CN111298025A - Private nursing antibacterial spray and preparation method thereof - Google Patents
Private nursing antibacterial spray and preparation method thereof Download PDFInfo
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- CN111298025A CN111298025A CN202010260745.7A CN202010260745A CN111298025A CN 111298025 A CN111298025 A CN 111298025A CN 202010260745 A CN202010260745 A CN 202010260745A CN 111298025 A CN111298025 A CN 111298025A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P17/04—Antipruritics
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- A61P31/04—Antibacterial agents
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention discloses a private nursing bacteriostatic spray, which belongs to the technical field of traditional Chinese medicine preparations and is prepared from the following raw materials in percentage by weight: ginseng extract 0.02-0.04%, double kidney extract 0.02-0.04%, cynomorium songaricum extract 0.01-0.03%, clove extract 0.01-0.03%, aloe gel juice 0.5-1.5%, zanthoxylum piperitum extract 0.01-0.03%, chlorhexidine gluconate solution 0.5-2.5%, and purified water in balance; the chlorhexidine gluconate solution has a mass percentage concentration of 20%. The bacteriostatic spray disclosed by the invention selects the clove extract, the pericarpium zanthoxyli extract, the fructus renifoliae extract and the aloe gel juice with bacteriostatic effects, is supplemented with chlorhexidine gluconate with antibacterial effect, and is added with the ginseng extract and the cynomorium songaricum extract to play a role in enhancing the immune care, so as to assist the synergistic effect and have a suppressive effect on staphylococcus aureus, escherichia coli and candida albicans.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a private nursing antibacterial spray and a preparation method thereof.
Background
With the improvement of living standard and the increasing of health consciousness of people, people pay more and more attention to their own sanitation level, including the sanitation level of private parts. The male private parts comprise perineum parts including penis, external orifice of urethra, foreskin, scrotum, groin and perianal, because of natural physiological characteristics, a lot of dirt is inevitably hidden, if cleaning is not in place, bacteria are easy to breed, such as candida albicans, staphylococcus aureus and the like, infection is caused, inflammation is caused, and meanwhile, the bacteria can be transmitted to women through sexual intercourse, so that women can be infected with gynecological diseases. The male cleans the private parts of the male, not only can protect the private parts of the male and keep the body healthy, but also can protect the sexual partner and keep the sexual life harmonious. Therefore, men pay more and more attention to private part cleaning, the demand of men care products for private part cleaning is increasing, and the requirements on the men care products are also higher and higher.
At present, most of male bacteriostatic spray has two main types, one type is liquid prepared from a pure antibacterial preparation, and the bacteriostatic and antibacterial effects are usually exerted only when the bacteriostatic or antibacterial concentration is higher, but the bacteriostatic and antibacterial effects have obvious irritation, such as tingling, dryness and astringency, and the like. The other is liquid prepared from pure traditional Chinese medicines, the liquid has unobvious bacteriostatic and antibacterial effects, and the effective time and the cure time are still not ideal and need to be further improved.
Disclosure of Invention
The invention provides a private care antibacterial spray and a preparation method thereof.
The technical scheme of the invention is as follows:
a privacy nursing bacteriostatic spray is prepared from the following raw materials in percentage by weight: ginseng extract 0.02-0.04%, double kidney extract 0.02-0.04%, cynomorium songaricum extract 0.01-0.03%, clove extract 0.01-0.03%, aloe gel juice 0.5-1.5%, zanthoxylum piperitum extract 0.01-0.03%, chlorhexidine gluconate solution 0.5-2.5%, and purified water in balance; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
Wherein, preferably, the ginseng extract is prepared by the following method: extracting Ginseng radix with water, concentrating the filtrate to obtain extract, spray drying, and pulverizing.
Wherein, preferably, the double kidney extract is prepared by the following method: selecting and cleaning the raw materials of the kidney and the kidney, carrying out water extraction, concentrating filtrate to obtain extract, carrying out spray drying, and crushing to obtain the traditional Chinese medicine composition.
Wherein, preferably, the cynomorium songaricum extract is prepared by the following preparation method: soaking herba Cynomorii in 90 deg.C hot water for 2.5 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
Wherein, the clove extract is preferably prepared by the following preparation method: extracting flos Caryophylli with water for 6-10 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
Wherein, the aloe gel juice is preferably prepared by the following preparation method: cleaning Aloe, peeling, squeezing, centrifuging, filtering to remove fiber, sterilizing, and making into Aloe gel juice.
Wherein, the zanthoxylum piperitum extract is preferably prepared by the following preparation method: extracting fructus Zanthoxyli with water, concentrating the filtrate to obtain extract, spray drying, and pulverizing.
A preparation method of a privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
The invention has the beneficial effects that:
1. the clove extract, the pericarpium zanthoxyli extract, the fructus renifoliae extract and the aloe gel juice with the antibacterial effect are selected as the antibacterial spray, the chlorhexidine gluconate with the antibacterial effect is added, the ginseng extract and the cynomorium songaricum extract are added, the immunity is enhanced, the synergistic effect is assisted, the antibacterial spray has the inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans, and is mild and non-irritating.
2. The male bacteriostatic spray disclosed by the invention has the advantages that through mutual matching and scientific compatibility of the natural active ingredients, the effects of all the components are exerted, the bacteriostatic effect is enhanced, meanwhile, the male bacteriostatic spray has no irritation to the skin of the male private parts, and also has the effects of relieving itching and removing peculiar smell, various uncomfortable symptoms of the skin of the male private parts can be effectively relieved and eliminated, and the male bacteriostatic spray is easy to wash, good in comfortable sensation and high in refreshing degree, and is particularly suitable for cleaning the male private parts.
3. The product of the invention has easily obtained raw materials, simple and convenient preparation method, is suitable for large-scale production and has good application prospect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following examples, each of the herbal extracts was prepared by the following preparation method.
The ginseng extract is prepared by the following method: extracting Ginseng radix with water, concentrating the filtrate to obtain extract, spray drying, and pulverizing.
The shuangshenzi extract is prepared by the following method: selecting and cleaning the raw materials of the kidney and the kidney, carrying out water extraction, concentrating filtrate to obtain extract, carrying out spray drying, and crushing to obtain the traditional Chinese medicine composition.
The cynomorium songaricum extract is prepared by the following preparation method: soaking herba Cynomorii in 90 deg.C hot water for 2.5 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
The clove extract is prepared by the following preparation method: extracting flos Caryophylli with water for 6-10 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
The aloe gel juice is prepared by the following preparation method: cleaning Aloe, peeling, squeezing, centrifuging, filtering to remove fiber, sterilizing, and making into Aloe gel juice.
The zanthoxylum piperitum extract is prepared by the following preparation method: extracting fructus Zanthoxyli with 75% ethanol, standing for layering, removing water layer to obtain crude oleum Zanthoxyli Bungeani extract, dewatering the residual oil layer to obtain oleum Zanthoxyli Bungeani, and mixing with the crude oleum Zanthoxyli Bungeani extract to obtain fructus Zanthoxyli extract.
Example 1
The embodiment provides a privacy nursing bacteriostatic spray which is prepared from the following raw materials in percentage by weight: 0.03% of ginseng extract, 0.03% of fructus reniae, 0.02% of cynomorium songaricum extract, 0.02% of clove extract, 1.0% of aloe gel juice, 0.02% of pericarpium zanthoxyli extract, 1.5% of chlorhexidine gluconate solution and the balance of purified water; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
The preparation method of the privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
Example 2
The embodiment provides a privacy nursing bacteriostatic spray which is prepared from the following raw materials in percentage by weight: 0.02% of ginseng extract, 0.04% of fructus reniae, 0.01% of cynomorium songaricum extract, 0.03% of clove extract, 0.5% of aloe gel juice, 0.03% of pericarpium zanthoxyli extract, 0.5% of chlorhexidine gluconate solution and the balance of purified water; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
The preparation method of the privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
Example 3
The embodiment provides a privacy nursing bacteriostatic spray which is prepared from the following raw materials in percentage by weight: 0.04% of ginseng extract, 0.02% of fructus reniae, 0.03% of cynomorium songaricum extract, 0.01% of clove extract, 1.5% of aloe gel juice, 0.01% of pericarpium zanthoxyli extract, 2.5% of chlorhexidine gluconate solution and the balance of purified water; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
The preparation method of the privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
Example 4
The embodiment provides a privacy nursing bacteriostatic spray which is prepared from the following raw materials in percentage by weight: 0.03% of ginseng extract, 0.04% of fructus reniae, 0.02% of cynomorium songaricum extract, 0.03% of clove extract, 1.2% of aloe gel juice, 0.01% of pericarpium zanthoxyli extract, 2.2% of chlorhexidine gluconate solution and the balance of purified water; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
The preparation method of the privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
Example 5
The embodiment provides a privacy nursing bacteriostatic spray which is prepared from the following raw materials in percentage by weight: 0.04% of ginseng extract, 0.02% of fructus reniae, 0.02% of cynomorium songaricum extract, 0.02% of clove extract, 0.9% of aloe gel juice, 0.02% of pericarpium zanthoxyli extract, 2.1% of chlorhexidine gluconate solution and the balance of purified water; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
The preparation method of the privacy care bacteriostatic spray comprises the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
Skin irritation test
1. Laboratory animal information
1.1 animal strains and grades: new Zealand rabbits, general grade.
1.2 animal sources: the professional cooperative society of silver sea rabbit industry in Tongxiang city produces license number SCXK (Zhe) 2013-.
1.3 feeding environment: ordinary level animal house, use license number: SYXK (Zhe) 2016-0012, room temperature 20.6-23.5 deg.C, relative humidity 53.2-69.8%.
2. Results of skin irritation test
TABLE 1 results of multiple skin irritation tests
Bacteriostatic property
1. The detection method comprises the following steps: samples of example 1 were taken and tested according to GB15979-2002 appendix C4.
2. And (3) detection results:
the test results are given in the following table:
TABLE 2 results of the bacteriostatic test
Stability (antibacterial performance)
1. The detection method comprises the following steps: samples of example 1 were taken and tested according to GB15979-2002 appendix C4.
2. And (3) stability testing: and (3) placing the original packaging sample in a constant temperature box at 37 ℃ for 3 months, keeping the relative humidity of 76%, and carrying out bacteriostatic performance test.
3. And (3) detection results:
TABLE 3 stability of the bacteriostatic test results
The present invention is not limited to the above-described preferred embodiments, but rather, the present invention is to be construed broadly and cover all modifications, equivalents, and improvements falling within the spirit and scope of the present invention.
Claims (8)
1. A private nursing bacteriostatic spray is characterized by being prepared from the following raw materials in percentage by weight: ginseng extract 0.02-0.04%, double kidney extract 0.02-0.04%, cynomorium songaricum extract 0.01-0.03%, clove extract 0.01-0.03%, aloe gel juice 0.5-1.5%, zanthoxylum piperitum extract 0.01-0.03%, chlorhexidine gluconate solution 0.5-2.5%, and purified water in balance; the chlorhexidine gluconate solution has a mass percentage concentration of 20%.
2. The intimate care bacteriostatic spray of claim 1, wherein: the ginseng extract is prepared by the following method: extracting Ginseng radix with water, concentrating the filtrate to obtain extract, spray drying, and pulverizing.
3. The intimate care bacteriostatic spray of claim 1, wherein: the double kidney extract is prepared by the following steps: selecting and cleaning the raw materials of the kidney and the kidney, carrying out water extraction, concentrating filtrate to obtain extract, carrying out spray drying, and crushing to obtain the traditional Chinese medicine composition.
4. The intimate care bacteriostatic spray of claim 1, wherein: the cynomorium songaricum extract is prepared by the following preparation method: soaking herba Cynomorii in 90 deg.C hot water for 2.5 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
5. The intimate care bacteriostatic spray of claim 1, wherein: the clove extract is prepared by the following preparation method: extracting flos Caryophylli with water for 6-10 hr, filtering, concentrating the filtrate to obtain extract, spray drying, pulverizing, and mixing.
6. The intimate care bacteriostatic spray of claim 1, wherein: the aloe gel juice is prepared by the following preparation method: cleaning Aloe, peeling, squeezing, centrifuging, filtering to remove fiber, sterilizing, and making into Aloe gel juice.
7. The intimate care bacteriostatic spray of claim 1, wherein: the zanthoxylum bungeanum maxim extract is prepared by the following preparation method: extracting fructus Zanthoxyli with water, concentrating the filtrate to obtain extract, spray drying, and pulverizing.
8. A method of preparing a privacy care bacteriostatic spray according to any one of claims 1 to 7, which is characterized by comprising the following steps: adding Ginseng radix extract, fructus Bruceae extract, herba Cynomorii extract, flos Caryophylli extract, Aloe gel juice, fructus Zanthoxyli extract and chlorhexidine gluconate solution into half of purified water, and stirring; then adding the other half of the purified water, and stirring uniformly to obtain the product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010260745.7A CN111298025A (en) | 2020-04-03 | 2020-04-03 | Private nursing antibacterial spray and preparation method thereof |
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| CN202010260745.7A CN111298025A (en) | 2020-04-03 | 2020-04-03 | Private nursing antibacterial spray and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158199A (en) * | 2017-06-09 | 2017-09-15 | 安振东 | A kind of Male external spray and preparation method thereof |
| CN107281367A (en) * | 2017-07-20 | 2017-10-24 | 天马（安徽）国药科技股份有限公司 | It is a kind of to be directed to male's antibacterial, anti-inflammatory, the pharmaceutical composition of delay |
| CN109200188A (en) * | 2017-07-07 | 2019-01-15 | 潍坊红阳药业有限公司 | The excellent good bacteriostasis spray of energy |
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- 2020-04-03 CN CN202010260745.7A patent/CN111298025A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158199A (en) * | 2017-06-09 | 2017-09-15 | 安振东 | A kind of Male external spray and preparation method thereof |
| CN109200188A (en) * | 2017-07-07 | 2019-01-15 | 潍坊红阳药业有限公司 | The excellent good bacteriostasis spray of energy |
| CN107281367A (en) * | 2017-07-20 | 2017-10-24 | 天马（安徽）国药科技股份有限公司 | It is a kind of to be directed to male's antibacterial, anti-inflammatory, the pharmaceutical composition of delay |
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Effective date of registration: 20210422 Address after: 261000 Shandong city of Weifang Province River Road Economic Development Zone No. 3177 high tech Industrial Park, No. 4 building two layer Applicant after: WEIFANG HONGYANG PHARMACY Co.,Ltd. Applicant after: HANGZHOU NETEASE YANXUAN TRADING Co.,Ltd. Address before: 261000 Shandong city of Weifang Province River Road Economic Development Zone No. 3177 high tech Industrial Park, No. 4 building two layer Applicant before: WEIFANG HONGYANG PHARMACY Co.,Ltd. |
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Application publication date: 20200619 |