1。这些凹槽可以将真空吸力均匀地分布在环状的周围,以产生环状分布的力,使眼球1和患者接口130有效地固定在一起,从而使眼球1固定。
在其他实施例中,患者接口130可以包括机械啮合部分,用于增强对眼球1的机械啮合力。该机械啮合部分可以包括突起、锐化边缘、紧缩构件或增强摩擦构件。这些突起,或边缘,将力集中到角膜5的小目标区域,或更外围的巩膜的小目标区域。这些突起可以可逆性地压入角膜5,从而提高了眼球1的稳定和不动性。
在光可调节晶状体辐照系统100的一些实施例中,患者接口130可以是一体式患者接口130。这样的一体式患者接口130既可以与光学系统120耦合,也可以与患者的眼球1耦合。然而,在实际工作中,医生有时会发现,要将眼球1与一体式患者接口130对准,一步到位地对接,是具有挑战性的。患者有时会在患者接口向其眼球移动时产生本能反应。对于医生来说,由于调节器122可能只能在有限的范围内调节患者接口130的位置,因此,医生在响应于移动眼球时移动患者接口130是具有挑战性的。而且,眼球1的表面是滑的,在尝试对接时,眼球1的表面可能会旋转离开。这样的反应可能导致对接失败,或偏离中心、为对准对接。有时,医生可能需要多次尝试才能成功对接患者接口130,这可能导致所有参与的人都感到沮丧。
图5A-B示出了可以提高对接成功率的两件式患者接口130的实施例。所示的两件式患者接口130将对接分成两个阶段。该两件式患者接口130可以包括设备对接部分134,配置为与光学系统120对接,以及眼球控制部分135,配置为耦合到患者的眼球1。设备对接部分134和眼球控制部分135可以被配置成耦合在一起以形成完整的两件式患者接口130。
在实践中,医生可以首先将设备对接部分134连接到光学系统120的远端,例如连接到其物镜121。然后,医生可以随后独立地操纵眼睛控制部分135以与眼球1对准并对接。由于眼球控制部分135不与光学系统120耦合,因此,这些操纵可以在比调节器122可以调节一体式患者接口130的位置的宽得多的范围内自由地进行。因此,对接眼睛控制部分135的成功率可以非常高。
在与眼球1对接后,医生可以将对接的眼睛控制部分135缓慢地朝设备对接部分134移动。当足够小心的情况下,可以保持与眼球1的对接连接,从而使眼球1以及内部的光调节晶状体10与光学系统120处的装置对接部分134缓慢对准。最后,当眼球控制部分135与装置对接部分134良好地对准时,两个部分可以对接,或相互耦合以形成完整的患者接口130。
在一些实施例中,眼球控制部分135可以包括图4的真空吸力增强的实施例。一旦眼球控制部分135与眼球1对接,真空吸力可以被激活,以增加将眼球控制部分135和眼球1固定在一起的对接力。虽然灭菌要求可能优选一次性设备对接部分134,但在一些实施例中,设备对接部分134可以是光学系统120的永久性部分。
图5B示出了在一些其他实施例中,眼球控制部分135可以包括紧缩机构136,用于操作者在患者接口130的眼球控制部分135和眼球1之间建立了初始接触之后,紧缩与眼球1的机械耦合。紧缩机构136可以是各种方案中的任何一种。例如,它可以包括类似于镊子的爪子,由手指操作的手柄来被驱动,如图所示。医生可以通过手指操作的手柄施加力,将紧缩机构136压紧或收紧到眼球上。
图6示出了光可调节晶状体辐照系统100的一些实施例可以是非常紧凑的。这种紧凑化的一个关键控制器是可以取消双目显微镜123作为全尺寸显微镜的可能性,因为该双目显微镜123的尺寸是迫使整个光可调节晶状体辐照系统100的形式因素和规模可观的重要因素。例如,如果在这样的一个实施例中,双目显微镜123的功能由单独的数码相机和显示器来执行,则该相机可以被大大地小型化,从而使整个LAL辐照系统100的外形系数和规模可大幅缩小。
在这样的实施例中,辐照光源110、光学系统120和患者接口130可以组合成所示的可穿戴式LAL辐照系统100。这样的可穿戴式LAL辐照系统100可以包括患者头带137,以使可穿戴式LAL辐照系统100相对于患者的头部稳定。
虽然本文包含许多具体内容、细节和数字范围,但这些不应理解为对本发明和权利要求书的范围的限制,而是,作为对本发明的特定实施例的特定特征的描述。在本文中描述的某些特征在单独的实施例的背景下也可以在单一实施例中组合实施。相反地,在单一实施例的上下文中描述的各种特征也可以在多个实施例中单独或以任何合适的子组合实施。此外,尽管特征可以被描述为在某些组合中作用于某些组合,甚至最初声称是这样的,但在某些情况下,从所声称的组合中的一个或多个特征可以从该组合中切除,并且所声称的组合可以指向另一个子组合或一个子组合的变体。
Claims (11)
1.一种光可调节晶状体辐照系统,包括:
辐照光源,用于产生紫外(UV)光束;
光学系统,用于将UV光束引向植入在患者的眼球内的光可调节眼内晶状体;和
患者接口,耦合到光学系统,用于使眼球相对于光学系统稳定,以实现光可调节眼内晶状体和UV光束的对准。
2.根据权利要求1所述的光可调节晶状体辐照系统,其中,光学系统包括物镜;和
患者接口耦合到光学系统的物镜。
3.根据权利要求1所述的光可调节晶状体辐照系统,包括。
患者啮合框架,用于与患者的头部啮合;其中
患者接口耦合到患者啮合框架。
4.根据权利要求1所述的光可调节晶状体辐照系统,包括:
真空泵;用于产生真空吸力;以及
吸力头,用于将真空泵耦合到患者接口,以通过流体连接传递真空吸力,其中
患者接口包括环形设置在患者接口的周边的弹性裙部,用于将真空吸力施加到眼球以稳定眼球。
5.根据权利要求1所述的光可调节晶状体辐照系统,所述患者接口包括:
机械啮合部分,用于增强对眼球的机械啮合力,通过包括以下至少一个:
凸出物、锐化边缘、紧缩构件和增强摩擦构件。
6.根据权利要求1所述的光可调节晶状体辐照系统,其中。
患者接口是一体式患者接口,用于耦合到光学系统和患者的眼球两者。
7.根据权利要求1所述的光可调节晶状体辐照系统,其中:
患者接口为两件式患者接口,包括
设备对接部分,配置为耦合到光学系统,以及
眼球控制部分,配置为耦合到患者的眼球;其中
设备对接部分和眼球控制部分被配置成耦合在一起。
8.根据权利要求7所述的光可调节晶状体辐照系统,眼球控制部分包括:
紧缩机构,用于操作者在患者接口的眼球控制部分与眼球之间建立了初始接触后,紧缩与眼球的机械耦合。
9.根据权利要求1所述的光可调节晶状体辐照系统,其中:
辐照光源、光学系统和患者接口组合成可穿戴式光可调节晶状体辐照系统。
10.根据权利要求9所述的光可调节晶状体辐照系统,包括:
头带,用于将可穿戴式光可调节晶状体辐照系统相对于患者的头部稳定。
11.根据权利要求1所述的光可调节晶状体辐照系统,其中,所述光学系统包括:数字镜设备,
用于将UV光束引向眼球,以及
用于调节UV光束以达到径向强度轮廓。
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EP3713469A4 (en) | 2021-08-25 |
JP7328963B2 (ja) | 2023-08-17 |
JP2021504008A (ja) | 2021-02-15 |
US10456240B2 (en) | 2019-10-29 |
EP3713469A1 (en) | 2020-09-30 |
WO2019104256A1 (en) | 2019-05-31 |
US20190159889A1 (en) | 2019-05-30 |
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