CN111328335A - 基于突变igg六聚体的治疗性抗体 - Google Patents

基于突变igg六聚体的治疗性抗体 Download PDF

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Publication number
CN111328335A
CN111328335A CN201880050867.4A CN201880050867A CN111328335A CN 111328335 A CN111328335 A CN 111328335A CN 201880050867 A CN201880050867 A CN 201880050867A CN 111328335 A CN111328335 A CN 111328335A
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antibody
seq
pharmaceutical composition
region
antibodies
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Chinese (zh)
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M.H.詹森
L.S.哈洛夫
A.哈加曼
C.哈尔布莱布
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Genmab BV
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Genmab BV
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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CN201880050867.4A 2017-06-07 2018-06-07 基于突变igg六聚体的治疗性抗体 Pending CN111328335A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762516489P 2017-06-07 2017-06-07
US62/516,489 2017-06-07
US201862614801P 2018-01-08 2018-01-08
US62/614,801 2018-01-08
PCT/EP2018/065071 WO2018224609A1 (en) 2017-06-07 2018-06-07 Therapeutic antibodies based on mutated igg hexamers

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CN111328335A true CN111328335A (zh) 2020-06-23

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CN201880050867.4A Pending CN111328335A (zh) 2017-06-07 2018-06-07 基于突变igg六聚体的治疗性抗体

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US (1) US20200247897A1 (enExample)
EP (1) EP3635005A1 (enExample)
JP (2) JP2020522543A (enExample)
KR (1) KR20200027944A (enExample)
CN (1) CN111328335A (enExample)
BR (1) BR112019025328A2 (enExample)
MA (1) MA49259A (enExample)
MX (1) MX2019014407A (enExample)
TW (1) TW201919692A (enExample)
WO (1) WO2018224609A1 (enExample)

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EP3580233A1 (en) 2017-02-10 2019-12-18 Genmab B.V. Polypeptide variants and uses thereof
MX2020011552A (es) 2018-05-03 2020-11-24 Genmab Bv Combinaciones de variantes de anticuerpos y usos de las mismas.
EP3966241A1 (en) * 2019-05-09 2022-03-16 Genmab B.V. Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
US20230293680A1 (en) * 2020-07-23 2023-09-21 Genmab B.V. A composition of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
US11912781B2 (en) 2021-01-13 2024-02-27 Visterra, Inc. Humanized complement 5A receptor 1 antibodies and methods of use thereof

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WO2014006217A1 (en) * 2012-07-06 2014-01-09 Genmab B.V. Dimeric protein with triple mutations
EP2684896A1 (en) * 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
WO2014108198A1 (en) * 2013-01-10 2014-07-17 Genmab B.V. Human igg1 fc region variants and uses thereof

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