CN111315782A - 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 - Google Patents

结合nkg2d、cd16和肿瘤相关抗原的蛋白质 Download PDF

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CN111315782A
CN111315782A CN201880071464.8A CN201880071464A CN111315782A CN 111315782 A CN111315782 A CN 111315782A CN 201880071464 A CN201880071464 A CN 201880071464A CN 111315782 A CN111315782 A CN 111315782A
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chain variable
protein
ser
variable domain
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格雷戈里·P·常
安·F·张
威廉·哈尼
布拉德利·M·伦德
比昂卡·普林茨
阿斯亚·格林贝格
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Dragonfly Therapy Co ltd
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Dragonfly Therapy Co ltd
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Priority to CN202110251101.6A priority Critical patent/CN113004417A/zh
Priority to CN202411838715.4A priority patent/CN119735693A/zh
Publication of CN111315782A publication Critical patent/CN111315782A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880071464.8A 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 Pending CN111315782A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202110251101.6A CN113004417A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质
CN202411838715.4A CN119735693A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762555110P 2017-09-07 2017-09-07
US62/555,110 2017-09-07
US201762566824P 2017-10-02 2017-10-02
US62/566,824 2017-10-02
PCT/US2018/050073 WO2019051308A1 (en) 2017-09-07 2018-09-07 NKG2D, CD16 BINDING PROTEINS AND ANTIGEN ASSOCIATED WITH A TUMOR

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CN202110251101.6A Division CN113004417A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质
CN202411838715.4A Division CN119735693A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质

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CN201880071464.8A Pending CN111315782A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质
CN202411838715.4A Pending CN119735693A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质
CN202110251101.6A Pending CN113004417A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质

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CN202110251101.6A Pending CN113004417A (zh) 2017-09-07 2018-09-07 结合nkg2d、cd16和肿瘤相关抗原的蛋白质

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US (3) US20200277383A1 (https=)
EP (2) EP3925976A1 (https=)
JP (4) JP7431392B2 (https=)
KR (3) KR20240167101A (https=)
CN (3) CN111315782A (https=)
AU (3) AU2018329937B2 (https=)
BR (1) BR112020004489A2 (https=)
CA (2) CA3074840A1 (https=)
IL (2) IL273067A (https=)
MX (2) MX420258B (https=)
RU (1) RU2021110369A (https=)
SG (2) SG11202001930QA (https=)
WO (1) WO2019051308A1 (https=)

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EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
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AU2019392090A1 (en) 2018-12-03 2021-06-17 Agensys, Inc. Pharmaceutical compositions comprising anti-191P4D12 antibody drug conjugates and methods of use thereof
CN115427439A (zh) * 2019-10-30 2022-12-02 德克萨斯A&M大学系统 用于双靶标嵌合抗原受体t细胞疗法的蛋白酶开关
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JP7512394B2 (ja) 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
KR20230091885A (ko) * 2020-09-17 2023-06-23 어젠시스 인코포레이티드 191p4d12 단백질에 결합하는 항체 약물 접합체(adc)로 암을 치료하는 방법
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
KR20240083868A (ko) * 2021-08-20 2024-06-12 탈락 테라퓨틱스, 인크. 넥틴-4 항체 및 접합체
AR127162A1 (es) * 2021-09-29 2023-12-27 Dragonfly Therapeutics Inc Proteínas que se unen a nkg2d, cd16 y baff-r
KR20230060546A (ko) * 2021-10-22 2023-05-04 상트네어바이오사이언스 주식회사 두개의 Fc 도메인을 포함하는 항원 결합 단백질 및 이의 용도
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