CN111184665B - Composition with sun-screening, whitening and anti-aging effects and application thereof - Google Patents
Composition with sun-screening, whitening and anti-aging effects and application thereof Download PDFInfo
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- CN111184665B CN111184665B CN202010101512.2A CN202010101512A CN111184665B CN 111184665 B CN111184665 B CN 111184665B CN 202010101512 A CN202010101512 A CN 202010101512A CN 111184665 B CN111184665 B CN 111184665B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention provides a composition with sun-screening, whitening and anti-aging effects and application thereof, belonging to the technical field of cosmetics. The composition comprises scutellaria root extract, rutin, curcumin and ferulic acid, and the mass ratio of the four components is that the scutellaria root extract: rutin: curcumin: ferulic acid 2-18: 1-14: 0.1-8: 0.1-5, under the synergistic effect of the four components, the composition has excellent sun-screening, whitening and anti-aging effects, is natural and safe, and is easy for industrial production, popularization and application.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to a composition with sun-screening, whitening and anti-aging effects and application thereof.
Background
In recent years, with the occurrence of partial holes in the ozone layer of the atmosphere, the ultraviolet ray filtering effect is reduced, and the radiation intensity of sunlight is increased. Although the sun ultraviolet is a necessary condition for all things to grow, excessive ultraviolet can damage the immune system of the human body, damage collagen and elastin in the dermis, reduce the elasticity of the skin, generate wrinkles and cause skin aging. Meanwhile, long-time and high-intensity ultraviolet irradiation can enable the skin to generate a large number of free radicals to induce peroxidation of cell membranes, so that melanocytes generate a large number of melanin, and then the melanin moves layer by layer through cell metabolism to the epidermis of the skin, and skin problems such as color spots, uneven skin color and the like seen by people are formed. Therefore, the importance of sun protection is an important way to maintain the health of skin.
Throughout the cosmetic market, most products contain sunscreens, which integrate the concept of sunscreen protection into the daily skin care life. However, most sunscreen products add a large amount of organic uv absorbers in the pursuit of high SPF sunscreen effect, which undoubtedly will greatly increase the possibility of skin irritation and irritation. Under the background that whitening and anti-aging become an industrial hotspot, natural plant extracts integrating a plurality of functions of sun-screening, whitening and anti-aging are developed and researched, and the natural plant extracts have good application prospects.
Disclosure of Invention
In order to overcome the above disadvantages and shortcomings of the prior art, the present invention aims to provide a composition with sunscreen, whitening and anti-aging effects and applications thereof.
In order to realize the purpose, the invention adopts the technical scheme that:
in a first aspect, the present invention provides a composition with sunscreen, whitening and anti-aging effects, which comprises scutellaria baicalensis root extract, rutin, curcumin and ferulic acid, wherein the mass ratio of the scutellaria baicalensis root extract to the rutin to the curcumin to the ferulic acid is as follows: rutin: curcumin: ferulic acid 2-18: 1-14: 0.1-8: 0.1-5.
As a further preferred embodiment of the composition of the present invention, the mass ratio of the scutellaria root extract, rutin, curcumin and ferulic acid is that the scutellaria root extract: rutin: curcumin: ferulic acid 15-18: 10-14: 5-8: 5.
the Scutellariae radix extract has antibacterial, antiinflammatory, antioxidant, and immunoregulatory effects; rutin has antiinflammatory, antioxidant, free radical scavenging, and radioprotective effects; curcumin is a yellow pigment extracted from rhizome of Curcuma rhizome of Zingiberaceae, and has antiinflammatory, antioxidant, skin whitening, and antiaging effects; ferulic acid has whitening, antioxidant, and sunscreen effects. The inventor uses the scutellaria root extract, rutin, curcumin and ferulic acid in a combined way, finds that the four components can be used for synergistically preventing sun, whitening and resisting aging, and when the mass ratio of the scutellaria root extract, the rutin, the curcumin and the ferulic acid is that of the scutellaria root extract: rutin: curcumin: ferulic acid 2-18: 1-14: 0.1-8: 0.1-5, the composition has good sun-screening, whitening and anti-aging effects, and especially when the mass ratio of the scutellaria root extract to rutin to curcumin to ferulic acid is as follows: rutin: curcumin: ferulic acid 15-18: 10-14: 5-8: 5, the composition has better sun-screening, whitening and anti-aging effects.
As a preferred embodiment of the composition of the present invention, the ratio by mass of the scutellaria root extract, rutin, curcumin and ferulic acid is scutellaria root extract: rutin: curcumin: ferulic acid 18:14:8: 5.
As a preferred embodiment of the composition of the present invention, the ratio by mass of the scutellaria root extract, rutin, curcumin and ferulic acid is scutellaria root extract: rutin: curcumin: ferulic acid 15:10:5: 5.
As a preferred embodiment of the composition of the present invention, the scutellaria root extract comprises at least one of baicalin, wogonin, and baicalein.
In a second aspect, the present invention provides a cosmetic product comprising the above composition.
As a preferred embodiment of the cosmetic, the cosmetic comprises the following components in percentage by mass: 0.01-18% of scutellaria root extract, 0.01-14% of rutin, 0.01-8% of curcumin and 0.01-8% of ferulic acid.
As a further preferable embodiment of the cosmetic of the present invention, the cosmetic comprises the following components by mass: 0.1-15% of scutellaria root extract, 1-12% of rutin, 0.1-7% of curcumin and 0.05-8% of ferulic acid.
As a further preferred embodiment of the cosmetic according to the invention, the composition represents 11 to 55% by mass of the cosmetic. Thus, the SPF value of the cosmetic is greater than 15.
As a preferred embodiment of the cosmetic of the present invention, the cosmetic further comprises the following components in percentage by mass: 10-40% of cosmetic matrix and the balance of deionized water
As a preferred embodiment of the cosmetic of the present invention, the cosmetic base comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a neutralizer, a preservative, a physical sunscreen agent, a chelating agent, and a fragrance.
In a preferred embodiment of the cosmetic of the present invention, the cosmetic is in the form of a liquid, an emulsion, a cream, or a solid.
In a further preferred embodiment of the cosmetic of the present invention, the cosmetic is in the form of an emulsion or cream.
In a third aspect, the present invention also provides a method for preparing the above cosmetic, which comprises the steps of:
(1) mixing glycerol, xanthan gum, EDTA disodium, propylene glycol and water, and heating to 75-85 deg.C to obtain phase A; mixing cetearyl glucoside, C14-22 alcohol, C12-20 alkyl glucoside, polydimethylsiloxane, glyceryl monostearate, titanium white powder slurry, isononyl isononanoate, white oil, curcumin, methyl hydroxybenzoate and propyl hydroxybenzoate, and heating to 75-85 deg.C to obtain phase B; adding phase B into phase A, mixing, homogenizing and emulsifying for 5-10min to obtain AB emulsified phase;
(2) cooling the AB emulsified phase to 60-70 deg.C, adding baicalin, rutin, ferulic acid, polyacrylamide, C13-14 isoparaffin and laureth-7, homogenizing and emulsifying for 3-5min, cooling to below 40 deg.C, and filtering to obtain the cosmetic.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the composition has excellent effects of sun screening, whitening and anti-aging through the synergistic effect among the scutellaria baicalensis root extract, the rutin, the curcumin and the ferulic acid.
(2) The functional components in the composition are derived from plants, are natural and safe, can be applied to cosmetics, and the obtained cosmetics not only have excellent sun-screening, whitening and anti-aging effects, but also are easy to popularize and apply.
(3) The preparation method of the cosmetic is simple and is easy for industrial production.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 4 and comparative examples 5 to 8 each relate to a composition, the composition of which is shown in table 1; comparative examples 1 to 4 each relate to a natural substance, and the kinds of the natural substances are shown in Table 1.
TABLE 1 composition of the compositions or Natural substances/parts by weight
| Components | Baicalin | Rutin (rutin) | Curcumin (curcumin) | Ferulic acid |
| Example 1 | 18 | 14 | 8 | 5 |
| Example 2 | 15 | 10 | 5 | 5 |
| Example 3 | 7 | 3 | 0.5 | 1 |
| Example 4 | 2 | 1 | 0.8 | 0.5 |
| Comparative example 1 | 18 | 0 | 0 | 0 |
| Comparative example 2 | 0 | 14 | 0 | 0 |
| Comparative example 3 | 0 | 0 | 8 | 0 |
| Comparative example 4 | 0 | 0 | 0 | 5 |
| Comparative example 5 | 0 | 14 | 8 | 5 |
| Comparative example 6 | 18 | 0 | 8 | 5 |
| Comparative example 7 | 18 | 14 | 0 | 5 |
| Comparative example 8 | 18 | 14 | 8 | 0 |
Effect example 1 tyrosinase Activity inhibition Rate test
Tyrosinase is a polyphenol oxidase, is a key enzyme and a rate-limiting enzyme in the process of forming skin melanin, the activity of the tyrosinase is in positive correlation with the melanin synthesis amount, and the activity change of the tyrosinase can cause pigmentation disorder dermatosis. The tyrosinase inhibitor can be used for preventing and treating pigmentation by inhibiting tyrosinase activity and preventing melanin formation.
Test samples: the compositions or natural substances in examples 1 to 4 and comparative examples 1 to 8 were each formulated into a solution of 0.1mg/mL using 0.2mol/L Phosphate Buffered Saline (PBS) having pH of 6.8 as a solvent, to obtain a test sample.
The test method comprises the following steps: to each of the above test samples (0.1 mg/mL) was added 1mL of L-tyrosine (0.3mol) and 1mL of Phosphate Buffer (PBS) having a pH of 6.8, and the mixture was preheated in a constant temperature water bath at 37 ℃ for 10min, then 0.1mL of an aqueous solution of tyrosinase (1.0mg/mL, mcllains buffer) was added, the mixture was sufficiently stirred, and after a reaction at 37 ℃ for 15 minutes, absorbance at 475nm was measured (D)1). In addition, the same reaction was carried out using the above phosphate buffer solution in place of the 0.1mg/mL solution prepared from the composition prepared in examples 1-4 and comparative examples 1-5, and the absorbance (D) was measured2). For comparison, the absorbance was measured without adding the sample solution and tyrosinase (D)3). The tyrosinase activity inhibition was calculated using the following formula:
tyrosinase activity inhibition ratio (%) - (D)2-D1)/(D2-D3)×100％；
The test results are shown in table 2.
TABLE 2 tyrosinase activity inhibition test results
And (4) test conclusion: in comparative examples 1 to 4, one of the four natural substances, namely the scutellaria root extract, rutin, curcumin and ferulic acid, is independently used, and as can be seen in comparison with example 1, the tyrosinase activity inhibition rate is remarkably lower than that of the composition provided by the invention when any one of the four natural substances is independently used; comparative examples 5 to 8 are compositions obtained by using any three of the four natural substances, and the same as other conditions of example 1, it can be seen that the clearance is improved compared with the clearance of one of the natural substances used alone, but the effect is different from that of the composition of the invention, which indicates that the composition of the invention can achieve a remarkable tyrosinase activity inhibition effect under the synergistic effect of the four extracts.
Effect example 2 melanin production inhibition test
The test method comprises the following steps: selecting the same generation of cells in logarithmic growth phase, blowing and beating the cells into single cell suspension after conventional pancreatin digestion treatment, counting and quantitatively inoculating the cells into a 96-well plate. After 24 hours, the supernatant was discarded, and the culture solutions containing examples 1-4 and arbutin, a positive control, 50. mu.g/ml, were added, respectively (the volume contents of the respective compositions were the same). At 37 deg.C, 5% by volume CO2Culturing under saturation and humidity conditions, adding RPMI1640 culture solution into a control hole, culturing for three days, replacing the culture solution once in the middle, then removing supernatant, counting cell density after conventional pancreatin digestion treatment, centrifuging to obtain cell precipitate, washing twice with PBS, centrifuging to remove supernatant, quantitatively adding 1N NaOH solution containing 10 vol% DMSO, carrying out water bath at 80 ℃ for 50 minutes, and then measuring the light absorption value at 450nm of an enzyme-labeling instrument. The inhibition of melanin production was calculated by the following formula:
the melanin production inhibition (%) was (test absorbance/control absorbance) × 100%;
the test results are shown in table 3.
TABLE 3 test results of melanin production inhibition
| Item | Inhibition of melanogenesis/%) |
| Example 1 | 69.35 |
| Example 2 | 65.72 |
| Example 3 | 60.37 |
| Example 4 | 51.12 |
| Positive control drug-arbutin | 54.34 |
And (4) test conclusion: the compositions of examples 1 to 3 all had the effect of inhibiting melanin production, and the composition of example 4 had the effect of inhibiting melanin production equivalent to arbutin, and was applied to whitening cosmetics.
Effect example 3 anti-wrinkle test
The free radicals can damage the skin from various aspects, so that the aging of the skin is accelerated, and therefore, whether the anti-aging product has an anti-aging effect can be judged by the effects of scavenging and inhibiting the free radicals.
(1) DPPH radical scavenging ability test
The test method comprises the following steps: the compositions of examples 1 to 4, the natural substances of comparative examples 1 to 4 and the groups of comparative examples 5 to 8The compound is prepared into a solution with the concentration of 0.1mg/mL, and the solution is respectively diluted to 40, 80, 120, 160 and 200 mu M by absolute ethyl alcohol; taking 1.4mg of DPPH and adding 17.5mL of absolute ethanol to obtain 0.2mmol/L DPPH solution; 100 mu L of the sample solution with different concentrations is added into a 96-hole enzyme label plate, then 100 mu L of the ready-made DPPH solution is added, and the final concentration of the sample is 20, 40, 60, 80 and 100 mu M. The enzyme label plate is insulated for 30min at 30 ℃, and then the absorbance value of the sample at the wavelength of 517nm is measured (A)1) Simultaneously, the absorbance (A) of a blank sample (100. mu.L of absolute ethanol instead of DPPH) without DPPH free radical reagent was measured2) And the absorbance (A) of the sample (100. mu.L of absolute ethanol instead of the sample) with the DPPH radical reagent3). The DPPH radical clearance was calculated using the following formula:
DPPH radical scavenging ratio (%) - [1- (A)1-A2)/A3]×100％；
The test results are shown in table 4.
TABLE 4 DPPH radical scavenging Rate test results
(2) Superoxide anion radical scavenging ability test
The test method comprises the following steps: preparing a buffer system (Tris-HCl-EDTA) with the pH value of 8.20, adding 0.6mL of a sample to be detected into a 10mL centrifuge tube, adding 5.2mL of buffer solution, adding 0.045mol/L pyrogallol solution 0.2mL by using a pipette, shaking up quickly, waiting for reaction for 5 minutes (time must be accurate), quickly placing in a dry cuvette, measuring the absorbance value at 325nm, and marking as A0And measuring after 10min as A4. The corresponding absorbance values measured by using distilled water instead of the sample are respectively recorded as B0And B4. The average value is obtained by 3 parallel operations, and the inhibition ratio of superoxide anion is calculated by the following formula:
inhibition of superoxide anionsThe yield (%) - (B)4－B0)－(A4－A0)]/(B4－B0)×100％；
The test results are shown in table 5.
TABLE 5 inhibition test results for superoxide anions
(3) Hydroxy radical scavenging ability test
The test method comprises the following steps: respectively taking 1mL, 0.4mmol/L crystal violet, 3mL, 0.2mol/L pH 7.4 phosphate buffer solution, 1mL, 0.001mol/L FeSO4Solution, 1mL of sample to be tested, was added to 10mL centrifuge tube, and finally 1mL 30% H2O2Reacting at room temperature for 1H, centrifuging at 12000r/min for 5min, collecting supernatant, measuring absorbance at 510nm as C, replacing sample with distilled water as C1, and replacing sample with distilled water and H2O2The light absorption value of time is recorded as C2. The mean values were obtained in 3 parallel runs and the hydroxyl radical clearance of the sample was calculated using the following formula:
clearance rate of hydroxyl radical (C-C)1)/(C2－C1)×100％；
The test results are shown in table 6.
TABLE 6 hydroxyl radical scavenging test results
| Item | Clearance of hydroxy radicals/%) |
| Example 1 | 76.95 |
| Example 2 | 78.52 |
| Example 3 | 67.65 |
| Example 4 | 64.88 |
| Comparative example 1 | 46.38 |
| Comparative example 2 | 45.65 |
| Comparative example 3 | 38.87 |
| Comparative example 4 | 43.31 |
| Comparative example 5 | 53.17 |
| Comparative example 6 | 56.32 |
| Comparative example 7 | 62.17 |
| Comparative example 8 | 60.36 |
As can be seen from tables 4, 5 and 6, the compositions of examples 1 to 4 of the present invention all have strong ability to scavenge free radicals and resist oxidation, and the best effect is obtained in examples 1 to 2.
When the effect is tested, the comparative examples 1 to 8 have the same conditions as the examples 1 to 4, and it can be seen that the free radical clearance rate is obviously lower than that of the composition of the invention when one of 4 natural substances or the composition consisting of any 3 of the 4 natural substances is singly used, which shows that the composition of the invention can achieve obvious whitening and anti-oxidation effects under the synergistic effect of the four substances.
The skin-care creams of examples 5 to 9 were all those having sunscreen, whitening and anti-aging effects, and the compositions thereof are shown in table 7, while the control cream was also provided, and the compositions thereof are also shown in table 7.
TABLE 7 composition/wt% of creams in examples 5-9
The preparation method of the creams in examples 5-9 comprises the following steps:
(1) mixing glycerol, xanthan gum, EDTA disodium and water, and heating to 75-85 deg.C to obtain phase A; mixing cetearyl glucoside, C14-22 alcohol, C12-20 alkyl glucoside, polydimethylsiloxane, glyceryl monostearate, isononyl isononanoate, white oil, titanium white powder slurry, curcumin, methyl hydroxybenzoate and propyl hydroxybenzoate, and heating to 75-85 deg.C to obtain phase B; adding phase B into phase A, mixing, homogenizing and emulsifying for 5-10min to obtain AB emulsified phase;
(2) cooling the AB emulsified phase to 65 deg.C, adding baicalin, rutin, ferulic acid, polyacrylamide, C13-14 isoparaffin and laureth-7, homogenizing and emulsifying for 3-5min, cooling to below 40 deg.C, and filtering to obtain the cream.
The control and creams of examples 5-9 were tested for sun protection index using SPF 290s (optometrics) and the results are shown in table 8.
Table 8 SPF value test results
| Item | SPF value |
| Control group | 12.1 |
| Example 5 | 17.6 |
| Example 6 | 16.1 |
| Example 7 | 23.6 |
| Example 8 | 18.9 |
| Example 9 | 15.4 |
Compared with a control group, the sun protection indexes of the embodiments 5 to 9 are remarkably improved, the SPF value reaches 15 to 25, the sunscreen cream can be used as a daily skin care product with a sun protection effect, and meanwhile, compared with a product using a chemical sunscreen agent to reach the sun protection indexes, the sunscreen cream is safer to the skin.
It should be finally noted that the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (8)
1. The composition with the effects of sun screening, whitening and anti-aging is characterized by comprising baicalin, rutin, curcumin and ferulic acid, wherein the mass ratio of the baicalin to the rutin to the curcumin to the ferulic acid is as follows: rutin: curcumin: ferulic acid = 15-18: 10-14: 5-8: 5.
2. a cosmetic comprising the composition of claim 1.
3. The cosmetic according to claim 2, wherein the cosmetic comprises the following components in percentage by mass: baicalin 0.01-18%, rutin 0.01-14%, curcumin 0.01-8%, and ferulic acid 0.01-8%.
4. The cosmetic according to claim 3, wherein the cosmetic comprises the following components in percentage by mass: baicalin 0.1-15%, rutin 1-12%, curcumin 0.1-7%, and ferulic acid 0.05-8%.
5. The cosmetic according to claim 3, wherein the composition accounts for 11 to 55% by mass of the cosmetic.
6. The cosmetic according to claim 3, further comprising the following components in percentage by mass: 10-40% of cosmetic matrix and the balance of deionized water; the cosmetic base comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a neutralizer, a preservative, a physical sunscreen, a chelating agent, and a fragrance.
7. The cosmetic according to claim 2, wherein the cosmetic is in a liquid form, a cream form or a solid form.
8. A process for the preparation of a cosmetic product according to any one of claims 2 to 7, characterized in that it comprises the following steps:
(1) mixing glycerol, xanthan gum, EDTA disodium, propylene glycol and water, and heating to 75-85 deg.C to obtain phase A; mixing cetearyl glucoside, C14-22 alcohol, C12-20 alkyl glucoside, polydimethylsiloxane, glyceryl monostearate, isononyl isononanoate, titanium white powder slurry, white oil, curcumin, methyl hydroxybenzoate and propyl hydroxybenzoate, and heating to 75-85 deg.C to obtain phase B; adding phase B into phase A, mixing, and homogenizing and emulsifying for 5-10min to obtain phase AB;
(2) cooling the AB emulsified phase to 60-70 deg.C, adding baicalin, rutin, ferulic acid, polyacrylamide, C13-14 isoparaffin and laureth-7, homogenizing and emulsifying for 3-5min, cooling to below 45 deg.C, and filtering to obtain the cosmetic.
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| CN1988879A (en) * | 2004-07-23 | 2007-06-27 | 宝洁公司 | Skin care composition containing a flavonoid and vitamin b3 |
| JP2014114289A (en) * | 2013-12-13 | 2014-06-26 | Showa Denko Kk | Cosmetic and skin external preparation |
| ES2933563T3 (en) * | 2015-04-16 | 2023-02-10 | Symrise Ag | Use of a liposome composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1112827A (en) * | 1994-05-30 | 1995-12-06 | 乌力吉 | Long lasting multi-function nutritive cream for skin care containing extract of Chinese soft shelled turtle and the prepn. method |
| CN106038342A (en) * | 2016-07-09 | 2016-10-26 | 陕西畅想制药有限公司 | Novel sunscreen anti-oxidation skin-whitening cosmetic composition and preparation method thereof |
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