CN111296632A - Chinese herbal medicine compound preparation for preventing and treating gibelism hemorrhage of carassius auratus gibelio and preparation method thereof - Google Patents
Chinese herbal medicine compound preparation for preventing and treating gibelism hemorrhage of carassius auratus gibelio and preparation method thereof Download PDFInfo
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Abstract
The application discloses a Chinese herbal medicine compound preparation for preventing and treating gill hemorrhage of carassius auratus gibelio and a preparation method thereof, wherein the Chinese herbal medicine compound preparation comprises 14 parts of rapeseed meal, 12 parts of fish meal, 4 parts of soybean oil, 5 parts of corn flour, 2 parts of premix, 2 parts of monocalcium phosphate, 10 parts of microcrystalline cellulose, 17 parts of wheat flour, 4 parts of fish oil, 28 parts of soybean meal and 2 parts of Chinese herbal medicine leachate, the Chinese herbal medicine comprises the following components in parts by mass, 18.75 parts of houttuynia cordata, 18.75 parts of astragalus membranaceus, 12.5 parts of honeysuckle, 12.5 parts of medlar, 12.5 parts of isatis root, 12.5 parts of fructus forsythiae and 12.5 parts of golden cypress, the Chinese herbal medicine and the water are soaked for 1h, then the Chinese herbal medicine leachate is boiled for 0.5h with; the green, environment-friendly and safe immunity-enhanced compound feed can improve the self immunity of the carassius auratus gibelio, thereby improving the disease resistance of the carassius auratus gibelio.
Description
Technical Field
The invention belongs to the technical field of fishery biological products in animal and maintenance industries, and particularly relates to a Chinese herbal medicine compound preparation for preventing and treating gibelism of carassius auratus gibelio and a preparation method thereof.
Background
Carassius auratus gibelio is a new Carassius auratus breeding variety which is developed by inducing eggs of triploid Carassius auratus gibelio to perform gynogenesis by utilizing triploid fang zheng silver crucian (female parent) and diploid Xingguo red carp (male parent) through an artificial hybridization method. The variety has the characteristics of strong adaptability, high survival rate, high growth speed, short feeding period and the like, and particularly achieves great success in popularization and cultivation in Subei areas of Jiangsu province. However, in recent years, the carassius auratus gibelio breeding industry is severely restricted by diseases (such as carassius auratus herpesvirus disease, bacterial septicemia and myxosporidiosis) frequently, and the economic loss caused by the diseases is about 30 billion yuan each year. In order to prevent and control the spread of diseases, farmers add a large amount of chemical drugs such as antibiotics and the like into the feed, so that the drug resistance of the fish body is increased, and the drug residue of the finished fish is serious. Therefore, the development of the green, environment-friendly and safe immunity-enhanced compound feed for improving the self immunity of the carassius auratus gibelio has great significance for improving the disease resistance of the carassius auratus gibelio.
Chinese patent CN 201811152003.1 discloses a mandarin fish disease-resistant Chinese herbal medicine and yolk antibody compound additive, which is prepared from a mandarin fish bacterial septicemia-resistant yolk antibody, 3 Chinese herbal medicine leachates and β -cyclodextrin, wherein the mandarin fish bacterial septicemia-resistant yolk antibody is mainly used for reducing or preventing infection of mandarin fish by strongly pathogenic aeromonas hydrophila, rhubarb in the 3 Chinese herbal medicine leachates can inhibit or kill pathogenic aeromonas hydrophila and has the effect of reducing or preventing mandarin fish from being infected by the strongly pathogenic aeromonas hydrophila, glossy privet fruit has the effect of enhancing immunity and hay fever with a detoxifying effect, and β -cyclodextrin mainly enables a mixture of the yolk antibody and the Chinese herbal medicine leachates to have adhesion and slow-release pathogenic effects.
Disclosure of Invention
The technical problem to be solved is as follows: the application mainly provides a Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio and a preparation method thereof, solves the technical problems that in the prior art, the variety of Chinese herbal medicines is few, the effect is possibly incomplete, the carassius auratus gibelio has unicity, the preparation process of an egg yolk antibody solution is complex and the like, improves the disease resistance of the carassius auratus gibelio, which is a high-quality breeding variety, to CyHV-2 virus, and enhances the immunity of the carassius auratus gibelio from the perspective of a Chinese herbal medicine additive so as to increase.
The technical scheme is as follows:
the Chinese herbal medicine compound preparation for preventing and treating the carassius auratus gibelio bleeding disease comprises the following raw materials in parts by mass: 12-16 parts of rapeseed meal, 10-14 parts of fish meal, 2-6 parts of soybean oil, 3-7 parts of corn flour, 1-3 parts of premix, 1-3 parts of monocalcium phosphate, 8-12 parts of microcrystalline cellulose, 15-19 parts of wheat flour, 2-6 parts of fish oil, 26-30 parts of soybean meal and 1-3 parts of Chinese herbal medicine leachate.
As a preferred technical scheme of the invention: the Chinese herbal medicine compound preparation for preventing and treating the gibelism of the carassius auratus gibelio is prepared from the following raw materials in parts by mass: 14 parts of rapeseed meal, 12 parts of fish meal, 4 parts of soybean oil, 5 parts of corn flour, 2 parts of premix, 2 parts of monocalcium phosphate, 10 parts of microcrystalline cellulose, 17 parts of wheat flour, 4 parts of fish oil, 28 parts of soybean meal and 2 parts of Chinese herbal medicine leachate.
As a preferred technical scheme of the invention: the premix is a mineral and vitamin premix, wherein the premix comprises 5500IU of magnesium sulfate, 4g of cobalt chloride, 3g of manganese sulfate, 8g of aluminum chloride, 7g of potassium iodide, 140g of zinc sulfate, 150g of ferric citrate, 0.6g of sodium selenite, 15000IU of monocalcium phosphate, 4000IU of potassium chloride, 8g of copper sulfate, 5mg of biotin, 200mg of inositol, 150mg of vitamin B, 220 mg of vitamin B, 650mg of vitamin B, 120.1mg of vitamin B, 250IU of nicotinic acid, 50mg of pantothenic acid, 15mg of folic acid, 5000IU of vitamin A, 400mg of vitamin C, 32000 IU of vitamin D, 400mg of vitamin E and 340 mg of vitamin K340 mg.
As a preferred technical scheme of the invention: the Chinese herbal medicine leachate is prepared by soaking Chinese herbal medicines and water for 1h, then decocting with strong fire for 0.5h, and repeating twice to obtain the Chinese herbal medicine leachate.
As a preferred technical scheme of the invention: the Chinese herbal medicine comprises the following components, by mass, 18.5-19 parts of houttuynia cordata, 18.5-19 parts of astragalus membranaceus, 12-13 parts of honeysuckle, 12-13 parts of medlar, 12-13 parts of isatis root, 12-13 parts of fructus forsythiae and 12-13 parts of golden cypress.
As a preferred technical scheme of the invention: the Chinese herbal medicine comprises the following components, by mass, 18.75 parts of houttuynia cordata, 18.75 parts of astragalus membranaceus, 12.5 parts of honeysuckle, 12.5 parts of medlar, 12.5 parts of isatis root, 12.5 parts of fructus forsythiae and 12.5 parts of golden cypress.
A preparation method of a Chinese herbal medicine compound preparation for preventing and treating carassius auratus gibelio bleeding disease comprises the following steps:
the first step is as follows: soaking the Chinese medicinal materials in water for 1 hr, decocting with strong fire for 0.5 hr, and repeating twice to obtain Chinese medicinal extractive solution;
step two, preparing basic feed raw materials: pulverizing rapeseed meal, fish meal, corn flour, wheat flour and soybean meal, sieving with 80 mesh sieve, and mixing;
the third step: preparing a base feed powder mixture: uniformly mixing monocalcium phosphate, microcrystalline cellulose and the premix, and uniformly mixing the mixture with the basic feed raw material mixture again to obtain a basic feed powder mixture;
the fourth step: gradually adding the Chinese medicinal extract and the mixed powder mixture of the basic feed into the raw materials of the basic feed, and uniformly mixing to obtain a raw material mixture;
the fifth step: slowly adding the soybean oil and the fish oil into the raw material mixture, then adding 10-20% of distilled water, uniformly stirring, processing into granules on a small granulator, drying at 70 ℃, and standing at-20 ℃ for later use to obtain the hard pellet feed.
Has the advantages that: compared with the prior art, the Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of the carassius auratus gibelio and the preparation method thereof adopt the technical scheme, and have the following technical effects:
1. and (3) performing a gradient infection experiment, recording the death rate of the recorder, wherein the result of the death rate of the infection experiment in 14 days shows that the cumulative death rate of the group added with the Chinese herbal medicine compound preparation in the feed is obviously reduced compared with the control group under the condition of virus infection of each concentration.
2. Through crucian experiment, the growth data of the crucian is recorded and compared, the weight gain rate of the Chinese herbal medicine group is nearly 3 times of that of the control group, and the good growth promoting effect of the Chinese herbal medicine compound preparation on the carassius auratus gibelio is shown.
3. Green, environment-friendly and safe immunity-enhanced compound feed.
4. Improving the immunity of the carassius auratus gibelio, thereby improving the disease resistance of the carassius auratus gibelio.
5. The product has low cost and simple preparation method, and is suitable for various crucian varieties.
Description of the drawings:
fig. 1 is a graph of cumulative mortality.
Detailed Description
Example 1:
the Chinese herbal medicine compound preparation for preventing and treating the carassius auratus gibelio bleeding disease comprises the following raw materials in parts by mass: 12 parts of rapeseed meal, 1 part of fish meal, 2 parts of soybean oil, 1 part of corn flour, 1 part of premix, 1 part of monocalcium phosphate, 8 parts of microcrystalline cellulose, 15 parts of wheat flour, 2 parts of fish oil, 26 parts of soybean meal and 1 part of Chinese herbal medicine leachate.
The premix is a mineral and vitamin premix, wherein the premix comprises 5500IU of magnesium sulfate, 4g of cobalt chloride, 3g of manganese sulfate, 8g of aluminum chloride, 7g of potassium iodide, 140g of zinc sulfate, 150g of ferric citrate, 0.6g of sodium selenite, 15000IU of monocalcium phosphate, 4000IU of potassium chloride, 8g of copper sulfate, 5mg of biotin, 200mg of inositol, 150mg of vitamin B, 220 mg of vitamin B, 650mg of vitamin B, 120.1mg of vitamin B, 250IU of nicotinic acid, 50mg of pantothenic acid, 15mg of folic acid, 5000IU of vitamin A, 400mg of vitamin C, 32000 IU of vitamin D, 400mg of vitamin E and 340 mg of vitamin K340.
The Chinese herbal medicine leachate is prepared by soaking Chinese herbal medicines and water for 1h, then decocting with strong fire for 0.5h, and repeating twice to obtain the Chinese herbal medicine leachate.
The Chinese herbal medicine comprises the following components, by mass, 18.5 parts of houttuynia cordata, 18.5 parts of astragalus membranaceus, 12 parts of honeysuckle, 12 parts of medlar, 12 parts of isatis root, 12 parts of fructus forsythiae and 12 parts of golden cypress.
A preparation method of a Chinese herbal medicine compound preparation for preventing and treating carassius auratus gibelio bleeding disease comprises the following steps:
the first step is as follows: soaking the Chinese medicinal materials in water for 1 hr, decocting with strong fire for 0.5 hr, and repeating twice to obtain Chinese medicinal extractive solution;
step two, preparing basic feed raw materials: pulverizing rapeseed meal, fish meal, corn flour, wheat flour and soybean meal, sieving with 80 mesh sieve, and mixing;
the third step: preparing a base feed powder mixture: uniformly mixing monocalcium phosphate, microcrystalline cellulose and the premix, and uniformly mixing the mixture with the basic feed raw material mixture again to obtain a basic feed powder mixture;
the fourth step: gradually adding the Chinese medicinal extract and the mixed powder mixture of the basic feed into the raw materials of the basic feed, and uniformly mixing to obtain a raw material mixture;
the fifth step: slowly adding the soybean oil and the fish oil into the raw material mixture, then adding 10-20% of distilled water, uniformly stirring, processing into granules on a small granulator, drying at 70 ℃, and standing at-20 ℃ for later use to obtain the hard pellet feed.
Example 2
The Chinese herbal medicine compound preparation for preventing and treating the carassius auratus gibelio bleeding disease comprises the following raw materials in parts by mass: 16 parts of rapeseed meal, 14 parts of fish meal, 6 parts of soybean oil, 7 parts of corn flour, 3 parts of premix, 3 parts of monocalcium phosphate, 12 parts of microcrystalline cellulose, 19 parts of wheat flour, 6 parts of fish oil, 30 parts of soybean meal and 3 parts of Chinese herbal medicine leachate.
The premix is a mineral and vitamin premix, wherein the premix comprises 5500IU of magnesium sulfate, 4g of cobalt chloride, 3g of manganese sulfate, 8g of aluminum chloride, 7g of potassium iodide, 140g of zinc sulfate, 150g of ferric citrate, 0.6g of sodium selenite, 15000IU of monocalcium phosphate, 4000IU of potassium chloride, 8g of copper sulfate, 5mg of biotin, 200mg of inositol, 150mg of vitamin B, 220 mg of vitamin B, 650mg of vitamin B, 120.1mg of vitamin B, 250IU of nicotinic acid, 50mg of pantothenic acid, 15mg of folic acid, 5000IU of vitamin A, 400mg of vitamin C, 32000 IU of vitamin D, 400mg of vitamin E and 340 of vitamin K340 mg.
The Chinese herbal medicine leachate is prepared by soaking Chinese herbal medicines and water for 1h, then decocting with strong fire for 0.5h, and repeating twice to obtain the Chinese herbal medicine leachate.
The Chinese herbal medicine comprises the following components, by mass, 19 parts of houttuynia cordata, 19 parts of astragalus membranaceus, 13 parts of honeysuckle, 13 parts of medlar, 13 parts of isatis root, 13 parts of fructus forsythiae and 13 parts of golden cypress.
A preparation method of a Chinese herbal medicine compound preparation for preventing and treating carassius auratus gibelio bleeding disease comprises the following steps:
the first step is as follows: soaking the Chinese medicinal materials in water for 1 hr, decocting with strong fire for 0.5 hr, and repeating twice to obtain Chinese medicinal extractive solution;
step two, preparing basic feed raw materials: pulverizing rapeseed meal, fish meal, corn flour, wheat flour and soybean meal, sieving with 80 mesh sieve, and mixing;
the third step: preparing a base feed powder mixture: uniformly mixing monocalcium phosphate, microcrystalline cellulose and the premix, and uniformly mixing the mixture with the basic feed raw material mixture again to obtain a basic feed powder mixture;
the fourth step: gradually adding the Chinese medicinal extract and the mixed powder mixture of the basic feed into the raw materials of the basic feed, and uniformly mixing to obtain a raw material mixture;
the fifth step: slowly adding the soybean oil and the fish oil into the raw material mixture, then adding 10-20% of distilled water, uniformly stirring, processing into granules on a small granulator, drying at 70 ℃, and standing at-20 ℃ for later use to obtain the hard pellet feed.
Example 3
The Chinese herbal medicine compound preparation for preventing and treating the carassius auratus gibelio bleeding disease comprises the following raw materials in parts by mass: 14 parts of rapeseed meal, 12 parts of fish meal, 4 parts of soybean oil, 5 parts of corn flour, 2 parts of premix, 2 parts of monocalcium phosphate, 10 parts of microcrystalline cellulose, 17 parts of wheat flour, 4 parts of fish oil, 28 parts of soybean meal and 2 parts of Chinese herbal medicine leachate.
The premix is a mineral and vitamin premix, wherein the premix comprises 5500IU of magnesium sulfate, 4g of cobalt chloride, 3g of manganese sulfate, 8g of aluminum chloride, 7g of potassium iodide, 140g of zinc sulfate, 150g of ferric citrate, 0.6g of sodium selenite, 15000IU of monocalcium phosphate, 4000IU of potassium chloride, 8g of copper sulfate, 5mg of biotin, 200mg of inositol, 150mg of vitamin B, 220 mg of vitamin B, 650mg of vitamin B, 120.1mg of vitamin B, 250IU of nicotinic acid, 50mg of pantothenic acid, 15mg of folic acid, 5000IU of vitamin A, 400mg of vitamin C, 32000 IU of vitamin D, 400mg of vitamin E and 340 of vitamin K340 mg.
The Chinese herbal medicine leachate is prepared by soaking Chinese herbal medicines and water for 1h, then decocting with strong fire for 0.5h, and repeating twice to obtain the Chinese herbal medicine leachate.
The Chinese herbal medicine comprises the following components, by mass, 18.75 parts of houttuynia cordata, 18.75 parts of astragalus membranaceus, 12.5 parts of honeysuckle, 12.5 parts of medlar, 12.5 parts of isatis root, 12.5 parts of fructus forsythiae and 12.5 parts of golden cypress.
A preparation method of a Chinese herbal medicine compound preparation for preventing and treating carassius auratus gibelio bleeding disease comprises the following steps:
the first step is as follows: soaking the Chinese medicinal materials in water for 1 hr, decocting with strong fire for 0.5 hr, and repeating twice to obtain Chinese medicinal extractive solution;
step two, preparing basic feed raw materials: pulverizing rapeseed meal, fish meal, corn flour, wheat flour and soybean meal, sieving with 80 mesh sieve, and mixing;
the third step: preparing a base feed powder mixture: uniformly mixing monocalcium phosphate, microcrystalline cellulose and the premix, and uniformly mixing the mixture with the basic feed raw material mixture again to obtain a basic feed powder mixture;
the fourth step: gradually adding the Chinese medicinal extract and the mixed powder mixture of the basic feed into the raw materials of the basic feed, and uniformly mixing to obtain a raw material mixture;
the fifth step: slowly adding the soybean oil and the fish oil into the raw material mixture, then adding 10-20% of distilled water, uniformly stirring, processing into granules on a small granulator, drying at 70 ℃, and standing at-20 ℃ for later use to obtain the hard pellet feed.
As shown in fig. 1, a gradient infection experiment was performed to record the mortality rate, and from the mortality rate results of the 14-day infection experiment, the cumulative mortality rate of the group added with the herbal compound preparation in the feed was significantly reduced compared to the control group at each concentration of virus infection.
The data in table 1 are from breeding experiments, the concentrations of the Chinese herbal medicines for feeding are consistent, the feeds of the control group are also consistent, the experiment mentioned in the figure 1 is an artificial infection experiment for evaluating the effect of the Chinese herbal medicine compound preparation, the artificial virus injection is carried out on the fish bred for one month, the fish bred is divided into three groups of high concentration, medium concentration and low concentration, the injected virus is the cyprinus carpio herpetiformis type II virus, the cyprinus carpio koidz virus is a virus which is widely possibly diseased and has the high concentration of 4.5 multiplied by 10 and is a crucian breeding carp, and the high concentration is 4.5 multiplied by 108Copies/Fish (copy number/Fish) medium concentration of 4.5X 107Copies/Fish, low concentration 4.5X 1096Copies/Fish (copy number/Fish).
The growth data table is shown in table 1:
TABLE 1
As shown in table 1, the weight gain rate of the Chinese herbal medicine group is nearly 3 times that of the control group, and the compound Chinese herbal medicine preparation shows good growth promoting effect on carassius auratus gibelio.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (7)
1. A Chinese herbal medicine compound preparation for preventing and treating gill hemorrhage of carassius auratus gibelio is characterized in that: the Chinese herbal medicine compound preparation for preventing and treating the gibelism of the carassius auratus gibelio is prepared from the following raw materials in parts by mass: 12-16 parts of rapeseed meal, 10-14 parts of fish meal, 2-6 parts of soybean oil, 3-7 parts of corn flour, 1-3 parts of premix, 1-3 parts of monocalcium phosphate, 8-12 parts of microcrystalline cellulose, 15-19 parts of wheat flour, 2-6 parts of fish oil, 26-30 parts of soybean meal and 1-3 parts of Chinese herbal medicine leachate.
2. The Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio according to claim 1, which is characterized in that: the Chinese herbal medicine compound preparation for preventing and treating the gibelism of the carassius auratus gibelio is prepared from the following raw materials in parts by mass: 14 parts of rapeseed meal, 12 parts of fish meal, 4 parts of soybean oil, 5 parts of corn flour, 2 parts of premix, 2 parts of monocalcium phosphate, 10 parts of microcrystalline cellulose, 17 parts of wheat flour, 4 parts of fish oil, 28 parts of soybean meal and 2 parts of Chinese herbal medicine leachate.
3. The Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio according to claim 1, which is characterized in that: the premix is a mineral and vitamin premix, wherein 5500IU of magnesium sulfate, 4g of cobalt chloride, 3g of manganese sulfate, 8g of aluminum chloride, 7g of potassium iodide, 140g of zinc sulfate, 150g of ferric citrate, 0.6g of sodium selenite, 15000IU of calcium dihydrogen phosphate, 4000IU of potassium chloride, 8g of copper sulfate, 5mg of biotin, 200mg of inositol, 150mg of vitamin B, 220 mg of vitamin B, 650mg of vitamin B, 120.1 mg of vitamin B, 250IU of nicotinic acid, 50mg of pantothenic acid, 15mg of folic acid, 5000IU of vitamin A, 400mg of vitamin C, 32000 IU of vitamin D, 400mg of vitamin E and 340 mg of vitamin K.
4. The Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio according to claim 1, which is characterized in that: the Chinese herbal medicine leachate is prepared by soaking Chinese herbal medicines and water for 1h, then decocting with strong fire for 0.5h, and repeating twice to obtain the Chinese herbal medicine leachate.
5. The Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio according to claim 4, which is characterized in that: the Chinese herbal medicine comprises the following components, by mass, 18.5-19 parts of houttuynia cordata, 18.5-19 parts of astragalus membranaceus, 12-13 parts of honeysuckle, 12-13 parts of medlar, 12-13 parts of isatis root, 12-13 parts of fructus forsythiae and 12-13 parts of golden cypress.
6. The Chinese herbal medicine compound preparation for preventing and treating the gill hemorrhage of carassius auratus gibelio according to claim 5, which is characterized in that: the Chinese herbal medicine comprises the following components, by mass, 18.75 parts of houttuynia cordata, 18.75 parts of astragalus membranaceus, 12.5 parts of honeysuckle, 12.5 parts of medlar, 12.5 parts of isatis root, 12.5 parts of fructus forsythiae and 12.5 parts of golden cypress.
7. A preparation method of the Chinese herbal medicine compound preparation for preventing and treating the carassius auratus gibelio hemorrhagic disease as claimed in any one of claims 1 to 6, comprises the following steps:
the first step is as follows: soaking the Chinese medicinal materials in water for 1 hr, decocting with strong fire for 0.5 hr, and repeating twice to obtain Chinese medicinal extractive solution;
step two, preparing basic feed raw materials: pulverizing rapeseed meal, fish meal, corn flour, wheat flour and soybean meal, sieving with 80 mesh sieve, and mixing;
the third step: preparing a base feed powder mixture: uniformly mixing monocalcium phosphate, microcrystalline cellulose and the premix, and uniformly mixing the mixture with the basic feed raw material mixture again to obtain a basic feed powder mixture;
the fourth step: gradually adding the Chinese medicinal extract and the mixed powder mixture of the basic feed into the raw materials of the basic feed, and uniformly mixing to obtain a raw material mixture;
the fifth step: slowly adding the soybean oil and the fish oil into the raw material mixture, then adding 10-20% of distilled water, uniformly stirring, processing into granules on a small granulator, drying at 70 ℃, and standing at-20 ℃ for later use to obtain the hard pellet feed.
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| CN102018142A (en) * | 2010-11-21 | 2011-04-20 | 盐城恒兴饲料有限公司 | Carassius aurutus gibelio compound feed and preparation method thereof |
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