CN114376935A - Composition containing phytochelatin and application thereof - Google Patents
Composition containing phytochelatin and application thereof Download PDFInfo
- Publication number
- CN114376935A CN114376935A CN202210028145.7A CN202210028145A CN114376935A CN 114376935 A CN114376935 A CN 114376935A CN 202210028145 A CN202210028145 A CN 202210028145A CN 114376935 A CN114376935 A CN 114376935A
- Authority
- CN
- China
- Prior art keywords
- phytochelatin
- composition
- trehalose
- heavy metal
- chelating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010076986 Phytochelatins Proteins 0.000 title claims abstract description 55
- 239000000203 mixture Substances 0.000 title claims abstract description 55
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 31
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 28
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 28
- 239000002537 cosmetic Substances 0.000 claims abstract description 15
- 229930183111 sapindoside Natural products 0.000 claims abstract description 8
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 22
- 229930182490 saponin Natural products 0.000 claims description 22
- 150000007949 saponins Chemical class 0.000 claims description 22
- 241000580938 Sapindus Species 0.000 claims description 17
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims description 3
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910001385 heavy metal Inorganic materials 0.000 abstract description 40
- 229910052753 mercury Inorganic materials 0.000 abstract description 16
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract description 14
- 239000000126 substance Substances 0.000 abstract description 11
- 238000005406 washing Methods 0.000 abstract description 11
- 150000002500 ions Chemical class 0.000 abstract description 9
- 210000002615 epidermis Anatomy 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- WLZRMCYVCSSEQC-UHFFFAOYSA-N cadmium(2+) Chemical compound [Cd+2] WLZRMCYVCSSEQC-UHFFFAOYSA-N 0.000 abstract description 4
- 238000001784 detoxification Methods 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract description 2
- 239000002738 chelating agent Substances 0.000 description 16
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 12
- 229910021645 metal ion Inorganic materials 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 241000694414 Sapindus saponaria Species 0.000 description 7
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 7
- 229910052793 cadmium Inorganic materials 0.000 description 7
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 7
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 6
- 229910052804 chromium Inorganic materials 0.000 description 6
- 239000011651 chromium Substances 0.000 description 6
- 229960003180 glutathione Drugs 0.000 description 6
- -1 sodium alkyl benzene Chemical class 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
- 108010054010 glutathione gamma-glutamylcysteinyltransferase Proteins 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
- 239000003344 environmental pollutant Substances 0.000 description 4
- 231100000719 pollutant Toxicity 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 108010024636 Glutathione Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 229910052785 arsenic Inorganic materials 0.000 description 3
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 3
- 239000012459 cleaning agent Substances 0.000 description 3
- 230000000536 complexating effect Effects 0.000 description 3
- 239000000447 pesticide residue Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 231100000739 chronic poisoning Toxicity 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- 231100001084 no genetic toxicology Toxicity 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- DPZHKLJPVMYFCU-UHFFFAOYSA-N 2-(5-bromopyridin-2-yl)acetonitrile Chemical compound BrC1=CC=C(CC#N)N=C1 DPZHKLJPVMYFCU-UHFFFAOYSA-N 0.000 description 1
- DHKVCYCWBUNNQH-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(1,4,5,7-tetrahydropyrazolo[3,4-c]pyridin-6-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)C=NN2 DHKVCYCWBUNNQH-UHFFFAOYSA-N 0.000 description 1
- BTXXTMOWISPQSJ-UHFFFAOYSA-N 4,4,4-trifluorobutan-2-one Chemical compound CC(=O)CC(F)(F)F BTXXTMOWISPQSJ-UHFFFAOYSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- BQACOLQNOUYJCE-FYZZASKESA-N Abietic acid Natural products CC(C)C1=CC2=CC[C@]3(C)[C@](C)(CCC[C@@]3(C)C(=O)O)[C@H]2CC1 BQACOLQNOUYJCE-FYZZASKESA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- DRAJWRKLRBNJRQ-UHFFFAOYSA-N Hydroxycarbamic acid Chemical compound ONC(O)=O DRAJWRKLRBNJRQ-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- NEAPKZHDYMQZCB-UHFFFAOYSA-N N-[2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]ethyl]-2-oxo-3H-1,3-benzoxazole-6-carboxamide Chemical compound C1CN(CCN1CCNC(=O)C2=CC3=C(C=C2)NC(=O)O3)C4=CN=C(N=C4)NC5CC6=CC=CC=C6C5 NEAPKZHDYMQZCB-UHFFFAOYSA-N 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 101000829035 Schizosaccharomyces pombe (strain 972 / ATCC 24843) Glutathione synthetase large chain Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
The invention discloses a composition containing phytochelatin and application thereof. The composition can be used for preparing cosmetics, washing products and oral care products. Compared with the prior art, the composition has the synergistic effect in chelating heavy metal ions and biological detoxification, particularly in removing lead, mercury and cadmium ions by compounding phytochelatin, sapindoside and trehalose, and can effectively remove heavy metal pollution of daily chemical products and human epidermis.
Description
Technical Field
The invention relates to a composition containing phytochelatin and application thereof, in particular to application in daily chemical products.
Background
In general, heavy metals refer to metals having a density greater than 5, including gold, silver, copper, iron, lead, cadmium, and the like. Heavy metals accumulate in the human body to a certain extent, and chronic poisoning can be caused. In terms of environmental pollution, heavy metals mainly refer to heavy metal elements with significant biological toxicity, such as mercury (mercury), cadmium, lead, chromium, and metalloid arsenic. Heavy metals can interact strongly with proteins and enzymes in the human body, so that the heavy metals lose activity and can also accumulate in certain organs of the human body to cause chronic poisoning.
Heavy metal pollutants can enter a human body through eating, drinking, breathing and the like, and can enter the human body through transdermal absorption, namely through skin, so that the function of the human body is damaged. With the improvement of living standard, people pay more and more attention to health, and the problem of heavy metal pollutants in daily chemical products also becomes the focus of attention of people.
CN105997628A, CN105796476A and CN106038373A disclose a series of moisture-retaining anti-aging cosmetics containing plant extracts, and the cosmetics also contain a chelating agent which can chelate heavy metals and eliminate heavy metal pollution. CN10079397A discloses a cleaning agent for cleaning fruit and vegetable dust and removing heavy metal and pesticide residue, which is composed of sodium alkyl benzene sulfonate and sodium citrate. Wherein the addition ratio range of the sodium alkyl benzene sulfonate and the sodium citrate is 0.1-99.9: 0.01-20, and the plant cleaning agent has the functions of: wetting and dissolving pesticide residues, chelating and removing metal ions, cleaning dust, being suitable for clean water quality such as tap water, well water, mineral water and the like, and being capable of quickly removing heavy metals or pesticide residues on the surfaces of vegetables and fruits. CN109758967A discloses a low-foam type cleaning agent, which contains 10-20% of heavy metal chelating agent, has good stability, low foam and washing effect, can remove solid particles and oil pollutants, and has strong chelating ability for heavy metal ions.
At present, chelating agents in daily chemical products can be classified into inorganic metal ion chelating agents and organic metal ion chelating agents, wherein the inorganic metal ion chelating agents can be polyphosphate chelating agents, and the organic metal ion chelating agents can be carboxylic acid type organic polyphosphonic acid and the like. The carboxylic acid type chelating agents which are commonly used mainly include aminocarboxylic acids and hydroxycarboxylic acids, such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (also called nitrilotriacetic acid NTA), diethylenetriaminepentaacetic acid and salts thereof; the hydroxycarboxylic acid chelating agent mainly includes Citric Acid (CA), Tartaric Acid (TA), Gluconic Acid (GA), etc.; typical representatives of hydroxylamino carboxylic acid chelating agents are hydroxyethylethylenediaminetriacetic acid (HEDTA) and Dihydroxyethylglycine (DEG).
However, both inorganic metal ion chelating agents and organic metal ion chelating agents have strong chelating ability for common metal ions such as iron, calcium, magnesium and the like, and have relatively weak chelating ability for heavy metal ions with strong biological toxicity, so that the chelating ability is not obvious in the aspect of biological detoxification; furthermore, the conditions of application are also limited, for example, the chelating ability of inorganic metal ion chelating agents is greatly influenced by pH value, and the inorganic metal ion chelating agents are generally only suitable for being used as chelating agents under alkaline conditions.
Phytochelatin (PC) is a small molecular polypeptide which is rich in Cys and is catalytically synthesized by phytochelatin synthase (PCS) by taking Glutathione (GSH) as a substrate, can complex heavy metal through-SH of Cys, and is mainly used for treating heavy metal polluted soil and water. In 2020, the applicant develops a research on eliminating heavy metal pollution in daily chemical products, firstly applies phytochelatin to washing products (CN111449983A) and cosmetics (CN111374903A), reduces the damage of heavy metal pollutants in water and air to human bodies, and finds that the phytochelatin and ascorbic acid used together have a synergistic effect in chelating heavy metal ions and biologically detoxifying.
At present, scientific research on the aspect of removing heavy metal pollution of daily chemical products and human epidermis by using phytochelatin is relatively less, so that research and development of a phytochelatin composition with a synergistic effect have important significance in efficiently removing heavy metal pollution of daily chemical products and human epidermis.
Disclosure of Invention
The composition plays a synergistic role in chelating heavy metal ions and biological detoxification, particularly in removing lead ions, mercury ions and cadmium ions by compounding the phytochelatin, the sapindus saponin and the trehalose, and can effectively remove heavy metal pollution of daily chemical products and human epidermis.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composition contains phytochelatin, sapindus saponin and trehalose.
Preferably, the phytochelatin has the structural formula: (γ -Glu-Cys) n-Gly, wherein n ═ 2-11; further preferably n is 3-8.
Preferably, the mass ratio of the phytochelatin to the sapindus saponin to the trehalose is 5-10: 15-28: 10-20.
Further preferably, the mass ratio of the phytochelatin to the sapindus saponin to the trehalose is 6-8: 20-25: 15-18.
Most preferably, the mass ratio of the phytochelatin to the sapindus saponin to the trehalose is 7: 22: 16.
the invention also provides the application of the composition in preparing cosmetics.
Preferably, the cosmetic includes, but is not limited to, a cream, a mask, a lotion, a serum.
Preferably, the mass percentage of the composition in the cosmetic is 0.3-1.5%.
The invention also provides the application of the composition in preparing washing products.
Preferably, the washing products include but are not limited to body wash, facial cleanser, shampoo and liquid detergent.
Preferably, the mass percentage of the composition in the washing article is 0.1-2.5%.
The invention also provides application of the composition in preparing oral care products.
Preferably, the oral care product includes, but is not limited to, toothpaste, tooth powder, oral cleaning water, mouthwash, cleaning mist.
Preferably, the composition is 0.1-2.5% by weight of the oral care product.
The invention has the beneficial effects that:
the phytochelatin in the present invention is not a product encoded by a gene, but can be synthesized using glutathione as a substrate under the catalysis of a phytochelatin synthase. Wherein, PCS can be activated by metal ions, the highly conserved N-terminal is a catalytic domain, and the C-terminal is variable; GSH is a tripeptide containing gamma-amido bond and sulfhydryl group, is composed of glutamic acid, cysteine and glycine, widely exists in plant cells, and has extremely strong heavy metal chelating capacity. The soapberry saponin is triterpenoid glycoside extracted from soapberry false pericarp, is a natural surfactant, is completely biodegradable, has no genetic toxicity such as causing outburst and deformity, and can be used in various washing and caring products and cosmetics. The soapberry saponin has a good cleaning effect on lead, manganese, cadmium, chromium, arsenic and mercury, and trehalose is a surfactant and can promote the occurrence of a system complexing reaction. Compared with the prior art, the phytochelatin, the sapindoside and the trehalose play a synergistic role in chelating heavy metal ions and biologically detoxifying, particularly in removing lead, mercury and cadmium ions, and can effectively remove heavy metal pollution of daily chemical products and human epidermis.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The sources of the raw materials used in the present invention are not limited, and the raw materials used in the present invention are all those commonly available in the art unless otherwise specified.
A composition contains phytochelatin, sapindus saponin and trehalose.
The mass ratio of the phytochelatin to the soapberry saponin to the trehalose is 5-10: 15-28: 10-20 parts of; preferably 6 to 8: 20-25: 15-18; most preferably 7: 22: 16.
in order to further understand the technical effects achieved by the present invention, the present invention is explained in detail by specific examples and experiments below. The phytochelatin in this example was purchased from Shanghai Mujin Biotechnology Co., Ltd, cat # MJ 211026-5; the sapindoside is purchased from Shanxi Xintiandoman biotechnology limited company, the product specification is 40 percent, and the trehalose is purchased from Shanxi brocade pharmaceutic adjuvant limited company, CAS 99-20-7.
Example 1A composition containing phytochelatin
A composition contains phytochelatin 5g, sapindus saponin 15g, and trehalose 20 g.
Example 2A composition containing phytochelatin
A composition contains phytochelatin 10g, sapindus saponin 28g, and trehalose 10 g.
Example 3A composition containing phytochelatin
A composition contains phytochelatin 6g, sapindus saponin 20g, and trehalose 18 g.
Example 4A composition containing phytochelatin
A composition contains phytochelatin 8g, sapindus saponin 25g, and trehalose 15 g.
Example 5A composition containing phytochelatin
A composition contains phytochelatin 7g, sapindus saponin 22g, and trehalose 16 g.
Example 6A composition containing phytochelatin
A composition contains phytochelatin 12g, sapindus saponin 10g, and trehalose 25 g.
Example 7A composition containing phytochelatin
A composition contains phytochelatin 5g, sapindus saponin 30g, and trehalose 15 g.
Example 8A composition containing phytochelatin
A composition contains phytochelatin 7g, sapindus saponin 22g, and trehalose 0 g.
Example 9A composition containing phytochelatin
A composition contains phytochelatin 7g, sapindus saponin 0g, and trehalose 15 g.
TABLE 1 EXAMPLES 1-9 Components and amounts of phytochelatin-containing compositions
| Phytochelatin (g) | Sapindus saponin (g) | Trehalose (g) | |
| Example 1 | 5 | 15 | 20 |
| Example 2 | 10 | 28 | 10 |
| Example 3 | 6 | 20 | 18 |
| Example 4 | 8 | 25 | 15 |
| Example 5 | 7 | 22 | 16 |
| Example 6 | 12 | 10 | 25 |
| Example 7 | 5 | 30 | 15 |
| Example 8 | 7 | 22 | 0 |
| Example 9 | 7 | 0 | 15 |
Respectively adding 200mg of the compositions of examples 1-9 into 20g of essence, adding 200mg of deionized water into a control group, uniformly stirring, standing for 10min, and measuring the content of heavy metals.
The formula of the essence comprises: the component content is calculated by weight percent and comprises the following components: 2% of ceramide, 3% of glycerol, 15% of vitamin E essence, 0.2% of abietic acid and the balance of deionized water.
First, testing complexing performance of heavy metal
Carrying out heavy metal detection on the prepared essence according to technical specifications for cosmetic safety (2015 edition), wherein a first graphite furnace atomic absorption spectrophotometry is adopted as a lead determination method; the total mercury was measured by a second mercury analyzer method, and the results are shown in Table 2.
Table 2 heavy metal test results
| Lead mg/kg | Mercury mg/kg | Cadmium mg/kg | |
| Example 1 | 0.36 | 0.0008 | 0.020 |
| Example 2 | 0.28 | 0.0007 | 0.018 |
| Example 3 | 0.32 | 0.0008 | 0.017 |
| Example 4 | 0.20 | 0.0006 | 0.015 |
| Example 5 | 0.16 | 0.0005 | 0.010 |
| Example 6 | 1.33 | 0.0026 | 0.055 |
| Example 7 | 1.41 | 0.0028 | 0.062 |
| Example 8 | 1.30 | 0.0025 | 0.050 |
| Example 9 | 1.25 | 0.0023 | 0.046 |
| Control group | 1.50 | 0.0030 | 0.080 |
As can be seen from the above, the serum without the phytochelatin composition of the present invention was found to detect lead (mg/kg)1.50, mercury (mg/kg)0.0030, and cadmium (mg/kg) 0.080. The essence added with phytochelatin composition of examples 1 to 5 of the present invention detected lead (mg/kg)0.16 to 0.36, mercury (mg/kg)0.0008 to 0.0005, and cadmium (mg/kg)0.010 to 0.020. The plant chelating peptide composition of the embodiment 1-5 has obvious chelating effect on heavy metals, and can effectively remove the pollution of the heavy metals such as lead, mercury, chromium and the like.
The chelating effect of the phytochelatin compositions of examples 6 to 7 on heavy metals such as lead, mercury and chromium is significantly weaker than that of examples 1 to 5 of the present invention, and it can be seen that the chelating effect of the phytochelatin, sapindoside and trehalose is greatly affected, and meanwhile, it can be seen from examples 8 and 9 that, after any one of the components of trehalose or sapindoside is omitted, although the amount of the phytochelatin is increased, the chelating effect on heavy metals such as lead, mercury and chromium is significantly reduced.
On the basis, the invention provides the application of the composition in preparing cosmetics/washing products/oral care products.
Preferably, the cosmetic includes, but is not limited to, a cream, a mask, a lotion, a serum, a moisturizer.
Preferably, the mass percentage of the composition in the cosmetics is 0.1-2.5%.
Preferably, the washing products include but are not limited to body wash, facial cleanser, shampoo and liquid detergent.
Preferably, the mass percentage of the composition in the washing article is 0.1-2.5%.
Preferably, the oral care product includes, but is not limited to, toothpaste, tooth powder, oral cleaning water, mouthwash, cleaning mist.
Preferably, the composition is 0.1-2.5% by weight of the oral care product.
The phytochelatin is not a coding product of a gene, but can be synthesized by taking glutathione as a substrate under the catalysis of phytochelatin synthetase, and the structural formula of the phytochelatin is as follows: (γ -Glu-Cys) n-Gly, wherein n ═ 2-11; further preferably n is 3-8. Wherein, PCS can be activated by metal ions, the highly conserved N-terminal is a catalytic domain, and the C-terminal is variable; GSH is a tripeptide containing gamma-amido bond and sulfhydryl group, is composed of glutamic acid, cysteine and glycine, widely exists in plant cells, and has extremely strong heavy metal chelating capacity. The soapberry saponin is triterpenoid glycoside extracted from soapberry false pericarp, is a natural surfactant, is completely biodegradable, has no genetic toxicity such as causing outburst and deformity, and can be used in various washing and caring products and cosmetics. The soapberry saponin has a good cleaning effect on lead, manganese, cadmium, chromium, arsenic and mercury, and trehalose is a surfactant and can promote the occurrence of a system complexing reaction. Compared with the prior art, the phytochelatin, the sapindoside and the trehalose play a synergistic role in chelating heavy metal ions and biologically detoxifying, particularly in removing lead ions, mercury ions and cadmium ions, can effectively remove heavy metal pollution of daily chemical products and human epidermis, and provides guarantee for safety of daily chemical products and human bodies.
The present invention has been further described with reference to specific embodiments, which are only exemplary and do not limit the scope of the present invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A composition containing phytochelatin is characterized by comprising phytochelatin, sapindus saponin and trehalose.
2. The composition of claim 1, wherein the phytochelatin has the formula: (γ -Glu-Cys) n-Gly, wherein n ═ 2-11.
3. The composition according to claim 1, wherein the mass ratio of phytochelatin to sapindoside to trehalose is 5-10: 15-28: 10-20.
4. The composition according to claim 4, wherein the mass ratio of phytochelatin to sapindoside to trehalose is 6-8: 20-25: 15-18.
5. Use of a composition according to any one of claims 1 to 4 for the preparation of a cosmetic product.
6. The use according to claim 6, wherein the composition is present in the cosmetic composition in an amount of 0.1 to 2.5% by weight.
7. Use of a composition according to any of claims 1 to 4 in the manufacture of a laundry product.
8. Use according to claim 8, wherein the composition is present in the article in an amount of 0.1 to 2.5% by weight.
9. Use of a composition according to any one of claims 1 to 4 in the manufacture of an oral care product.
10. The use of claim 9, wherein the composition is present in the oral care product in an amount of 0.1 to 2.5% by weight.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86106616A (en) * | 1986-10-07 | 1987-04-22 | 广西壮族自治区职业病防治研究所 | Dertergent for washing away pollutant from heavy metals |
| JP2002080385A (en) * | 2000-06-27 | 2002-03-19 | Hayashibara Biochem Lab Inc | Metal deposition inhibitor |
| CN105647669A (en) * | 2015-12-27 | 2016-06-08 | 泉州市简能环保科技有限公司 | Detergent containing sapindoside |
| US20180296461A1 (en) * | 2015-05-08 | 2018-10-18 | Cyra Consultora Limitada | Arsenic-chelating composition |
| CN111374903A (en) * | 2020-05-22 | 2020-07-07 | 英国纽歌芬生物科技国际集团控股有限公司 | Cosmetic composition containing phytochelatin |
-
2022
- 2022-01-11 CN CN202210028145.7A patent/CN114376935A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86106616A (en) * | 1986-10-07 | 1987-04-22 | 广西壮族自治区职业病防治研究所 | Dertergent for washing away pollutant from heavy metals |
| JP2002080385A (en) * | 2000-06-27 | 2002-03-19 | Hayashibara Biochem Lab Inc | Metal deposition inhibitor |
| US20180296461A1 (en) * | 2015-05-08 | 2018-10-18 | Cyra Consultora Limitada | Arsenic-chelating composition |
| CN105647669A (en) * | 2015-12-27 | 2016-06-08 | 泉州市简能环保科技有限公司 | Detergent containing sapindoside |
| CN111374903A (en) * | 2020-05-22 | 2020-07-07 | 英国纽歌芬生物科技国际集团控股有限公司 | Cosmetic composition containing phytochelatin |
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