CN111374903A - Cosmetic composition containing phytochelatin - Google Patents

Abstract

The invention discloses a cosmetic composition, which contains phytochelatin, wherein the phytochelatin has the following structural formula: (gamma-Glu-Cys) n-Gly, wherein n is 2-11, has extremely strong heavy metal chelating capacity. The cosmetic composition of the present invention may be a cream, a pack, a lotion, an essence, etc. The cosmetic composition provided by the invention adopts the plant chelating peptide with excellent chelating capacity for heavy metal substances, so that the harm of heavy metal pollutants in the air to human bodies is reduced.

Description

Cosmetic composition containing phytochelatin

Technical Field

The invention relates to a cosmetic composition, in particular to a cosmetic composition containing phytochelatin, such as cream, facial mask, lotion, essence and the like.

Background

Heavy metal pollutants in the environment, particularly in the air, are of increasing concern. In general, heavy metals refer to metals having a density greater than 5, including gold, silver, copper, iron, lead, cadmium, and the like. Heavy metals accumulate in the human body to a certain extent, and chronic poisoning can be caused. In terms of environmental pollution, heavy metals mainly refer to heavy metal elements with significant biological toxicity, such as mercury (mercury), cadmium, lead, chromium, and metalloid arsenic. Heavy metals can interact strongly with proteins and enzymes in the human body, so that the heavy metals lose activity and can also accumulate in certain organs of the human body to cause chronic poisoning.

For example, the heavy metal Hg mainly damages the central nervous system, damages the brain, causes symptoms such as numbness of limbs, movement disorder, visual field narrowing, and dysaudia caused by Hg poisoning encephalopathy, and also can damage the skin mucosa and urinary and reproductive systems. Under the action of microorganisms, the methyl mercury is formed after methylation, and the toxicity is higher than that of mercury. The heavy metal cadmium Cd can be accumulated in human body to cause acute and chronic poisoning, the acute poisoning can cause hematemesis, abdominal pain and death, and the chronic poisoning can cause renal function injury, damage bone, cause bone pain, osteomalacia and paralysis. The heavy metal chromium Cr has irritation and corrosiveness to skin, mucosa and digestive tract, so as to cause skin congestion, erosion, ulcer, nasal perforation and skin cancer, and can accumulate in liver, kidney and lung. Chronic poisoning of metalloid arsenic As can cause skin lesions, disorders of the nervous system, the digestive and cardiovascular systems, with cumulative toxic effects, destroying the metabolic system of human cells. Heavy metal lead Pb mainly harms nerves, hematopoietic system and kidney, damages bone hematopoietic system to cause anemia, cerebral anoxia, cerebral edema, and abnormal movement and sensation.

Heavy metal pollutants in the air can enter a human body through eating, drinking, breathing and the like, and can enter the human body through skin through transdermal absorption, so that the function of the human body is further violated.

The main effects of the cosmetics are beautifying skin, resisting wind and sun, brightening skin color, and the like. The trend of new cosmetics is to promote health or protect health while beautifying and making up.

For example, Guangdong Ba Wei Biotechnology corporation, CN 201910209737.7, discloses a cosmetic additive with anti-pollution effect and a cosmetic thereof, wherein the cosmetic additive comprises the following components in parts by weight: 3-12 parts of water shield leaf extract, 1-10 parts of quercus robur root extract, 1-7 parts of pterospermum indicum seed extract, 2-8 parts of carex glauca extract, 1-6 parts of aureobasidium pullulans fermentation product and 2-7 parts of ginkgo leaf extract. The application aims to effectively reduce the attachment of pollutants to the skin, protect skin cells and resist the invasion of external pollutants. According to the application, the water shield leaf extract and the quercus robur root extract can prevent benzopyrene (representative substances of PAHs) from being combined with an aromatic hydrocarbon receptor (AhR) in skin cells, avoid the expression of CYP1A1 enzyme and resist the PAHs brought by air pollution; the synergistic use of the aureobasidium pullulans fermentation product, the carex glauca extract and the brasenia schreberi leaf extract can prevent the adsorption and permeation of pollutants on the skin.

A pigment-free beauty powder and a preparation method thereof are disclosed in CN 201811551530.X by Jinhua purple flower commercial and trade Limited company in Wuxyloqi City, and the pigment-free beauty powder comprises the following components in parts by weight: 12-18 parts of vitamin E; 10-16 parts of carotene; 16-25 parts of soybean protein micromolecule peptide; 5-8 parts of saussurea involucrate extract; 3-6 parts of grape seeds; 9-15 parts of edible olive oil; 55-75 parts of deionized water. This application claims enhancement of the skin's own resistance to external contaminants, but does not clearly show its mechanism of operation.

SEPPIC and marine biotechnology companies in france disclose in CN 201780068651.6 a cosmetic formulation comprising at least one cosmetically acceptable excipient and an effective amount of at least one glycolic acid extract (GE) of a single algal biomass derived from small multicellular macroalgae of the class rhodophyceae. The extract is used in a therapeutic method to prevent or slow the appearance of unattractive signs on the skin, scalp, hair or mucous membranes caused by pollutants present in the atmosphere.

CN 201780004912.8 discloses a cosmetic composition containing an antioxidant, which composition contains, in addition to a cosmetically acceptable carrier such as an emulsifier, an ultraviolet absorber, a thickener, a polyol, an appropriate amount of a chelating agent, a preservative, a perfume and deionized water: 1. 0.05-0.6% curcumin by weight of the composition; 2. 0.05-1.0% of curcumin analogue in the composition weight, wherein the curcumin analogue is fluorine-containing curcumin. The curcumin and fluorine-containing curcumin compound has excellent antioxidant effect, can capture harmful oxygen free radicals, and particularly has good synergistic effect on the aspect of improving the sun protection index of sunscreen cosmetics.

CN 201710678129.1 discloses a composition for anti-pollution cosmetics, liposome, cream type cosmetics, emulsion type cosmetics, a preparation method and application thereof, so as to solve the technical problem that the existing cosmetics cannot effectively isolate pollutants in the air and achieve self-cleaning and nursing repair effects. The invention integrates the components of the Hibiscus alpine Leontopodium extract, the Moringa oleifera seed extract and the Hibiscus syriacus bark extract, exerts the synergistic effect of the three and has pollution resistance, not only can form a barrier to skin, but also can reduce the attachment of air pollutants.

Italian Dener Limited discloses in CN 201780021503.9 a cosmetic composition comprising an oak extract, a grape seed extract and a green tea extract for use in protecting the skin, scalp, hair and external mucous membranes against airborne contaminants.

French opal corporation discloses in CN 201680090162.6 a cosmetic process for protecting keratin materials from contaminants, comprising: applying at least one composition, preferably at least one cosmetic composition, to the keratin materials, the composition comprising at least one particle having a wet point to oil of at least 100ml/100g and a wet point to water of at least 100ml/100 g.

The prior art generally employs metal ion chelating agents to remove metal ions, such as metal ions in water. The metal chelating agent can contain metal ions into the chelating agent through the strong binding action of the chelating agent molecules and the metal ions, so that the metal ions are changed into stable compounds with larger molecular weight, the metal ions are prevented from acting, and the metal chelating agent can be used for the aspects of detoxification, printing and dyeing, scale inhibition and the like.

The metal ion chelating agent can be classified into an inorganic metal ion chelating agent and an organic metal ion chelating agent, wherein the inorganic metal ion chelating agent can be a polyphosphate chelating agent, and the organic metal ion chelating agent can be a carboxylic acid type organic polyphosphonic acid or the like. The carboxylic acid type chelating agents which are commonly used mainly include aminocarboxylic acids and hydroxycarboxylic acids, such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (also called nitrilotriacetic acid NTA), diethylenetriaminepentaacetic acid and salts thereof; the hydroxycarboxylic acid chelating agent mainly includes Citric Acid (CA), Tartaric Acid (TA), Gluconic Acid (GA), etc.; typical representatives of hydroxylamino carboxylic acid chelating agents are hydroxyethylethylenediaminetriacetic acid (HEDTA) and Dihydroxyethylglycine (DEG).

However, both inorganic metal ion chelating agents and organic metal ion chelating agents have strong chelating ability for common metal ions such as iron, calcium, magnesium and the like, and have relatively weak chelating ability for heavy metal ions with strong biological toxicity, so that the chelating ability is not obvious in the aspect of biological detoxification; furthermore, the conditions of application are also limited, for example, the chelating ability of inorganic metal ion chelating agents is greatly influenced by pH value, and the inorganic metal ion chelating agents are generally only suitable for being used as chelating agents under alkaline conditions.

Therefore, there is a need to provide a cosmetic for heavy metal pollution in the air to eliminate the harm of heavy metal to human body as much as possible.

Disclosure of Invention

In view of the deficiencies of the prior art, the technical problem to be solved by the present invention is to provide a cosmetic composition for heavy metal pollution in the air, so as to eliminate the harm of heavy metal to human body as much as possible.

To this end, the invention provides a cosmetic, in particular dermatological, composition comprising phytochelatin having the following structural formula: (γ -Glu-Cys) n-Gly, wherein n-2-11.

In the invention, Phytochelatin (PC) is a micromolecule polypeptide which is rich in Cys and is catalytically synthesized by phytochelatin synthase (PCS) and Glutathione (GSH) serving as a substrate, and can complex heavy metal through-SH of Cys. Therefore, in the present invention, the primary role of phytochelatin is to function as a metal chelator.

In the present invention, phytochelatin has a structure of (γ -Glu-Cys) n-Gly (n ═ 2-11), which is not a product encoded by a gene, but synthesized using glutathione as a substrate under the catalysis of phytochelatin synthase. Wherein, PCS can be activated by metal ions, the highly conserved N-terminal is a catalytic domain, and the C-terminal is variable; GSH is a tripeptide containing gamma-amide bond and sulfhydryl group, is composed of glutamic acid, cysteine and glycine, and is widely present in plant cells.

Preferably, the phytochelatin used in the present invention comprises three units of γ -Glu-Cys, or four units of γ -Glu-Cys. The phytochelatin with the length has relatively low synthesis difficulty, low cost and extremely strong heavy metal chelating capacity.

For example, Phytochelatin 3(Phytochelatin 3, PC3), molecular weight 772.9, which contains three units of r-Glu-Cys, sequence H-r-Glu-Cys-r-Glu-Cys-r-Glu-r-Cys-OH; phytochelatin 4(PC 4) manufactured by the same company, molecular weight 1004.1, which contains four units of r-Glu-Cys, may also be used, and the sequence is H-r-Glu-Cys-r-Glu-Cys-r-Glu-Cys-OH.

In the cosmetic composition of the present invention, other metal chelating agents, for example, inorganic metal ion chelating agents, organic metal ion chelating agents, etc., may be added in addition to the phytochelatin, but it is preferable that only phytochelatin is added to the cosmetic composition of the present invention, and no other metal chelating agents are added, because even if the inorganic metal ion chelating agent and/or the organic metal ion chelating agent of the prior art are/is added to the cosmetic composition of the present invention, the action is to chelate common metal ions such as iron, calcium, magnesium, etc., and not heavy metal ions having strong biological toxicity.

The cosmetic composition of the present invention can achieve the object of the present invention by adding only a trace amount of phytochelatin. For example, the content of phytochelatin is 1 to 30ppm, preferably 2 to 10 ppm.

Preferably, the cosmetic composition of the present invention further comprises 10 to 1000ppm of ascorbic acid, an ascorbic acid salt and/or an ascorbic acid derivative. Ascorbic acid (vitamin C) can reduce the interference of the synthesis process of multiple steps of melanin such as dopaquinone and the like to the generation of melanin by interacting with copper ions at the active part of tyrosinase, has good effects of whitening and removing freckles, and has the effect of diminishing inflammation. However, the vitamin C derivative is easy to be oxidized and yellowed in the air and is often replaced by the vitamin C derivative. The ascorbic acid component is suitable for 6 types of skin such as pigmented skin, wrinkle skin, oily skin, dry skin, tight skin, and tolerant skin.

The inventor of the invention further finds that the combined use of phytochelatin and ascorbic acid has a synergistic effect in chelating heavy metal ions and in biological detoxification.

Ascorbic acid compounds useful in the present invention include ascorbic acid, ascorbic acid salts and derivatives thereof which are L-type per se, ascorbic acid salts useful in the present invention include sodium salts, potassium salts, lithium salts, calcium salts, magnesium salts, barium salts, ammonium salts and protamine salts, ascorbic acid derivatives useful in the present invention include, for example, esters of ascorbic acid and ester salts of ascorbic acid, for example, 2-o- α -D-glucopyranosyl-L-ascorbic acid (also referred to as L-ascorbic acid-2-glucoside, or ascorbyl glucoside) and metal salts thereof, L-ascorbic acid phosphate salts (such as sodium ascorbyl phosphate, potassium ascorbyl phosphate, magnesium ascorbyl phosphate, calcium ascorbyl phosphate and the like), commercially available ascorbic acid compounds include 2-o- α -D-glucopyranosyl-L-ascorbic acid sodium phosphate (available from hayabara) and L-ascorbic acid sodium phosphate available from Roche under the trade name STAY C.

The cosmetic composition of the present invention may be in the form of a care product, a sunscreen product, a after-sun product, a day light protection care product, a body care product, a foundation for the face or neck, a concealer product, a skin tone correction fluid, a moisturizer, a facial make-up base or a body make-up composition.

In one embodiment of the present invention, the cosmetic composition of the present invention is a cream which further contains an emollient, a humectant, an emulsifier, a thickener, an aromatic agent, etc., in addition to phytochelatin or phytochelatin and ascorbic acid, and may further contain a preservative, a pH adjuster, etc. For example, as a specific embodiment, the composition of the present invention comprises 10 to 36% of an emollient, 5 to 12% of a humectant, 2 to 6% of an emulsifier, 0.3 to 1% of a thickener, 0.01 to 0.2% of a fragrance, 1 to 30ppm of phytochelatin, and the balance deionized water.

In the cream of the present invention, the emollient used may be one or more of the following group: butyrospermum parkii, squalane, tocopheryl acetate, cyclopentadimethylsiloxane, octylmethicone, dioctyl carbonate, isododecane, caprylic/capric triglyceride, dimethicone, C_10-18Fatty acid triglycerides, hydrogenated polyisobutene, ethylhexyl palmitate, pentaerythritol tetraisostearate, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, and dimethiconol;

the humectant used may be one or more of the following group of materials: glycerin, propylene glycol, butylene glycol, 1, 3-propanediol, betaine, sodium hyaluronate, xylitol, and sorbitol; preferably a lower polyol;

the emulsifier employed may be one or more of the following group of materials: polyglyceryl-6 distearate, PEG-20 tribehenate, cetearyl glucoside, polyglyceryl-3-methylglucidistearate, cetearyl olivate, sorbitan olivate, etc.; further, it may also contain co-emulsifier such as polysorbate-20, glyceryl stearate, PEG-100 stearate, coco glucoside, polyacrylamide, C13-14 isoparaffin, laureth-7, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polysorbate-80, etc.;

in the used thickening agent, the oil phase can be cetearyl alcohol, beeswax and/or stearic acid; the water phase is one or more of the following substances: carbomer, xanthan gum, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and ammonium acryloyldimethyl taurate/VP copolymer;

the adopted aromatic can be one or more of common aromatic in cosmetics, such as flower fragrance, fruit fragrance, flower and fruit fragrance, and radix aucklandiae;

the antiseptic is also one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, benzyl alcohol, sodium benzoate, potassium sorbate, anisic acid, and sodium acetyllactone.

As another embodiment of the present invention, the cosmetic composition of the present invention is a composition for a mask, which is attached to a water-insoluble substrate, and further comprises a skin conditioner and a gel composition in addition to phytochelatin or phytochelatin and ascorbic acid, the gel composition comprising: (1) a first gel-forming composition comprising a water-soluble polymeric gelling agent; (2) a second gel-forming composition comprising a gel strengthening agent; (3) a rheology modifier.

In the above composition for facial mask, the skin conditioning agent may comprise emollient, humectant, etc. The emollient used herein can be the same emollient used in the cream described above, and the humectant used can be the same humectant used in the cream described above.

Preferably, the composition for a mask of the present invention comprises at least one skin conditioning agent. Skin conditioning agents of the present invention include those known in the art, such as water-soluble humectants, long-term whitening agents, skin tone altering or depigmenting agents, peptides, flavonoids, and mixtures thereof. In addition, the skin conditioning agent may further include antioxidants, cleansing agents, radical scavengers, moisturizers, skin color altering agents, anti-acne agents, anti-dandruff agents, anti-aging agents, emollients, anti-wrinkle agents, keratolytic agents, anti-inflammatory agents, skin texture treatment agents, fresheners, healing agents, lipid regulating agents, vascular protective agents, antibacterial agents, fungicides, antiperspirants, deodorants, skin conditioning agents, anesthetics, nutritional agents, sebum absorbents, and moisture absorbents. These ingredients are generally present in the mask composition at a level of typically no more than about 10% by weight of the mask composition. The mask composition of the present invention preferably comprises a moisturizer as a skin conditioner. Humectants not only provide moisturizing benefits to the skin, but may also aid in the dispersion of water-soluble thickeners and the dissolution/dispersion of other more difficult to handle components in aqueous carriers. The humectant is preferably present at a level of from 0.1% to 30%, preferably from 5% to 10% by weight of the composition for a mask.

The moisturizer used in the composition for facial mask of the present invention includes polyhydric alcohols such as glycerin, diglycerin, propylene glycol, dipropylene glycol, butylene glycol, hexylene glycol, sorbitol, ethoxylated glucose, 1, 2-hexanediol, hexanetriol, erythritol, trehalose, xylitol, maltitol, maltose, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, pyrrolidone carbonate, glucosamine, cyclodextrin, and a mixture thereof.

The material usable as the water-insoluble substrate in the above mask is not particularly limited as long as the following conditions are satisfied: (i) sufficient wet strength and sufficient softness, (ii) appropriate size, (iii) appropriate air permeability and hydrophilicity. Such as nonwoven substrates, woven substrates, hydroentangled substrates, air-jet substrates, natural sponges, synthetic sponges, polymeric meshes, and the like. Preferably, a nonwoven substrate, such as a nonwoven fabric, is used.

In the above-mentioned mask composition, the first gel-forming composition is formed of a water-soluble polymeric gelling agent selected from the group consisting of synthetic or natural polymers and mixtures thereof, preferably natural polymers including gelatin, polysaccharides and mixtures thereof. Polysaccharides useful in the present invention include: red seaweed polysaccharide; glucomannan; galactomannan; a fermented polysaccharide or derivative thereof; brown seaweed polysaccharide; marine invertebrate extracts; starch or a derivative thereof; a natural fruit extract; a plant fiber derivative; seaweed; natural plant exudates and resin gums; and mixtures thereof. The water-soluble polymeric gelling agent is contained in the first gel-forming composition at a content of preferably 0.1% to 10%, more preferably 0.3% to 5%, still more preferably 0.5% to 2% by weight.

The first gel-forming composition described above may further comprise a carrier, such as water and/or glycerin, and may further comprise preservatives and preservative enhancers, such as water-soluble or dispersible preservatives including methyl paraben, ethyl paraben, propyl paraben, imidazolidinyl urea, methyl, ethyl, propyl and butyl parabens, benzyl alcohol, EDTA, bromonitropropanediol (2-bromo-2-nitropropane-1, 3-diol), sodium salicylate, phenoxypropanol, ethanol, isopropanol, butanediol, pentanediol, hexanediol, and mixtures thereof. Other preservatives and preservative enhancers commonly used in cosmetic/skin care and similar products are generally applicable to the present invention.

In the above-mentioned mask composition, the second gel-forming composition comprises a gel enhancer, for example, sugar, alcohol, any monovalent or multivalent salt or metal ion, and a mixture thereof. Suitable cations for the salts of the present invention may be selected from potassium, sodium, ammonium, zinc, aluminum, calcium, iron and magnesium ions, and mixtures thereof. Suitable anions in combination with the above cations may be selected from chloride, citrate, sulfate, carbonate, borate, and phosphate anions, and mixtures thereof. Gel strengthening agents are included in the second gel-forming composition preferably at a level of from about 0.1% to about 10%, more preferably from about 0.3% to 5%, and still more preferably from about 0.5% to about 2% by weight.

The second gel-forming composition described above further comprises a carrier such as water, and may also include preservatives and preservative enhancers such as water-soluble or dispersible preservatives including methyl paraben, ethyl paraben, propyl paraben, imidazolidinyl urea, methyl, ethyl, propyl and butyl parabens, benzyl alcohol, EDTA, bromonitropropanediol (2-bromo-2-nitropropane-1, 3-diol), sodium salicylate, phenoxypropanol, ethanol, isopropanol, butanediol, pentanediol, hexanediol, and mixtures thereof.

When the first and second gel-forming compositions are combined, a gel structure is formed. When applied to a water-insoluble substrate, this gel structure penetrates the substrate, imparting different texture, feel and fit characteristics than the substrate itself. Therefore, hydrophilic substrates are preferred in the present invention.

In addition to the gel composition, the facial mask composition of the present invention further comprises providing at least one rheology modifier. Suitable rheology modifiers include synthetic thickeners, water-soluble or water-miscible polymers, and the like.

In the present invention, the synthetic thickener may be, for example, laponite, natural clays such as bentonite and hectorite. The rheology modifier is preferably present in the mask composition at a level of from 0.5% to about 10%, preferably from 0.5% to 5%, more preferably from 0.8% to 2% by weight. The presence of the rheology modifier provides a mask composition having different viscosity characteristics, preferably higher viscosity characteristics. After application to the skin, the viscosity of the mask composition of the present invention increases due to the presence of the rheology modifier. The degree of viscosity increase depends on the amount of rheology modifier added to the mask composition.

In the present invention, the water-soluble or water-miscible polymer can help improve the stability and physical properties of the mask composition, help prevent syneresis, and can be compatible with other components used in the mask composition. The water-soluble thickening polymer includes an anionic polymer and a nonionic polymer. Water-soluble thickening polymers useful in the present invention include, for example, acrylic polymers, cellulose and its derivatives (e.g., hydroxyethyl cellulose), polyvinylpyrrolidone, polyvinyl alcohol, gums (e.g., guar gum, xanthan gum), carrageenan, pectin, agar, quince seed, starch (rice starch, corn starch, potato starch, wheat starch), alginate gum (algae extract), dextran, succinoglucan, carboxymethyl starch, methylhydroxypropyl starch, sodium alginate, propylene glycol alginate, and the like.

For example, the facial mask composition of the present invention comprises 2-10% of a skin conditioning agent, 30-50% of a first gel-forming composition, 30-50% of a second gel-forming composition, 0.5-10% of a rheology modifier, 1-30ppm phytochelatin, and 0.01-0.1% ascorbic acid. Further, in the first gel-forming composition, the water-soluble polymeric gelling agent comprises from 0.1% to 10% by weight thereof, the balance being carrier, preservative/preservative enhancer; in the second gel-forming composition, the gel strengthening agent comprises from 0.1% to 10% by weight thereof, the balance being a carrier, preservative/preservative enhancer.

In another embodiment of the present invention, the cosmetic composition of the present invention is a lotion. The toning lotion of the invention is generally transparent liquid, can remove dirt and oily secretion on the skin, keeps the stratum corneum of the skin with proper moisture, and has the functions of promoting the physiological action of the skin, softening the skin, preventing the skin from being rough and the like.

The lotion of the present invention can be classified into skin lotion, astringent lotion, soft lotion, etc. according to the purpose of use, wherein the soft lotion is intended to keep the skin soft and moist, and can supplement moisture and moisture-retaining components to the stratum corneum of the skin to soften the skin and keep the skin comfortable and smooth; the astringent lotion can mainly supplement moisture and moisture content of skin stratum corneum, and also has effects of inhibiting excessive sebum secretion, astringing and regulating skin; the washing lotion is mainly used for removing light makeup or used as a face cleaning agent, and the formula of the washing lotion contains more surfactants, humectants and ethanol, so that the washing lotion has an effect of cleaning the skin.

The cosmetic water of the present invention may be a transparent viscous liquid cosmetic water containing a polymer, or may be a multi-layer cosmetic water, for example, a cosmetic water composed of two or more layers. The multi-layer lotion is generally in two layers, e.g., an oil layer-an aqueous layer or an aqueous layer-a powder layer, and the lotion becomes an emulsion or a powder dispersion when shaken at the time of use.

Generally, the cosmetic water of the present invention includes refined water (e.g., deionized water) and ethanol, in addition to phytochelatin or phytochelatin and ascorbic acid. Further, the lotion of the present invention further comprises isopropyl alcohol and/or polyhydric alcohol substances such as glycerin, butylene glycol, etc., and the polyhydric alcohol has a main role of moisturizing, dissolving ingredients, sterilizing, etc.

Preferably, the toning lotion also comprises other moisturizing agents and/or emollients, wherein the other moisturizing agents can be polyethylene glycol, polysaccharide, hyaluronic acid and the like, and the emollients can be low-carbon fatty acid, natural oil and fat, silicon wax and the like.

Preferably, the lotions according to the invention also comprise solubilisers capable of solubilising the oil-soluble ingredients, such as oleylpolyether-20/PEG-60, castor oil, C_16-18Alcohol ether-25, and the like.

Of course, the lotions of the present invention may also contain fragrances, preservatives, buffers (e.g., sodium citrate-citrate, sodium lactate-lactate, etc.), other skin conditioning agents (e.g., various extracts, vitamins, hydrolyzed collagen, amino acid derivatives, etc.), and/or rheological agents (e.g., water soluble polymers, xanthan gum, hydroxyethyl cellulose, carbomer, etc.).

For example, as a specific example, the lotion of the present invention comprises the following components (wt%): 1-5% of ethanol, 1-5% of isopropanol, 1-5% of polyalcohol (such as glycerol), 1-30ppm of phytochelatin and the balance of refined water.

In another embodiment of the present invention, the cosmetic composition of the present invention is a cosmetic composition. The essence is one of skin care products, especially facial skin care products, contains precious functional components, and has the effects of preventing aging, resisting wrinkle, moisturizing, whitening, removing speckles and the like.

The essence of the invention further comprises an extract, ceramide and/or squalane in addition to phytochelatin or phytochelatin and ascorbic acid. Further, the lotion of the present invention further comprises a bactericide. The bactericide in the essence of the present invention may be a bactericide which is generally used in cosmetics/skin care and the like, such as polyhydric alcohol, organic acid (e.g., salicylic acid, benzoic acid, usnic acid, abietic acid, etc.), phenols (e.g., dichlorophen, hexachlorophene, chlorothymol, etc.), copper zinc pyrithione, dodecyldimethylbenzylammonium chloride, propolis, sitosterol, limonene, etc.

In the essence of the present invention, the extract may be a plant extract, for example, an essence extracted from various wild or artificially planted plants, such as mulberry leaf essence, rose essence, calendula essence, aloe essence, which are mostly effective bioactive polypeptide sequences; the extract can also be fruit acid essence, which is skin caring substance extracted from fruit such as sweet apricot essence, lemon essence, juicy peach essence, and apple essence; the extract can also be animal essence such as Lac Regis Apis essence, squalene essence, etc.; the extract may also be vitamin essence, i.e., essence extracted from vitamins beneficial to the skin, such as vitamin E essence, vitamin C essence, etc.

For example, as a specific example, the essence of the present invention comprises the following components (wt%): 1-3% of ceramide, 1-3% of glycerol, 5-30% of vitamin E essence, 1-30ppm of phytochelatin, 0.1-0.5% of abietic acid and the balance of deionized water; as another specific example, the essence comprises the following components (wt%): 1-3% of squalane, 1-3% of butanediol, 5-30% of aloe essence, 1-30ppm of phytochelatin, 0.01-0.1% of ascorbic acid, 0.05-0.1% of salicylic acid and the balance of deionized water.

The cosmetic composition provided by the invention adopts the plant chelating peptide with excellent chelating capacity for heavy metal substances, so that the harm of heavy metal pollutants in the air to human bodies is reduced.

The present invention will be described in detail with reference to specific embodiments, but the scope of the present invention is not limited by the description. It will be appreciated by those skilled in the art that appropriate modifications or substitutions of certain components and amounts thereof can be made without affecting the practice of the invention.

Detailed Description

Example 1

The cosmetic composition of this example is a cream which can be prepared according to conventional methods for preparing a cream, including heating and maintaining the oil phase, heating and dissolving the aqueous phase, mixing the aqueous phase and the oil phase for emulsification and homogenization, and then cooling and adding the other phases. This example produced a cream having the following formulation (wt%):

1-3% of squalane, 2-6% of octyl polymethylsiloxane, 0.5-1% of tocopherol acetate, 2-10% of cyclopenta dimethyl siloxane, 1-3% of capric triglyceride, 2-10% of hydrogenated polyisobutene and 1-3% of ethylhexyl palmitate; 1-6% of glycerol, 1-5% of 1, 3-propylene glycol, 1-3% of butanediol and 1-3% of betaine; 0.5-2% of polyglycerol-6 distearate, 0.5-2% of PEG-20 tribehenate and 0.3-3% of cetearyl glucoside; 0.1-1% of cetearyl alcohol, 0.1-1% of beeswax and 0.1-1% of xanthan gum; 0.1% of essence; 10-30ppm of phytochelatin; 0.05 percent of L-ascorbic acid sodium phosphate.

Example 2

The cosmetic composition of this example is a mask composition comprising a first gel-forming composition, a second gel-forming composition, and a treatment composition comprising a skin treatment and rheology modifier, the mask composition being applied to a 0.8g nonwoven substrate sheet. Wherein a nonwoven substrate sheet is first coated with from 20.0g to 25.0g of a first gel-forming composition, followed by from 20.0g to 25.0g of a second gel-forming composition, and then uniformly or selectively coated with from 4.0g to 10.0g of a treatment composition. Wherein:

the first gel-forming composition may be prepared by: all the components except the water-soluble polymeric gelling agent are dissolved in water and mixed uniformly (if necessary, heated), and then the water-soluble polymeric gelling agent is added to the above mixture and mixed uniformly with high-speed stirring. The first gel-forming composition comprises by weight: 0.5% of sodium alginate, 1% of sodium pectate, 0.5% of sodium salicylate, 0.05% of methyl p-hydroxybenzoate, 0.2% of benzyl alcohol, 5% of glycerol, 5% of butanediol and the balance of deionized water;

the second gel-forming composition is prepared by: all components were dissolved in water and mixed well. The second gel-forming composition comprises by weight of itself: 0.5% of calcium chloride, 0.5% of aluminum chloride, 0.5% of calcium citrate, 0.1% of methyl p-hydroxybenzoate, 0.2% of benzyl alcohol and the balance of deionized water;

the treatment composition may be prepared by: the rheology modifier is pre-dispersed in a water-soluble humectant in a container, all other ingredients are dissolved in water in another container and mixed well, then the two are mixed and homogenized at high speed. The treatment composition comprises by weight of the treatment composition: 5% of bentonite, 3% of glycerol, 3% of butanediol, 1% of dipropylene glycol, 0.1% of methyl p-hydroxybenzoate, 0.2% of benzyl alcohol, 0.1% of ascorbic acid, 2% of nicotinamide, 1% of panthenol, 100ppm of phytochelatin and the balance of deionized water.

Example 3

The cosmetic composition of this example is a lotion obtained by compounding the following ingredients of the formulation (if not otherwise specified, the ingredient contents are in wt%): 1-5% of ethanol, 1-5% of isopropanol, 1-5% of glycerol, 1-30ppm of phytochelatin and the balance of deionized water.

Example 4

The cosmetic composition of this example is also a lotion obtained by compounding the following ingredients of the formulation (if not specifically mentioned, the contents of the ingredients are in wt%): 2-5% of ethanol, 2-3% of isopropanol, 1-2% of glycerol, 1-2% of butanediol, 0.02-0.2% of sodium hyaluronate, 0.01-0.1% of ascorbic acid, 1-30ppm of phytochelatin and the balance of deionized water.

Example 5

The cosmetic composition of this example is an essence, which can be obtained by compounding the following ingredients (if not specifically mentioned, the contents of the ingredients are in wt%): 1-3% of ceramide, 1-3% of glycerol, 5-30% of vitamin E essence, 0.1-0.5% of abietic acid, 1-30ppm of phytochelatin and the balance of deionized water.

Example 6

The cosmetic composition of this example is also an essence, which can be obtained by compounding the following ingredients (if not specifically mentioned, the contents of the ingredients are in wt%): 1-3% of squalane, 1-3% of butanediol, 5-30% of aloe essence, 0.01-0.1% of ascorbic acid, 0.05-0.1% of salicylic acid, 1-30ppm of phytochelatin and the balance of deionized water.

Claims (10)

1. A cosmetic composition, in particular a dermatological composition, comprising phytochelatin, which phytochelatin has the following structural formula: (γ -Glu-Cys) n-Gly, wherein n-2-11.

2. The composition of claim 1, wherein the phytochelatin peptide comprises three units of γ -Glu-Cys.

3. The composition of claim 1, wherein the phytochelatin peptide comprises four units of γ -Glu-Cys.

4. The composition according to claim 1, wherein the phytochelatin is contained in the composition in an amount of 1 to 30 ppm.

5. The composition of claim 4, wherein the composition further comprises 10-1000ppm ascorbic acid, an ascorbic acid salt and/or an ascorbic acid derivative.

6. Composition according to any one of claims 1 to 5, wherein the composition is in the form of a care product, a sunscreen product, a after-sun product, a day-light care product, a body care product, a foundation for the face or neck, a concealer product, a skin tone correction fluid, a moisturizer, a facial make-up base or a body make-up composition.

7. The composition of claim 6, wherein said composition is a cream further comprising emollient 10-36%, humectant 5-12%, emulsifier 2-6%, thickener 0.3-1%, and fragrance 0.01-0.1%.

8. The composition of claim 6, wherein the composition is a mask composition for application to a water-insoluble substrate, further comprising a skin conditioning agent and a gel composition, the gel composition comprising: (1) a first gel-forming composition comprising a water-soluble polymeric gelling agent; (2) a second gel-forming composition comprising a gel strengthening agent; (3) a rheology modifier.

9. The composition according to claim 6, wherein the composition is a cosmetic water, and the cosmetic water further comprises isopropyl alcohol and/or polyhydric alcohol in addition to purified water and ethanol.

10. The composition of claim 6, wherein the composition is a serum comprising an extract of a plant, a fruit acid, an animal and/or a vitamin; preferably, the serum further comprises ceramide and/or squalane.