CN107648131A - A kind of Skin whitening care cosmeticses containing natural plant extracts - Google Patents
A kind of Skin whitening care cosmeticses containing natural plant extracts Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of Skin whitening care cosmeticses containing natural plant extracts, it is made up of white-skinned face function component, matrix components and deionized water, the white-skinned face function component is made up of the raw material of following parts by weight:3 10 parts of the n-hexane extract of daffodil petal, 3 10 parts of the chloroform extract of the Radix Astragali, 3 10 parts of the chloroform extract of red sage root leaf, 3 10 parts of the chloroform extract of the fruit of Chinese wolfberry.The white-skinned face function of skin care item of the present invention is notable, by the way that the chloroform extract of the n-hexane extract of daffodil petal, the chloroform extract of the Radix Astragali, the chloroform extract of red sage root leaf, the fruit of Chinese wolfberry is combined in specific proportions, obvious synergistic function is served in terms of tyrosinase activity is suppressed, achieves unexpected white-skinned face function.Skin care item of the present invention comply fully with country's promulgation《Cosmetics safety technical specification(Version in 2015)》In indices, to no skin irritation, securely and reliably.
Description
Technical field
The present invention relates to daily cosmetics field, is specifically related to a kind of whitening and skin-protecting containing natural plant extracts
Product.
Background technology
The effect of skin-lightening cosmetic of commercial type adds at present raw material mainly includes ursin, kojic acid, anti-bad
One or more in the raw materials such as hematic acid, Porcine HGF, the skin-lightening cosmetic containing above-mentioned raw materials is with whitening effect
While also cause certain injury to skin, and cause product easily to produce the spoiled unstable phenomenon of discoloration.Such as bear
Fruit glycosides has the photosensitivity of height, easy to change unstable during a large amount of additions in the product;Kojic acid is easy when addition is larger
Cause contact dermatitis;Ascorbic acid be unfavorable for skin absorption, and when heat, light easily oxidation stain and lose whitening effect;
The active shelf-life of Porcine HGF is shorter, is not easy to preserve for a long time.Common most whitening agents are water solubility, are unfavorable for skin
Absorb, skin surface can only be reached or even rest on skin surface, and basalis can not be reached, largely have impact on U.S.
White effect.Common skin-lightening cosmetic is there is also very big potential safety hazard, because the effect and its concentration of many whitening agents are close
Cut is closed, and generally concentration is higher, and pH is lower, and whitening effect is more obvious, but excitant is also bigger, when serious even
Possible permanent damage is caused to skin.
With the development of plant extract technology, increasing plant extracts is applied in white-skinned face function cosmetics, into
For effective both effectiveness composition in cosmetics.Though there are the diversified cosmetics containing plant extracts at present, due to kind
Kind reason, its using effect is simultaneously not fully up to expectations, therefore, it is imperative to develop the significant skin care item of new white-skinned face function.
The content of the invention
In view of the deficienciess of the prior art, it is an object of the invention to provide a kind of whitening containing natural plant extracts
Skin care item, realized particular by following technical scheme:
A kind of Skin whitening care cosmeticses containing natural plant extracts, are made up of white-skinned face function component, matrix components and deionized water,
The white-skinned face function component is made up of the raw material of following parts by weight:
3 ~ 10 parts of the n-hexane extract of daffodil petal
3 ~ 10 parts of the chloroform extract of the Radix Astragali
3 ~ 10 parts of the chloroform extract of red sage root leaf
3 ~ 10 parts of the chloroform extract of the fruit of Chinese wolfberry.
Preferably, the preparation method of the n-hexane extract of the daffodil petal is:Original is used as using the petal of daffodil
Material, the volume parts for adding 5 ~ 10 times of amounts are to soak 12-48h in 93%-98% ethanol solution, then heating and refluxing extraction 1-
4 times, each reflux extracting time is 1-5h, and extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, and uses
Isometric n-hexane extraction to aqueous phase is in colourless, dries, produces after the recovered solvent of gained n-hexane extract.
Preferably, the preparation method of the chloroform extract of the Radix Astragali is:Using the Radix Astragali as raw material, 5 ~ 10 times of amounts of addition
Volume parts are to soak 12-48h in 93%-98% ethanol solution, then heating and refluxing extraction 1-4 times, each refluxing extraction
Time is 1-5h, and extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, and is extracted with isometric chloroform
It is in colourless to aqueous phase, dries, produce after the recovered solvent of gained chloroform extract.
Preferably, the preparation method of the chloroform extract of the red sage root leaf is:Using red sage root leaf as raw material, 5 ~ 10 times are added
The volume parts of amount are to soak 12-48h in 93%-98% ethanol solution, then heating and refluxing extraction 1-4 times, backflow every time
Extraction time is 1-5h, and extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, with isometric chloroform
It is in colourless to be extracted to aqueous phase, dries, produces after the recovered solvent of gained chloroform extract.
Preferably, the preparation method of the chloroform extract of the fruit of Chinese wolfberry is:Using the fruit of Chinese wolfberry as raw material, 5 ~ 10 times are added
The volume parts of amount are to soak 12-48h in 93%-98% ethanol solution, then heating and refluxing extraction 1-4 times, backflow every time
Extraction time is 1-5h, and extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, with isometric chloroform
It is in colourless to be extracted to aqueous phase, dries, produces after the recovered solvent of gained chloroform extract.
Further, the parts by weight of the matrix components in Skin whitening care cosmeticses of the present invention and deionized water are as follows:
Stearic acid 20-40 parts
Beeswax 3-7 parts
Hexadecanol 10-15 parts
Saualane 0.5-3 parts
Glycerin monostearate 5-10 parts
Propane diols 3-10 parts
Triethanolamine 1-3 parts
Essence 0.02-0.05 parts
Deionized water 100-200 parts.
Preferably, a kind of Skin whitening care cosmeticses containing natural plant extracts, are made up of the raw material of following parts by weight:
5 parts of the n-hexane extract of daffodil petal
5 parts of the chloroform extract of the Radix Astragali
5 parts of the chloroform extract of red sage root leaf
5 parts of the chloroform extract of the fruit of Chinese wolfberry
30 parts of stearic acid
5 parts of beeswax
13 parts of hexadecanol
1.5 parts of saualane
8 parts of glycerin monostearate
7 parts of propane diols
2 parts of triethanolamine
0.05 part of essence
150 parts of deionized water.
Present invention also offers the preparation method of the above-mentioned Skin whitening care cosmeticses containing natural plant extracts, specific steps are such as
Under:
(1)Stearic acid, beeswax, hexadecanol, saualane, glycerin monostearate, propane diols and triethanolamine are mixed, are heated to
80-90℃;
(2)By the n-hexane extract of deionized water and daffodil petal, the chloroform extract of the Radix Astragali, red sage root leaf chloroform recovery
The chloroform extract of thing and the fruit of Chinese wolfberry mixes, and is heated to 80-90 DEG C;
(3)By above-mentioned steps(1)With(2)The material mixing of gained, homogeneous;
(4)Be cooled to 30-40 DEG C, add spices, be uniformly mixed, be cooled to room temperature can be prepared by it is described containing natural extraction
The Skin whitening care cosmeticses of thing.
Compared with prior art, the beneficial effects of the present invention are:The white-skinned face function of skin care item of the present invention is notable, by by water
The celestial being flower n-hexane extract of petal, the chloroform extract of the Radix Astragali, the chloroform extract of red sage root leaf, the chloroform extract of the fruit of Chinese wolfberry
Combine in specific proportions, serve obvious synergistic function in terms of tyrosinase activity is suppressed, achieve and make us imaginary
Less than white-skinned face function.Skin care item of the present invention comply fully with country's promulgation《Cosmetics safety technical specification(Version in 2015)》In
Indices, to no skin irritation, securely and reliably.
Embodiment
The present invention is described in further detail with reference to embodiment.
Embodiment 1:
A kind of Skin whitening care cosmeticses containing natural plant extracts, are made up of the raw material of following parts by weight:
5 parts of the n-hexane extract of daffodil petal
5 parts of the chloroform extract of the Radix Astragali
5 parts of the chloroform extract of red sage root leaf
5 parts of the chloroform extract of the fruit of Chinese wolfberry
30 parts of stearic acid
5 parts of beeswax
13 parts of hexadecanol
1.5 parts of saualane
8 parts of glycerin monostearate
7 parts of propane diols
2 parts of triethanolamine
0.05 part of essence
150 parts of deionized water.
The preparation method of the n-hexane extract of the daffodil petal is:Original is used as using the drying petal of 100g daffodil
Material, the volume parts for adding 10 times of amounts are to soak 12h in 98% ethanol solution, then heating and refluxing extraction 2 times, backflow every time
Extraction time is 1h, and extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, with isometric n-hexane
Aqueous phase is extracted in colourless, dry solid powder after the recovered solvent of gained n-hexane extract.
The preparation method of the chloroform extract of the Radix Astragali is:Using the 100g Radixs Astragali as raw material, the volume of 10 times of amounts is added
Number is to soak 12h in 98% ethanol solution, and then heating and refluxing extraction 2 times, each reflux extracting time is 1h, extract solution
Filter, be condensed into medicinal extract after the recovered ethanol of filtrate, be dissolved in water, it is in colourless, gained to be extracted to aqueous phase with isometric chloroform
Dry solid powder after the recovered solvent of chloroform extract.
The preparation method of the chloroform extract of the red sage root leaf is:Using 100g reds sage root leaf as raw material, 10 times of amounts of addition
Volume parts are to soak 12h in 98% ethanol solution, and then heating and refluxing extraction 2 times, each reflux extracting time is 1h, is carried
Take liquid to filter, be condensed into medicinal extract after the recovered ethanol of filtrate, be dissolved in water, aqueous phase is extracted in colourless with isometric chloroform,
Dry solid powder after the recovered solvent of gained chloroform extract.
The preparation method of the chloroform extract of the fruit of Chinese wolfberry is:Fruit of Chinese wolfberry chloroform extract solution:With the 100g fruits of Chinese wolfberry
As raw material, the volume parts for adding 10 times of amounts are to soak 12h in 98% ethanol solution, then heating and refluxing extraction 2 times, often
Secondary reflux extracting time is 1h, extract solution filtering, is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, with isometric
Chloroform is extracted to aqueous phase in colourless, dry solid powder after the recovered solvent of gained chloroform extract.
The preparation method of the above-mentioned Skin whitening care cosmeticses containing natural plant extracts is as follows:
(1)Stearic acid, beeswax, hexadecanol, saualane, glycerin monostearate, propane diols and triethanolamine are mixed, are heated to
85℃;
(2)By the n-hexane extract of deionized water and daffodil petal, the chloroform extract of the Radix Astragali, red sage root leaf chloroform recovery
The chloroform extract of thing and the fruit of Chinese wolfberry mixes, and is heated to 85 DEG C;
(3)By above-mentioned steps(1)With(2)The material mixing of gained, homogeneous;
(4)It is cooled to 40 DEG C, adds spices, be uniformly mixed, is cooled to room temperature and can be prepared by described containing natural extract
Skin whitening care cosmeticses.
For natural plant extracts of the present invention suppress the testing experiment of tyrosinase activity:
First, the preparation of sample solution:
(1)Daffodil petal n-hexane extract solution:Daffodil petal n-hexane extract made from appropriate embodiment 1 is taken,
Then with pH6.8 phosphate buffered salines into mass concentration be 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125
G/L sample solution;
(2)Radix Astragali chloroform extract solution:Radix Astragali chloroform extract made from appropriate embodiment 1 is taken, then with pH6.8 phosphate
Buffer is into the sample solution that mass concentration is 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125 g/L;
(3)Red sage root leaf chloroform extract solution:Red sage root leaf chloroform extract made from appropriate embodiment 1 is taken, then with pH6.8 phosphorus
Phthalate buffer is configured to mass concentration as 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125 g/L sample solution;
(4)Fruit of Chinese wolfberry chloroform extract solution:Fruit of Chinese wolfberry chloroform extract made from appropriate embodiment 1 is taken, then with pH6.8 phosphorus
Phthalate buffer is configured to mass concentration as 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and 0.3125 g/L sample solution;
(5)Mass ratio 1:1:1:1 combined extracts solution:Four kinds of extracts made from identical weight embodiment 1 are taken, mixing is
It is even, then with pH6.8 phosphate buffered salines into mass concentration be 5g/L, 2.5g/L, 1.25g/L, 0.625g/L and
0.3125 g/L sample solution.
2nd, method of testing:For the sample solution of every kind of concentration, take four test tubes put on respectively No. 1, No. 2, No. 3,4
Number;With reference to the reagent dosage and concentration of table 1, the respective reaction liquid listed by each row is separately added into four test tubes, shaking mixes
Uniformly, 10min is preheated in 37 DEG C, 5mmol/L L-3,4 dihydroxyphenylalanine reaction solution 1ml is then separately added into each test tube, in 37 DEG C of standards
Really reaction 5min, is transferred quickly in cuvette, and absorbance is surveyed at 475nm(A).The sample solution of every kind of concentration repeats to survey
Examination is averaged afterwards three times.
3rd, the inhibiting rate to tyrosinase is calculated as follows:
Inhibiting rate=[1- (A3-A4)/(A1-A2)] × 100%
In formula:A1, A2, A3, A4 represent respectively in table 3 No. 1, No. 2, No. 3, in No. 4 four test tubes reaction after 475nm
The absorbance that place measures.
The inhibiting rate data of various concentrations extract solution are used into GraphPad Prism Software on Drawing standard curves, and
The 503nhibiting concentration IC50 of each extract is calculated, as a result referring to table 2.To cause the inhibitor of tyrosinase vigor decline 50% dense
Degree(IC50)The effect of to characterize inhibitor, IC50 numerical value is smaller, shows that the ability of extract suppression tyrosinase activity is got over
By force.
Table 1:The composition of prepare liquid(Unit:ml)
Reaction solution | No. 1 | No. 2 | No. 3 | No. 4 |
50U/ml Mushroom Tyrosinase solution | 1 | 0 | 1 | 0 |
Sample solution | 0 | 0 | 1 | 1 |
PH6.8 phosphate buffers | 2 | 3 | 1 | 2 |
Table 2:Each sample suppresses tyrosine activity testing result(Unit:mg/ml)
Sample | IC50(Unit:mg/ml) |
The n-hexane extract of daffodil petal | 20.36 |
The chloroform extract of the Radix Astragali | 3.52 |
The chloroform extract of red sage root leaf | 2.56 |
The chloroform extract of the fruit of Chinese wolfberry | 3.85 |
The composition of four kinds of extracts(1:1:1:1) | 0.105 |
The Clinical practice effect data of Skin whitening care cosmeticses made from the embodiment of the present invention 1:
30 women white collar workers are chosen as subject, the range of age 22 ~ 36 years old, average age 28 years old, health, work and rest
Rule, no skin disease and allergy medical history can be by Normalization rule cosmetics.It is dark skin to be present in the skin of face of above-mentioned subject
Heavy, pigmentation, lacklustre problem.
Method of testing:Test environment temperature is 22 DEG C ± 1 DEG C, and humidity is 50% ± 5%, using the MX18 skins of German CK companies
Skin detector for pigment 1 day melanin content for determining its skin of face after 7 days with continuous use skin care item before using cosmetics,
Repeat to survey every time to average three times.
The application method of cosmetics:After respectively being washed one's face respectively at early morning and just before going to bed with warm water, the appropriate present invention is taken to implement
The skin care item of example 1 are uniformly applied to face, and then gently massage makes cosmetics uniform pickup.All subjects were testing
Without using other any cosmetics or skin care item in journey.
Melanin reduced rate=(Use second day after the melanin content of 1 day before cosmetics-continuous use cosmetics 7 days
Melanin content)/ use melanin content × 100% of 1 day before cosmetics.Melanin reduced rate is higher, illustrates that whitening effect is got over
Substantially.
Effect criterion:It is 1. effective:The colour of skin highlights, pigmentation fading effect is fairly obvious, and melanin reduced rate exists
More than 30%;It is 2. effective:The colour of skin improves, pigmentation fading effect is more apparent, and melanin reduced rate is between 5% ~ 30%;3. nothing
Effect:The colour of skin, pigmentation no significant change compared with before testing, melanin reduced rate are less than 5%.
Result of the test:Effective 24, effective 6, invalid 0, obvious effective rate 80%, total effective rate 100%.
Above-described embodiment is only currently preferred case study on implementation, it is impossible to limits present invention model claimed with this
Enclose, any unsubstantiality and replacement that those skilled in the art is done on the basis of the present invention belongs to application claims
The scope of protection.
Claims (8)
- A kind of 1. Skin whitening care cosmeticses containing natural plant extracts, by white-skinned face function component, matrix components and deionized water group Into, it is characterised in that the white-skinned face function component is made up of the raw material of following parts by weight:N-hexane extract 3-10 parts of daffodil petalChloroform extract 3-10 parts of the Radix AstragaliChloroform extract 3-10 parts of red sage root leafChloroform extract 3-10 parts of the fruit of Chinese wolfberry.
- A kind of 2. Skin whitening care cosmeticses containing natural plant extracts according to claim 1, it is characterised in that the water The preparation method of n-hexane extract of celestial being flower petal is:Using the petal of daffodil as raw material, the volume of 5 ~ 10 times of amounts is added Number is to soak 12-48h in 93%-98% ethanol solution, then heating and refluxing extraction 1-4 times, each reflux extracting time For 1-5h, extract solution filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, with isometric n-hexane extraction extremely Aqueous phase is in colourless, dries, produces after the recovered solvent of gained n-hexane extract.
- A kind of 3. Skin whitening care cosmeticses containing natural plant extracts according to claim 1, it is characterised in that the Huang The preparation method of the chloroform extract of stilbene is:Using the Radix Astragali as raw material, the volume parts for adding 5 ~ 10 times of amounts are 93%-98%'s 12-48h being soaked in ethanol solution, then heating and refluxing extraction 1-4 times, each reflux extracting time is 1-5h, and extract solution filters, Medicinal extract is condensed into after the recovered ethanol of filtrate, is dissolved in water, aqueous phase is extracted in colourless, gained chloroform extraction with isometric chloroform Dry, produce after taking the recovered solvent of liquid.
- A kind of 4. Skin whitening care cosmeticses containing natural plant extracts according to claim 1, it is characterised in that the pellet The preparation method of chloroform extract for joining leaf is:Using red sage root leaf as raw material, the volume parts for adding 5 ~ 10 times of amounts are 93%- 12-48h is soaked in 98% ethanol solution, then heating and refluxing extraction 1-4 times, each reflux extracting time is 1-5h, extraction Liquid filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, it is in colourless, institute to be extracted to aqueous phase with isometric chloroform Dry, produce after obtaining the recovered solvent of chloroform extract.
- A kind of 5. Skin whitening care cosmeticses containing natural plant extracts according to claim 1, it is characterised in that the Chinese holly The preparation method of the chloroform extract of matrimony vine is:Using the fruit of Chinese wolfberry as raw material, the volume parts for adding 5 ~ 10 times of amounts are 93%- 12-48h is soaked in 98% ethanol solution, then heating and refluxing extraction 1-4 times, each reflux extracting time is 1-5h, extraction Liquid filters, and is condensed into medicinal extract after the recovered ethanol of filtrate, is dissolved in water, it is in colourless, institute to be extracted to aqueous phase with isometric chloroform Dry, produce after obtaining the recovered solvent of chloroform extract.
- A kind of 6. Skin whitening care cosmeticses containing natural plant extracts according to claim 1, it is characterised in that the base The parts by weight of matter component and deionized water are as follows:Stearic acid 20-40 partsBeeswax 3-7 partsHexadecanol 10-15 partsSaualane 0.5-3 partsGlycerin monostearate 5-10 partsPropane diols 3-10 partsTriethanolamine 1-3 partsEssence 0.02-0.05 partsDeionized water 100-200 parts.
- 7. a kind of Skin whitening care cosmeticses containing natural plant extracts according to any one of claim 1 ~ 6, its feature exist In being made up of the raw material of following parts by weight:5 parts of the n-hexane extract of daffodil petal5 parts of the chloroform extract of the Radix Astragali5 parts of the chloroform extract of red sage root leaf5 parts of the chloroform extract of the fruit of Chinese wolfberry30 parts of stearic acid5 parts of beeswax13 parts of hexadecanol1.5 parts of saualane8 parts of glycerin monostearate7 parts of propane diols2 parts of triethanolamine0.05 part of essence150 parts of deionized water.
- A kind of 8. Skin whitening care cosmeticses containing natural plant extracts according to claim 7, it is characterised in that preparation side Method is as follows:(1)Stearic acid, beeswax, hexadecanol, saualane, glycerin monostearate, propane diols and triethanolamine are mixed, are heated to 80-90℃;(2)By the n-hexane extract of deionized water and daffodil petal, the chloroform extract of the Radix Astragali, red sage root leaf chloroform recovery The chloroform extract of thing and the fruit of Chinese wolfberry mixes, and is heated to 80-90 DEG C;(3)By above-mentioned steps(1)With(2)The material mixing of gained, homogeneous;(4)Be cooled to 30-40 DEG C, add spices, be uniformly mixed, be cooled to room temperature can be prepared by it is described containing natural extraction The Skin whitening care cosmeticses of thing.
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102366478A (en) * | 2011-11-14 | 2012-03-07 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
CN104666172A (en) * | 2015-01-22 | 2015-06-03 | 李健 | Whitening and moisturizing skin care product |
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- 2017-11-24 CN CN201711190133.XA patent/CN107648131B/en active Active
- 2017-11-24 CN CN202010328484.8A patent/CN111329812A/en not_active Withdrawn
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102366478A (en) * | 2011-11-14 | 2012-03-07 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
CN104666172A (en) * | 2015-01-22 | 2015-06-03 | 李健 | Whitening and moisturizing skin care product |
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CN107648131B (en) | 2020-06-02 |
CN111329812A (en) | 2020-06-26 |
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