CN111372936A - Mcl-1选择性抑制剂及其制备和用途 - Google Patents

Mcl-1选择性抑制剂及其制备和用途 Download PDF

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Publication number
CN111372936A
CN111372936A CN201880075917.4A CN201880075917A CN111372936A CN 111372936 A CN111372936 A CN 111372936A CN 201880075917 A CN201880075917 A CN 201880075917A CN 111372936 A CN111372936 A CN 111372936A
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China
Prior art keywords
alkyl
phenyl
methyl
substituted
methoxy
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CN201880075917.4A
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English (en)
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CN111372936B (zh
Inventor
刘志华
陈坤成
袁保昆
焦楠
解博闻
闵汪洋
许新合
刘希杰
孙莹
徐枫
孙颖慧
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Centaurus Biopharma Co Ltd
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Centaurus Biopharma Co Ltd
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Priority claimed from CN201711189194.4A external-priority patent/CN109824690A/zh
Priority claimed from CN201810425784.0A external-priority patent/CN110452253A/zh
Application filed by Centaurus Biopharma Co Ltd filed Critical Centaurus Biopharma Co Ltd
Publication of CN111372936A publication Critical patent/CN111372936A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明提供了Mcl‑1选择性抑制剂及其制备和用途；本发明同时提供了一系列由通式(I)所表示的化合物及其药学上可接受的盐、溶剂化物、多晶型物或前药、包含这些化合物的药物组合物，以及用此类化合物治疗由过度表达或失调的MCL‑1蛋白引起的或加重的疾病的方法。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880075917.4A 2017-11-23 2018-11-22 Mcl-1选择性抑制剂及其制备和用途 Active CN111372936B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201711189194.4A CN109824690A (zh) 2017-11-23 2017-11-23 Mcl-1选择性抑制剂及其制备和用途
CN2017111891944 2017-11-23
CN2018104257840 2018-05-08
CN201810425784.0A CN110452253A (zh) 2018-05-08 2018-05-08 Mcl-1选择性抑制剂及其制备和用途
PCT/CN2018/117014 WO2019101144A1 (zh) 2017-11-23 2018-11-22 Mcl-1选择性抑制剂及其制备和用途

Publications (2)

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CN111372936A true CN111372936A (zh) 2020-07-03
CN111372936B CN111372936B (zh) 2022-12-02

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CN (1) CN111372936B (zh)
WO (1) WO2019101144A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113024577B (zh) * 2019-12-09 2023-06-30 首药控股(北京)股份有限公司 一种抗凋亡蛋白选择性抑制剂的制备方法
CN113024578A (zh) * 2019-12-09 2021-06-25 首药控股(北京)有限公司 一种mcl1选择性抑制剂的多晶型物及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) * 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207217A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207225A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207216A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
CN108424417A (zh) * 2017-12-21 2018-08-21 河南美泰宝生物制药有限公司 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用
CN109824690A (zh) * 2017-11-23 2019-05-31 北京赛林泰医药技术有限公司 Mcl-1选择性抑制剂及其制备和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3567043B1 (en) * 2017-01-05 2023-12-06 Henan Genuine Biotech Co., Ltd. 2-[[5-[(4-hydroxy-3-chloro-2-methyl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl]oxy]-3-(2-methoxybenzene)propanoic acid derivatives as mcl-1 and bcl-2 inhibitors for treating cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) * 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207217A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207225A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207216A1 (en) * 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
CN109824690A (zh) * 2017-11-23 2019-05-31 北京赛林泰医药技术有限公司 Mcl-1选择性抑制剂及其制备和用途
CN108424417A (zh) * 2017-12-21 2018-08-21 河南美泰宝生物制药有限公司 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用

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CN111372936B (zh) 2022-12-02
WO2019101144A1 (zh) 2019-05-31

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