CN111329812A - A whitening skin care product containing natural plant extract - Google Patents
A whitening skin care product containing natural plant extract Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a whitening skin care product containing natural plant extracts, which is prepared from the following raw materials in parts by weight: 5 parts of normal hexane extract of narcissus petals, 5 parts of chloroform extract of astragalus membranaceus, 5 parts of chloroform extract of salvia miltiorrhiza leaves, 5 parts of chloroform extract of medlar, 30 parts of stearic acid, 5 parts of beeswax, 13 parts of cetyl alcohol, 1.5 parts of squalane, 8 parts of glyceryl monostearate, 7 parts of propylene glycol, 2 parts of triethanolamine, 0.05 part of essence and 150 parts of deionized water. The skin care product has remarkable whitening effect, and has obvious synergistic effect on the aspect of inhibiting the activity of tyrosinase by combining the normal hexane extract of narcissus petals, the chloroform extract of astragalus, the chloroform extract of salvia miltiorrhiza leaves and the chloroform extract of medlar according to a specific proportion, thereby achieving the unexpected whitening effect. The skin care product completely meets indexes in technical specifications for cosmetic safety (2015 edition) issued by the nation, has no irritation to skin, and is safe and reliable.
Description
Technical Field
The invention relates to the field of daily cosmetics, in particular to a whitening skin care product containing natural plant extracts.
Background
The whitening cosmetics containing the raw materials have a whitening effect and cause certain damage to skin, and the products are easy to discolor and have unstable taste. For example, arbutin has high photosensitivity, and is easy to discolor and unstable when being added in a large amount in the product; kojic acid easily causes contact dermatitis when added in a large amount; ascorbic acid is not easy to be absorbed by skin, and is easy to be oxidized and discolored when being heated and lighted, so that the whitening effect is lost; the activity of the cell growth factor has short shelf life and is not easy to store for a long time. Most of common whitening agents are water-soluble, are not easy to be absorbed by skin, can only reach the surface layer of the skin and even stay on the surface of the skin, but can not reach the basal layer, and influence the whitening effect to a great extent. The general whitening cosmetics also have great safety hazards because the effects of many whitening agents are closely related to the use concentration thereof, and generally, the higher the use concentration, the lower the pH, the more obvious the whitening effect, but the greater the irritation, and even permanent damage to the skin in severe cases.
With the development of plant extraction technology, more and more plant extracts are applied to whitening cosmetics and become effective functional components in the cosmetics. At present, various cosmetics containing plant extracts are available, but the use effect is not satisfactory for various reasons, and therefore, it is imperative to develop new skin care products having remarkable whitening efficacy.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a whitening skin care product containing natural plant extracts, which is realized by the following technical scheme:
a whitening skin care product containing natural plant extracts comprises whitening efficacy components, matrix components and deionized water, wherein the whitening efficacy components comprise the following raw materials in parts by weight:
3-10 parts of normal hexane extract of daffodil petals
3-10 parts of chloroform extract of astragalus
3-10 parts of chloroform extract of salvia miltiorrhiza leaves
3-10 parts of chloroform extract of the medlar.
Preferably, the preparation method of the n-hexane extract of the narcissus petals comprises the following steps: the method comprises the steps of taking petals of narcissus as a raw material, adding 5-10 times of 93-98% ethanol solution in parts by volume, soaking for 12-48h, heating and refluxing for extraction for 1-4 times, wherein the reflux extraction time is 1-5h each time, filtering an extracting solution, recovering ethanol from a filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with isometric n-hexane until a water phase is colorless, recovering a solvent from an obtained n-hexane extracting solution, and drying to obtain the narcissus extract.
Preferably, the preparation method of the chloroform extract of astragalus comprises the following steps: the method comprises the steps of taking astragalus membranaceus as a raw material, adding the astragalus membranaceus into a 5-10 times of 93-98% ethanol solution in parts by volume, soaking for 12-48 hours, heating and refluxing for extraction for 1-4 times, wherein the reflux extraction time is 1-5 hours each time, filtering an extracting solution, recovering ethanol from a filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with chloroform of the same volume until a water phase is colorless, recovering a solvent from an obtained chloroform extracting solution, and drying to obtain the active compound.
Preferably, the preparation method of the chloroform extract of the salvia miltiorrhiza leaves comprises the following steps: the method comprises the steps of taking salvia miltiorrhiza leaves as a raw material, adding 5-10 times of 93-98% ethanol solution in parts by volume, soaking for 12-48h, heating and refluxing for extraction for 1-4 times, wherein the reflux extraction time is 1-5h each time, filtering an extracting solution, recovering ethanol from a filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with chloroform of the same volume until a water phase is colorless, recovering a solvent from an obtained chloroform extracting solution, and drying to obtain the salvia miltiorrhiza leaf extract.
Preferably, the preparation method of the chloroform extract of the medlar comprises the following steps: the method comprises the steps of taking wolfberry fruits as raw materials, adding 5-10 times of 93-98% ethanol solution in parts by volume, soaking for 12-48 hours, heating and refluxing for extraction for 1-4 times, wherein the refluxing time is 1-5 hours each time, filtering an extracting solution, recovering ethanol from filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with chloroform of the same volume until a water phase is colorless, recovering a solvent from an obtained chloroform extracting solution, and drying to obtain the traditional Chinese medicine composition.
Further, the matrix component and the deionized water in the whitening skin care product are as follows in parts by weight:
20-40 parts of stearic acid
3-7 parts of beeswax
10-15 parts of hexadecanol
0.5 to 3 portions of squalane
5-10 parts of glycerin monostearate
3-10 parts of propylene glycol
1-3 parts of triethanolamine
0.02-0.05 part of essence
100 portions and 200 portions of deionized water.
Preferably, the whitening skin care product containing the natural plant extract is prepared from the following raw materials in parts by weight:
narcissus petal n-hexane extract 5 parts
Chloroform extract of astragalus root 5 parts
Chloroform extract of red sage root leaf 5 parts
5 parts of chloroform extract of medlar
30 portions of stearic acid
5 parts of beeswax
13 portions of hexadecanol
1.5 parts of squalane
8 parts of glycerin monostearate
Propylene glycol 7 parts
Triethanolamine 2 parts
0.05 part of essence
And 150 parts of deionized water.
The invention also provides a preparation method of the whitening skin care product containing the natural plant extract, which comprises the following specific steps:
(1) mixing stearic acid, beeswax, cetyl alcohol, squalane, glyceryl monostearate, propylene glycol and triethanolamine, and heating to 80-90 deg.C;
(2) mixing deionized water with n-hexane extract of daffodil petal, chloroform extract of radix astragali, chloroform extract of radix Salviae Miltiorrhizae leaf and chloroform extract of fructus Lycii, and heating to 80-90 deg.C;
(3) mixing the materials obtained in the steps (1) and (2) and homogenizing;
(4) cooling to 30-40 deg.C, adding perfume, stirring, mixing, and cooling to room temperature to obtain the skin whitening and caring product containing natural extract.
Compared with the prior art, the invention has the beneficial effects that: the skin care product has remarkable whitening effect, and has obvious synergistic effect on the aspect of inhibiting the activity of tyrosinase by combining the normal hexane extract of narcissus petals, the chloroform extract of astragalus, the chloroform extract of salvia miltiorrhiza leaves and the chloroform extract of medlar according to a specific proportion, thereby achieving the unexpected whitening effect. The skin care product completely meets indexes in technical specifications for cosmetic safety (2015 edition) issued by the nation, has no irritation to skin, and is safe and reliable.
Detailed Description
The present invention will be further specifically described with reference to the following examples.
Example 1:
a whitening skin care product containing natural plant extracts is prepared from the following raw materials in parts by weight:
narcissus petal n-hexane extract 5 parts
Chloroform extract of astragalus root 5 parts
Chloroform extract of red sage root leaf 5 parts
5 parts of chloroform extract of medlar
30 portions of stearic acid
5 parts of beeswax
13 portions of hexadecanol
1.5 parts of squalane
8 parts of glycerin monostearate
Propylene glycol 7 parts
Triethanolamine 2 parts
0.05 part of essence
And 150 parts of deionized water.
The preparation method of the n-hexane extract of the narcissus petals comprises the following steps: taking 100g of dried petals of daffodil as a raw material, adding 10 times of 98% ethanol solution by volume, soaking for 12h, heating and refluxing for 2 times, wherein the refluxing time is 1h each time, filtering the extracting solution, recovering ethanol from the filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with equal volume of n-hexane until the water phase is colorless, recovering the solvent from the obtained n-hexane extract, and drying to obtain solid powder.
The preparation method of the chloroform extract of the astragalus comprises the following steps: 100g of astragalus is used as a raw material, 10 times of 98% ethanol solution in parts by volume is added into the astragalus to be soaked for 12 hours, then the mixture is heated and refluxed and extracted for 2 times, the reflux extraction time is 1 hour each time, the extracting solution is filtered, the filtrate is concentrated into extract after recovering ethanol, water is added for dissolution, the mixture is extracted by chloroform with the same volume until the water phase is colorless, and the obtained chloroform extracting solution is dried after recovering the solvent to obtain solid powder.
The preparation method of the chloroform extract of the salvia miltiorrhiza leaves comprises the following steps: 100g of salvia miltiorrhiza leaves are taken as a raw material, 10 times of ethanol solution with the volume fraction of 98% is added to soak for 12 hours, then the mixture is heated and refluxed and extracted for 2 times, the reflux extraction time is 1 hour each time, the extracting solution is filtered, the filtrate is concentrated into extract after recovering ethanol, water is added to dissolve the extract, the extract is extracted by chloroform with the same volume until the water phase is colorless, and the obtained chloroform extracting solution is dried after recovering the solvent to obtain solid powder.
The preparation method of the chloroform extract of the medlar comprises the following steps: wolfberry chloroform extract solution: 100g of medlar serving as a raw material is added into a 10-time ethanol solution with the volume portion of 98% to be soaked for 12 hours, then the heating reflux extraction is carried out for 2 times, the reflux extraction time is 1 hour each time, the extracting solution is filtered, the filtrate is concentrated into an extract after the ethanol is recovered, water is added for dissolution, the chloroform with the same volume is used for extraction until the water phase is colorless, and the obtained chloroform extracting solution is dried after the solvent is recovered to obtain solid powder.
The preparation method of the whitening skin care product containing the natural plant extract comprises the following steps:
(1) mixing stearic acid, beeswax, cetyl alcohol, squalane, glyceryl monostearate, propylene glycol and triethanolamine, and heating to 85 deg.C;
(2) mixing deionized water with n-hexane extract of daffodil petal, chloroform extract of radix astragali, chloroform extract of radix Salviae Miltiorrhizae leaf and chloroform extract of fructus Lycii, and heating to 85 deg.C;
(3) mixing the materials obtained in the steps (1) and (2) and homogenizing;
(4) cooling to 40 ℃, adding the perfume, stirring and mixing uniformly, and cooling to room temperature to obtain the whitening skin care product containing the natural extract.
The test for tyrosinase inhibitory activity was performed on natural plant extracts used in the present invention:
firstly, preparing a sample solution:
(1) narcissus petal n-hexane extract solution: taking a proper amount of the narcissus petal n-hexane extract prepared in the example 1, and then preparing a sample solution with the mass concentration of 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125g/L by using a phosphate buffer solution with the pH value of 6.8;
(2) chloroform extract solution of radix astragali: taking a proper amount of the astragalus chloroform extract prepared in the example 1, and preparing sample solutions with the mass concentrations of 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125g/L by using a phosphate buffer solution with the pH value of 6.8;
(3) chloroform extract solution of salvia miltiorrhiza leaves: taking a proper amount of the chloroform extract of the salvia miltiorrhiza leaves prepared in the example 1, and then preparing sample solutions with the mass concentrations of 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125g/L by using a phosphate buffer solution with the pH value of 6.8;
(4) wolfberry chloroform extract solution: taking a proper amount of the wolfberry chloroform extract prepared in the example 1, and preparing sample solutions with the mass concentrations of 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125g/L by using a phosphate buffer solution with the pH value of 6.8;
(5) the mass ratio is 1: 1: 1: 1 combined extract solution: the four extracts prepared in example 1 were mixed uniformly in the same weight, and then prepared into sample solutions with mass concentrations of 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125g/L with a phosphate buffer solution of pH 6.8.
Secondly, a test method comprises the following steps: for sample solution with each concentration, taking four test tubes and respectively marking the test tubes with No. 1, No. 2, No. 3 and No. 4; referring to the reagent amount and concentration in Table 1, the corresponding reaction solution listed in each column was added to four tubes, mixed uniformly with shaking, preheated at 37 ℃ for 10min, then 1ml of 5 mmol/L-dopa reaction solution was added to each tube, reacted at 37 ℃ for 5min accurately, transferred to a cuvette rapidly, and the absorbance value (A) was measured at 475 nm. The sample solutions at each concentration were tested in triplicate and averaged.
Thirdly, calculating the inhibition rate of tyrosinase according to the following formula:
inhibition rate = [1- (A3-A4)/(A1-A2) ] × 100%
In the formula: a1, A2, A3 and A4 represent absorbance values at 475nm after reaction in four test tubes No. 1, No. 2, No. 3 and No. 4 in Table 1, respectively.
The inhibition data for the different concentrations of the extract solutions were plotted using GraphPad Prism software to generate a standard curve and calculate the half-inhibitory concentration IC50 for each extract, the results of which are shown in table 2. The efficacy of the inhibitor was characterized by the concentration of the inhibitor (IC 50) that resulted in a 50% decrease in tyrosinase activity, with smaller values of IC50 indicating a greater ability of the extract to inhibit tyrosinase activity.
Table 1: composition of the solution to be tested (unit: ml)
| Reaction solution | Number 1 | Number 2 | No. 3 | Number 4 |
| 50U/ml mushroom tyrosinase solution | 1 | 0 | 1 | 0 |
| Sample solution | 0 | 0 | 1 | 1 |
| pH6.8 phosphate buffer | 2 | 3 | 1 | 2 |
Table 2: results of detection of inhibition of tyrosine Activity by Each sample (unit: mg/ml)
| Sample (I) | IC50 (Unit: mg/ml) |
| Narcissus petal n-hexane extract | 20.36 |
| Chloroform extract of radix astragali | 3.52 |
| Chloroform extract of Salvia miltiorrhiza leaves | 2.56 |
| Chloroform extract of fructus Lycii | 3.85 |
| Composition of four extracts (1: 1: 1: 1) | 0.105 |
The clinical use effect data of the whitening skin care product prepared in the embodiment 1 of the invention are as follows:
30 female white-collar workers are selected as subjects, the age range is 22-36 years, the average age is 28 years, the health and the regular work and rest are realized, no skin disease or allergic disease history exists, and cosmetics can be used according to the specification. The facial skin of the above subjects had problems of dull skin, pigmentation, and dullness.
The test method comprises the following steps: the test environment temperature is 22 deg.C + -1 deg.C, humidity is 50% + -5%, and the melanin content of facial skin is measured by MX18 skin pigment detector of CK company of Germany 1 day before application of cosmetics and 7 days after continuous application of skin care products, and the average value is obtained by repeating the measurement three times.
The use method of the cosmetic comprises the following steps: after the face is washed with warm boiled water respectively in the morning and before bedtime, a proper amount of the skin care product of the embodiment 1 of the invention is uniformly smeared on the face, and then the face is gently massaged to ensure that the cosmetic is uniformly absorbed. All subjects did not use any other cosmetic or skin care product during the test.
Melanin reduction rate = (melanin content 1 day before using cosmetics-black pigment content on the second day after 7 days of continuous using cosmetics)/melanin content 1 day before using cosmetics × 100%.
The effect judgment standard is that ① has obvious effects of brightening skin color and obviously lightening pigmentation, the reduction rate of melanin is more than 30%, ② has the effects of improving skin color and obviously lightening pigmentation, the reduction rate of melanin is between 5% and 30%, ③ has no effect that the skin color and the pigmentation are not obviously changed compared with the skin color and the pigmentation before the test, and the reduction rate of melanin is lower than 5%.
And (3) test results: 24 cases of significant effect, 6 cases of effect and 0 case of no effect, the significant efficiency is 80 percent, and the total effective rate is 100 percent.
The above-mentioned embodiments are merely preferred embodiments of the present invention, and the scope of the present invention should not be limited thereby, and those skilled in the art should not make any insubstantial changes and substitutions based on the present invention.
Claims (1)
1. A whitening skin care product containing natural plant extracts is characterized by being prepared from the following raw materials in parts by weight:
narcissus petal n-hexane extract 5 parts
Chloroform extract of astragalus root 5 parts
Chloroform extract of red sage root leaf 5 parts
5 parts of chloroform extract of medlar
30 portions of stearic acid
5 parts of beeswax
13 portions of hexadecanol
1.5 parts of squalane
8 parts of glycerin monostearate
Propylene glycol 7 parts
Triethanolamine 2 parts
0.05 part of essence
150 parts of deionized water
The preparation method of the n-hexane extract of the narcissus petals comprises the following steps: taking 100g of dried petals of daffodil as a raw material, adding 10 times of 98% ethanol solution in parts by volume for soaking for 12 hours, then heating and refluxing for extraction for 2 times, wherein the reflux extraction time is 1 hour each time, filtering the extract, recovering ethanol from the filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with equal volume of n-hexane until the water phase is colorless, recovering the solvent from the obtained n-hexane extract, and drying to obtain solid powder;
the preparation method of the chloroform extract of the astragalus comprises the following steps: 100g of astragalus is taken as a raw material, 10 times of ethanol solution with the volume fraction of 98% is added to be soaked for 12 hours, then the mixture is heated and refluxed and extracted for 2 times, the reflux extraction time is 1 hour each time, the extracting solution is filtered, the filtrate is concentrated into extract after recovering the ethanol, water is added to dissolve the extract, the extract is extracted by chloroform with the same volume until the water phase is colorless, and the obtained chloroform extracting solution is dried after recovering the solvent to obtain solid powder;
the preparation method of the chloroform extract of the salvia miltiorrhiza leaves comprises the following steps: taking 100g of salvia miltiorrhiza leaves as a raw material, adding 10 times of 98% ethanol solution in parts by volume, soaking for 12h, heating and refluxing for 2 times, wherein the reflux extraction time is 1h each time, filtering the extracting solution, recovering ethanol from the filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with chloroform of the same volume until the water phase is colorless, recovering the solvent from the obtained chloroform extract, and drying to obtain solid powder;
the preparation method of the chloroform extract of the medlar comprises the following steps: wolfberry chloroform extract solution: taking 100g of wolfberry fruits as a raw material, adding 10 times of 98% ethanol solution in parts by volume, soaking for 12 hours, heating and refluxing for 2 times, wherein the refluxing time is 1 hour each time, filtering an extracting solution, recovering ethanol from filtrate, concentrating the filtrate into an extract, adding water for dissolving, extracting with chloroform of the same volume until a water phase is colorless, recovering a solvent from an obtained chloroform extracting solution, and drying to obtain solid powder;
the preparation method of the whitening skin care product containing the natural plant extract comprises the following steps:
(1) mixing stearic acid, beeswax, cetyl alcohol, squalane, glyceryl monostearate, propylene glycol and triethanolamine, and heating to 85 deg.C;
(2) mixing deionized water with n-hexane extract of daffodil petal, chloroform extract of radix astragali, chloroform extract of radix Salviae Miltiorrhizae leaf and chloroform extract of fructus Lycii, and heating to 85 deg.C;
(3) mixing the materials obtained in the steps (1) and (2) and homogenizing;
(4) cooling to 40 ℃, adding the perfume, stirring and mixing uniformly, and cooling to room temperature to obtain the whitening skin care product containing the natural extract.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366478A (en) * | 2011-11-14 | 2012-03-07 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
| CN104666172A (en) * | 2015-01-22 | 2015-06-03 | 李健 | Whitening and moisturizing skin care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366478A (en) * | 2011-11-14 | 2012-03-07 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
| CN104666172A (en) * | 2015-01-22 | 2015-06-03 | 李健 | Whitening and moisturizing skin care product |
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Application publication date: 20200626 |
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